OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	157
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	115
The Role of Membrane Lipids in the Formation and Function of Caveolae	107
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	101
Post-Translational Regulation of HMG CoA Reductase	79
Fisher's Geometric Model as a Tool to Study Speciation	72
Fibroblast Heterogeneity in Healthy and Wounded Skin	69
Angiogenesis in Wound Repair: Too Much of a Good Thing?	62
A Mechanometabolism Toolbox for Studying Cell Migration	61
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	59
Telomere Dynamics in Human Health and Disease	54
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	54
Petabase-Scale Homology Search for Structure Prediction	54
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	53
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	48
A History of Cancer Research: Retroviral Insertional Mutagenesis	48
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	47
Diversity of Fibroblasts and Their Roles in Wound Healing	47
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	46
Mapping the Retina onto the Brain	44
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	44
Blastocrithidia —A Genetic Alien from the Planet Earth	43
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	43
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	43
The Biology of Lipids	39

Interneuron Diversity: How Form Becomes Function	39
Neotropics as a Cradle for Adaptive Radiations	37
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	37
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	33
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	33
Sticking to Membranes: Structure, Function, and Cellular Roles of the Annexin Family of Ca²⁺- and Membrane-Binding Proteins	32
Glial Cell Development and Function in the Zebrafish Central Nervous System	31
A History of Cancer Research: Oncogenic Transcription Factors	31
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	30
Chromosome Ends in Motion: Telomeres as Hazards and Hubs in Meiosis	30
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	30
Variability in Neural Circuit Formation	29
Regulators of Oligodendrocyte Differentiation	27
Machine Learning for Protein Science and Engineering	27
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	26
Growth Factor and Cytokine Delivery Systems for Wound Healing	26
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	25
Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications	25
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	24
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	24
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	24
Quantitative Analyses of Coupling in Hybrid Zones	24
Genetically Encoded Ca ²⁺ Sensors	23
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	23
Developmental Control of Cell Cycle and Signaling	23
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	22
Calcium Signaling in Migrating Neutrophils	22
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	21
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	20
Glia at Transition Zones	20
Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments	20
Caspases and Their Substrates	20
Ca²⁺ Fluxes across Membrane Contact Sites	19
The Sensory Ecology of Speciation	19
Glia Development and Function in the NematodeCaenorhabditis elegans	19
Remyelination in the Central Nervous System	18
Lipid Sorting and Organelle Identity	18
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	18
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	18
Development of Prefrontal Circuits and Cognitive Abilities	17
Structural Biology of Telomerase and Associated Factors	16
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	16
Artificial Intelligence Learns Protein Prediction	15
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	15
The Unusual Effectiveness of Evolution in Systems Neuroscience	15
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	15
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	14
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	14
Physical Forces in Regeneration of Cells and Tissues	14
The Wound Microbiome	14

Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	14
Role of Microglia in Central Nervous System Development and Plasticity	13
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	13
Endocytic Roles of Glycans on Proteins and Lipids	13
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	13
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	13
Mechanisms of Alternative Lengthening of Telomeres	13
Anthropogenic Change and the Process of Speciation	13
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	12
Intracellular Cholesterol Trafficking	11
Shedding Light on Telomere Replication, Insights from the Fission YeastSchizosaccharomyces pombe	11
Sex Differences in Circadian Rhythms	11
Bioinspired Strategies for Wound Regeneration	11
Leading the Way: Molecular Drivers of Single-Cell Migration	11
Traveling in a Pack: The Border Cells’ Collective Journey Guided by Landscapes and Chemical Cues	11
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	11
The Mechanics of Building Functional Organs	11
Caspase Activation and Inhibition	11
Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions	11
Inflammasomes and Other Caspase-Activation Platforms	10
Telomere Crisis Shapes Cancer Evolution	10
Mendel's Pea Genes	10
Building, Breaking, and Repairing Neuromuscular Synapses	10
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	10
Agritech to Tame the Nitrogen Cycle	9
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	9
The Role of Hybridization in Species Formation and Persistence	9
Schwann Cell Development and Myelination	9
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Epigenetics of Human Telomeres	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Endothelial CRAC Channels	8
Cellular Senescence in Acute and Chronic Wound Repair	8
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	8
Building Representation Learning Models for Antibody Comprehension	8
Astrocyte Calcium Signaling	8
Modeling and Simulating Single and Collective Cell Motility	8
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	8
Forces Shaping the Blastocyst	8
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	8
Glial Malignancies	8
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	7
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	7
Autophagy in Skeletal Muscle	7
Phosphoinositides in New Spaces	7
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	7
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	6
Plant Breeding and the Origins of Genetics	6
Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans	6
Mitochondrial Calcium Signaling in Hepatocyte Health and Disease	6
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	6
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	6
A Matter of Life and Death	6
The Contribution of Innervation to Tissue Repair and Regeneration	6
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	6
Telomerase in Cancer Therapeutics	6
The Burial: Clearance and Consequences	6