OOIR: Observatory of International Research

Papers

(The H4-Index of ACS Medicinal Chemistry Letters is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Issue Publication Information	91
Issue Editorial Masthead	90
Issue Publication Information	78
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	57
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	50
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	50
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	49
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	48
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	48
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	44
Clozapine as an E3 Ligand for PROTAC Technology	42
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	40
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	40
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	36
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	35
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	35
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	34
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	33
In This Issue, Volume 14, Issue 5	32
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	32
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	32
Targeting the “Undruggable” Driver Protein, KRAS^G12D, as Potential Therapy in Prostate Cancer	32
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	30
Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs	28
Novel Histone Acetyltransferase (HAT) Inhibitors for Treating Diseases	28

Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	28
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	27
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors	27