Science Signaling

Article	Citations
Aging and age-related disorders, cell by cell	158
Avoiding conflict with strigolactones	138
Cholinergic signals and antibodies	135
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	110
Nuclear pore decoys fool viruses	98
Pathogenic putrescine	80
The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα i1/3 to reduce depressive-like behaviors in mice	79
A Caenorhabditis elegans spatiotemporal proximity atlas reveals the MAPK p38 as a generator of phenotypic plasticity in vivo	76
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	64
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	60
Vagal activation inhibits insulin release through neuronal nitric oxide synthase in obese male mice	58
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons	54
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	54
Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice	53
Estrogen-powered kidney protection	53
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	49
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	48
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	48
APOE ε4 on immunity	46
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	46
Turning a negative into a positive	46
Metabolic pressure from sensory neurons	45
Ring around the mitochondria	45
Lipid drops in on Alzheimer’s disease	44
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	43

A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	42
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	41
The APC/C adaptor Cdh1 stabilizes STING to potentiate innate immune activation in renal cell carcinoma	41
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	41
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	41
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	41
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	41
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	41
Gut bugs on drugs	40
cAMPing up cancer immunotherapy	39
The fragile state of opioid withdrawal	39
Modulation by macrocyclic peptides	38
A metabolic regulator for parietal cells	38
Innate depression	37
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	36
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	36
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	35
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	34
Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia	34
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	33
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	33
Telomeres to go	31
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	31
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	30
An ion channel’s high five	29
Stressed Hippo kinase turns to autophagy	29
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	29
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	29
Sleep and longevity tied to glia	29
Stress with ketamine tackles depression	29
Tales from the cryptic pocket	28
Environmental regulation of mucosal-associated invariant T cells: Adding food for thought	28
A spartin approach to lipophagy	28
Designer binders	28
Jump-starting IFN-I responses and epithelial regeneration	27
EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer	27
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	27
Data-driven design of orthogonal protein-protein interactions	27
Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B	26
A spatiotemporal Notch interaction map from plasma membrane to nucleus	26
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	26
A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging	25
Glia are powerhouses for sleep	25
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	25
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	25
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	25
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	25
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	24
Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca 2+ influx	23
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	23

IL-6 drives hepatocyte dedifferentiation	23
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	23
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	23
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	22
Activation of GPR97/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration	22
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	22
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	21
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	21
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	21
Erratum for the Research Article “IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice”	21
Fattening mother’s milk with oxytocin	21
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	20
A gut punch for PCOS	20
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	20
Retraction	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	20
Get moving to clear β-amyloid	19
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	19
TYK2 on tau	19
Stress granules plug holes	19
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	19
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	19
Allosteric ligands with distinct properties uncover tissue-specific physiological regulation mediated by free fatty acid receptor 2	19
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	18
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	18
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	18
Restraining neuroinflammation in Alzheimer’s disease	18
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	18
Fungi facilitate gut healing	17
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	17
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	17
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	17
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	17
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	17
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling	17
Sleep loss is a metabolic disorder	16
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	16
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	16
The lactate wasteland	16
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	16
Rebuilding duct work from the gallbladder	15
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	15
Aging from adipose accumulation of antibodies	15
Interferon with ovarian cancer	15
Blebby survivors	15
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	15
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
Antimuscarinic drugs exert β-arrestin–biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis	14
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	14
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulation	14
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	14
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	14
The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells	14
Charting metastasis	14
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK –driven lung cancer by concurrent integrin and MET signaling	14
Hox-C12 coordinates β 2 -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	14
Stroke of DNA	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
The cancer risk of repeat RNAs	13
Poor sleep for pass-out drunks	13
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
The polarizing nature of fructose	13
Taking down tumors takes atypical integrins	13
The biology of addiction	13
Keeping inflammasomes in check during bone resorption	13
Neuronal-glioma cross-talk	13
Catalytic site mutations confer multiple states of G protein activation	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	12
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway	12
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	12
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	12

Complement-ary immunity to lung cancer	12
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	12
Senataxin promotes recombination fidelity during antigen receptor gene diversification	12
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	12
SIRT2 versus Lck	12
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	12
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	12
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	12
Stress signaling boosts interferon-induced gene transcription in macrophages	11
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	11
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	11
PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	11
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation	11
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	11
Exploring protein-protein interactions for the development of new analgesics	11
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	10
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	10
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	10
PTPN22 regulates T cell synapse formation through PSTPIP1-dependent actin remodeling	10
In lonely mice, astrocytes turn inhibitory	10
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	10
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	10
JMJD8 reduces cancer’s STING	10
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	10
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
Cholesterol sensing goes vegetarian	9
Skewing p53 to tumor-suppressor targets	9
Macrophages de liver growth	9
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	9
Neural control of gut repair	9
Nanobody pharmacology	9
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	9
Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization	9
Cleanup on IL-2	9
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	9
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	8
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	8
NDRG1 expression in cancers confers dependence on DNA damage repair and sensitivity to quinacrine	8
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	8
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	8
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	8
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	8
Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment	8
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	8
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	8
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	8
Antigen affinity modulates ERK pulsing frequency during T cell activation	8
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	8
Extracellular vesicles as central regulators of blood vessel function in cancer	8
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	8
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	7
The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD	7
Rewiring the logic board of IFN signaling	7
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	7
Treating neuroinflammation through the nose	7
Bypassing ACE2	7
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	7
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	7
Keeping brown fat brown	7
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	7
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	7
Poachers turned gamekeepers in T cells	7
The long-lasting effects of NO	7
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	7
RHOA drivers take alternate routes in gastric cancer	7
Bring in the B team	7
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	7
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	7
Extracellular WNT conveyors	7
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer	7
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	7
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	6
Dopamine suppresses ILC2s	6
Hitching a ride in macrophages	6
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis	6
Actin’ off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse	6
Erratum for the Focus “LIPID MAPS: Powering discovery in lipidomics”	6
Polycystin goes with the flow	6
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	6
The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice	6
TIM3 is a context-dependent coregulator of cytotoxic T cell function	6
The TMEM16A anion channel as a versatile regulator of vascular tone	6
Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins	6
The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification	6
Protecting the liver with PKD1	6
Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosomes	6
The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells	6
The acetyltransferase GCN5 contributes to neuroinflammation in mice by acetylating and activating the NF-κB subunit p65 in microglia	5
Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain–containing CAR	5
Immunogenic Lncs to cancer therapy	5
STING’s cysteine modifications	5
Switching off the bat signal	5