OOIR: Observatory of International Research

Papers

(The TQCC of Mucosal Immunology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	266
Editorial Board	223
Memorial for Nils Lycke	206
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	147
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	121
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	114
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	110
Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis	107
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	85
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	82
Role of the humoral immune response during COVID-19: guilty or not guilty?	69
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	68
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	53
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	52
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	48
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	48
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	48
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	47
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	46
Microbial regulation of intestinal motility provides resistance against helminth infection	46
Fibroblasts sense commensal-derived metabolites and regulate group 2 innate lymphoid cells-dependent defense in the stomach	45
Differential effects of SARS-CoV-2-targeted infection of ATII, club cells, and macrophages on lung immunopathology and antiviral responses	45
The neuroendocrine peptide catestatin promotes clearance of cutaneous Staphylococcus aureus through mast cell Mrgpr activation	44
Epithelial barrier DUOX2 serves as early immune defense in intestinal pathogen control	43
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	42

Early postnatal eosinophil expansion associates with gut microbial-metabolic features and type 2 immunity in preterm infants	42
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	41
Inhaled Acinetobacter lwoffii exposure promotes lung PD-L1+ neutrophils and dampens viral-induced type 2 immunity	39
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	39
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	37
NOD1 signaling regulates early tissue inflammation during helminth infection	36
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	35
Organismal mucosal immunology: A perspective through the eyes of game theory	35
Mast cells disrupt the function of the esophageal epithelial barrier	34
Microbial antigen in human milk: a natural vaccine?	34
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	33
Gut segmented filamentous Bacteria impedes growth of B16F10 subcutaneous tumors via modulating T cell function	33
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	32
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	32
Impaired neutrophil migration underpins host susceptibility to infectious colitis	32
Chronological maturation of the skin immune barrier is topographically different	32
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	32
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	31
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	30
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity	30
Learning immunology from mothers and babies	29
ADP-ribosylation factor 1 sustains regulatory T cell function and mucosal immune homeostasis in ulcerative colitis	29
The gut-liver axis modulates intestinal immune homeostasis	28
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	28
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	28
Airway epithelial cells as drivers of severe asthma pathogenesis	28
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	27
Editorial Board	27
Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming	26
Role of IL-10 signaling in the circadian control of host response to influenza infection	26
Pregnancy stages differentially impact maternal alveolar macrophages' function and immunity to SARS-CoV-2 infection	25
Ileal mucus viscoelastic properties differ in Crohn’s disease	25
Neuronal VIP wires the intestinal epithelial cell function	25
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	24
Optimized hookworm-derived biologic, AIP-2NTQ48 restores mucosal tolerance and down-regulates colon cancer-associated gene expression in TNBS-induced colitis	24
Metabolic regulation of macrophage-tissue interactions in the lung	24
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	24
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	23
TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages	23
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	23
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	22
Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages	22
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	22
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	22
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	21
Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis	20
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	20
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	20
Dynamics of virus-specific CD8+ T cells in the human nasal cavity	20
Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection	20

Seminal fluid expands the uterine gamma/delta T cell pool during early pregnancy in mice	19
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	19
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	19
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	19
M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps	19
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	19
4-1BBL on monocyte lineage cells rather than on classical dendritic cells drives CD8+ T cell accumulation in the respiratory tract and protects from severe respiratory influenza infection	18
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury	18
Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production	18
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	17
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	17
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	17
Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells	17
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	17
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	17
Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism	16
Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling	16
From the gut to the lung: microbiota-associated metabolites as regulators of respiratory immunometabolism	16
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	15
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	15
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	15
Homeostatic and inflammatory functions of pulmonary GM-CSF	15
Fibrinogen and lipopolysaccharide promote TLR4-dependent glucocorticoid resistance in airway mycosis-driven allergic airway disease	15
Single-cell RNA sequencing reveals intrinsic and microbiota-associated sex differences in murine lung	15
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	15
Integrin β7 sustains ileal humoral immunity and microbial biogeography during chronic TNF-driven ileitis	15
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	15
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	14
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	14
Beyond pathogen recognition: C-type lectin receptors in microbiota regulation	14
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	14
Editorial Board	14
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	14
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	14
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	14
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma	14
Shining the spotlight on urinary tract immunology	14
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	14
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	14
The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease	14
Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination	13
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	13
Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction	13
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	13
Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss	13
CD39 regulates P2RX7-mediated lung necrotic lesions in severe experimental tuberculosis	13
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	13
Short-course intranasal LAT9997 therapy limits post-influenza bacterial pneumonia by recalibrating lung immunity	13