OOIR: Observatory of International Research

Papers

(The H4-Index of Science Translational Medicine is 89. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice	550
A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care	451
Evolution of inflammation and immunity in a dengue virus 1 human infection model	352
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair	300
Point-of-care diagnostic tests for tuberculosis disease	258
A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors	248
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation	232
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection	231
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant	221
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans	209
Antigenic distance between primary and secondary dengue infections correlates with disease risk	208
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting	205
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment	202
Stronger regulation of AI in biomedicine	201
A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain	198
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans	192
Advancing beyond the twists and turns of T cell exhaustion in cancer	185
Increased brain microvascular hemoglobin concentrations in children with cerebral malaria	185
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms	169
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics	168
SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 ⁺ T cells	166
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England	163
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer	158
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies	156
In vivo gene immunotherapy for cancer	151

Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer	151
Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer	150
Engineering CAR-T therapies for autoimmune disease and beyond	147
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine	146
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome	146
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging	145
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment	142
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery	134
A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer	132
Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes	129
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens	127
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis	121
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa	120
Erratum for the Research Article: “The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis” by S. S. Pullamsetti, R. Savai, R. Dumitrascu, B. K. Dahal, J. Wilhelm, M. Koni	120
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models	118
Translating insights into therapies for Long Covid	118
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans	118
Molecular hallmarks of hydrocephalus	116
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer	116
Generating functionally stable and antigen-specific T _reg cells from effector T cells for cell therapy of inflammatory diseases	116
Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation	116
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice	113
Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas	112
Development and preclinical validation of 2-deoxy 2-[ ¹⁸ F]fluorocellobiose as an Aspergillus -specific PET tracer	111
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease	111
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection	110
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease	110
Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation	109
NAD ⁺ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction	109
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction	109
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons	109
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis	107
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease	107
Integrating the gut microbiome and pharmacology	107
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry	106
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager	105
Next-generation CAR T cell therapies for glioblastoma	105
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes	104
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe	104
TREM1 activation of myeloid cells promotes antitumor immunity	103
The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons	102
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy	101
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron	101
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting	100
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models	99
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)	99
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia	97
T cell receptor precision editing of regulatory T cells for celiac disease	96
Obesity and lifespan, a complex tango	96
A nose for tau	96

Diet shapes the metabolite profile in the intact human ileum, which affects PYY release	96
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers	95
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis	95
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer	94
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria	93
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants	93
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis	93
Assessment of cholesterol homeostasis in the living human brain	92
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses	92
Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice	91
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease	91
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis	90
Harnessing regulatory T cells to establish immune tolerance	90
Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes	89