Translational Research

Article	Citations
Information for Readers	446
Information for Readers	129
Editorial Advisory Board	120
Author Guidelines	111
Contents	103
Contents	95
Editorial Advisory Board	89
Information for Readers	86
Contents	86
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	73
Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients	72
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	67
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	51
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	51
Contents	50
Author Guidelines	50
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	50
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	49
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	48
Clonal hematopoiesis and bone marrow inflammation	47
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	46
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	46
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	45
Diabetic wound healing in soft and hard oral tissues	43
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	43

Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	41
Masthead	41
Author Guidelines	41
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	39
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	39
Contents	39
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	38
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	37
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	35
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	33
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	31
COVID-19 Survival and its impact on chronic kidney disease	30
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	30
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	30
Kidney organoids: a pioneering model for kidney diseases	28
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	28
Information for Readers	26
Understanding the adipose tissue acetylome in obesity and insulin resistance	26
Post-COVID-19 patients show an increased endothelial progenitor cell production	26
Masthead	25
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	25
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes	25
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	25
Masthead	25
Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery	25
Information for Readers	24
Contents	24
Editorial Advisory Board	24
Contents	23
Editorial Advisory Board	23
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	23
Editorial Advisory Board	23
Contents	23
Information for Readers	23
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	22
Contents	22
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	22
Editorial Advisory Board	22
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	21
Information for Readers	21
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	21
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	21
Information for Readers	21
Author Guidelines	21
Masthead	21
Masthead	21
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	20
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	20
Catalytic iron mediated renal stress responses during experimental cardiorenal syndrome 1 (“CRS-1”)	20
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	20

Author Guidelines	19
Contents	19
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	19
Masthead	18
Author Guidelines	18
Contents	18
Contents	18
Contents	18
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	18
Masthead	18
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling	17
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	17
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	17
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	17
Corrected cerebral blood flow and reduced cerebral inflammation in berk sickle mice with higher fetal hemoglobin	17
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	17
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	17
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	17
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities	17
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	17
Author Guidelines	16
Contents	16
Contents	16
Editorial Advisory Board	16
Contents	16
Influence of immunomodulatory drugs on the gut microbiota	16
Information for Readers	16
Contents	16
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	15
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	15
Contents	15
Intranasal application of adeno-associated viruses: a systematic review	15
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	15
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	15
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	15
Contents	14
Contents	14
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	14
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	14
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	14
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	14
Information for Readers	14
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	14
Masthead	14
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	14
Contents	14
Contents	14
Author Guidelines	14
Serum metabolomic analysis reveals several novel metabolites in association with excessive alcohol use – an exploratory study	14
Contents	13
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	13
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	13
Editorial Advisory Board	13
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	13
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	12
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	12
Masthead	12
Masthead	12
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	12
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	12
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	12
Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation	12
Information for Readers	12
Information for Readers	12
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	12
Contents	12
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	12
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	11
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	11
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	11
Contents	11
Editorial Advisory Board	11
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	11
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	11
Topical captopril: a promising treatment for secondary lymphedema	11
Masthead	11
Masthead	11
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	11
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	11
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	11

Information for Readers	11
Contents	11
Author Guidelines	11
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	11
Editorial Advisory Board	10
Editorial Advisory Board	10
Contents	10
Extra-nuclear TERT counteracts oxidative stress and promotes progression in papillary thyroid carcinoma	10
Masthead	10
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	10
Masthead	10
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	10
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	10
Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells	10
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	10
Brain mechanisms of chronic pain: critical role of translational approach	10
Masthead	10
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets	9
Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	9
Gene therapy for bone healing: lessons learned and new approaches	9
Editorial Advisory Board	9
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease	9
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta	9
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	9
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	9
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	9
Masthead	9
J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway	9
Caspase-12 exhibits non-redundant functions in response to endoplasmic reticulum stress to promote GSDMD-mediated NETosis, leading to thoracic aortic dissection	9
Information for Readers	9
Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism	9
Gender-sex differences in autoimmune atrophic gastritis	9
Appreciation to reviewers	9
Editorial Advisory Board	9
Clonal hematopoiesis of indeterminate potential and cardiovascular disease	8
Mechanism of adipose-derived stem cell-derived extracellular vesicles affecting macrophage efferocytosis by mediating ADAM17/MerTK in the apoptosis of tubular epithelial cells after sepsis-associated	8
Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF	8
Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage	8
Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation	8
Infectious agents in the pathogenesis of autoimmune rheumatic diseases	8
Contents	8
The proteasome activator REGγ promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway	8
Development of oncolytic viruses for cancer therapy	8
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling	8
Contents	8
Immune cell distribution and DNA methylation signatures differ between tumor and stroma enriched compartment in pancreatic ductal adenocarcinoma	8
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models	7
Author Guidelines	7
Information for Readers	7
Alteration of grey matter volume is associated with pain and quality of life in children with sickle cell disease	7
Central nervous system outcomes of COVID-19	7
Editorial Advisory Board	7
Contents	7
Contents	7
Lympho-myeloid aggregate-infiltrating CD20+ B cells display a double-negative phenotype and correlate with poor prognosis in esophageal squamous cell carcinoma	7
Information for Readers	7
Contents	7
Contents	7
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease	7
Aldosterone suppresses cardiac mitochondria	7
Author Guidelines	7
Inflammasome signaling in colorectal cancer	6
Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature	6
Information for Readers	6
Editorial Advisory Board	6
Corrigendum to Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer [Translational Research 231C (202	6
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease	6
Author Guidelines	6
Information for Readers	6
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis	6
Editorial Advisory Board	6
Editorial Advisory Board	6
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI	6
Metabolic signatures in pericardial fluid and serum are associated with new-onset atrial fibrillation after isolated coronary artery bypass grafting	6
Messenger ribonucleic acid vaccines for severe acute respiratory syndrome coronavirus-2 – a review	6
Masthead	6
Contents	6
Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation	6
Masthead	6
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics	6
Editorial Advisory Board	6
Epigenetically-regulated miR-30a/c-5p directly target TWF1 and hamper ccRCC cell aggressiveness	6
Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury	6
Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice	5
Contents	5
Author Guidelines	5
Contents	5
Author Guidelines	5
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis	5
Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy	5
Information for Readers	5
PCSK9 inhibition protects mice from food allergy	5
Author Guidelines	5
Apolipoprotein A1-encoding recombinant adenovirus remodels cholesterol metabolism in tumors and the tumor microenvironment to inhibit hepatocellular carcinoma	5
Masthead	5