Mucosal Immunology

Article	Citations
Editorial Board	217
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	209
Editorial Board	166
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	136
Response to Lauro and Zorzetti	126
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	111
Role of the humoral immune response during COVID-19: guilty or not guilty?	100
Memorial for Nils Lycke	91
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	88
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	74
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	73
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	73
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	72
The fellowship of regulatory and tissue-resident memory cells	72
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	71
α4β7 expression guides B cells to front lines of defense in the gut	67
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	61
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	59
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	58
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	57
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	55
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	53
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	48
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	46
Microbial regulation of intestinal motility provides resistance against helminth infection	45

Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	45
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	44
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	43
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	42
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	42
Tissue resident memory T cells in the respiratory tract	41
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	41
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	40
NOD1 signaling regulates early tissue inflammation during helminth infection	39
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	38
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	38
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	38
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	37
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	36
Organismal mucosal immunology: A perspective through the eyes of game theory	34
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	33
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	33
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	32
Mast cells disrupt the function of the esophageal epithelial barrier	31
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	31
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	31
Impaired neutrophil migration underpins host susceptibility to infectious colitis	30
Microbial antigen in human milk: a natural vaccine?	30
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	30
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	30
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	29
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	29
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	28
Airway epithelial cells as drivers of severe asthma pathogenesis	28
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	27
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	27
Chronological maturation of the skin immune barrier is topographically different	27
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	27
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	27
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	26
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	26
Ileal mucus viscoelastic properties differ in Crohn’s disease	26
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	25
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	25
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	25
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	24
Correction to: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	24
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	24
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	24
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	24
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	23
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	22
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	22
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	22
TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages	22

MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	22
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	22
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	21
Dynamics of virus-specific CD8+ T cells in the human nasal cavity	21
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	21
Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection	21
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	21
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	20
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	20
M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps	19
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	19
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	18
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	18
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	18
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	18
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	18
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	18
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	18
Human mucosal tissue-resident memory T cells in health and disease	18
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	18
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	18
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	18
Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells	17
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	17
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	17
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	17
Editorial Board	17
Shining the spotlight on urinary tract immunology	17
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	17
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	17
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	17
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	16
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	16
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	16
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	16
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	16
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	16
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	16
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	15
How the early life microbiome shapes immune programming in childhood asthma and allergies	15
Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction	15
Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development	15
Tissue-specific immunity in helminth infections	15
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	15
The role of retinoic acid in the production of immunoglobulin A	15
Editorial Board	14
CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone	14
Sensory neuroimmune interactions at the barrier	14
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	14
Innate immunity of the gut epithelium: Blowing in the WNT?	14
Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD	13
Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection	12
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ	12
Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life	12
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques	12
Aiolos: a molecular guardian of type 2 innate immune cell residency and response	12
Epithelial regulation of microbiota-immune cell dynamics	11
The IL-33-ILC2 pathway protects from amebic colitis	11
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity	11
The impact of biological sex on diseases of the urinary tract	11
Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells	11
KappaBle fluorescent reporter mice enable low-background single-cell detection of NF-κB transcriptional activity in vivo	11
Editorial Board	11
Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1	11
Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response	10
IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation	10
IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma	10
Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas	10
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD	10
CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity	10
Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections	10
Editorial Board	10
Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α	10
Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis	10
Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathways	10
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice	10
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution	10
IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections	9
Neuromedin U promotes human type 2 immune responses	9
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection	9

Tear duct M cells exacerbate allergic conjunctivitis by facilitating germinal-center reactions	9
Antibiotic-induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice	9
Interaction of microbiota, mucosal malignancies, and immunotherapy—Mechanistic insights	9
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation	9
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	9
Cellular and functional heterogeneity of the airway epithelium	9
Living on the edge: Mucus-associated microbes in the colon	9
Type-I interferons in Vulvovaginal Candidiasis: Mechanism of epithelial early defense and immune regulation against Candida albicans	9
Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection	9
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation	9
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity	9
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy	9
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	9
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling	9
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes	9
Inflammatory monocyte-derived amphiregulin mediates intestinal fibrosis in Crohn’s disease by activating PI3K/AKT	9
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology	8
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8	8
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	8
Correction to: Redefining intestinal immunity with single-cell transcriptomics	8
The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection	8
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum	8
Candida vaginitis: the importance of mitochondria and type I interferon signalling	8
Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H2O2	8
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense	8
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization	8
A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells	8
Redefining intestinal immunity with single-cell transcriptomics	8
MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation	8
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node	8
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses	8
Correction to: Trained immunity in type 2 immune responses	8
Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy	8
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines	8
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in na	7
Stem cell factor inhibition reduces Th2 inflammation and cellular infiltration in a mouse model of eosinophilic esophagitis	7
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity	7
PAD4 inhibition impacts immune responses in SARS-CoV-2 infection	7
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium	7
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses	7
Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells	6
Response to: “Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease”	6
Intestinal immunoregulation: lessons from human mendelian diseases	6
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity	6
Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells	6
Microbiome-based interventions to modulate gut ecology and the immune system	6
A novel link driving immune cell-fibroblast interactions in intestinal fibrosis	6
CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages	6
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine	6
A reappraisal of IL-9 in inflammation and cancer	6
STAT4 increases the phenotypic and functional heterogeneity of intestinal tissue-resident memory T cells	6
Dendritic cell functions in the inductive and effector sites of intestinal immunity	6
Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation	6
Parasite and host immune factors that impact the development of a mucosal vaccine for Cryptosporidium	6
Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease	5
Exposure to environmental microbiota may modulate gut microbial ecology and the immune system	5
The urothelium: a multi-faceted barrier against a harsh environment	5
Local antigen encounter promotes generation of tissue-resident memory T cells in the large intestine	5
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation	5
Regulation of tissue-resident memory T cells by the Microbiota	5
High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity	5
Regulation of intestinal immunity by dietary fatty acids	5
Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases	5
Local complement activation and modulation in mucosal immunity	5
Diabetes impairs IFNγ-dependent antibacterial defense in the lungs	5
Innate immunity of the lungs in homeostasis and disease	5
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	5
Activation of the SST-SSTR5 signaling pathway enhances corneal wound healing in diabetic mice	5
Mucosal-associated invariant T cells have therapeutic potential against ocular autoimmunity	5
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection	5
Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases	5
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism	5
Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses	5
Editorial Board	5
A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection	5
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	5
Understanding the molecular mechanisms of anti-trafficking therapies and their clinical relevance in inflammatory bowel disease	5
Skin immunity: dissecting the complex biology of our body's outer barrier	5
RSV infection in neonatal mice and gastrointestinal microbiome alteration contribute to allergic predisposition	5
Atopic dermatitis and food allergy: More than sensitization	5
Lung microbial-host interface through the lens of multi-omics	5