OOIR: Observatory of International Research

Papers

(The TQCC of Science Signaling is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	107
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	95
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	93
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	91
Nuclear pore decoys fool viruses	79
Aging and age-related disorders, cell by cell	79
Shining a light on rhodopsin signaling	78
Pathogenic putrescine	75
Intrapore lipids hydrophobically gate pannexin-1 channels	74
Avoiding conflict with strigolactones	66
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	65
Editorial expression of concern	64
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	61
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	61
Estrogen-powered kidney protection	60
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	59
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs	58
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	50
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	47
Turning a negative into a positive	46
APOE ε4 on immunity	45
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	44
Ring around the mitochondria	43
A sensitive biosensor of endogenous Gα _i activity enables the accurate characterization of endogenous GPCR agonist responses	43
Lipid drops in on Alzheimer’s disease	42

Targeting AML at the intersection of epigenetics and signaling	41
Metabolic pressure from sensory neurons	41
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	40
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	39
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	39
ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	39
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	38
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	38
Telomeres to go	37
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	37
Gut bugs on drugs	36
The fragile state of opioid withdrawal	35
cAMPing up cancer immunotherapy	35
Modulation by macrocyclic peptides	34
A metabolic regulator for parietal cells	34
Innate depression	33
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	33
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	33
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	33
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	32
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	31
A message for microglia from microbiota	31
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	30
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	30
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	30
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	30
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	29
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na ⁺ /H ⁺ exchanger	28
Protein-PAINT: Superresolution microscopy with signaling proteins	28
The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration	28
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	28
A spartin approach to lipophagy	27
Stress with ketamine tackles depression	27
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	27
Stressed Hippo kinase turns to autophagy	27
Data-driven design of orthogonal protein-protein interactions	27
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	27
An ion channel’s high five	26
Sleep and longevity tied to glia	26
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	25
Tales from the cryptic pocket	25
Sustained Gα _s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	25
Glia are powerhouses for sleep	25
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	24
Themis is indispensable for IL-2 and IL-15 signaling in T cells	24
Adhesion to laminin-1 and collagen IV induces the formation of Ca ²⁺ microdomains that sensitize mouse T cells for activation	24
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	23
Obesity and antitumor immunity	23
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	23
A spatiotemporal Notch interaction map from plasma membrane to nucleus	23

Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	23
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	23
Fibrous stroma: Driver and passenger in cancer development	23
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	23
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	23
Quantal leaps in understanding Ca ²⁺ signaling: A “Taylored” approach	22
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	22
A gut punch for PCOS	21
IL-6 drives hepatocyte dedifferentiation	21
Adenosine signaling activates ATP-sensitive K ⁺ channels in endothelial cells and pericytes in CNS capillaries	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	20
THEMIS increases TCR signaling in CD4 ⁺ CD8 ⁺ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	19
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	19
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	19
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	19
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	19
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	18
Convergent activation of Ca ²⁺ permeability in two-pore channel 2 through distinct molecular routes	18
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	18
Compartmentalized prions	18
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP	18
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	18
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	18
Retraction	17
Exploiting lysosomal advantage in tumors	17
Brain aging by gut AGE	17
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	17
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	17
Stress granules plug holes	16
TYK2 on tau	16
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	16
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	16
Restraining neuroinflammation in Alzheimer’s disease	16
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	16
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	16
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	16
Get moving to clear β-amyloid	16
Sleep loss is a metabolic disorder	16
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	15
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	15
Aberrant Ca ²⁺ signaling by IP ₃ Rs in adipocytes links inflammation to metabolic dysregulation in obesity	15
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	15
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	15
The lactate wasteland	15
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	15
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	15
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	14
Aging from adipose accumulation of antibodies	14
Charting metastasis	14
Blebby survivors	14
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	14
The biology of addiction	13
Hox-C12 coordinates β ₂ -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
K _v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
The polarizing nature of fructose	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	13
The cancer risk of repeat RNAs	13
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	13
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
Taking down tumors takes atypical integrins	13
Neuronal-glioma cross-talk	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	13
Interferon with ovarian cancer	13
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	13
Rebuilding duct work from the gallbladder	13
Stroke of DNA	13
Poor sleep for pass-out drunks	13
Activation of gp130 signaling in T cells drives T _H 17-mediated multi-organ autoimmunity	13
Redox-dependent internalization of the purinergic P2Y ₆ receptor limits colitis progression	13