OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	109
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	106
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	87
Fisher's Geometric Model as a Tool to Study Speciation	85
The Role of Membrane Lipids in the Formation and Function of Caveolae	84
Nucleotide Metabolism	81
Fibroblast Heterogeneity in Healthy and Wounded Skin	79
Post-Translational Regulation of HMG CoA Reductase	78
Angiogenesis in Wound Repair: Too Much of a Good Thing?	76
A History of Cancer Research: Retroviral Insertional Mutagenesis	71
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	70
Telomere Dynamics in Human Health and Disease	67
The Impact of Space and Time on the Functional Output of the Genome	66
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	59
Petabase-Scale Homology Search for Structure Prediction	58
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	54
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	53
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	51
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	46
Diversity of Fibroblasts and Their Roles in Wound Healing	46
Mapping the Retina onto the Brain	45
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	42
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	42
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	41
Interneuron Diversity: How Form Becomes Function	40

Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism	38
3D or Not 3D: Shaping the Genome during Development	38
The Biology of Lipids	37
Building and Maintaining the Skin	36
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	34
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	34
The Nuclear Lamina	34
Neotropics as a Cradle for Adaptive Radiations	33
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	32
Auxin in Root Development	31
Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome	31
Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration	31
A History of Cancer Research: Oncogenic Transcription Factors	28
Variability in Neural Circuit Formation	28
Machine Learning for Protein Science and Engineering	28
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	27
Glial Cell Development and Function in the Zebrafish Central Nervous System	27
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	27
Regulators of Oligodendrocyte Differentiation	26
Growth Factor and Cytokine Delivery Systems for Wound Healing	26
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	26
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook	25
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	24
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	24
Essential Roles for RNA in Shaping Nuclear Organization	24
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	23
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	23
Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions	23
Polyploidy in Tissue Repair and Regeneration	22
The Diverse Manifestations of Regeneration and Why We Need to Study Them	21
Lipid Metabolism	21
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	21
Quantitative Analyses of Coupling in Hybrid Zones	21
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture	21
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	20
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	20
Developmental Control of Cell Cycle and Signaling	20
Caspases and Their Substrates	20
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	19
Glia at Transition Zones	19
Glia Development and Function in the NematodeCaenorhabditis elegans	19
The Sensory Ecology of Speciation	18
All for One and One for All: Regenerating Skeletal Muscle	18
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	17
Remyelination in the Central Nervous System	17
Development of Prefrontal Circuits and Cognitive Abilities	17
Pancreatic β-Cell Development and Regeneration	17
Lipid Sorting and Organelle Identity	17
Artificial Intelligence Learns Protein Prediction	16
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	16

Structural Biology of Telomerase and Associated Factors	16
Innate Mechanisms of Heart Regeneration	16
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	16
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	15
The Wound Microbiome	15
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	15
Genetic and Cellular Contributions to Liver Regeneration	14
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	14
Physical Forces in Regeneration of Cells and Tissues	14
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	13
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	13
Anthropogenic Change and the Process of Speciation	13
Role of Microglia in Central Nervous System Development and Plasticity	13
Mechanisms of Alternative Lengthening of Telomeres	13
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	13
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	13
Imaginal Disc Regeneration: Something Old, Something New	13
The Molecular and Nuclear Dynamics of X-Chromosome Inactivation	13
Endocytic Roles of Glycans on Proteins and Lipids	12
Caspase Activation and Inhibition	12
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	12
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	11
Intracellular Cholesterol Trafficking	11
Insect Gut Regeneration	11
Sex Differences in Circadian Rhythms	11
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration	11
Auxin Transporters—A Biochemical View	11
The Mechanics of Building Functional Organs	11
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	11
Basics of Metabolic Reactions	11
Shedding Light on Telomere Replication, Insights from the Fission YeastSchizosaccharomyces pombe	11
Bioinspired Strategies for Wound Regeneration	11
Inflammasomes and Other Caspase-Activation Platforms	11
Epigenetics of Human Telomeres	10
Chromatin Mechanisms Driving Cancer	10
Schwann Cell Development and Myelination	10
Building, Breaking, and Repairing Neuromuscular Synapses	10
Agritech to Tame the Nitrogen Cycle	10
The Role of Hybridization in Species Formation and Persistence	10
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Astrocyte Calcium Signaling	9
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Cellular Senescence in Acute and Chronic Wound Repair	9
Modeling and Simulating Single and Collective Cell Motility	9
Lung Regeneration: Cells, Models, and Mechanisms	9
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	9
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	9
Glial Malignancies	9
Forces Shaping the Blastocyst	9
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	8
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	8
Phosphoinositides in New Spaces	8
Building Representation Learning Models for Antibody Comprehension	8
Quantifying Sex Differences in Behavior in the Era of “Big” Data	8
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	8
Autophagy in Skeletal Muscle	8
Evidence for Perinatal Steroid Influence on Human Sexual Orientation and Gendered Behavior	8
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	7
The Contribution of Innervation to Tissue Repair and Regeneration	7
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	7
NADPH—The Forgotten Reducing Equivalent	7
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	7