OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 86. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis	598
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	351
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	345
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	271
Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models	263
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	260
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	237
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	229
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	225
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	221
Antigenic distance between primary and secondary dengue infections correlates with disease risk	202
Advancing beyond the twists and turns of T cell exhaustion in cancer	189
Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy in preclinical mouse models	186
Resilient nanostructured bioanalytic microneedle longitudinally monitors preclinical renal and hepatic drug clearance and dysfunction	184
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	172
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	164
Evolution of inflammation and immunity in a dengue virus 1 human infection model	162
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	162
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	161
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	161
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	152
Engineering CAR-T therapies for autoimmune disease and beyond	151
Stronger regulation of AI in biomedicine	145
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	144
Targeting neurotumoral signaling networks in cancer	143

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	142
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	141
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	138
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	138
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	134
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	134
In vivo gene immunotherapy for cancer	133
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	129
Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2 -related neurodevelopmental disorder	127
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	124
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	124
TREM1 activation of myeloid cells promotes antitumor immunity	122
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	122
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	122
Translating insights into therapies for Long Covid	121
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	120
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	119
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	118
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	118
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	116
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	115
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	114
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	114
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	114
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection	113
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	113
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	109
Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma	108
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis	105
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	102
Generating functionally stable and antigen-specific T _reg cells from effector T cells for cell therapy of inflammatory diseases	102
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	102
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	101
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	101
Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy	100
Molecular hallmarks of hydrocephalus	98
Next-generation CAR T cell therapies for glioblastoma	98
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	98
Integrating the gut microbiome and pharmacology	97
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	96
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	96
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	96
Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models	95
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment	94
T cell receptor precision editing of regulatory T cells for celiac disease	93
CD23 ⁺ IgG1 ⁺ memory B cells are poised to switch to pathogenic IgE production in food allergy	93
Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders	93
Extracellular BRICK1 drives heart repair after myocardial infarction in mice	92
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	92
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis	92

Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months	91
BDNF Val ⁶⁶ Met protects oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer	91
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer	90
Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice	90
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants	89
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice	89
Wastewater surveillance facilitates climate change–resilient pathogen monitoring	89
Harnessing regulatory T cells to establish immune tolerance	89
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease	89
Clinicogenomic analysis of EGFR -mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation	86
Transferrin in combination with induction chemotherapy improves outcomes in mouse models of acute myeloid leukemia	86