OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Biology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Teaching School Genetics in the 2020s: Why “Naive” Mendelian Genetics Has to Go	144
Proteins of the Triadic Excitation–Contraction Coupling Complex in Skeletal Muscle	104
Fibroblast Heterogeneity in Healthy and Wounded Skin	99
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance	94
The Role of Membrane Lipids in the Formation and Function of Caveolae	74
Fisher's Geometric Model as a Tool to Study Speciation	66
Post-Translational Regulation of HMG CoA Reductase	57
Angiogenesis in Wound Repair: Too Much of a Good Thing?	55
The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres	53
A History of Cancer Research: Retroviral Insertional Mutagenesis	52
Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences	51
A Mechanometabolism Toolbox for Studying Cell Migration	47
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information	46
Telomere Dynamics in Human Health and Disease	45
Diversity of Fibroblasts and Their Roles in Wound Healing	42
Petabase-Scale Homology Search for Structure Prediction	42
Regulation of Human Telomerase: from Molecular Interactions to Population Genetics	42
Lipids in Extracellular Vesicles: What Can Be Learned about Membrane Structure and Function?	41
Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks	41
Blastocrithidia—A Genetic Alien from the Planet Earth	40
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration	40
Maintaining Telomeres without Telomerase inDrosophila: Novel Mechanisms and Rapid Evolution to Save a Genus	39
Mapping the Retina onto the Brain	37
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale	37
Interneuron Diversity: How Form Becomes Function	35

Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration	34
Neotropics as a Cradle for Adaptive Radiations	33
The Biology of Lipids	33
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes	32
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum	31
Machine Learning for Protein Science and Engineering	29
Glial Cell Development and Function in the Zebrafish Central Nervous System	29
Variability in Neural Circuit Formation	28
Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity	26
A History of Cancer Research: Oncogenic Transcription Factors	26
Growth Factor and Cytokine Delivery Systems for Wound Healing	26
Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations	25
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum	25
Sticking to Membranes: Structure, Function, and Cellular Roles of the Annexin Family of Ca²⁺- and Membrane-Binding Proteins	25
Regulators of Oligodendrocyte Differentiation	23
Cancer Progression and the Calcium Signaling Toolkit: Expanding Dimensions and Perspectives	23
Calcium Signaling and Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Implications	23
Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation	22
Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective	22
Niche Theory as an Underutilized Resource for the Study of Adaptive Radiations	22
In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function	22
Quantitative Analyses of Coupling in Hybrid Zones	21
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)	20
Transformation of Plantation Forestry Productivity for Climate Change Mitigation and Adaptation	20
Developmental Control of Cell Cycle and Signaling	20
Caspases and Their Substrates	20
The Diverse Manifestations of Regeneration and Why We Need to Study Them	19
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function	19
Development of Prefrontal Circuits and Cognitive Abilities	18
Glia at Transition Zones	18
Hidden Treasures of the Genetic Systems in Yeast Mitochondria	18
Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling	18
Ca²⁺ Fluxes across Membrane Contact Sites	18
All for One and One for All: Regenerating Skeletal Muscle	17
Glia Development and Function in the NematodeCaenorhabditis elegans	17
Remyelination in the Central Nervous System	17
Lipid Sorting and Organelle Identity	17
The Sensory Ecology of Speciation	16
Structural Biology of Telomerase and Associated Factors	16
Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation	16
Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane	15
The Wound Microbiome	15
Artificial Intelligence Learns Protein Prediction	15
The Unusual Effectiveness of Evolution in Systems Neuroscience	15
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)	15
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin	14
Overcoming Obstacles to Gene-Edited Solutions to Climate Challenges	14
Physical Forces in Regeneration of Cells and Tissues	14
Genetic and Cellular Contributions to Liver Regeneration	13
Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models	13

Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance	12
Role of Microglia in Central Nervous System Development and Plasticity	12
Mechanisms of Alternative Lengthening of Telomeres	12
Anthropogenic Change and the Process of Speciation	12
Endocytic Roles of Glycans on Proteins and Lipids	12
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions	12
Integrating Sex Chromosome and Endocrine Theories to Improve Teaching of Sexual Differentiation	12
Imaginal Disc Regeneration: Something Old, Something New	11
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies	11
Caspase Activation and Inhibition	11
The Mechanics of Building Functional Organs	11
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives	11
Shedding Light on Telomere Replication, Insights from the Fission YeastSchizosaccharomyces pombe	11
Sex Differences in Circadian Rhythms	10
Telomere Crisis Shapes Cancer Evolution	10
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing	10
Leading the Way: Molecular Drivers of Single-Cell Migration	10
Intracellular Cholesterol Trafficking	10
Bioinspired Strategies for Wound Regeneration	10
Cellular Senescence in Acute and Chronic Wound Repair	9
Schwann Cell Development and Myelination	9
Photosynthesis 2.0: Realizing New-to-Nature CO₂-Fixation to Overcome the Limits of Natural Metabolism	9
Modeling and Simulating Single and Collective Cell Motility	9
Astrocyte Calcium Signaling	9
Building, Breaking, and Repairing Neuromuscular Synapses	9
The Role of Hybridization in Species Formation and Persistence	9
Epigenetics of Human Telomeres	9
Coevolutionary Interactions between Sexual and Habitat Isolation during Reinforcement	9
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System	9
Mendel's Pea Genes	9
Inflammasomes and Other Caspase-Activation Platforms	9
Forces Shaping the Blastocyst	9
Agritech to Tame the Nitrogen Cycle	9
Lung Regeneration: Cells, Models, and Mechanisms	8
Negative Coupling: The Coincidence of Premating Isolating Barriers Can Reduce Reproductive Isolation	8
Modern Modeling of Single-Cell Migration: From Membrane Tension and Galvanotaxis to Machine Learning	8
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders	8
Building Representation Learning Models for Antibody Comprehension	7
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold	7
Evidence for Perinatal Steroid Influence on Human Sexual Orientation and Gendered Behavior	7
Glial Malignancies	7
Autophagy in Skeletal Muscle	6
The Contribution of Innervation to Tissue Repair and Regeneration	6
Phosphoinositides in New Spaces	6
How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?	6
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers	6
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination	6
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds	6
Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation	6
The Burial: Clearance and Consequences	5
Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds	5
A Matter of Life and Death	5
Guiding Cell Migration with Electric Fields: Mechanisms and Applications of Galvanotaxis	5
Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration	5
Plant Breeding and the Origins of Genetics	5
Telomerase in Cancer Therapeutics	5
How Does Selfing Affect the Pace and Process of Speciation?	5
The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases	5
Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans	5
Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?	5
Targeting Recoding by trans-Translation to Develop Antibiotics	5
The Mitochondrial Pathway of Apoptosis Part II: The BCL-2 Protein Family	5
Modeling the Emergence of Circuit Organization and Function during Development	5