OOIR: Observatory of International Research

Papers

(The median citation count of ACS Medicinal Chemistry Letters is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	163
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	139
Issue Editorial Masthead	92
Issue Publication Information	74
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	62
Clozapine as an E3 Ligand for PROTAC Technology	56
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	53
Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket	51
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	48
Design and Synthesis of a Structurally Stabilized B-Chain Antagonist Targeting Relaxin Family Peptide Receptor 3 (RXFP3)	48
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	46
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	44
In This Issue, Volume 14, Issue 5	43
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	41
Novel Phosphorylpurinone Compounds for Treating Cancer	40
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	39
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	39
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	38
Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6	37
Modulation of Cancer Networks through Protein Degradation, DNA Repair Inhibition, and Quantitative Interactomics	36
Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity	36
Multimodal Control of STAT6 Signaling through Small-Molecule Modulation and Targeted Degradation	33
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	33
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	33
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	32

Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	31
Discovery of Quinazolinone Derivatives as Potent PARP1 Inhibitors	31
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	31
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	30
Targeting the “Undruggable” Driver Protein, KRAS^G12D, as Potential Therapy in Prostate Cancer	30
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	29
Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain	27
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	26
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	26
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	25
Structure–Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region	25
Design and Synthesis of Phosphonoproline-Proline Bioisosteric Mimetics of Proline Dimers: Pseudopeptide Constructs as Potential Inhibitors of the Zn-Metalloprotease PPEP-1 Associated with	24
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	24
Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids	23
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	22
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	22
Discovery of a Novel sp³-Rich M₁ Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	22
Tricyclic and Novel Chemotypes as Selective WRN Helicase Inhibitors for MSI-H Cancer Therapy	22
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	22
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	22
Novel Indazole Compounds as PKMYT1 Kinase Inhibitors for Treating Cancer	21
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	21
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	21
N -Myristoyltransferase Inhibitors as a Potential Starting Point for the Development of Antischistosomal Agents	21
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	21
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	21
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	21
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	21
Issue Editorial Masthead	21
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	20
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	20
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	20
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	20
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	20
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	20
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	19
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	19
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	19
Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment	19
Identification and Exploration of a Series of SARS-Cov-2 M^Pro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group	19
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	18
Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics	18
Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold	18
N -Alkyl and N -Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable P	18
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	18
Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na _V 1.8 Inhibitors	18
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	18
Synthesis and In Vitro/In Silico α-Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole	17
Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	17
Synthesis and Preclinical Evaluation of Novel ⁶⁸Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	17

Mechanistic Insights from Differences in the Aggregate Morphologies of Amphotericin B and Its Less Toxic Variant Am-2-19 (Turletricin)	17
Novel Compounds as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity	17
Issue Publication Information	17
A Novel Peptide-Based PD-L1 PET Tracer: Design, Synthesis, and Preclinical Imaging Validation	17
Synthesis and Biochemical Characterization of Investigational Pyrazolopyrimidine-Based Allosteric KRAS Modulators	17
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	16
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	16
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction	16
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	16
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	16
Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase	16
Novel Indolinyl Compounds as Helicase Primase Inhibitors for Treating Viral Infections, in particular, Herpesvirus Infections	15
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	15
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	15
6,7-Dihalo-Benzothiadiazines as Potent and Selective AMPA Receptor Modulators for Cognitive Enhancement and Neuroprotection	15
Fragment Ligands of the m⁶A-RNA Reader YTHDF2	15
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	15
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	15
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	15
Issue Publication Information	14
Issue Editorial Masthead	14
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	14
Synthesis and Biological Evaluation of 3,5-Diaryl-Substituted 1,2,4-Oxadiazole Sulfamates as Potent Steroid Sulfatase Inhibitors	14
Discovery of VU6052959/BI’7927: A Selective mGlu ₃ Positive Allosteric Modulator (PAM) from an Orthogonal Benzoxazine Chemotype	14
Advancing New Chemical Modalities into Clinical Studies	14
Issue Editorial Masthead	14
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput ¹H NMR for Parallel Medicinal Chemistry	14
NADPH-Oxidase 4 (NOX4) Inhibitors as a Treatment for Idiopathic Pulmonary Disease, Fibrotic Diseases, Inflammatory Diseases, and Cancer	14
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	14
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	14
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	14
Issue Publication Information	14
Advancing Next-Generation Psychedelic Therapeutics through Selective 5-HT2A Activation, Precision Aerosol Delivery, and Optimized 5-MeO-DMT Treatment Paradigms	14
First-in-Class Potent, Dual HDAC6/Proteasome Inhibitors Lacking a Hydroxamic Acid Motif: Discovery of Novel Anti-Multiple Myeloma Agents	14
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	14
Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	13
Targeting the Glucokinase–Glucokinase Regulatory Protein Axis: Pharmacophore-Based Identification of Novel Antidiabetic Small Molecules	13
Chemical Design and Pharmacokinetics Enable Precision Psychedelic Therapeutics	13
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	13
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	13
Issue Editorial Masthead	13
Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate	13
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	13
Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics	13
From Solid-State Control to Predictive Precision: Building a Deployable Ecosystem for Psychedelic Therapeutics	13
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	12
Discovery of Small-Molecule GLP-1 Receptor Agonists with Improved Oral Pharmacokinetics Based on Orforglipron	12
Call for Papers: Allosteric Modulators in Drug Discovery	12
Novel Benzofuran Derivatives as SARM1 Inhibitors for Treating Axonal Degeneration	12
Novel Compounds for Treating Huntington’s Disease	12
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	12
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	12
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D ₂ Receptors	12
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	12
DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site	12
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT_2A Receptor Agonist	12
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	12
Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications	12
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	12
2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii	12
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	12
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	12
Targeted Degradation of EGFR and PKC Isoforms: Emerging Bifunctional and Peptidic Modalities in Oncology and Immune Regulation	11
In this Issue, Volume 16, Issue 5	11
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	11
Structure-Guided Temporin L Analogs Development to Inhibit the Main Protease of SARS-CoV-2	11
Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	11
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	11
Novel 2 H -Pyrazolo[3,4- d ]thiazole Compounds Targeting NLRP3 for the Treatment of Neurodegenerative Dise	11
The Value of Academic and Industrial Collaborations in Drug Discovery	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11
Novel Fused Heterocycles as 5-HT2A Receptor Agonists for Treating Neurological Diseases, Namely, Depression, Anxiety, Substance Abuse, and Headaches	11
Structure-Guided Virtual Screening of Small Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy	11
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	11
Issue Publication Information	11
Novel Nonpeptide as Oxytocin Receptor Agonist	11
Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR ₇ Allosteric Agonist	11
Issue Editorial Masthead	11
Tambjamines as Promising Leads for the Development of Next-Generation Antifungals against Candida auris	11
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	11

Novel Substituted Pyrazoles as 5-HT1A Agonists for Treating Neuropsychiatric Diseases	11
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11
Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	11
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	11
Issue Editorial Masthead	11
Novel Compounds as MALT1 Inhibitors for Treating Cancer	11
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	11
Novel Substituted Aryl Sulfonamides and Sulfuric Diamides As Transglutaminase 2 Inhibitors	11
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	10
Novel Compounds for Treating Hemoglobinopathies, Namely, Anemia, Sickle Cell Disease, or Thalassemia	10
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	10
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations	10
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	10
Fentanyl-Rewired: A 2-Azaspiro[3.3]heptane Core Preserves μ-Opioid Function	10
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen	10
Next-Generation GLUT Inhibitors: Lactone to Lactam Conversion in Rapaglutin A Confers Resistance to Plasma Esterases	10
5-Nitrofuran-Semicarbazone Hybrids as Antitrypanosomal Agents: Structure–Activity Relationship and Nitroreductase Activation	10
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	10
Fragment-Based Discovery of Drug-like LRH-1 Agonists	10
Potentiometric Determination of Acid Dissociation Constants (pK_a) for an Anticancer Pyrrole-Imidazole Polyamide	10
Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity	10
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	10
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	10
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	10
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	10
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	10
Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer	10
Identification of Boc₂Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	10
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders	10
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	10
Pyrroloquinolone-Based Compounds as a Novel Antimycobacterial Chemotype	10
Neutrophil Elastase-Responsive Linkers for Precision Antibody–Drug Conjugates	10
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	10
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	9
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	9
Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	9
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	9
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	9
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	9
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors	9
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	9
Issue Publication Information	9
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	9
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	9
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	9
Uncompetitive Allosteric Inhibition of PTP1B by BP-1-102 Reveals a Potential Dual-Target Strategy toward the PTP1B–STAT3 Oncogenic Axis: Biochemical and Computational Evidence	9
Issue Publication Information	9
Design, Synthesis, and Biological Evaluation of Tetrazol-2-yl-acetamides as Novel Antitubercular Agents	9
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	9
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	9
Novel Substituted Spiro-Ureas as Monoacylglycerol Lipase Inhibitors	9
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	9
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	9
Issue Editorial Masthead	9
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	9
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors	9
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	9
Engineering the Next Generation of Psychedelic Therapeutics through Serotonergic Precision and Pharmacokinetic Control	9
Issue Editorial Masthead	8
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	8
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	8
Synthesis and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological Recognition	8
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	8
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	8
Perspectives of Patents in Academic and Industrial Collaborations in Drug Discovery	8
Recent Advances in DNA-Encoded Library: High-Throughput Identification of Chemical Inducers of Proximity from Degraders to Non-degraders	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode	8
Integrated Advancements in Neuroplasticity, Psychedelic Therapeutics, and AI-Driven Innovations for Precision Medicine	8
Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid)	8
Issue Publication Information	8
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	8
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	8
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	8
4-Aminoalkylquinolines as Potent Antitubercular Agents Targeting the Cytochrome bc ₁ Complex	8
Structural Evaluations of a Selective Human STING^A230 Agonist and Its Use in Macrophage Immunotherapies	8
Synthesis of Marine-Inspired Multifaceted DNA Damaging Spirooxindoles Combating NSCLC and Associated Bacterial Infection	8
Discovery of a Colon-Targeted Prodrug As an Escherichia coli Biofilm Inhibitor for Treating Inflammatory Bowel Disease	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy	8
Issue Publication Information	8
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Biological Effects of Modifications of the Englerin A Glycolate	8
NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex	8
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	8
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	8
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders	8
Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B	8
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging	8
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists	8
In This Issue, Volume 15, Issue 4	8