Cell Stem Cell

Papers
(The median citation count of Cell Stem Cell is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery429
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic256
Brain organoids restore cortical damage249
Cut out that YAPping: Mechanisms to reduce scar formation213
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis200
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors196
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer184
Regrowing the heart, one TREE at a time183
Prolonged 3D culture unlocks black box of primate embryogenesis178
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR178
Oscillation steers differentiation171
Principles of signaling pathway modulation for enhancing human naive pluripotency induction166
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts165
Engineered heart tissue patches: A milestone in cardiac regenerative medicine163
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development161
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate154
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis146
Tissue morphology influences the temporal program of human brain organoid development145
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes143
Successful organoid-mediated generation of iPSC-derived CAR-T cells134
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos133
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model131
Refined transcriptional blueprint of human preimplantation embryos129
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis129
Paul S. Frenette (1965–2021)129
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination127
IRF6 hits the sweet spot126
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle119
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells118
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment117
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development116
Human biliary epithelial cells for regenerative medicine116
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells115
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells113
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease113
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero113
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells111
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development111
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD111
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis111
Perceiving the brain like never before110
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia110
Enchanted by the earliest stages of human life109
Healing takes nerve108
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering107
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids107
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation106
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes106
An oncogenic enhancer encodes selective selenium dependency in AML106
Early human development and stem cell-based human embryo models103
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion103
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease103
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification103
Progress in multicellular human cardiac organoids for clinical applications101
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure100
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging100
Stem cells and origins of cancer in the upper gastrointestinal tract97
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates96
Organ function is preserved despite reorganization of niche architecture in the hair follicle95
Human Down syndrome microglia are up for a synaptic feast91
Video, ergo sum: The search for response to natural light91
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development90
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons88
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window88
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models85
Mini kidney organoids deliver maximal drug screening impact83
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas83
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress82
Rebuilding and rebooting immunity with stem cells82
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation81
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model81
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons80
Epigenetic regulation of early human embryo development79
A human pluripotent stem cell-based somitogenesis model using microfluidics77
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells77
A reference human induced pluripotent stem cell line for large-scale collaborative studies75
iPSC model of congenital heart disease predicts disease outcome75
Advancing cell therapy for neurodegenerative diseases75
Maturation for regeneration74
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation73
Human hematopoietic stem cells expand beyond cytokines73
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease72
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes71
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing71
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution71
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis70
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity70
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins69
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids69
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.168
The clones have STRACK: Tracing responses to leukemic mutations68
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells68
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells67
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia67
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity66
Construction of multilayered small intestine-like tissue by reproducing interstitial flow66
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease65
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors64
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes64
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment64
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice64
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction64
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either63
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia63
Rewinding cells to reverse disease63
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells62
Hiding from allogeneic NK cells and macrophages by a synthetic receptor62
Chemical reprogramming takes the fast lane61
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation61
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 161
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia61
Hallmarks of stem cell aging60
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells60
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells60
Too little, too soon: Japan’s experiment in regenerative medicine deregulation60
Capybara: A computational tool to measure cell identity and fate transitions60
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity60
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy60
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases59
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise59
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate58
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration58
New evidence for adult beta cell neogenesis57
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells57
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair57
Embryonic macrophages support endocrine commitment during human pancreatic differentiation57
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal57
Patient-derived micro-organospheres enable clinical precision oncology55
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures54
Can’t touch this: Stromal-mediated ductal proliferation54
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease54
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia53
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity53
Human blastoids 3.053
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity53
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain52
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models51
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation51
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation51
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy51
Acetate to the rescue: Acetyl-CoA facilitates placental development50
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength50
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK350
Beyond transplantation: Gene-edited pig liver supports function in a human host50
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate49
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells49
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor49
Lung repair and regeneration: Advanced models and insights into human disease49
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients48
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis48
Human brain organoids assemble functionally integrated bilateral optic vesicles47
MDS/AML with del5q: An acquired “laminopathy”?46
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms46
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells46
The eyeball’s connected to the brain ball45
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia45
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury45
Mapping of clonal lineages across developmental stages in human neural differentiation45
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons45
Generation of human alveolar epithelial type I cells from pluripotent stem cells45
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells44
Anniversary reflections: Inspiring discoveries and the future of the field44
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling44
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development44
Hallmarks of stemness in mammalian tissues44
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs43
Generating human neural diversity with a multiplexed morphogen screen in organoids43
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease43
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages43
Effective regulatory responses to predatory stem cell markets in Australia and Canada43
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes43
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling42
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine42
Hair follicle stem cells feel the pressure42
From stem cells to regulatory T cells: A tale of plasticity42
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip41
Hallmarks of regeneration41
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites41
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk41
Setting the stage for embryo segmentation41
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis40
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development40
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction40
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia40
Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain40
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence40
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis39
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation39
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids39
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion39
Establishment, maintenance, and recall of inflammatory memory38
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming38
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo38
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells38
3D ECM-rich environment sustains the identity of naive human iPSCs37
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques37
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds37
The difficult translational pathway from animal models to patients36
From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP36
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis36
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions35
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei35
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas35
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies35
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells34
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy34
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo34
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration34
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease33
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification33
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche33
tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche33
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells33
Spatiotemporal single-cell roadmap of human skin wound healing32
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming31
Empowering human lung development31
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier31
Quickly moving too slowly: Interneuron migration in Timothy Syndrome31
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy31
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids30
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells30
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors30
Maternal gut microbiota influence stem cell function in offspring29
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling29
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance29
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation29
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells28
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages28
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches27
Forward steps in organoid-based forward screening27
Bioprinted platform for parallelized screening of engineered microtissues in vivo27
Inflation comes before the fall: How epithelial stretch drives crypt fission27
Amniogenesis occurs in two independent waves in primates26
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair26
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice26
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation26
Lymphatics act as a signaling hub to regulate intestinal stem cell activity25
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury25
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy24
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization24
Generating high-fidelity cochlear organoids from human pluripotent stem cells24
A time- and single-cell-resolved model of murine bone marrow hematopoiesis24
Multipotent stromal cells: One name, multiple identities23
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery23
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells23
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing23
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids22
T cell development made EZ22
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP22
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis22
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