OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Fisher's Geometric Model as a Tool to Study Speciation	193
Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging	100
Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain	97
Autophagy in Skeletal Muscle	87
The Diversity of Skeletal Muscle Fiber Types	79
Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells	78
Evidence for Perinatal Steroid Influence on Human Sexual Orientation and Gendered Behavior	76
A Single-Cell Perspective on Memory T-Cell Differentiation	76
Essential Roles for RNA in Shaping Nuclear Organization	75
The Biogenesis of Multipass Membrane Proteins	71
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	68
Quantifying Sex Differences in Behavior in the Era of “Big” Data	66
Temporal and Epigenetic Control of Plasticity and Fate Decision during CD8⁺T-Cell Memory Differentiation	62
Post-Translational Regulation of HMG CoA Reductase	61
Structure and Function of the Nuclear Pore Complex	59
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	58
Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	57
Hematopoietic Stem Cells and Regeneration	57
Understanding the Influence of Host Radiation on Symbiont Speciation through Parasites of Species Flocks	56
How Important Is Sexual Isolation to Speciation?	54
Reimagining Cortical Connectivity by Deconstructing Its Molecular Logic into Building Blocks	48
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	46
The Systems and Synthetic Biology of Auxin	45
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook	44
Glia in Neurodegenerative Disease	41

Glial Malignancies	39
Building Representation Learning Models for Antibody Comprehension	39
Perisynaptic Schwann Cells: Guardians of Neuromuscular Junction Integrity and Function in Health and Disease	38
Role of Microglia in Central Nervous System Development and Plasticity	36
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	35
Legumes and Linguistics: Translating Mendel for the Twenty-First Century	35
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	33
Angiogenesis in Wound Repair: Too Much of a Good Thing?	32
The Role of Membrane Lipids in the Formation and Function of Caveolae	32
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	31
Fibroblast Heterogeneity in Healthy and Wounded Skin	31
Anthropogenic Change and the Process of Speciation	31
Fourteen Stations of Auxin	29
Features, Fates, and Functions of Oligodendrocyte Precursor Cells	29
Sex Differences in Major Depressive Disorder (MDD) and Preclinical Animal Models for the Study of Depression	28
Phosphoinositides in New Spaces	28
Nucleotide Metabolism	27
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	26
Mechanisms of Alternative Lengthening of Telomeres	25
The Death Receptor Pathway of Apoptosis	25
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	24
Cholesterol Transport to the Endoplasmic Reticulum	24
Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing	24
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	24
The Impact of Space and Time on the Functional Output of the Genome	24
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	24
Telomere Dynamics in Human Health and Disease	23
Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions	23
A History of Cancer Research: Retroviral Insertional Mutagenesis	23
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	22
The Contribution of Innervation to Tissue Repair and Regeneration	21
Oxidative Stress and DNA Damage at Telomeres	21
Metabolic Control of Memory T-Cell Generation and Stemness	21
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	21
Uncovering How Auxin Optimizes Root Systems Architecture in Response to Environmental Stresses	20
The Stochastic Genome and Its Role in Gene Expression	18
Evolutionary Aspects of the Unfolded Protein Response	18
Stairways to Advanced Therapies for Epidermolysis Bullosa	18
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	17
Caspase Activation and Inhibition	17
Quantitative Analyses of Coupling in Hybrid Zones	17
Lipid Metabolism	17
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	16
Petabase-Scale Homology Search for Structure Prediction	16
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	16
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	16
The Impact of Chromosomal Rearrangements in Speciation: From Micro- to Macroevolution	16
Favored Races in the Struggle for Life: Racism and the Speciation Concept	15
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	15
Structural Variants and Speciation: Multiple Processes at Play	15

Glia as Functional Barriers and Signaling Intermediaries	15
Diversity of Fibroblasts and Their Roles in Wound Healing	14
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	14
Imaginal Disc Regeneration: Something Old, Something New	14
Endocytic Roles of Glycans on Proteins and Lipids	14
NADPH—The Forgotten Reducing Equivalent	14
Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in Hydra	14
Imaging Organization of RNA Processing within the Nucleus	13
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	13
Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging	13
Polyploidy in Tissue Repair and Regeneration	13
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	13
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture	13
Auxin Transporters—A Biochemical View	13
Genetic Coupling of Mate Recognition Systems in the Genomic Era	13
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	12
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration	12
Developmental Control of Cell Cycle and Signaling	12
Telomere Dynamics in Zebrafish Aging and Disease	12
Mitochondrial Maintenance in Skeletal Muscle	12
Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks	11
Chemical Approaches for Measuring and Manipulating Lipids at the Organelle Level	11
Mapping the Retina onto the Brain	11
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory	11
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	11
The Diverse Manifestations of Regeneration and Why We Need to Study Them	11
Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans	11
Basics of Metabolic Reactions	11
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	10
Telomerase in Cancer Therapeutics	10
An Agrigenomics Trifecta: Greenhouse Gas Drawdown, Food Security, and New Drugs	10
Plant Breeding and the Origins of Genetics	10
Positional Information and Stem Cells Combine to Result in Planarian Regeneration	10
Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory	10
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	10
Cell Death and Cancer	10
Computational Models of Auxin-Driven Patterning in Shoots	10
Microbial Catalysis for CO₂Sequestration: A Geobiological Approach	10
Sorting and Export of Proteins at the Endoplasmic Reticulum	9
The Mechanics of Building Functional Organs	9
Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing	9
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	9
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	9
Speciation	9
Life and Death without Telomerase: TheSaccharomyces cerevisiaeModel	9
Variant Effect Prediction in the Age of Machine Learning	9
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	9
Wound Healing from an Actin Cytoskeletal Perspective	9
Development and Evolution of Thalamocortical Connectivity	8
A Matter of Life and Death	8
Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming	8
Axon Regeneration: A Subcellular Extension in Multiple Dimensions	8
3D or Not 3D: Shaping the Genome during Development	7
The Nuclear Pore Complex as a Transcription Regulator	7
Structural Aspects of Auxin Signaling	7
Glycolysis	7
Uncovering the Principles of Genome Folding by 3D Chromatin Modeling	7
The Biology of Lipids	7
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	7
Caspases and Their Substrates	7
Development of Prefrontal Circuits and Cognitive Abilities	7
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	7
Motility Matters: How CD8⁺ T-Cell Trafficking Influences Effector and Memory Cell Differentiation	7
Transcription Factor Dynamics	7
Modeling the Emergence of Circuit Organization and Function during Development	6
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	6
Avian Island Radiations Shed Light on the Dynamics of Adaptive and Nonadaptive Radiation	6
Glia at Transition Zones	6
Glia Development and Function in the NematodeCaenorhabditis elegans	6
The Sensory Ecology of Speciation	6