Cell Stem Cell

Article	Citations
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	575
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	227
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	227
Regrowing the heart, one TREE at a time	220
Successful organoid-mediated generation of iPSC-derived CAR-T cells	215
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	213
Prolonged 3D culture unlocks black box of primate embryogenesis	192
Oscillation steers differentiation	186
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	178
Cut out that YAPping: Mechanisms to reduce scar formation	170
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	159
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders	157
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	149
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	146
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	145
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling	145
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	142
Brain organoids restore cortical damage	136
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	136
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	134
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	134
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	132
Tissue morphology influences the temporal program of human brain organoid development	131
From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	131
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	127

The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	126
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	126
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	118
IRF6 hits the sweet spot	118
Human biliary epithelial cells for regenerative medicine	117
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	114
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	113
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	112
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	112
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	109
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	109
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	108
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	106
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	105
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	102
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	102
Perceiving the brain like never before	99
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	98
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	97
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	96
Enchanted by the earliest stages of human life	96
An oncogenic enhancer encodes selective selenium dependency in AML	93
Unlocking human brain networks by assembling circuits in vitro and in vivo	92
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	91
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	91
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	91
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy	91
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	89
Early human development and stem cell-based human embryo models	88
Progress in multicellular human cardiac organoids for clinical applications	87
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	87
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	86
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	84
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	84
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	83
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	83
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	82
Rebuilding and rebooting immunity with stem cells	81
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	81
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	81
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	80
Human Down syndrome microglia are up for a synaptic feast	80
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	80
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	80
Video, ergo sum: The search for response to natural light	78
Mini kidney organoids deliver maximal drug screening impact	78
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	77
A reference human induced pluripotent stem cell line for large-scale collaborative studies	77
A human pluripotent stem cell-based somitogenesis model using microfluidics	77
Organ function is preserved despite reorganization of niche architecture in the hair follicle	77

Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	76
Advancing cell therapy for neurodegenerative diseases	76
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	76
Epigenetic regulation of early human embryo development	76
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	75
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	75
iPSC model of congenital heart disease predicts disease outcome	74
Human hematopoietic stem cells expand beyond cytokines	74
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	73
Vitamin C conveys geroprotection on primate ovaries	73
The clones have STRACK: Tracing responses to leukemic mutations	73
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial	72
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	71
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	71
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	71
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	71
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	71
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	70
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	70
Space-associated stem cell hallmarks of aging and resilience in astronauts	70
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	69
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	69
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	68
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	68
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	68
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	67
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	65
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	65
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	65
Face off: Stem cell therapy versus the immune system	65
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	64
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	64
Rewinding cells to reverse disease	63
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	63
Chemical reprogramming takes the fast lane	63
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	63
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	62
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	62
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	62
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	61
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	60
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	58
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	58
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	57
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	57
Patient-derived micro-organospheres enable clinical precision oncology	57
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	57
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	56
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	56
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	55
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	55
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	55
Hallmarks of stem cell aging	55
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	54
Capybara: A computational tool to measure cell identity and fate transitions	54
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	54
Human blastoids 3.0	54
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	53
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	53
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	53
Beyond transplantation: Gene-edited pig liver supports function in a human host	52
Unmasking cancer’s hidden nerve route with patient-derived organoids	52
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	52
Raising the bar for human post-implantation embryo models	52
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	52
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	52
Acetate to the rescue: Acetyl-CoA facilitates placental development	52
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	51
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	51
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	51
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages	50
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	50
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	50
Lung repair and regeneration: Advanced models and insights into human disease	49
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	49
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	49
MDS/AML with del5q: An acquired “laminopathy”?	49
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	49
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	49
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	48

HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	48
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	48
Mapping of clonal lineages across developmental stages in human neural differentiation	47
Hallmarks of stemness in mammalian tissues	47
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	47
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	47
Generation of human alveolar epithelial type I cells from pluripotent stem cells	47
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	46
Effective regulatory responses to predatory stem cell markets in Australia and Canada	46
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	46