Cell Stem Cell

Article	Citations
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	429
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	256
Brain organoids restore cortical damage	249
Cut out that YAPping: Mechanisms to reduce scar formation	213
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	200
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	196
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	184
Regrowing the heart, one TREE at a time	183
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	178
Prolonged 3D culture unlocks black box of primate embryogenesis	178
Oscillation steers differentiation	171
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	166
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	165
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	163
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	161
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	154
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	146
Tissue morphology influences the temporal program of human brain organoid development	145
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	143
Successful organoid-mediated generation of iPSC-derived CAR-T cells	134
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	133
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	131
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	129
Paul S. Frenette (1965–2021)	129
Refined transcriptional blueprint of human preimplantation embryos	129

Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	127
IRF6 hits the sweet spot	126
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	119
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	118
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	117
Human biliary epithelial cells for regenerative medicine	116
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	116
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	115
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	113
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	113
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	113
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	111
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	111
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	111
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	111
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia	110
Perceiving the brain like never before	110
Enchanted by the earliest stages of human life	109
Healing takes nerve	108
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	107
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	107
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	106
An oncogenic enhancer encodes selective selenium dependency in AML	106
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	106
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	103
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	103
Early human development and stem cell-based human embryo models	103
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	103
Progress in multicellular human cardiac organoids for clinical applications	101
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	100
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	100
Stem cells and origins of cancer in the upper gastrointestinal tract	97
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	96
Organ function is preserved despite reorganization of niche architecture in the hair follicle	95
Video, ergo sum: The search for response to natural light	91
Human Down syndrome microglia are up for a synaptic feast	91
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	90
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	88
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	88
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	85
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	83
Mini kidney organoids deliver maximal drug screening impact	83
Rebuilding and rebooting immunity with stem cells	82
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	82
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	81
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	81
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	80
Epigenetic regulation of early human embryo development	79
A human pluripotent stem cell-based somitogenesis model using microfluidics	77
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	77

iPSC model of congenital heart disease predicts disease outcome	75
Advancing cell therapy for neurodegenerative diseases	75
A reference human induced pluripotent stem cell line for large-scale collaborative studies	75
Maturation for regeneration	74
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	73
Human hematopoietic stem cells expand beyond cytokines	73
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	72
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	71
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	71
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	71
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	70
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	70
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	69
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	69
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	68
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	68
The clones have STRACK: Tracing responses to leukemic mutations	68
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	67
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	67
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	66
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	66
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	65
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	64
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	64
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	64
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	64
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	64
Rewinding cells to reverse disease	63
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	63
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	63
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	62
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	62
Chemical reprogramming takes the fast lane	61
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	61
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	61
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	61
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	60
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	60
Hallmarks of stem cell aging	60
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	60
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	60
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	60
Capybara: A computational tool to measure cell identity and fate transitions	60
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	59
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	59
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	58
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	58
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	57
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	57
New evidence for adult beta cell neogenesis	57
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	57
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	57
Patient-derived micro-organospheres enable clinical precision oncology	55
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	54
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	54
Can’t touch this: Stromal-mediated ductal proliferation	54
Human blastoids 3.0	53
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	53
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	53
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	53
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	52
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	51
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	51
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	51
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	51
Acetate to the rescue: Acetyl-CoA facilitates placental development	50
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	50
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	50
Beyond transplantation: Gene-edited pig liver supports function in a human host	50
Lung repair and regeneration: Advanced models and insights into human disease	49
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	49
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	49
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	49
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	48
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	48
Human brain organoids assemble functionally integrated bilateral optic vesicles	47
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	46
MDS/AML with del5q: An acquired “laminopathy”?	46
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	46
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	45

Generation of human alveolar epithelial type I cells from pluripotent stem cells	45
The eyeball’s connected to the brain ball	45
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	45
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	45
Mapping of clonal lineages across developmental stages in human neural differentiation	45
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	44
Hallmarks of stemness in mammalian tissues	44
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	44
Anniversary reflections: Inspiring discoveries and the future of the field	44
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	44
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	43
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	43
Generating human neural diversity with a multiplexed morphogen screen in organoids	43
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	43
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages	43
Effective regulatory responses to predatory stem cell markets in Australia and Canada	43