Science Signaling

Article	Citations
Bring in the B team	105
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	81
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	80
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells	80
Making MAVS better	77
A Siah3 of relief: A role for mitophagy as a fail-safe during developmental axon pruning	75
Stem cell health from mom’s gut	73
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	71
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation	66
An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis	63
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	61
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	61
Alarmin’ lymphoid developments	59
Rewiring the logic board of IFN signaling	58
Growth factor–dependent phosphorylation of Gα i shapes canonical signaling by G protein–coupled receptors	58
Bacteria-induced BBB breakdown	57
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	50
A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo	46
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	45
TheBacillus cereustoxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100	43
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	41
Nuclear pore decoys fool viruses	41
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	38
Promoting DNA repair to prevent fibrosis	38
Intrapore lipids hydrophobically gate pannexin-1 channels	37

The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	36
ARC unleashes elastase	35
Bile acids for immune tolerance	34
Connect-the-DOT from early stress to depression	34
Pathogenic putrescine	33
Interfacing with a receptor	33
Transporting leptin to its targets	33
Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α 2a -adrenergic receptors	32
Paving the way for metastasis	32
Hungry in the sun	32
Missing signals from Fragile astrocytes	31
Patching up B cells	31
Distributing apoptosis protects epithelia	31
Keeping brown fat brown	31
Aging and age-related disorders, cell by cell	31
TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis	30
Editorial expression of concern	30
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	30
Waking up melanoma	29
Bacteria benefit tumor cells	28
Shining a light on rhodopsin signaling	28
Taking the STING out of aging?	28
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	27
Pathogen-associated grooming	27
RNAs create a sticky situation	27
Stressing the gut-brain axis	27
Avoiding conflict with strigolactones	27
CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function	26
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	26
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	26
Erratum for the Research Article “Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation” by A. D White, K. A. Peña, L. J. Clark, C. Santa Maria, S. Liu, F.	26
The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury	26
Bile acid–induced metabolic changes in the colon promote Enterobacteriaceae expansion and associate with dysbiosis in Crohn’s disease	26
Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs	26
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	25
Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons	25
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	24
RHOA drivers take alternate routes in gastric cancer	24
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	24
Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes	24
Emerging roles of PLCγ1 in endothelial biology	23
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	23
Short stature and combined immunodeficiency associated with mutations in RGS10	23
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	23
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	23
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice	22
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis	22
The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells	22
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	22
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	21

The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse	21
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	21
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	21
Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling	20
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis	20
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	20
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	20
Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells	20
Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity	20
Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states	19
Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice	19
Making sense of gastric cancer	19
Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling	19
Metabolic pressure from sensory neurons	18
Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein	18
Turning a negative into a positive	18
Sensing stretch to suppress appetite	18
Aging from adipose accumulation of antibodies	18
USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling	18
Lipid drops in on Alzheimer’s disease	18
Protecting the liver with PKD1	18
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	17
Poachers turned gamekeepers in T cells	17
Blebby survivors	17
Arrestins lie in wait	17
To B or not to B	17
Extracellular WNT conveyors	17
Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning	17
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	17
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	17
An evolutionarily conserved coronin-dependent pathway defines cell population size	17
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	17
Hypoxia protects the gut	17
Cleaved to keep dying cells alive	17
Get up and sweat to treat cancer	16
Piquing our interest: Insights into the role of PEAK3 in signaling and disease	16
Hitching a ride in macrophages	16
Legionella takes aim at mitochondria	16
The expanding footprint of basic biology research in India	15
Bypassing ACE2	15
New connections: The selectivity and subversion of SLiMs	15
A check on the immunological synapse	15
A lifeline for immunotherapy	15
Metastatic dormancy needs STING	15
Actin’ off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse	15
Charting metastasis	15
A role for lipid transporters in PDAC	14
Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines	14
Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells	14
Interferon with ovarian cancer	14
Uncloaking tumors	14
An alternative to mitophagy	14
Insulin and T reg cells	14
The long-lasting effects of NO	14
Mind over asthma	14
SIRPα sequesters SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages	13
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	13
Expand, push, break, release, repair: A unique way to secrete macromolecules	13
HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling	13
Sleep to fight tumors	13
Ring around the mitochondria	12
Anxiety from the gut	12
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	12
Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism	12
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes	12
Balancing act of small GTPases downstream of plexin-A4 signaling motifs promotes dendrite elaboration in mammalian cortical neurons	12
Goblet cell stress management	12
The lactate wasteland	12
The TMEM16A anion channel as a versatile regulator of vascular tone	12
Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication	12
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	12
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	12
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	11
CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans	11
Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy	11
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	11
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	11
A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation	11
Neurons go antiviral	11
Treating neuroinflammation through the nose	11

The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression	11
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17	11
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	11
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA–binding protein 1	11
Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability	10
The transmembrane serine protease hepsin suppresses type I interferon induction by cleaving STING	10
ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation	10
Respiratory syncytial virus induces β 2 -adrenergic receptor dysfunction in human airway smooth muscle cells	10
TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22	10
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	10
Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells	10
Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING	10
DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression	10
Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity in Escherichia coli chemoreceptor arrays	10
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	10
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation	10
SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling	10
Rebuilding duct work from the gallbladder	10
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	9
A network of Gα i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF	9
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion	9
Targeting AML at the intersection of epigenetics and signaling	9
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu 2 /mGlu 4 receptor hetero	9
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK	9
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	9
Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites	9
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	9
Balancing energy and protein homeostasis at ER-mitochondria contact sites	9
Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery	9
Hepatic stellate cells: From bad reputation to mediators of liver homeostasis	9
G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling	9
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α	9
Lysine lactylation regulates metabolic pathways and biofilm formation in Streptococcus mutans	8
Stimulation of phospholipase Cβ1 by Gαqpromotes the assembly of stress granule proteins	8
Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain–containing CAR	8
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	8
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	8
A message for microglia from microbiota	8
Heterogeneity in RAS mutations: One size does not fit all	8
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	8
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	8
CMTM4 makes IL-17 signaling more complex	8
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection	8
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	8
Enhancing naloxone	8
Eliminating infection by promoting bacterial growth	7
Dopamine suppresses ILC2s	7
Neuronal-glioma cross-talk	7
Beige is the color of keeping weight off	7
The polarizing nature of fructose	7
Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders	7
Systemic inflammation from the brain	7
Mitochondrial fission fueled by fasting	7
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	7
Stress exhausts T cells	7
Phosphorylated Gβ is a directional cue during yeast gradient tracking	7
Microbes help honeybees learn	7
Innate depression	7
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	7
Polycystin goes with the flow	7
Telomeres to go	7
The gliogenic switch takes teamwork	7
Erratum for the Research Article “Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells” by T. Rosenlehner et al	7
The fragile state of opioid withdrawal	7
Protein rings are critical to the remarkable signaling properties of bacterial chemotaxis nanoarrays	7
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1	6
The type II TGF-β receptor phosphorylates Tyr 182 in the type I receptor to activate downstream Src signaling	6
A metabolic regulator for parietal cells	6
Stroke of DNA	6
Gut bugs on drugs	6
Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast	6
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling inDrosophilawing development	6
A noncanonical IRAK4-IRAK1 pathway counters DNA damage–induced apoptosis independently of TLR/IL-1R signaling	6
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	6
Impaired intracellular Ca 2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice	6
CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism	6
Long-chain polyphosphates impair SARS-CoV-2 infection and replication	6
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation	6
A plasma membrane–associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells	6
M 1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease	6
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP	5
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells	5
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment	5
Taking down tumors takes atypical integrins	5
Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1	5
Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance	5
Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS - and BRAF -mutant cancer cells	5
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS	5
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	5
Nude blebs expose cells to phagocytes	5
Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family	5
Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies	5
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	5
The biology of addiction	5
Skewing cPLA 2 α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis	5