Science Signaling

Article	Citations
Pathogenic putrescine	111
Avoiding conflict with strigolactones	87
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	84
Aging and age-related disorders, cell by cell	82
Shining a light on rhodopsin signaling	78
Editorial expression of concern	78
Transporting leptin to its targets	68
Intrapore lipids hydrophobically gate pannexin-1 channels	65
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	65
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	64
Nuclear pore decoys fool viruses	64
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	64
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	62
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	62
CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function	55
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	54
SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways	50
Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function	49
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	47
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	44
A lifeline for immunotherapy	43
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	42
Insulin and T reg cells	42
Lipid drops in on Alzheimer’s disease	41
Metabolic pressure from sensory neurons	41

Ring around the mitochondria	38
Turning a negative into a positive	38
Targeting AML at the intersection of epigenetics and signaling	37
The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola	37
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	37
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	35
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	35
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	35
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	34
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	34
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	33
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	33
Gut bugs on drugs	32
cAMPing up cancer immunotherapy	32
Innate depression	32
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	32
Telomeres to go	32
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	31
A message for microglia from microbiota	31
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	30
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	30
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	30
The fragile state of opioid withdrawal	30
Modulation by macrocyclic peptides	29
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	29
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	29
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	28
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	28
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H + exchanger	28
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	28
A metabolic regulator for parietal cells	28
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	28
Glia are powerhouses for sleep	27
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	27
Sleep and longevity tied to glia	27
Tales from the cryptic pocket	25
Stressed Hippo kinase turns to autophagy	25
A spartin approach to lipophagy	25
A savory way to gain weight	25
Stress with ketamine tackles depression	25
Themis is indispensable for IL-2 and IL-15 signaling in T cells	24
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	24
Obesity and antitumor immunity	24
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	23
Protein-PAINT: Superresolution microscopy with signaling proteins	23
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	22
An ion channel’s high five	22
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	22
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	22
Fibrous stroma: Driver and passenger in cancer development	22

A spatiotemporal Notch interaction map from plasma membrane to nucleus	22
Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	22
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	21
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	21
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	21
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	21
Data-driven design of orthogonal protein-protein interactions	21
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	21
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome	21
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	20
IL-6 drives hepatocyte dedifferentiation	20
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	20
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	20
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
A gut punch for PCOS	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	20
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	20
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	20
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	19
Get moving to clear β-amyloid	19
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	19
Exploiting lysosomal advantage in tumors	19
Compartmentalized prions	18
Retraction	18
Brain aging by gut AGE	18
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	18
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	18
Restraining neuroinflammation in Alzheimer’s disease	17
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	17
Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+signaling	17
TYK2 on tau	17
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	17
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	17
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	17
Stress granules plug holes	17
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors	17
Systems approach reveals distinct and shared signaling networks of the four PGE 2 receptors in T cells	16
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	16
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	16
Sleep loss is a metabolic disorder	16
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	16
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	16
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	16
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	15
The lactate wasteland	15
Short stature and combined immunodeficiency associated with mutations in RGS10	15
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	15
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	15
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	15
Interferon with ovarian cancer	15
Rebuilding duct work from the gallbladder	14
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	14
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	14
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	14
Aging from adipose accumulation of antibodies	14
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	13
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	13
Neuronal-glioma cross-talk	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
The cancer risk of repeat RNAs	13
Blebby survivors	13
Charting metastasis	13
Stroke of DNA	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
The biology of addiction	13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	13
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	13
Poor sleep for pass-out drunks	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	13
Taking down tumors takes atypical integrins	13
The polarizing nature of fructose	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	12

Improving IL-2 for T cell therapy	12
Complement-ary immunity to lung cancer	12
A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival	12
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	12
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	12
Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery	12
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	12
STING and arthritis	12
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	12
Dissecting the biology of mTORC1 beyond rapamycin	12
A twist in β-arrestin’s tail	12
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	12
RAP1 moonlights to activate NF-κB and Notch in ALT	12
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles	11
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2	11
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	11
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions	11
Erratum for the Research Article “IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice” by S. E. Catheline et al .	11
Formate for tumor progression	11
Mechanisms of biased agonism by Gα i/o -biased stapled peptide agonists of the relaxin-3 receptor	11
Catalytic site mutations confer multiple states of G protein activation	11
In lonely mice, astrocytes turn inhibitory	11
Stress signaling boosts interferon-induced gene transcription in macrophages	11
Acetylation makes a drug-resistant BRAF	11
MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel	11
The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms	11
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice	11
A pancreatic pause in breast cancer	11
Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1	11
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding	10
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice	10
JMJD8 reduces cancer’s STING	10
The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET	10
G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling	10
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis	10
Exploring protein-protein interactions for the development of new analgesics	10
Stressful memories	9
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells	9
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differenti	9
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation	9
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons	9
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells	9
Macrophages de liver growth	9
The GABA B receptor mediates neuroprotection by coupling to G 13	9
Neural control of gut repair	9
Cleanup on IL-2	9
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells	9
Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts	9
Nanobody pharmacology	9
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics	9
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors	9
TSLP shapes the pathogenic responses of memory CD4 + T cells in eosinophilic esophagitis	9
The dimeric form of CXCL12 binds to atypical chemokine receptor 1	9
Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al .	9
Extracellular vesicles as central regulators of blood vessel function in cancer	8
Loss-of-function Gα s rare disease variants exert mutation-specific effects on GPCR signaling	8
A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity	8
CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness	8
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness	8
Cholesterol sensing goes vegetarian	8
Lymph node colonization and metastasis	8
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure	8
Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition	8
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids	8
Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target	8
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells	8
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN	8
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors	8
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease	8
Bring in the B team	7
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification	7
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation	7
Bacteria benefit tumor cells	7
Keeping brown fat brown	7
Rewiring the logic board of IFN signaling	7
Erratum for the Research Article “Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation” by A. D White, K. A. Peña, L. J. Clark, C. Santa Maria, S. Liu, F.	7
Paving the way for metastasis	7
A BRET Ca 2+ sensor enables high-throughput screening in the presence of background fluorescence	7
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1	7
Waking up melanoma	7
Emerging roles of PLCγ1 in endothelial biology	6
Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas	6
Protecting the liver with PKD1	6
The TMEM16A anion channel as a versatile regulator of vascular tone	6
The long-lasting effects of NO	6
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory	6
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction	6
Treating neuroinflammation through the nose	6
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis	6
Bypassing ACE2	6
ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis	6
RHOA drivers take alternate routes in gastric cancer	6
Get up and sweat to treat cancer	6
Hitching a ride in macrophages	6
Extracellular WNT conveyors	6