Mucosal Immunology

Article	Citations
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	258
Editorial Board	215
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	199
Editorial Board	156
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	127
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	110
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	104
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	97
Response to Lauro and Zorzetti	93
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	91
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	84
Role of the humoral immune response during COVID-19: guilty or not guilty?	82
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	70
Memorial for Nils Lycke	70
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	66
α4β7 expression guides B cells to front lines of defense in the gut	66
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	65
The fellowship of regulatory and tissue-resident memory cells	64
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	62
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	59
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	57
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	54
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	54
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	52
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	51

Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	50
Microbial regulation of intestinal motility provides resistance against helminth infection	46
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	44
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	44
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	44
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	42
Tissue resident memory T cells in the respiratory tract	41
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	40
NOD1 signaling regulates early tissue inflammation during helminth infection	39
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	38
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	38
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	38
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	37
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	37
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	36
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	36
Organismal mucosal immunology: A perspective through the eyes of game theory	34
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	34
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	33
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	32
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	31
Microbial antigen in human milk: a natural vaccine?	31
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	31
Mast cells disrupt the function of the esophageal epithelial barrier	31
Airway epithelial cells as drivers of severe asthma pathogenesis	30
Chronological maturation of the skin immune barrier is topographically different	30
Impaired neutrophil migration underpins host susceptibility to infectious colitis	29
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	28
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	28
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	27
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	27
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	26
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	26
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	26
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	26
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	25
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	25
Ileal mucus viscoelastic properties differ in Crohn’s disease	25
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	25
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	25
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	24
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	24
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	24
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	24
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	23
Correction to: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	23
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	23
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	23
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	23
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	23

Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	22
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	22
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	22
Human mucosal tissue-resident memory T cells in health and disease	21
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	21
CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation	21
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	21
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	21
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	20
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	20
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	20
Notch-activated basophils support intestinal CD4+ T cell fate and function during helminth infection	20
Neutrophils in respiratory viral infections	20
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	20
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	19
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	19
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	18
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	18
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	18
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	18
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	18
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	18
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	18
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	18
Editorial Board	18
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	17
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	17
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	17
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	16
Shining the spotlight on urinary tract immunology	16
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	16
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	16
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	16
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	16
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	16
How the early life microbiome shapes immune programming in childhood asthma and allergies	16
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	16
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	16
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	15
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	15
Editorial Board	15
Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development	15
The role of retinoic acid in the production of immunoglobulin A	15
CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone	15
The human memory T cell compartment changes across tissues of the female reproductive tract	15
Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD	15
Tissue-specific immunity in helminth infections	15
KappaBle fluorescent reporter mice enable low-background single-cell detection of NF-κB transcriptional activity in vivo	14
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ	14
The impact of biological sex on diseases of the urinary tract	14
Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life	14
Aiolos: a molecular guardian of type 2 innate immune cell residency and response	14
Epithelial regulation of microbiota-immune cell dynamics	14
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques	14
Sensory neuroimmune interactions at the barrier	14
Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1	13
Editorial Board	13
Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections	13
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity	13
IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation	13
The IL-33-ILC2 pathway protects from amebic colitis	13
Editorial Board	12
IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma	12
Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells	12
Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathways	12
Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response	11
Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas	11
Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α	11
Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis	11
Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution	11
CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity	11
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity	10
Obesity-induced hyperglycemia impairs oral tolerance induction and aggravates food allergy	10
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation	10
Living on the edge: Mucus-associated microbes in the colon	10
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD	10
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice	10
Antibiotic-induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice	10
Cellular and functional heterogeneity of the airway epithelium	10
Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation	10

Neuromedin U promotes human type 2 immune responses	10
Tear duct M cells exacerbate allergic conjunctivitis by facilitating germinal-center reactions	10
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation	9
IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections	9
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node	9
Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection	9
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling	9
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease	9
A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells	9
Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection	9
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection	9
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes	9
Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1	9
Interaction of microbiota, mucosal malignancies, and immunotherapy—Mechanistic insights	9
Candida vaginitis: the importance of mitochondria and type I interferon signalling	8
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8	8
Correction to: Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism	8
The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection	8
MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation	8
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization	8
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses	8
Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H2O2	8
Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy	8
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum	8
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines	8
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense	8
Correction to: Trained immunity in type 2 immune responses	8
Correction to: Redefining intestinal immunity with single-cell transcriptomics	8
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease	8
Redefining intestinal immunity with single-cell transcriptomics	8
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in na	7
Stem cell factor inhibition reduces Th2 inflammation and cellular infiltration in a mouse model of eosinophilic esophagitis	7
Microbiome-based interventions to modulate gut ecology and the immune system	7
STAT4 increases the phenotypic and functional heterogeneity of intestinal tissue-resident memory T cells	7
Emc3 maintains intestinal homeostasis by preserving secretory lineages	7
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity	7
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium	7
A reappraisal of IL-9 in inflammation and cancer	7
Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells	7
From germ-free to wild: modulating microbiome complexity to understand mucosal immunology	7
PAD4 inhibition impacts immune responses in SARS-CoV-2 infection	7
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses	7
CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages	7
Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism	6
Parasite and host immune factors that impact the development of a mucosal vaccine for Cryptosporidium	6
Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation	6
High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity	6
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine	6
Response to: “Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease”	6
Dendritic cell functions in the inductive and effector sites of intestinal immunity	6
Understanding the molecular mechanisms of anti-trafficking therapies and their clinical relevance in inflammatory bowel disease	6
Atopic dermatitis and food allergy: More than sensitization	6
Intestinal immunoregulation: lessons from human mendelian diseases	6
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity	6
Activation of the SST-SSTR5 signaling pathway enhances corneal wound healing in diabetic mice	6
Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases	6
Editorial Board	5
MAIT cells, guardians of skin and mucosa?	5
Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases	5
Regulation of intestinal immunity by dietary fatty acids	5
Mucosal-associated invariant T cells have therapeutic potential against ocular autoimmunity	5
Lung microbial-host interface through the lens of multi-omics	5
Innate immunity of the lungs in homeostasis and disease	5
Exposure to environmental microbiota may modulate gut microbial ecology and the immune system	5
Local complement activation and modulation in mucosal immunity	5
TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling	5
Skin immunity: dissecting the complex biology of our body's outer barrier	5
Regulation of tissue-resident memory T cells by the Microbiota	5
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2	5
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism	5
Diabetes impairs IFNγ-dependent antibacterial defense in the lungs	5
A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection	5
Local antigen encounter promotes generation of tissue-resident memory T cells in the large intestine	5
The urothelium: a multi-faceted barrier against a harsh environment	5
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection	5
RSV infection in neonatal mice and gastrointestinal microbiome alteration contribute to allergic predisposition	5
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation	5
Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease	5