OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Stronger regulation of AI in biomedicine	496
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	400
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	313
Antigenic distance between primary and secondary dengue infections correlates with disease risk	290
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	236
Evolution of inflammation and immunity in a dengue virus 1 human infection model	221
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	213
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	202
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	202
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	202
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	200
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	191
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	190
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	190
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	187
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	187
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	186
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	185
In vivo gene immunotherapy for cancer	180
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	178
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	176
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	167
Erratum for the Research Article: “Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis” by M. Scherlinger, V. Guillotin, I. Douchet, P. Vacher, A. B	162
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	159
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer	155

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	147
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	143
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	142
Advancing beyond the twists and turns of T cell exhaustion in cancer	142
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	142
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	142
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	141
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	141
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia	135
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	134
Point-of-care diagnostic tests for tuberculosis disease	134
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	131
Engineering CAR-T therapies for autoimmune disease and beyond	128
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	125
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	125
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	124
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	123
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	122
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	122
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Koni	121
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	119
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	117
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	116
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	115
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	113
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	112
TREM1 activation of myeloid cells promotes antitumor immunity	111
Integrating the gut microbiome and pharmacology	110
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	110
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors	109
4-Aminopyridine is a promising treatment option for patients with gain-of-function KCNA2 -encephalopathy	109
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	108
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	108
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	107
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	107
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	106
Translating insights into therapies for Long Covid	105
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	105
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	103
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	103
Molecular hallmarks of hydrocephalus	103
Next-generation CAR T cell therapies for glioblastoma	103
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	103
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	102
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	101
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	100
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	100
Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer	99
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	99
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	98

Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	98
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	97
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort	95
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers	95
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models	94
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment	94
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria	94
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	93
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice	92
Harnessing regulatory T cells to establish immune tolerance	92
Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes	91
Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors	91
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease	91
Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire	91
Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity	90
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T _H 1 response with a diverse TCR repertoire	90
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer	90