OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	123
Post-Translational Regulation of HMG CoA Reductase	93
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	89
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	88
Fisher's Geometric Model as a Tool to Study Speciation	88
Fibroblast Heterogeneity in Healthy and Wounded Skin	88
Angiogenesis in Wound Repair: Too Much of a Good Thing?	88
The Role of Membrane Lipids in the Formation and Function of Caveolae	80
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	71
Telomere Dynamics in Human Health and Disease	67
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	64
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	59
Petabase-Scale Homology Search for Structure Prediction	55
A History of Cancer Research: Retroviral Insertional Mutagenesis	51
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	51
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	49
Diversity of Fibroblasts and Their Roles in Wound Healing	47
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	42
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	41
Blastocrithidia—A Genetic Alien from the Planet Earth	38
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	38
Mapping the Retina onto the Brain	38
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	37
Interneuron Diversity: How Form Becomes Function	36
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	35

The Nuclear Lamina	34
The Biology of Lipids	34
Building and Maintaining the Skin	32
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	30
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	30
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration	30
Neotropics as a Cradle for Adaptive Radiations	30
Machine Learning for Protein Science and Engineering	29
Variability in Neural Circuit Formation	28
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	27
A History of Cancer Research: Oncogenic Transcription Factors	27
Regulators of Oligodendrocyte Differentiation	27
Glial Cell Development and Function in the Zebrafish Central Nervous System	27
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	27
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook	26
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	26
Growth Factor and Cytokine Delivery Systems for Wound Healing	26
Essential Roles for RNA in Shaping Nuclear Organization	24
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	24
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	23
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	22
Quantitative Analyses of Coupling in Hybrid Zones	22
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture	22
Lipid Metabolism	22
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	21
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	21
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	21
The Diverse Manifestations of Regeneration and Why We Need to Study Them	21
Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions	21
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	20
Caspases and Their Substrates	20
Developmental Control of Cell Cycle and Signaling	20
Pancreatic β-Cell Development and Regeneration	19
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	19
Development of Prefrontal Circuits and Cognitive Abilities	19
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	19
Glia at Transition Zones	19
Lipid Sorting and Organelle Identity	18
Remyelination in the Central Nervous System	17
The Sensory Ecology of Speciation	17
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	17
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	17
All for One and One for All: Regenerating Skeletal Muscle	16
Structural Biology of Telomerase and Associated Factors	16
Glia Development and Function in the NematodeCaenorhabditis elegans	16
Artificial Intelligence Learns Protein Prediction	15
The Wound Microbiome	15
Physical Forces in Regeneration of Cells and Tissues	14
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	14
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	14

Genetic and Cellular Contributions to Liver Regeneration	14
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	14
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	14
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	14
Anthropogenic Change and the Process of Speciation	13
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	13
Role of Microglia in Central Nervous System Development and Plasticity	13
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	13
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	13
Caspase Activation and Inhibition	12
Endocytic Roles of Glycans on Proteins and Lipids	12
Mechanisms of Alternative Lengthening of Telomeres	12
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	12
Shedding Light on Telomere Replication, Insights from the Fission YeastSchizosaccharomyces pombe	12
Imaginal Disc Regeneration: Something Old, Something New	12
The Mechanics of Building Functional Organs	11
Sex Differences in Circadian Rhythms	11
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration	11
Basics of Metabolic Reactions	11
Leading the Way: Molecular Drivers of Single-Cell Migration	11
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	11
Bioinspired Strategies for Wound Regeneration	11
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	10
Schwann Cell Development and Myelination	10
Inflammasomes and Other Caspase-Activation Platforms	10
The Role of Hybridization in Species Formation and Persistence	10
Mendel's Pea Genes	10
Building, Breaking, and Repairing Neuromuscular Synapses	10
Intracellular Cholesterol Trafficking	10
Modeling and Simulating Single and Collective Cell Motility	9
Agritech to Tame the Nitrogen Cycle	9
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Epigenetics of Human Telomeres	9
Forces Shaping the Blastocyst	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Astrocyte Calcium Signaling	8
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	8
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	8
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	8
Lung Regeneration: Cells, Models, and Mechanisms	8
Glial Malignancies	8
Building Representation Learning Models for Antibody Comprehension	8
Autophagy in Skeletal Muscle	8
Cellular Senescence in Acute and Chronic Wound Repair	8
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	8
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	8
Phosphoinositides in New Spaces	8
Quantifying Sex Differences in Behavior in the Era of “Big” Data	7
Evidence for Perinatal Steroid Influence on Human Sexual Orientation and Gendered Behavior	7
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	7
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	6
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	6
Telomerase in Cancer Therapeutics	6
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	6
Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans	6
Plant Breeding and the Origins of Genetics	6
The Contribution of Innervation to Tissue Repair and Regeneration	6
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	6
A Matter of Life and Death	6