OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Stem Cell is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	685
Prolonged 3D culture unlocks black box of primate embryogenesis	282
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	269
Reconstructing tumor tissues in 3D: From organoids to bioengineered niches	254
Rebuilding the bridge: Functional AVN cells for cardiac repair	245
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	241
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	198
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	192
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	179
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	178
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	173
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	169
Tissue morphology influences the temporal program of human brain organoid development	168
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	166
Oscillation steers differentiation	158
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	154
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	151
A sculptor of modern regenerative medicine	148
Regrowing the heart, one TREE at a time	148
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders	148
Brain organoids restore cortical damage	135
A peripheral glial niche orchestrates the early stages of skin wound healing	134
Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids	128
From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	128
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	125

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	123
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	122
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	120
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	120
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	119
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	116
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	115
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	115
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	115
IRF6 hits the sweet spot	114
Transcriptional code for circuit integration in the injured brain by transplanted human neurons	112
Cradles for maturation: Turning progenitor cells into functional intestinal epithelium	112
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	110
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	109
Unlocking human brain networks by assembling circuits in vitro and in vivo	106
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	106
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	105
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	103
Enchanted by the earliest stages of human life	103
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	103
Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells	100
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	100
Perceiving the brain like never before	100
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	97
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience	94
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	93
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	93
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	92
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	91
Early human development and stem cell-based human embryo models	91
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	91
Human Down syndrome microglia are up for a synaptic feast	91
Mini kidney organoids deliver maximal drug screening impact	90
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	89
A human pluripotent stem cell-based somitogenesis model using microfluidics	89
High-content screening of organoids reveals the mechanisms of human pancreas acinar specification	88
Endogenous aldehydes: A driver of clonal hematopoiesis from within?	86
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	86
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis	86
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	86
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	86
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	85
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	84
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	84
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	83
Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo	83
Epigenetic regulation of early human embryo development	82
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	82
Organ function is preserved despite reorganization of niche architecture in the hair follicle	81
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	80

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	80
Advancing cell therapy for neurodegenerative diseases	79
Face off: Stem cell therapy versus the immune system	78
A reference human induced pluripotent stem cell line for large-scale collaborative studies	78
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	78
Rebuilding and rebooting immunity with stem cells	78