OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	215
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	156
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	82
Fisher's Geometric Model as a Tool to Study Speciation	81
Leukocyte Chemotaxis and the Elusive Negative Signals that Make It Work	77
The Role of Membrane Lipids in the Formation and Function of Caveolae	73
Post-Translational Regulation of HMG CoA Reductase	72
A History of Cancer Research: Retroviral Insertional Mutagenesis	71
Petabase-Scale Homology Search for Structure Prediction	70
A Mechanometabolism Toolbox for Studying Cell Migration	69
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	69
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	64
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	64
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	63
Diversity of Fibroblasts and Their Roles in Wound Healing	61
Telomere Dynamics in Human Health and Disease	57
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	56
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	55
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	54
Blastocrithidia —A Genetic Alien from the Planet Earth	52
Roles and Regulation of the Hippo Signaling Pathway in Mammalian Preimplantation Development	51
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	51
Mapping the Retina onto the Brain	47
The Multifaceted Roles of the Hippo–Yes-Associated Protein (YAP)/Transcriptional Coactivator with a PDZ-Binding Motif Pathway in Regulating the Tumor Microenvironment	45
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	45

Interneuron Diversity: How Form Becomes Function	45
The Biology of Lipids	41
Cell Migration	38
Growth Control and Beyond: Functional Diversity and Regulation of the Hippo Pathway in the Nervous System	38
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	37
Neotropics as a Cradle for Adaptive Radiations	37
Glial Cell Development and Function in the Zebrafish Central Nervous System	36
Machine Learning for Protein Science and Engineering	36
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	36
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	35
Chromosome Ends in Motion: Telomeres as Hazards and Hubs in Meiosis	35
Sticking to Membranes: Structure, Function, and Cellular Roles of the Annexin Family of Ca²⁺- and Membrane-Binding Proteins	34
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	34
A History of Cancer Research: Oncogenic Transcription Factors	33
Regulators of Oligodendrocyte Differentiation	32
Variability in Neural Circuit Formation	32
Structural Studies of Core Hippo Pathway Components	31
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	31
Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications	31
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	31
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	30
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	29
Genetically Encoded Ca ²⁺ Sensors	29
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	28
Quantitative Analyses of Coupling in Hybrid Zones	28
Calcium Signaling and Pathogenesis of Neurodegenerative Disorders: Potential Therapeutic Opportunities	27
Telomeres and Telomerase	26
Mechanobiology of the Hippo–YAP Signaling Network	25
Developmental Control of Cell Cycle and Signaling	25
Soft Matter Physics Meets Cell Biology: Transitions of Collective Cell Migration in 3D Environments	23
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	23
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	23
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	22
Calcium Signaling in Migrating Neutrophils	22
Glia at Transition Zones	22
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	20
Ca²⁺ Fluxes across Membrane Contact Sites	20
Remyelination in the Central Nervous System	19
Glia Development and Function in the NematodeCaenorhabditis elegans	19
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	19
Development of Prefrontal Circuits and Cognitive Abilities	19
The Sensory Ecology of Speciation	19
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	19
The Unusual Effectiveness of Evolution in Systems Neuroscience	17
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	17
Lipid Sorting and Organelle Identity	17
The Wound Microbiome	17
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	17
Artificial Intelligence Learns Protein Prediction	17
Neutrophil Migration: Using All the Tricks of Mesenchymal and Amoeboid Cells to Navigate Many Environments	17

Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	16
Translational Recoding in Tumors	16
Physical Forces in Regeneration of Cells and Tissues	16
Structural Biology of Telomerase and Associated Factors	16
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	15
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	14
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	14
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	14
Anthropogenic Change and the Process of Speciation	14
Mechanisms of Alternative Lengthening of Telomeres	14
Role of Microglia in Central Nervous System Development and Plasticity	14
Endocytic Roles of Glycans on Proteins and Lipids	13
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	13
Targeting Yes-Associated Protein (YAP)/Transcriptional Coactivators with PDZ-Binding Motif (TAZ)-Transcriptional Enhanced Associate Domain (TEAD) for Cancer and Regenerative Medicine	13
Caspase Activation and Inhibition	13
The Mechanics of Building Functional Organs	12
Traveling in a Pack: The Border Cells’ Collective Journey Guided by Landscapes and Chemical Cues	12
Leading the Way: Molecular Drivers of Single-Cell Migration	12
Shedding Light on Telomere Replication, Insights from the Fission Yeast Schizosaccharomyces pombe	12
Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions	12
Telomere Crisis Shapes Cancer Evolution	11
Bioinspired Strategies for Wound Regeneration	11
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	11
Building, Breaking, and Repairing Neuromuscular Synapses	10
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	10
Recent Developments in (Archaeal) Pyrrolysine and Selenocysteine Specification and Metabolism	10
Schwann Cell Development and Myelination	10
Mendel's Pea Genes	10
Intracellular Cholesterol Trafficking	10
The Role of Hybridization in Species Formation and Persistence	10
Core Components of the Hippo Pathway	10
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	9
Many Cells Make Light Work: Self-Generated Gradients Organize Dictyostelium Aggregates and Neutrophil Swarms	9
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	9
Agritech to Tame the Nitrogen Cycle	9
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	9
Epigenetics of Human Telomeres	9
Modeling and Simulating Single and Collective Cell Motility	9
Astrocyte Calcium Signaling	8
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	8
Endothelial CRAC Channels	8
Forces Shaping the Blastocyst	8
Building Representation Learning Models for Antibody Comprehension	8
Control of Inositol 1,4,5-Trisphosphate Receptor Activity by Posttranslational Modifications	8
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	8
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	8
Telomerase in Cancer Therapeutics	7
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	7
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	7
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	7
Glial Malignancies	7
Autophagy in Skeletal Muscle	7
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	7
Mitochondrial Calcium Signaling in Hepatocyte Health and Disease	7
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	7
Phosphoinositides in New Spaces	7
Modulation of Inositol 1,4,5-Trisphosphate Receptors by Their Primary Physiological Ligands, IP ₃ , Ca ²⁺	6
Collective Mesoderm and Endoderm Cell Migration during Vertebrate Gastrulation	6
Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?	6
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	6
The Burial: Clearance and Consequences	6
Plant Breeding and the Origins of Genetics	6