Science Signaling

Article	Citations
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	111
Aging and age-related disorders, cell by cell	98
Nuclear pore decoys fool viruses	94
Shining a light on rhodopsin signaling	94
Pathogenic putrescine	89
Intrapore lipids hydrophobically gate pannexin-1 channels	80
Avoiding conflict with strigolactones	79
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	75
Editorial expression of concern	70
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	66
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	66
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target	64
Estrogen-powered kidney protection	61
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	61
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	60
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	51
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	46
Turning a negative into a positive	45
APOE ε4 on immunity	44
A sensitive biosensor of endogenous Gα i activity enables the accurate characterization of endogenous GPCR agonist responses	44
Metabolic pressure from sensory neurons	43
Lipid drops in on Alzheimer’s disease	43
Ring around the mitochondria	43
Targeting AML at the intersection of epigenetics and signaling	41
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	40

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis	39
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	39
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	39
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	38
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	38
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	38
SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response	37
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	36
Telomeres to go	35
The fragile state of opioid withdrawal	35
Gut bugs on drugs	35
cAMPing up cancer immunotherapy	34
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	33
A metabolic regulator for parietal cells	33
Innate depression	33
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	33
Modulation by macrocyclic peptides	33
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	32
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	32
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury	31
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	30
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	30
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	30
ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3	30
Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na + /H +	29
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	29
Protein-PAINT: Superresolution microscopy with signaling proteins	28
Stressed Hippo kinase turns to autophagy	28
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	28
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	28
The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth	27
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	27
Stress with ketamine tackles depression	27
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	27
Glia are powerhouses for sleep	26
An ion channel’s high five	26
Tales from the cryptic pocket	26
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	26
Sleep and longevity tied to glia	26
Themis is indispensable for IL-2 and IL-15 signaling in T cells	24
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy	24
A spatiotemporal Notch interaction map from plasma membrane to nucleus	24
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	24
Jump-starting IFN-I responses and epithelial regeneration	24
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	24
Obesity and antitumor immunity	24
Data-driven design of orthogonal protein-protein interactions	24
Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	24
A spartin approach to lipophagy	23
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis	23

Sustained Gα s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	23
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	21
Adhesion to laminin-1 and collagen IV induces the formation of Ca 2+ microdomains that sensitize mouse T cells for activation	21
Fibrous stroma: Driver and passenger in cancer development	20
THEMIS increases TCR signaling in CD4 + CD8 + thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	20
A gut punch for PCOS	20
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach	20
IL-6 drives hepatocyte dedifferentiation	20
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	19
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	19
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	19
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals	19
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	19
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	19
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	18
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	18
Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries	18
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	18
Compartmentalized prions	18
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	18
Brain aging by gut AGE	18
Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production	18
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	17
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	17
Get moving to clear β-amyloid	17
Restraining neuroinflammation in Alzheimer’s disease	17
TYK2 on tau	17
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	17
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	16
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes	16
The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice	16
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	16
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	16
Sleep loss is a metabolic disorder	16
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	16
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	16
Stress granules plug holes	16
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	16
The lactate wasteland	15
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	15
Blebby survivors	15
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	15
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	15
Hox-C12 coordinates β 2 -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	15
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	15
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
Charting metastasis	14
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	14
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	14
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	14
Rebuilding duct work from the gallbladder	14
Aging from adipose accumulation of antibodies	14
Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	14
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	14
Interferon with ovarian cancer	14
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	14
The polarizing nature of fructose	13
Neuronal-glioma cross-talk	13
K v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
Activation of gp130 signaling in T cells drives T H 17-mediated multi-organ autoimmunity	13
Poor sleep for pass-out drunks	13
The cancer risk of repeat RNAs	13
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice	13
Stroke of DNA	13
Redox-dependent internalization of the purinergic P2Y 6 receptor limits colitis progression	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13
Taking down tumors takes atypical integrins	13
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulation	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs	13
The biology of addiction	12
The actin-binding protein CAP1 represses MRTF-SRF–dependent gene expression in mouse cerebral cortex	12
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse	12
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1	12
STING and arthritis	12

A twist in β-arrestin’s tail	12
The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells	12