Cell Stem Cell

Article	Citations
Releasing the brake on protein synthesis in hematopoietic stem cells	330
Know thy neighbor: Modeling spatiotemporal cell-fate patterns in a neural stem cell niche	250
Can’t touch this: Stromal-mediated ductal proliferation	228
Human blastoids 3.0	227
Early-career researchers in the time of COVID-19: Adapting to uncertainty	210
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	209
Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism	208
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	195
Systems immunology analysis of human immune organoids identifies host-specific correlates of protection to different influenza vaccines	184
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	167
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	166
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	164
New dog, old tricks: Developmental programs resurface in inflammation	151
Introductions to the community: Early-career researchers in the time of COVID-19	149
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	143
Cultivating mentorship, cooperation, and community during COVID-19 and beyond	143
Human 8-cell-like cells discovered	142
Having a blast(oid): Modeling human embryo peri-implantation development with blastoids	142
Successful organoid-mediated generation of iPSC-derived CAR-T cells	140
Pervasive donor DNA integration defies precision gene editing of hematopoietic stem cells	137
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	134
Uncovering the origins and lineage markers of human heart fields	133
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	131
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	129
Brain organoids restore cortical damage	127

Lymphatic endothelia stakeout cryptic stem cells	125
Addressing challenges for repairing adult spinal cord with insights from neonates	122
Genetic and non-genetic mechanisms of inflammation may promote transformation in leukemia	119
A deep learning platform to assess drug proarrhythmia risk	117
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	116
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	115
Genetic reporter for live tracing fluid flow forces during cell fate segregation in mouse blastocyst development	113
Cut out that YAPping: Mechanisms to reduce scar formation	113
Regrowing the heart, one TREE at a time	113
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation	111
Development, maturation, and maintenance of human prostate inferred from somatic mutations	110
Early stem cell aging in the mature brain	107
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease	105
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury	104
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity	103
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	102
New readers and writers of RNA modifications unique to leukemia stem cells	101
New monkey embryo models—it’s getting complicated	101
Prolonged 3D culture unlocks black box of primate embryogenesis	100
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	100
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models	99
A one-way street recognition approach to mediate allogeneic immune cell therapies	99
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases	99
A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1	99
Mini-colons predict drug toxicity in vitro	99
Forward steps in organoid-based forward screening	98
An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells	98
Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia	97
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption	96
New guidelines for stem cell and embryo research from the ISSCR	96
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	95
Inflation comes before the fall: How epithelial stretch drives crypt fission	94
New York Stem Cell Foundation Robertson Investigators	94
A mechanical niche promotes the rejuvenation of blood stem cells	93
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	93
Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets	92
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	91
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	91
Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment	91
Regulation of advanced therapies in Europe: Are we on the right track?	91
Lung repair and regeneration: Advanced models and insights into human disease	91
Oscillation steers differentiation	90
Apart and back again: Reestablished neuronal connections restore walking after paralysis	90
Acetate to the rescue: Acetyl-CoA facilitates placental development	89
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	83
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	82
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	82
Overcoming gene dosage barriers in mammalian development: An imprinting balancing act	81
Cell competition and the regulative nature of early mammalian development	81
An iron rheostat controls hematopoietic stem cell fate	81

Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease	80
Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals	79
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	78
Glioblastoma stem cell HISTArionics	78
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	77
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	77
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	76
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	74
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	73
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	72
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	70
Human brain organoids assemble functionally integrated bilateral optic vesicles	70
Human inducible pluripotent stem cells: Realization of initial promise in drug discovery	70
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow	69
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation	68
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	68
Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation	67
CAR macrophages tuning the immune symphony of anti-cancer therapies	66
Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation	66
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	66
Tissue morphology influences the temporal program of human brain organoid development	66
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	65
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk	65
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing	64
Unlocking the secrets of cancer stem cells: Immune checkpoint inhibitors face their formidable foes	63
Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea	62
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	62
Exploring the human lacrimal gland using organoids and single-cell sequencing	62
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease	62
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function	61
Advances and challenges toward developing kidney organoids for clinical applications	61
The American stem cell sell in 2021: U.S. businesses selling unlicensed and unproven stem cell interventions	61
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	61
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	60
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	59
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	58
Multimodal characterization of murine gastruloid development	57
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	57
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	56
Bioengineered human colon organoids with in vivo-like cellular complexity and function	56
Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids	56
Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells	55
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	55
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors	55
Generating high-fidelity cochlear organoids from human pluripotent stem cells	55
Multipotent stromal cells: One name, multiple identities	54
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	54
Dawn of development: Exploring early human embryogenesis using stem cells	54
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes	54
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells	54
Seizing hope: Advancing cell therapy for pharmaco-resistant epilepsy toward the clinic	54
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	54
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	54
Amniogenesis occurs in two independent waves in primates	54
Stripe out for brain evolution: Astrocytes go human	53
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids	52
MDS/AML with del5q: An acquired “laminopathy”?	52
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	52
c-Maf: The magic wand that turns on LSEC fate	52
Taking the guesswork out of journal submission with Community Review	52
Stem cell-derived β cells go in monkeys	51
Pre-birth stem cell education: A gift from mother’s bugs	51
Androgens increase excitement in brain organoid research	51
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP	51
Human biliary epithelial cells for regenerative medicine	51
Refined transcriptional blueprint of human preimplantation embryos	50
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	50
Paul S. Frenette (1965–2021)	50
Multicellular dynamics of zonal liver regeneration mapped in space and time	50
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	49
A step closer to autologous cell therapy for Parkinson’s disease	49
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	49
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration	49
Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming	48
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging	47
Into the multiverse of gene edited NK cell-based therapeutic strategies	46
Breathing-induced forces influence lung cell fate	46
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	46
Advancing cell-based cancer immunotherapy through stem cell engineering	45
Taming the transposon: H3K9me3 turns foe to friend in human development	45

The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids	45
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	45
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity	45
Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection	44
A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells	44
3D bioprinting of human neural tissues with functional connectivity	44
Next steps in regenerative medicine	44
What is the scope of Cell Stem Cell now and in the future?	44
The future belongs to those who prepare for it today	44
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	43
Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing	43
Effects of diet choice on stem cell function necessitate clarity in selection and reporting	43
Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules	42
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum	42
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	42
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	42
Generation of ventralized human thalamic organoids with thalamic reticular nucleus	41
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia	40
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	40
Pancreatic plasticity: Unlocking exocrine lineage specification	40
Seeing is believing: Representation as a powerful tool in the fight against racism in science	40
Bioenergetics matter to metabolic health—from a fat progenitor view	40
IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy	40
The eyeball’s connected to the brain ball	40
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants	40
Targeting differentiation blockade in AML: New hope from cell-surface-based CRISPR screens	40
Replacing microglia to treat Alzheimer’s disease	39
T cell development made EZ	39
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	39
Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development	39
Functional renal collecting ducts from human PSCs	39
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly	39
Greasing the machinery toward maturation of stem cell-derived β cells	38
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	38
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium	37
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients	37
Modified lentiviral globin gene therapy for pediatric β0/β0 transfusion-dependent β-thalassemia: A single-center, single-arm pilot trial	37
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis	37
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands	37
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids	36
Mapping of clonal lineages across developmental stages in human neural differentiation	36
Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis	36
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation	36
IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration	35
Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer	35
Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity	35
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	35
Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers	35
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets	34
Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy	34
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration	34
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting	34
Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy	34
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	34
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	34
The next generation of endothelial differentiation: Tissue-specific ECs	33
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis	33
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	33
Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease	33
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids	33
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells	33
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	33
Structural and functional integration of human forebrain organoids with the injured adult rat visual system	32
Programming hydrogels to probe spatiotemporal cell biology	32
Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives	32
Generation of human alveolar epithelial type I cells from pluripotent stem cells	32
LIF signaling regulates outer radial glial to interneuron fate during human cortical development	32
Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury	32
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	31
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy	30
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	30
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis	29
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	29
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes	29
Hallmarks of stemness in mammalian tissues	29
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk	28
Detoxifying chemotherapy with genetics-guided stem cell modeling: A personalized affair	28
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool	28
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity	28
Naive stem cell blastocyst model captures human embryo lineage segregation	28
Mapping human brain organoids on a spatial atlas	28
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids	28
Unraveling barriers to iPSC-derived CAR-T cell differentiation	27
Early human development and stem cell-based human embryo models	26
An HLA-homozygous haplobank resource to promote safer cell therapies	26
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	26
Current status of cell-based interventions in Japan	26
Enchanted by the earliest stages of human life	25
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	25
Breathing room: Toward next-generation tracheal engineering	25
From brain to blood and back again: Linking chronic stress, myelopoiesis, and depression	25
Anniversary reflections: Inspiring discoveries and the future of the field	25
Actin pushes open a leaky lumen	24
Human-monkey chimeras: Monkey see, monkey do	24
A physician-scientist’s call to arms	24