Science Signaling

Article	Citations
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	107
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	95
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	93
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	91
Aging and age-related disorders, cell by cell	79
Nuclear pore decoys fool viruses	79
Shining a light on rhodopsin signaling	78
Pathogenic putrescine	75
Intrapore lipids hydrophobically gate pannexin-1 channels	74
Avoiding conflict with strigolactones	66
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	65
Editorial expression of concern	64
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	61
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	61
Estrogen-powered kidney protection	60
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	59
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	58
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	50
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	47
Turning a negative into a positive	46
APOE ε4 on immunity	45
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	44
Ring around the mitochondria	43
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	43
Lipid drops in on Alzheimer’s disease	42

Targeting AML at the intersection of epigenetics and signaling	41
Metabolic pressure from sensory neurons	41
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	40
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	39
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	39
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	39
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	38
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	38
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	37
Telomeres to go	37
Gut bugs on drugs	36
cAMPing up cancer immunotherapy	35
The fragile state of opioid withdrawal	35
A metabolic regulator for parietal cells	34
Modulation by macrocyclic peptides	34
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	33
Innate depression	33
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	33
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	33
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	32
A message for microglia from microbiota	31
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	31
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	30
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	30
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	30
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	30
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	29
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	28
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	28
Protein-PAINT: Superresolution microscopy with signaling proteins	28
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	28
Data-driven design of orthogonal protein-protein interactions	27
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	27
A spartin approach to lipophagy	27
Stress with ketamine tackles depression	27
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	27
Stressed Hippo kinase turns to autophagy	27
Sleep and longevity tied to glia	26
An ion channel’s high five	26
Glia are powerhouses for sleep	25
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	25
Tales from the cryptic pocket	25
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	25
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	24
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	24
Themis is indispensable for IL-2 and IL-15 signaling in T cells	24
Fibrous stroma: Driver and passenger in cancer development	23
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	23
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	23
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	23

Obesity and antitumor immunity	23
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	23
A spatiotemporal Notch interaction map from plasma membrane to nucleus	23
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	23
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	23
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	22
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	22
A gut punch for PCOS	21
IL-6 drives hepatocyte dedifferentiation	21
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	20
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	19
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	19
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	19
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	19
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	19
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	18
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	18
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	18
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	18
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	18
Compartmentalized prions	18
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	18
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	17
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	17
Retraction	17
Exploiting lysosomal advantage in tumors	17
Brain aging by gut AGE	17
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	16
Get moving to clear β-amyloid	16
Sleep loss is a metabolic disorder	16
Stress granules plug holes	16
TYK2 on tau	16
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	16
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	16
Restraining neuroinflammation in Alzheimer’s disease	16
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	16
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	16
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	15
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	15
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	15
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	15
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	15
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	15
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	15
The lactate wasteland	15
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	14
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	14
Aging from adipose accumulation of antibodies	14
Charting metastasis	14
Blebby survivors	14
Interferon with ovarian cancer	13
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	13
Rebuilding duct work from the gallbladder	13
Stroke of DNA	13
Poor sleep for pass-out drunks	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
The biology of addiction	13
Hox-C12 coordinates β 2 -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
The polarizing nature of fructose	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	13
The cancer risk of repeat RNAs	13
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
Taking down tumors takes atypical integrins	13
Neuronal-glioma cross-talk	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13

Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	12
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	12
Complement-ary immunity to lung cancer	12
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	12
A twist in β-arrestin’s tail	12
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway	11
Stress signaling boosts interferon-induced gene transcription in macrophages	11
Catalytic site mutations confer multiple states of G protein activation	11
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	11
STING and arthritis	11
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	11
Senataxin promotes recombination fidelity during antigen receptor gene diversification	11
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	11
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	11
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	11
A pancreatic pause in breast cancer	10
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	10
JMJD8 reduces cancer’s STING	10
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	10
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	10
In lonely mice, astrocytes turn inhibitory	10
Formate for tumor progression	10
PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells	10
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	10
Erratum for the Research Article “IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice” by S. E. Catheline et al .	10
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	10
Acetylation makes a drug-resistant BRAF	9
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	9
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	9
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	9
Exploring protein-protein interactions for the development of new analgesics	9
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	9
Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment	9
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	9
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	9
Cholesterol sensing goes vegetarian	9
Neural control of gut repair	8
Macrophages de liver growth	8
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	8
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	8
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	8
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	8
Lymph node colonization and metastasis	8
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	8
Cleanup on IL-2	8
Nanobody pharmacology	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	7
Extracellular vesicles as central regulators of blood vessel function in cancer	7
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	7
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	7
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	7
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	7
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	7
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	7
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	7
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	7
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	7
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	7
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	7
Keeping brown fat brown	6
Waking up melanoma	6
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	6
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	6
Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins	6
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	6
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	6
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	6
Bring in the B team	6
Paving the way for metastasis	6
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	6
TIM3 is a context-dependent coregulator of cytotoxic T cell function	6
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	6
Rewiring the logic board of IFN signaling	6
Bacteria benefit tumor cells	6
The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD	6
RHOA drivers take alternate routes in gastric cancer	6
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	6
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	6
The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier function	5
USP5 deubiquitylates and stabilizes FcεRIγ to enhance IgE-induced mast cell activation and allergic inflammation	5
A cholinergic signaling pathway underlying cortical circuit activation of quiescent neural stem cells in the lateral ventricle	5
Protein rings are critical to the remarkable signaling properties of bacterial chemotaxis nanoarrays	5
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP	5
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis	5
Polycystin goes with the flow	5
Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice	5
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells	5
Enhancing naloxone	5
Dopamine suppresses ILC2s	5
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	5