Translational Research

Article	Citations
Information for Readers	155
Contents	133
Author Guidelines	82
Contents	78
Information for Readers	71
Information for Readers	64
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation	62
Editorial Advisory Board	62
Kv1.3 expression on CD4 (+) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma	56
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine	51
Unveiling the molecular mechanisms of hemorrhagic shock and acute lung injury: An integrative RNA-Seq and network analysis	48
The biomimetic extracellular matrix: a therapeutic tool for breast cancer research	48
Polymerized human hemoglobin with low and high oxygen affinity in trauma models	45
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I	43
ALKBH5 as a therapeutic target for hypertension: Inhibiting vascular smooth muscle cell phenotypic switch via the TEAD3/PDZK1 axis	41
An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy	40
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration	40
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease	39
Masthead	38
Clonal hematopoiesis and bone marrow inflammation	38
Masthead	36
Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation	35
Understanding the adipose tissue acetylome in obesity and insulin resistance	35
Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition	34
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction	34

Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts	33
Canagliflozin inhibits hedgehog interacting protein (Hhip) induction of tubulopathy in diabetic Akita mice	32
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway	32
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway	31
Kidney organoids: a pioneering model for kidney diseases	31
Information for Readers	30
Unlocking the future of cancer diagnosis – promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer	30
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis	30
STIM1 deletion in regulatory T cells restores redox balance and protects against hypertension-induced cardiovascular complications	29
Masthead	29
Editorial Advisory Board	29
Reassessment of mitochondrial cyclophilin D as a target for improving cardiac arrest outcomes in the era of therapeutic hypothermia	28
Editorial Advisory Board	27
Editorial Advisory Board	27
Contents	27
Information for Readers	27
Editorial Advisory Board	27
Contents	27
Contents	26
Masthead	26
FAK-TRIM25 promotes HSC activation and glycolysis by inhibiting c-Myc ubiquitination via FBXW7	25
Angiogenic and reparative potency of a human cardiac CD90− mesenchymal subpopulation in heart ischemic model	25
Contents	25
Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development	25
Editorial Advisory Board	25
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes	24
Contents	24
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction	24
Editorial Advisory Board	24
Next-generation CAR-T cell engineering by Chinese scientists: Structural innovation, tumor microenvironment remodeling, and clinical translation	24
Contents	23
Information for Readers	23
Author Guidelines	23
Masthead	23
Contents	22
Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine	22
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas	22
Contents	22
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis	22
Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β signaling in head and neck squamous cell carcinoma	22
Information for Readers	22
Author Guidelines	22
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype	22
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice	22
Author Guidelines	22
Contents	21
Effectiveness of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid for predicting metachronous peritoneal metastasis of gastric cancer	21
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis	21
Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors	21
Masthead	21

Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma	21
Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders	20
Contents	19
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment	19
Artificial intelligence-assisted proteomic signatures for discriminating malignant from benign pulmonary nodules	19
Spatial proteomics and transcriptomics of the maternal-fetal interface in placenta accreta spectrum	19
Intranasal application of adeno-associated viruses: a systematic review	18
Masthead	18
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring	18
Author Guidelines	18
Information for Readers	18
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations	18
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis	18
Inhibiting CCR3 expands cancer stem cells via c-Myc–NTSR1 axis and associates with tumor innervation features	18
Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers	18
Contents	17
Author Guidelines	17
Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment	17
Editorial Advisory Board	17
Contents	17
Emerging evidence on the role of clonal hematopoiesis of indeterminate potential in chronic kidney disease	17
Contents	17
Information for Readers	17
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1	16
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease	16
TSG-6 exacerbates myocardial ischemia-reperfusion injury by activating NLRP3 inflammasome and regulating macrophage polarization	16
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics	16
Contents	15
Information for Readers	15
Contents	15
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions	15
Platelet bound B cells and their role in SSc: Implications for disease subtypes and clinical outcomes	15
Contents	15
Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response	15
Contents	15
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma	14
DUSP5 deficiency suppresses the progression of acute kidney injury by enhancing autophagy through AMPK/ULK1 pathway	14
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury	14
Genome-wide characterization of extrachromosomal circular DNA in SLE and functional analysis reveal their association with apoptosis	14
Trimethylamine N-oxide exacerbates myocardial ischemia-reperfusion injury by sustaining PERK/eIF2α activation and impairing ferredoxin reductase-dependent mitochondrial function	14
Trehalose-driven TFEB Activation Reprograms Immunosuppressive Macrophages in Glioblastoma	14
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression	14
Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs	14
SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway	14
Information for Readers	14
Masthead	13
Masthead	13
Masthead	13
Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-dependent sFRP2-ATF6-NF-κB pathway	13
Author Guidelines	13
Information for Readers	13
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein	13
Masthead	13
Contents	13
Contents	13
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling	12
Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration	12
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway	12
Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant	12
Bronchoscopy-guided synergistic pulsed irreversible electroporation ablation as a novel intervention therapy for lung lesions: A pilot study in a preclinical model	12
Topical captopril: a promising treatment for secondary lymphedema	12
High-concentration estradiol promotes platelet activation and thrombosis through Src-ADP axis	12
Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research	12
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner	11
Masthead	11
Editorial Advisory Board	11
Masthead	11
Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS	11
IgG from anti-MDA5⁺ CADM patients impairs NK cell function via CD16 in RP-ILD	11
Editorial Advisory Board	11
Single-cell RNA sequencing in the context of neuropathic pain: progress, challenges, and prospects	11
Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury	11
Contents	11
Contents	11
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful	10
The key role of cellular plasticity in the development of colorectal cancer	10
Contents	10
Unraveling PANoptosis a key player in acute kidney injury and its clinical implications	10
Extra-nuclear TERT counteracts oxidative stress and promotes progression in papillary thyroid carcinoma	10
Masthead	10

Progesterone receptor impairs immune respond and down-regulates sensitivity to anti-LAG3 in breast cancer	10
Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism	10
Gender-sex differences in autoimmune atrophic gastritis	10
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B	10