OOIR: Observatory of International Research

Papers

(The TQCC of Science Signaling is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Aging and age-related disorders, cell by cell	158
Avoiding conflict with strigolactones	138
Cholinergic signals and antibodies	135
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease	110
Nuclear pore decoys fool viruses	98
Pathogenic putrescine	80
The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα _i1/3 to reduce depressive-like behaviors in mice	79
A Caenorhabditis elegans spatiotemporal proximity atlas reveals the MAPK p38 as a generator of phenotypic plasticity in vivo	76
ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress	64
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease	60
Vagal activation inhibits insulin release through neuronal nitric oxide synthase in obese male mice	58
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons	54
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors	54
Estrogen-powered kidney protection	53
Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice	53
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization	49
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney	48
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis	48
APOE ε4 on immunity	46
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition	46
Turning a negative into a positive	46
Metabolic pressure from sensory neurons	45
Ring around the mitochondria	45
Lipid drops in on Alzheimer’s disease	44
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment	43

A sensitive biosensor of endogenous Gα _i activity enables the accurate characterization of endogenous GPCR agonist responses	42
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses	41
The APC/C adaptor Cdh1 stabilizes STING to potentiate innate immune activation in renal cell carcinoma	41
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation	41
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth	41
IL-33–ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways	41
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells	41
Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke	41
Gut bugs on drugs	40
cAMPing up cancer immunotherapy	39
The fragile state of opioid withdrawal	39
Modulation by macrocyclic peptides	38
A metabolic regulator for parietal cells	38
Innate depression	37
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity	36
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP	36
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer	35
Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice	34
Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia	34
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model	33
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β	33
Telomeres to go	31
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis	31
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2	30
An ion channel’s high five	29
Stressed Hippo kinase turns to autophagy	29
The early bird catches the IL-2 in C-type lectin receptor–dependent activation of dendritic cells	29
A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling	29
Sleep and longevity tied to glia	29
Stress with ketamine tackles depression	29
Tales from the cryptic pocket	28
Environmental regulation of mucosal-associated invariant T cells: Adding food for thought	28
A spartin approach to lipophagy	28
Designer binders	28
Jump-starting IFN-I responses and epithelial regeneration	27
EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer	27
Sustained Gα _s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent	27
Data-driven design of orthogonal protein-protein interactions	27
Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B	26
A spatiotemporal Notch interaction map from plasma membrane to nucleus	26
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration	26
A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging	25
Glia are powerhouses for sleep	25
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism	25
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies	25
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells	25
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans	25
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer	24
Adhesion to laminin-1 and collagen IV induces the formation of Ca ²⁺ microdomains that sensitize mouse T cells for activation	23
Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca ²⁺ influx	23

Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease	23
IL-6 drives hepatocyte dedifferentiation	23
Quantal leaps in understanding Ca ²⁺ signaling: A “Taylored” approach	23
Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways	22
Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation	22
Activation of GPR97/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration	22
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1	21
THEMIS increases TCR signaling in CD4 ⁺ CD8 ⁺ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1	21
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING	21
Erratum for the Research Article “IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice”	21
Fattening mother’s milk with oxytocin	21
Siah3 acts as a physiological mitophagy suppressor that facilitates axonal degeneration	20
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation	20
Retraction	20
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis	20
The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition	20
A gut punch for PCOS	20
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo	20
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release	20
TYK2 on tau	19
Stress granules plug holes	19
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons	19
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens	19
Allosteric ligands with distinct properties uncover tissue-specific physiological regulation mediated by free fatty acid receptor 2	19
Get moving to clear β-amyloid	19
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile	19
Convergent activation of Ca ²⁺ permeability in two-pore channel 2 through distinct molecular routes	18
Restraining neuroinflammation in Alzheimer’s disease	18
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop	18
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation	18
Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage	18
Evolution of growth factor signaling to the TSC complex to regulate mTORC1	17
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P	17
Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase	17
The adrenal stress response is an essential host response against therapy-induced lethal immune activation	17
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling	17
Fungi facilitate gut healing	17
The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters	17
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages	16
The lactate wasteland	16
Insights into the intramembrane protease SPPL2b and its substrates: Functions and disease implications	16
Sleep loss is a metabolic disorder	16
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice	16
Interferon with ovarian cancer	15
Blebby survivors	15
The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans	15
Rebuilding duct work from the gallbladder	15
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells	15
Aging from adipose accumulation of antibodies	15
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2	14
Expand, push, break, release, repair: A unique way to secrete macromolecules	14
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition	14
The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells	14
Charting metastasis	14
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK –driven lung cancer by concurrent integrin and MET signaling	14
Hox-C12 coordinates β ₂ -adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer	14
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells	14
Antimuscarinic drugs exert β-arrestin–biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis	14
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells	14
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulation	14
The cancer risk of repeat RNAs	13
Poor sleep for pass-out drunks	13
K _v 1.3-induced hyperpolarization is required for efficient Kaposi’s sarcoma–associated herpesvirus lytic replication	13
Activation of gp130 signaling in T cells drives T _H 17-mediated multi-organ autoimmunity	13
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow	13
The polarizing nature of fructose	13
Taking down tumors takes atypical integrins	13
The biology of addiction	13
Keeping inflammasomes in check during bone resorption	13
Neuronal-glioma cross-talk	13
Stroke of DNA	13
The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization	13
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis	13
Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response	13