Science Signaling

Article	Citations
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	120
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	95
Pathogenic putrescine	88
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	87
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	84
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	83
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	72
Shining a light on rhodopsin signaling	71
Avoiding conflict with strigolactones	69
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	69
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	68
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	64
CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function	64
Transporting leptin to its targets	60
Editorial expression of concern	57
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	56
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	56
Intrapore lipids hydrophobically gate pannexin-1 channels	54
Aging and age-related disorders, cell by cell	53
Nuclear pore decoys fool viruses	51
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	45
Turning a negative into a positive	44
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	44
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	42
Insulin and T reg cells	42

Ring around the mitochondria	42
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	40
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	39
Lipid drops in on Alzheimer’s disease	38
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	37
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	37
Metabolic pressure from sensory neurons	37
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	37
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	37
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	37
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	36
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	36
Targeting AML at the intersection of epigenetics and signaling	35
Telomeres to go	33
Gut bugs on drugs	33
cAMPing up cancer immunotherapy	32
A metabolic regulator for parietal cells	32
The fragile state of opioid withdrawal	32
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	31
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	31
Innate depression	31
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	30
Modulation by macrocyclic peptides	30
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	30
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	30
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	29
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	29
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	28
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	28
A message for microglia from microbiota	28
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	27
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	27
Fibrous stroma: Driver and passenger in cancer development	26
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	26
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	26
Glia are powerhouses for sleep	26
Themis is indispensable for IL-2 and IL-15 signaling in T cells	25
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	25
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	25
Stressed Hippo kinase turns to autophagy	25
Data-driven design of orthogonal protein-protein interactions	25
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	25
Tales from the cryptic pocket	24
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	24
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	24
A savory way to gain weight	24
Stress with ketamine tackles depression	24
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	24
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	23
A spartin approach to lipophagy	23

STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	23
Sleep and longevity tied to glia	22
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome	22
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	22
An ion channel’s high five	22
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	22
Protein-PAINT: Superresolution microscopy with signaling proteins	21
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	21
Obesity and antitumor immunity	21
A spatiotemporal Notch interaction map from plasma membrane to nucleus	21
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	20
A gut punch for PCOS	20
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	20
IL-6 drives hepatocyte dedifferentiation	20
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	20
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	19
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	19
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	19
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	19
Restraining neuroinflammation in Alzheimer’s disease	18
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	18
Get moving to clear β-amyloid	18
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+signaling	18
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	18
Stress granules plug holes	18
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	18
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	18
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	17
Brain aging by gut AGE	17
Exploiting lysosomal advantage in tumors	17
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	17
Retraction	17
TYK2 on tau	17
Compartmentalized prions	17
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	16
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	16
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells	16
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	16
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	16
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	16
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	15
Sleep loss is a metabolic disorder	15
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	15
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	15
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	15
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	15
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	15
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	15
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	15
Expand, push, break, release, repair: A unique way to secrete macromolecules	15
Rebuilding duct work from the gallbladder	14
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	14
Charting metastasis	14
Aging from adipose accumulation of antibodies	14
Interferon with ovarian cancer	14
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	14
The lactate wasteland	14
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	14
Taking down tumors takes atypical integrins	13
Blebby survivors	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
Dissecting the biology of mTORC1 beyond rapamycin	13
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13
The cancer risk of repeat RNAs	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
The polarizing nature of fructose	13
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	13
The biology of addiction	13
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Poor sleep for pass-out drunks	12
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	12

Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	12
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	12
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	12
Stroke of DNA	12
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	12
Improving IL-2 for T cell therapy	12
Stress signaling boosts interferon-induced gene transcription in macrophages	12
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	12
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	12
Neuronal-glioma cross-talk	12
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	12
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	12
A twist in β-arrestin’s tail	12
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	12
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway	12
A pancreatic pause in breast cancer	11
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	11
STING and arthritis	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
Formate for tumor progression	11
Catalytic site mutations confer multiple states of G protein activation	11
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	11
Erratum for the Research Article “IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice” by S. E. Catheline et al .	11
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	11
Complement-ary immunity to lung cancer	11
Acetylation makes a drug-resistant BRAF	11
Exploring protein-protein interactions for the development of new analgesics	10
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	10
In lonely mice, astrocytes turn inhibitory	10
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	10
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	10
JMJD8 reduces cancer’s STING	10
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	10
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	9
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	9
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	9
Extracellular vesicles as central regulators of blood vessel function in cancer	9
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	9
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	9
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	9
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	9
Nanobody pharmacology	9
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	9
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	9
The dimeric form of CXCL12 binds to atypical chemokine receptor 1	9
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	9
Lymph node colonization and metastasis	9
The GABA B receptor mediates neuroprotection by coupling to G 13	9
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	9
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	8
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	8
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	8
Cleanup on IL-2	8
Neural control of gut repair	8
Stressful memories	8
Cholesterol sensing goes vegetarian	8
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	8
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	8
Macrophages de liver growth	8
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	8
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	8
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	7
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	7
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	7
Rewiring the logic board of IFN signaling	7
Paving the way for metastasis	7
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	7
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	7
Keeping brown fat brown	7
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	7
Emerging roles of PLCγ1 in endothelial biology	7
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	7
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	7
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	6
Erratum for the Research Article “Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation” by A. D White, K. A. Peña, L. J. Clark, C. Santa Maria, S. Liu, F.	6
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	6
RHOA drivers take alternate routes in gastric cancer	6
The long-lasting effects of NO	6
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	6
Hitching a ride in macrophages	6
Bring in the B team	6
Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins	6
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer	6
Actin’ off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse	6
Bypassing ACE2	6
Protecting the liver with PKD1	6
Bacteria benefit tumor cells	6
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	6
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	6
Treating neuroinflammation through the nose	6
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	6