Translational Research

Article	Citations
Information for Readers	453
Information for Readers	133
Editorial Advisory Board	128
Author Guidelines	111
Contents	103
Contents	96
Information for Readers	95
Editorial Advisory Board	95
Contents	86
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	76
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	73
Author Guidelines	69
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human	53
Contents	53
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	52
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	51
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	50
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	50
Clonal hematopoiesis and bone marrow inflammation	49
Diabetic wound healing in soft and hard oral tissues	49
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	48
Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial	46
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	45
Author Guidelines	43
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	43

Masthead	42
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	41
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	41
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	40
Contents	40
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir	39
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	34
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	33
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	31
Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises	31
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	30
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	30
Understanding the adipose tissue acetylome in obesity and insulin resistance	29
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	27
COVID-19 Survival and its impact on chronic kidney disease	27
Post-COVID-19 patients show an increased endothelial progenitor cell production	26
Kidney organoids: a pioneering model for kidney diseases	26
Information for Readers	26
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	26
Masthead	25
Contents	25
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	25
Masthead	25
Editorial Advisory Board	25
Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery	25
Information for Readers	25
Editorial Advisory Board	24
Editorial Advisory Board	24
Information for Readers	24
Contents	23
Editorial Advisory Board	23
Contents	23
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes	22
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	22
Masthead	22
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection	22
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19	22
Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes	22
Contents	22
Masthead	21
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	21
Information for Readers	21
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	21
Information for Readers	21
Author Guidelines	20
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	20
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	20
Author Guidelines	19
Repurposing gestrinone for tumor suppressor through P21 reduction regulated by JNK in gynecological cancer	19
Contents	19

Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	19
Catalytic iron mediated renal stress responses during experimental cardiorenal syndrome 1 (“CRS-1”)	19
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	19
Masthead	18
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	18
Contents	18
Masthead	18
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	18
Contents	18
Author Guidelines	18
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?	18
In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure	17
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	17
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	17
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	17
Contents	17
At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities	17
Corrected cerebral blood flow and reduced cerebral inflammation in berk sickle mice with higher fetal hemoglobin	17
Editorial Advisory Board	16
Contents	16
Contents	16
Contents	16
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	16
Author Guidelines	16
Information for Readers	16
Contents	15
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	15
Intranasal application of adeno-associated viruses: a systematic review	15
Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study	15
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	15
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury	15
Contents	15
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	15
Contents	14
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	14
Serum metabolomic analysis reveals several novel metabolites in association with excessive alcohol use – an exploratory study	14
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	14
Author Guidelines	14
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	14
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	14
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	14
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	14
Masthead	14
Information for Readers	13
Contents	13
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	13
Contents	13
Editorial Advisory Board	13
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	13
Contents	13
Contents	13
Information for Readers	13
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	12
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	12
Information for Readers	12
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	12
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	12
Platelet bound B cells and their role in SSc: Implications for disease subtypes and clinical outcomes	12
Masthead	12
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	12
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	12
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	12
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	12
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	11
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	11
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	11
Topical captopril: a promising treatment for secondary lymphedema	11
Masthead	11
Author Guidelines	11
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	11
Altered KCa3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation	11
Information for Readers	11
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	11
Contents	11
Contents	11
Editorial Advisory Board	11
Contents	11
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling	11
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	11
Masthead	11

Masthead	11
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	10
Editorial Advisory Board	10
Masthead	10
Editorial Advisory Board	10
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	10
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	10
Masthead	10
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis	10
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	10
Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells	10
Contents	10
Masthead	10
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials	9
Appreciation to reviewers	9
Editorial Advisory Board	9
Gene therapy for bone healing: lessons learned and new approaches	9
Extra-nuclear TERT counteracts oxidative stress and promotes progression in papillary thyroid carcinoma	9
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	9
Editorial Advisory Board	9
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease	9
Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	9
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	9
Gender-sex differences in autoimmune atrophic gastritis	9
Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism	9
Information for Readers	9
J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway	9
Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets	9
Brain mechanisms of chronic pain: critical role of translational approach	9