OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Stem Cell is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	376
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	269
Brain organoids restore cortical damage	244
Cut out that YAPping: Mechanisms to reduce scar formation	234
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	224
Regrowing the heart, one TREE at a time	221
Prolonged 3D culture unlocks black box of primate embryogenesis	206
Oscillation steers differentiation	191
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	180
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	175
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	167
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	162
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	162
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	158
Exploring the human lacrimal gland using organoids and single-cell sequencing	152
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	152
Tissue morphology influences the temporal program of human brain organoid development	147
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	147
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	145
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	143
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	138
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	136
Successful organoid-mediated generation of iPSC-derived CAR-T cells	132
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	132
Refined transcriptional blueprint of human preimplantation embryos	127

Paul S. Frenette (1965–2021)	123
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets	123
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	123
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	120
IRF6 hits the sweet spot	117
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	115
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	115
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	115
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	113
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	112
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	111
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	110
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	109
Human biliary epithelial cells for regenerative medicine	109
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	107
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	105
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	105
Naive stem cell blastocyst model captures human embryo lineage segregation	105
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	105
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	104
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	104
Perceiving the brain like never before	103
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	103
Enchanted by the earliest stages of human life	102
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	102
Healing takes nerve	102
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	101
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	101
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	101
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	100
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	99
An oncogenic enhancer encodes selective selenium dependency in AML	98
Progress in multicellular human cardiac organoids for clinical applications	98
Stem cells and origins of cancer in the upper gastrointestinal tract	98
Early human development and stem cell-based human embryo models	97
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	94
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	93
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	92
Organ function is preserved despite reorganization of niche architecture in the hair follicle	91
Video, ergo sum: The search for response to natural light	88
Mini kidney organoids deliver maximal drug screening impact	87
Human Down syndrome microglia are up for a synaptic feast	87
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	85
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	84
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	83
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	82
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	81
Rebuilding and rebooting immunity with stem cells	81
Planarian stem cells specify fate yet retain potency during the cell cycle	80
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	80

Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	80
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	78
Advancing cell therapy for neurodegenerative diseases	77
Epigenetic regulation of early human embryo development	77