OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 86. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	543
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	307
Resilient nanostructured bioanalytic microneedle longitudinally monitors preclinical renal and hepatic drug clearance and dysfunction	289
Antigenic distance between primary and secondary dengue infections correlates with disease risk	279
Advancing beyond the twists and turns of T cell exhaustion in cancer	265
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	248
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	239
Stronger regulation of AI in biomedicine	228
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	220
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	220
Engineering CAR-T therapies for autoimmune disease and beyond	197
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	196
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	196
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	182
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	171
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	167
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	166
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	161
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	155
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	150
Evolution of inflammation and immunity in a dengue virus 1 human infection model	148
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	143
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	141
In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis	138
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	134

In vivo gene immunotherapy for cancer	133
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	130
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	128
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	128
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	127
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	127
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	127
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	126
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	126
Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma	125
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection	123
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	120
TREM1 activation of myeloid cells promotes antitumor immunity	119
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	119
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	119
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	116
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	113
Integrating the gut microbiome and pharmacology	112
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	112
Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2 -related neurodevelopmental disorder	110
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	110
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	110
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	109
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	108
Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy	108
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis	108
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	107
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	106
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	105
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	105
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	104
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	104
Next-generation CAR T cell therapies for glioblastoma	102
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	101
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	99
Translating insights into therapies for Long Covid	99
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	99
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	96
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	95
Molecular hallmarks of hydrocephalus	95
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	95
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	94
Generating functionally stable and antigen-specific T _reg cells from effector T cells for cell therapy of inflammatory diseases	92
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	92
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	92
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	91
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	91
A nose for tau	91
Obesity and lifespan, a complex tango	90
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants	90

Extracellular BRICK1 drives heart repair after myocardial infarction in mice	89
Wastewater surveillance facilitates climate change–resilient pathogen monitoring	89
Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice	88
Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders	88
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	88
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria	88
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers	88
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease	87
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	87
T cell receptor precision editing of regulatory T cells for celiac disease	87
Diet shapes the metabolite profile in the intact human ileum, which affects PYY release	86
Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models	86