OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 89. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes	413
Increased β ₂ -adrenergic signaling promotes fracture healing through callus neovascularization in mice	366
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke	364
Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system	327
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	320
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation	276
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	272
Navigating regulatory pathways for translation of biologic cartilage repair products	223
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection	198
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	198
Evidence for the contribution of the gut microbiome to obesity and its reversal	194
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	190
Stronger regulation of AI in biomedicine	190
Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19	183
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer	182
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	177
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model	176
Pandemic preparedness strategies must go beyond vaccines	173
An identity crisis for lung cancer cells	172
Targeting electrochemical communication between neurons and cancer	171
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	165
Next-generation RSV vaccines avoid flipping out	160
The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells	158
An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript	157
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia	156

What’s next for cancer vaccines	156
Proteomic analysis of Alzheimer’s disease cerebrospinal fluid reveals alterations associated with APOE ε4 and atomoxetine treatment	155
Hemodynamic evaluation of biomaterial-based surgery for Tetralogy of Fallot using a biorobotic heart, in silico, and ovine models	153
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer	150
FcγRIIB expressed on CD8⁺T cells limits responsiveness to PD-1 checkpoint inhibition in cancer	147
The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis	146
Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”	143
Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity	143
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose	142
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	132
In-line miniature 3D-printed pressure-cycled ventilator maintains respiratory homeostasis in swine with induced acute pulmonary injury	131
Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation	131
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	131
Erratum for the Research Article: “Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis” by M. Scherlinger, V. Guillotin, I. Douchet, P. Vacher, A. B	131
Advancing beyond the twists and turns of T cell exhaustion in cancer	129
What keeps me up at night	127
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	123
Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variants	123
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	121
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis	120
Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy	118
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models	116
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	115
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections	114
Passive monitoring by smart toilets for precision health	113
A metabolic role for CD47 in pancreatic β cell insulin secretion and islet transplant outcomes	113
Restoring arm function with a soft robotic wearable for individuals with amyotrophic lateral sclerosis	110
A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers	109
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds	109
Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern	108
An anti–TNF–glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases	107
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine	106
Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma	105
Point-of-care diagnostic tests for tuberculosis disease	104
Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains	104
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	101
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes	101
A new chapter in lipid signaling and kidney fibrosis	100
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	100
Drug discovery in Africa tackles zoonotic and related infections	100
Erratum for the Research Article “Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer” by H.-H. Wu et al	100
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination	99
Closing the loop on adrenal health, dysfunction, and disease	99
Sexual dimorphism in functional pain syndromes	98
Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents	98
Keratinocytes: From passive targets to active mediators of systemic autoimmunity	98
High-frequency epidural electrical stimulation reduces spasticity and facilitates walking recovery in patients with spinal cord injury	98
Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair	96
Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy	96
Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients	95

A humanized antibody against mucormycosis targets angioinvasion and augments the host immune response	95
Vaccines for a sustainable planet	94
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models	93
Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration	93
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C	93
Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy	93
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	92
Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration	92
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	91
Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies	91
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease	90
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	90
The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI	89
Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients	89