OOIR: Observatory of International Research

Papers

(The TQCC of Mucosal Immunology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Editorial Board	217
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	209
Editorial Board	166
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	136
Response to Lauro and Zorzetti	126
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	111
Role of the humoral immune response during COVID-19: guilty or not guilty?	100
Memorial for Nils Lycke	91
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	88
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	74
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	73
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	73
The fellowship of regulatory and tissue-resident memory cells	72
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	72
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	71
α4β7 expression guides B cells to front lines of defense in the gut	67
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	61
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	59
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	58
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	57
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	55
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	53
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	48
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	46
Microbial regulation of intestinal motility provides resistance against helminth infection	45

Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	45
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	44
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	43
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	42
Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	42
Tissue resident memory T cells in the respiratory tract	41
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	41
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	40
NOD1 signaling regulates early tissue inflammation during helminth infection	39
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	38
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	38
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	38
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	37
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	36
Organismal mucosal immunology: A perspective through the eyes of game theory	34
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	33
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	33
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	32
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	31
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	31
Mast cells disrupt the function of the esophageal epithelial barrier	31
Microbial antigen in human milk: a natural vaccine?	30
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	30
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	30
Impaired neutrophil migration underpins host susceptibility to infectious colitis	30
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	29
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	29
Airway epithelial cells as drivers of severe asthma pathogenesis	28
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	28
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	27
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	27
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	27
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	27
Chronological maturation of the skin immune barrier is topographically different	27
Ileal mucus viscoelastic properties differ in Crohn’s disease	26
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	26
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	26
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	25
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	25
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	25
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	24
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	24
Correction to: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	24
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	24
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	24
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	23
TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages	22
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	22
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	22
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	22

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	22
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	22
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	21
Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection	21
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	21
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	21
Dynamics of virus-specific CD8+ T cells in the human nasal cavity	21
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	20
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	20
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	19
M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps	19
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	18
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	18
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	18
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	18
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	18
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	18
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	18
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	18
Human mucosal tissue-resident memory T cells in health and disease	18
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	18
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	18
Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells	17
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	17
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	17
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	17
Editorial Board	17
Shining the spotlight on urinary tract immunology	17
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	17
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	17
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	17
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	16
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	16
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	16
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	16
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	16
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	16
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	16