OOIR: Observatory of International Research

Papers

(The TQCC of Mucosal Immunology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Editorial Board	222
Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells	213
Editorial Board	170
Response to Lauro and Zorzetti	140
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma	137
Role of the humoral immune response during COVID-19: guilty or not guilty?	120
Memorial for Nils Lycke	104
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis	95
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation	92
Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus	78
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice	75
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice	75
α4β7 expression guides B cells to front lines of defense in the gut	75
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice	73
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling	72
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity	70
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms	64
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes	64
The fellowship of regulatory and tissue-resident memory cells	64
“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”	60
Correction to: Comment on “ILC1 drive intestinal epithelial and matrix remodeling”	58
Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates	53
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung	48
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling	47
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration	47

Intestinal immunological events of acute and resolved SARS-CoV-2 infection in non-human primates	46
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut	46
Microbial regulation of intestinal motility provides resistance against helminth infection	45
Tissue resident memory T cells in the respiratory tract	44
Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor	43
Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner	42
Host/microbiota interactions in health and diseases—Time for mucosal microbiology!	41
Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry	41
Peyer’s patch phagocytes acquire specific transcriptional programs that influence their maturation and activation profiles	40
Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”	39
NOD1 signaling regulates early tissue inflammation during helminth infection	39
Mast cells disrupt the function of the esophageal epithelial barrier	38
Microbial antigen in human milk: a natural vaccine?	38
Organismal mucosal immunology: A perspective through the eyes of game theory	36
Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease	36
Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract	35
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen	33
Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease	33
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues	33
Enteric neuroimmune interactions coordinate intestinal responses in health and disease	33
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells	32
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori	32
The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis	31
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival	31
HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa	31
Airway epithelial cells as drivers of severe asthma pathogenesis	30
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease	30
Impaired neutrophil migration underpins host susceptibility to infectious colitis	29
Chronological maturation of the skin immune barrier is topographically different	29
Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age	29
PD-1 regulates ILC3-driven intestinal immunity and homeostasis	28
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells	28
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity	28
Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections	27
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis	27
A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up	27
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages	27
Ileal mucus viscoelastic properties differ in Crohn’s disease	26
Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen	26
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype	25
Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis	25
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands	24
Dynamics of virus-specific CD8+ T cells in the human nasal cavity	24
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus	24
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection	24
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination	24
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential	24
Correction to: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion	23
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults	23
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis	22

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells	22
TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages	22
Migratory CD103+CD11b+ cDC2s in Peyer’s patches are critical for gut IgA responses following oral immunization	22
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype	21
Human mucosal tissue-resident memory T cells in health and disease	21
Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells	21
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon	21
Comment on “Enterocyte–innate lymphoid cell crosstalk drives early IFNg-mediated control of Cryptosporidium”	21
M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps	21
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination	21
Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes	20
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis	20
Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection	20
Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells	20
Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome	19
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)	19
MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells	19
PD-1 signaling in neonates restrains CD8+ T cell function and protects against respiratory viral immunopathology	19
Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes	19
ETS translocation variant 5 (ETV5) promotes CD4+ T cell–mediated intestinal inflammation and fibrosis in inflammatory bowel diseases	19
Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells	18
A bacterial vesicle-based pneumococcal vaccine against influenza-mediated secondary Streptococcus pneumoniae pulmonary infection	18
Editorial Board	18
Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota	18
Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies	18
Antigen-specific memory Th17 cells promote cross-protection against nontypeable Haemophilus influenzae after mild influenza A virus infection	18
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis	18
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells	18
Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells	17
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria	17
Shining the spotlight on urinary tract immunology	17
Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity	17
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice	17
The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice	17
Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases	16
Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection	16
Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction	16
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding	16
Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation	16
CD38 and extracellular NAD+ regulate the development and maintenance of Hp vaccine‐induced CD4+ TRM in the gastric epithelium	16
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis	16
How the early life microbiome shapes immune programming in childhood asthma and allergies	16
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies	16