Mucosal Immunology

Article	Citations
Editorial Board	243
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	192
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	171
Editorial Board	153
Memorial for Nils Lycke	151
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	109
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	99
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	91
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	88
Role of the humoral immune response during COVID-19: guilty or not guilty?	87
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	80
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	78
α4β7 expression guides B cells to front lines of defense in the gut	76
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	72
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	67
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	63
The fellowship of regulatory and tissue-resident memory cells	60
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	56
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	55
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	55
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	55
Microbial regulation of intestinal motility provides resistance against helminth infection	53
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	52
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	51
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	50

“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	50
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	46
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	45
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	43
Tissue resident memory T cells in the respiratory tract	41
Organismal mucosal immunology: A perspective through the eyes of game theory	40
Microbial antigen in human milk: a natural vaccine?	40
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	40
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	39
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	39
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	38
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	37
NOD1 signaling regulates early tissue inflammation during helminth infection	35
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	35
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	34
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	34
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	34
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	33
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	32
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	32
Chronological maturation of the skin immune barrier is topographically different	32
Mast cells disrupt the function of the esophageal epithelial barrier	32
Impaired neutrophil migration underpins host susceptibility to infectious colitis	31
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity	31
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	31
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	29
Airway epithelial cells as drivers of severe asthma pathogenesis	29
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	28
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	28
The gut-liver axis modulates intestinal immune homeostasis	28
Ileal mucus viscoelastic properties differ in Crohn’s disease	27
Editorial Board	27
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	26
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	26
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	25
Role of IL-10 signaling in the circadian control of host response to influenza infection	25
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	25
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	25
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	25
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	24
TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages	24
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	24
Dynamics of virus-specific CD8+ T cells in the human nasal cavity	24
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	23
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	23
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	23
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	23
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	22
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	22
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	22

Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages	22
Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection	22
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	22
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	22
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury	21
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	21
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	21
M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps	21
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	21
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	21
Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells	20
Seminal fluid expands the uterine gamma/delta T cell pool during early pregnancy in mice	20
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	20
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	20
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	20
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	20
Human mucosal tissue-resident memory T cells in health and disease	20
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	20
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	20
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	19
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	19
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	19
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	19
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	19
Editorial Board	18
Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling	18
Shining the spotlight on urinary tract immunology	18
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	18
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	17
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	17
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	17
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	17
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	16
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	16
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	15
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	15
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	15
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	15
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	15
The role of retinoic acid in the production of immunoglobulin A	14
Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction	14
Editorial Board	13
Tissue-specific immunity in helminth infections	13
Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development	13
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	13
How the early life microbiome shapes immune programming in childhood asthma and allergies	13
Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD	13
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	13
Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss	13
KappaBle fluorescent reporter mice enable low-background single-cell detection of NF-κB transcriptional activity in vivo	12
Innate immunity of the gut epithelium: Blowing in the WNT?	12
The impact of biological sex on diseases of the urinary tract	12
Epithelial regulation of microbiota-immune cell dynamics	12
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques	12
ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation	12
Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection	12
Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities	12
Sensory neuroimmune interactions at the barrier	12
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity	11
Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells	11
Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathways	11
Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas	11
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation	11
IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma	11
The IL-33-ILC2 pathway protects from amebic colitis	11
Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1	11
Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections	11
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice	11
Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response	11
Editorial Board	11
Cytochrome P450 Cyp2s1 regulation of the intestinal metabolome and microbiome	11
IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation	11
Editorial Board	11
IFN-γ- GranzymeB + Natural killer cells are induced by IV BCG vaccination and associated with protection against tuberculosis in rhesus macaques	10
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy	10
Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis	10
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling	10
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation	10
Type-I interferons in Vulvovaginal Candidiasis: Mechanism of epithelial early defense and immune regulation against Candida albicans	10
Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α	10

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	10
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution	10
CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity	10
Neuromedin U promotes human type 2 immune responses	10
Antibiotic-induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice	10
Iron-Dependent allergenicity of Alt a 1: A link between fungal nutritional immunity and allergic sensitization	10
IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections	10
Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis	10
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD	10
T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors	10
Colonic macrophage heterogeneity revealed by CD11c and CD163	10
Inflammatory monocyte-derived amphiregulin mediates intestinal fibrosis in Crohn’s disease by activating PI3K/AKT	10
Tear duct M cells exacerbate allergic conjunctivitis by facilitating germinal-center reactions	10
Living on the edge: Mucus-associated microbes in the colon	10
Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection	9
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node	9
Pantothenic acid alleviates endometrial injury induced by vagotomy in mice	9
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection	9
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity	9
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense	9
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8	9
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	9
Interaction of microbiota, mucosal malignancies, and immunotherapy—Mechanistic insights	9
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses	9
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes	9
T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease	8
Correction to: Redefining intestinal immunity with single-cell transcriptomics	8
Placental intervillous blood harbors NK cells with distinct tissue-resident characteristics	8
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization	8
The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection	8
Redefining intestinal immunity with single-cell transcriptomics	8
Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H2O2	8
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	8
MDA5-MAVS and interferon-lambda signaling in the intestinal epithelium limit murine astrovirus infection	8
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines	8
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology	8
Correction to: Trained immunity in type 2 immune responses	8
A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells	8
Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy	8
Erratum to “Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells”. [Mucosal Immunol. 18(5) (2025) 1199–1217]	7
MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation	7
Stem cell factor inhibition reduces Th2 inflammation and cellular infiltration in a mouse model of eosinophilic esophagitis	7
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in na	7
A novel link driving immune cell-fibroblast interactions in intestinal fibrosis	7
Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells	7
Activation status of airway immune cells is a defining feature of severe asthma, regardless of fungal sensitisation	7
Corrigendum to “iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis” [Mucosal Immunol. 16(3) (2023) 326–340	7
A reappraisal of IL-9 in inflammation and cancer	7
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses	7
Microbiome-based interventions to modulate gut ecology and the immune system	7
STAT4 increases the phenotypic and functional heterogeneity of intestinal tissue-resident memory T cells	7
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity	7
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum	7
Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells	7
PAD4 inhibition impacts immune responses in SARS-CoV-2 infection	7
Parasite and host immune factors that impact the development of a mucosal vaccine for Cryptosporidium	7
CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages	7
Activation of the SST-SSTR5 signaling pathway enhances corneal wound healing in diabetic mice	6
High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity	6
Regulation of intestinal immunity by dietary fatty acids	6
Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases	6
Lung microbial-host interface through the lens of multi-omics	6
Dendritic cell functions in the inductive and effector sites of intestinal immunity	6
Understanding the molecular mechanisms of anti-trafficking therapies and their clinical relevance in inflammatory bowel disease	6
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	6
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	6
Mucosal-associated invariant T cells have therapeutic potential against ocular autoimmunity	6
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity	6
Corrigendum to “Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection” [Mucosal. Immun. 17 (2024) 1242–1255]	6
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism	6
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine	6
Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues	6
RSV infection in neonatal mice and gastrointestinal microbiome alteration contribute to allergic predisposition	6
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection	6
Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation	6
Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases	6