OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Erratum for the Research Article: “Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis” by M. Scherlinger, V. Guillotin, I. Douchet, P. Vacher, A. B	449
Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy	379
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	366
Stronger regulation of AI in biomedicine	296
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	287
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	225
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer	217
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	210
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	204
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	198
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	195
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	189
Evolution of inflammation and immunity in a dengue virus 1 human infection model	186
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	185
Point-of-care diagnostic tests for tuberculosis disease	185
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	180
Antigenic distance between primary and secondary dengue infections correlates with disease risk	180
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	179
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	178
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	176
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	171
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	169
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	168
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	167
In vivo gene immunotherapy for cancer	163

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	162
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	161
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	157
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	156
Advancing beyond the twists and turns of T cell exhaustion in cancer	153
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	141
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	140
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia	137
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	136
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	134
Engineering CAR-T therapies for autoimmune disease and beyond	134
A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification	134
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	131
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	128
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Koni	127
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	121
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	120
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	119
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	119
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	118
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	115
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	115
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	114
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	113
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	112
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	112
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	111
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	111
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	110
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors	110
Next-generation CAR T cell therapies for glioblastoma	107
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	106
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	106
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	106
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	106
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	103
4-Aminopyridine is a promising treatment option for patients with gain-of-function KCNA2 -encephalopathy	103
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	102
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	102
TREM1 activation of myeloid cells promotes antitumor immunity	102
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	100
Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer	100
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	100
Translating insights into therapies for Long Covid	99
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	99
Integrating the gut microbiome and pharmacology	99
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	99
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	99
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	98
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	97

Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	97
An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo	96
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models	96
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria	95
Short-course combination treatment for experimental chronic Chagas disease	95
A nose for tau	94
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	94
Astrocytic α2-Na ⁺ /K ⁺ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model	93
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice	93
Diet shapes the metabolite profile in the intact human ileum, which affects PYY release	92
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	92
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis	91
Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial	91
Obesity and lifespan, a complex tango	91
Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders	91
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer	90
Wastewater surveillance facilitates climate change–resilient pathogen monitoring	90
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration	90
Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors	90
Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months	90