OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Stem Cell is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	429
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	256
Brain organoids restore cortical damage	249
Cut out that YAPping: Mechanisms to reduce scar formation	213
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	200
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	196
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	184
Regrowing the heart, one TREE at a time	183
Prolonged 3D culture unlocks black box of primate embryogenesis	178
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	178
Oscillation steers differentiation	171
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	166
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	165
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	163
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	161
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	154
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	146
Tissue morphology influences the temporal program of human brain organoid development	145
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	143
Successful organoid-mediated generation of iPSC-derived CAR-T cells	134
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	133
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	131
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	129
Paul S. Frenette (1965–2021)	129
Refined transcriptional blueprint of human preimplantation embryos	129

Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	127
IRF6 hits the sweet spot	126
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	119
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	118
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	117
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	116
Human biliary epithelial cells for regenerative medicine	116
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	115
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	113
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	113
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	113
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	111
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	111
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	111
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	111
Perceiving the brain like never before	110
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	110
Enchanted by the earliest stages of human life	109
Healing takes nerve	108
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	107
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	107
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	106
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	106
An oncogenic enhancer encodes selective selenium dependency in AML	106
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	103
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	103
Early human development and stem cell-based human embryo models	103
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	103
Progress in multicellular human cardiac organoids for clinical applications	101
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	100
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	100
Stem cells and origins of cancer in the upper gastrointestinal tract	97
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	96
Organ function is preserved despite reorganization of niche architecture in the hair follicle	95
Human Down syndrome microglia are up for a synaptic feast	91
Video, ergo sum: The search for response to natural light	91
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	90
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	88
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	88
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	85
Mini kidney organoids deliver maximal drug screening impact	83
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	83
Rebuilding and rebooting immunity with stem cells	82
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	82
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	81
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	81
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	80
Epigenetic regulation of early human embryo development	79
A human pluripotent stem cell-based somitogenesis model using microfluidics	77
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	77

A reference human induced pluripotent stem cell line for large-scale collaborative studies	75
iPSC model of congenital heart disease predicts disease outcome	75
Advancing cell therapy for neurodegenerative diseases	75