OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 93. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
IgA dominates the early neutralizing antibody response to SARS-CoV-2	778
A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples	474
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19	474
Enhanced SARS-CoV-2 neutralization by dimeric IgA	365
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates	327
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters	319
COVID-19 diagnostics in context	287
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients	285
Importance of the pig as a human biomedical model	246
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus	242
Lung transplantation for patients with severe COVID-19	237
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma	224
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations	218
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis	205
Advanced bandages for diabetic wound healing	196
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome	194
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection	192
Prospects for a safe COVID-19 vaccine	189
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2	187
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys	182
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice	180
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance	177
An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates	172
Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits	169
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors	168

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice	168
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models	161
Sampling interstitial fluid from human skin using a microneedle patch	158
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages	155
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19	154
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection	152
Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs	150
The past, present, and future of antibiotics	150
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy	148
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia	147
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals	146
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans	140
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma	140
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide	140
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys	139
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors	139
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy	136
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19	136
Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice	135
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice	132
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity	128
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome	127
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals	127
cGAS-STING–mediated DNA sensing maintains CD8 ⁺ T cell stemness and promotes antitumor T cell therapy	126
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy	124
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	123
Reproducibility in machine learning for health research: Still a ways to go	121
Acute inflammatory response via neutrophil activation protects against the development of chronic pain	121
ctDNA monitoring using patient-specific sequencing and integration of variant reads	120
Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy	120
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice	119
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia	118
Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine	116
SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19	115
Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines	114
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma	114
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection	114
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness	113
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases	113
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline	112
PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity	111
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy	111
Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson’s disease	111
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease	110
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models	110
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils	110
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography	109
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models	108
Nicotinamide for the treatment of heart failure with preserved ejection fraction	107
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms	107

A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease	103
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy	103
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis	102
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses	102
Predicting the mutational drivers of future SARS-CoV-2 variants of concern	101
Biology of antimicrobial resistance and approaches to combat it	101
Toward robust mammography-based models for breast cancer risk	100
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation	100
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates	100
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms	100
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions	99
Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States	99
Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients	98
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination	97
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice	97
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components	95
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy	94
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension	94
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade	93