OOIR: Observatory of International Research

Papers

(The median citation count of ACS Medicinal Chemistry Letters is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Issue Publication Information	91
Issue Editorial Masthead	90
Issue Publication Information	78
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	57
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	50
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	50
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	49
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	48
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	48
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	44
Clozapine as an E3 Ligand for PROTAC Technology	42
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	40
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	40
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	36
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	35
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	35
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	34
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	33
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	32
Targeting the “Undruggable” Driver Protein, KRAS^G12D, as Potential Therapy in Prostate Cancer	32
In This Issue, Volume 14, Issue 5	32
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	32
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	30
Novel Histone Acetyltransferase (HAT) Inhibitors for Treating Diseases	28
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	28

Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs	28
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors	27
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	27
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	26
Novel Phosphorylpurinone Compounds for Treating Cancer	26
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	25
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	25
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	25
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors	24
Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain	24
Issue Editorial Masthead	24
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	24
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	24
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	24
Contemporary Computational Applications and Tools in Drug Discovery	24
Issue Editorial Masthead	24
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	24
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	23
Fragment Ligands of the m⁶A-RNA Reader YTHDF2	23
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	23
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	23
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	22
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	22
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	22
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	21
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	21
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	21
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	21
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	21
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	20
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	20
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	20
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	20
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	20
Interleukin-17A Peptide Aptamers with an Unexpected Binding Moiety Selected by cDNA Display under Heterogenous Conditions	19
Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents	19
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	19
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	19
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	19
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	19
Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	18
Synthesis and Preclinical Evaluation of Novel ⁶⁸Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	18
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	18
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	18
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	18
Thermal Degradation Kinetics and pH–Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles	17
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	17
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	17
Thermal Stability and Utility of Dienes as Protecting Groups for Acrylamides	17
Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics	17

Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists	17
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput ¹H NMR for Parallel Medicinal Chemistry	17
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	16
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	16
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	16
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	16
A Green-Absorbing, Red-Fluorescent Phenalenone-Based Photosensitizer as a Theranostic Agent for Photodynamic Therapy	16
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	16
Advancing New Chemical Modalities into Clinical Studies	15
Discovery of Pyridone-Substituted Triazolopyrimidine Dual A_2A/A₁ AR Antagonists for the Treatment of Ischemic Stroke	15
Lathyrane Diterpenoids as Novel hPXR Agonists: Isolation, Structural Modification, and Structure–Activity Relationships	15
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	15
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	15
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	15
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer	15
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition	15
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	15
Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones	15
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	15
Issue Publication Information	14
Issue Editorial Masthead	14
The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate	14
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	14
Issue Publication Information	14
Issue Publication Information	14
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	14
Issue Editorial Masthead	14
Issue Publication Information	14
Issue Publication Information	14
Identification and In Silico Binding Study of a Highly Potent DENV NS2B-NS3 Covalent Inhibitor	14
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	13
SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity	13
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	13
Spiro(isobenzofuranazetidine) Compounds for Treating Autoimmune Diseases	13
The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID	13
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT_2A Receptor Agonist	13
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	13
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	13
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids	13
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	13
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties	13
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	13
Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy	13
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	13
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2	13
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	12
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	12
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	12
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	12
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	12
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	12
Ir(III) Complex Dimer Nanoparticles for Photodynamic Therapy	12
Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	12
Issue Publication Information	12
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	12
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	12
Novel Nonpeptide as Oxytocin Receptor Agonist	12
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	12
Fragment-Based Discovery of Drug-like LRH-1 Agonists	12
Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids	12
Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro	12
Issue Publication Information	12
Issue Editorial Masthead	12
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	12
In this Issue, Volume 16, Issue 5	12
Identification of Boc₂Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	12
Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-κB Modulators	12
Design, Synthesis, and Biological Activity of l-1′-Homologated Adenosine Derivatives	12
In This Issue, Volume 12, Issue 7	11
Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization	11
Tetrazole Derivatives as TRPA1 Inhibitors for Treating Idiopathic Lung Disease or Cough	11
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	11
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	11
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups	11
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors	11
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	11
Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR₇ Allosteric Agonist	11
Application of Rapidly Accelerating Fibrosarcoma Protein Degraders in Drug Discovery	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11

Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	11
Synthesis of Benzoazepine Derivatives via Azide Rearrangement and Evaluation of Their Antianxiety Activities	11
Potentiometric Determination of Acid Dissociation Constants (pK_a) for an Anticancer Pyrrole-Imidazole Polyamide	11
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	11
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205	11
Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	11
A New Highly Deuterated [¹⁸F]AV-45, [¹⁸F]D15FSP, for Imaging β-Amyloid Plaques in the Brain	11
In This Issue, Volume 13, Issue 1	11
Targeting KRAS G12D Mutant for the Potential Treatment of Pancreatic Cancer	11
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	11
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR^T790M/C797S Mutants	11
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity	11
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	10
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	10
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	10
Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090	10
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	10
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	10
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	10
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	10
Issue Publication Information	10
Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes	10
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	10
Biological Effects of Modifications of the Englerin A Glycolate	10
Issue Publication Information	10
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	10
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	10
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	10
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	10
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors	10
Issue Publication Information	10
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir	10
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	10
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	10
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	10
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	10
In This Issue, Volume 12, Issue 11	9
Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745	9
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	9
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	9
ACS Medicinal Chemistry Letters: An Innovation Ten Years in the Making	9
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	9
Novel 6-Substituted-3-Phenylisoindolin-1-ones as Cbl-B Inhibitors for Treating Cancer	9
Readily Accessible High-Throughput Experimentation: A General Protocol for the Preparation of ChemBeads and EnzyBeads	9
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	9
Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors	9
Inhibitors of Na_v1.7 for the Treatment of Pain	9
Modulation of KRAS Mutant by Inhibiting PLK1 Kinase in Cancer Therapeutics	9
How a Blockchain Approach Can Improve Data Reliability in the COVID-19 Pandemic	9
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors	9
Structure–Activity Relationship of Anti-Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors	9
Issue Publication Information	9
BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis	9
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	9
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators	9
Intramolecular Ring-Opening Decomposition of Aryl Azetidines	9
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	9
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	9
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	9
Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds	9
Addition to “The Death of the Strategy of Classical Chiral Switches Is an Exaggeration”	9
Issue Publication Information	9
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery	9
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor	9
Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in Cancer	9
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol	8
Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity	8
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists	8
Novel Histone Deacetylase Inhibitors for Treating HIV Infection	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Novel AHR Agonists for Treating Psoriasis	8
Application of Compositions Comprising a KRAS G12C Inhibitor and an EGFR Inhibitor for the Potential Treatment of Cancer	8
Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials	8
Synthesis of Marine-Inspired Multifaceted DNA Damaging Spirooxindoles Combating NSCLC and Associated Bacterial Infection	8
Investigation of Isobactin Analogues of Teixobactin	8
Structural Evaluations of a Selective Human STING^A230 Agonist and Its Use in Macrophage Immunotherapies	8
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity	8
Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy	8
Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Inhibitors of Interleukin 4 Induced Protein 1 (IL4I1) as Potential Treatment for Cancer	8
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
Integrated Advancements in Neuroplasticity, Psychedelic Therapeutics, and AI-Driven Innovations for Precision Medicine	8
Issue Editorial Masthead	8
Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators	8
Issue Publication Information	8
In This Issue, Volume 15, Issue 4	8
Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation	8
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors	8
RNA: Opening New Doors in Medicinal Chemistry, a Special Issue	8
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode	8