OOIR: Observatory of International Research

Papers

(The H4-Index of ACS Medicinal Chemistry Letters is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	101
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	98
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	91
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	59
Clozapine as an E3 Ligand for PROTAC Technology	51
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	49
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	48
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	47
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	45
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors	45
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	43
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	41
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	41
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	37
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	37
Discovery of a Novel sp³-Rich M₁ Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	36
Issue Publication Information	34
Issue Editorial Masthead	34
Issue Publication Information	34
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	33
Targeting the “Undruggable” Driver Protein, KRAS^G12D, as Potential Therapy in Prostate Cancer	31
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	30
In This Issue, Volume 14, Issue 5	30
Novel Phosphorylpurinone Compounds for Treating Cancer	29
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors	29

Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	29
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	29
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	29
Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain	28