ACS Medicinal Chemistry Letters

Article	Citations
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	113
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	110
Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket	110
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	71
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain	58
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	52
Issue Editorial Masthead	49
Issue Publication Information	47
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	45
Issue Publication Information	45
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	43
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	41
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	39
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	39
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	39
Targeting the “Undruggable” Driver Protein, KRASG12D, as Potential Therapy in Prostate Cancer	38
In This Issue, Volume 14, Issue 5	37
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	36
Novel Phosphorylpurinone Compounds for Treating Cancer	35
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	33
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	33
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	32
Clozapine as an E3 Ligand for PROTAC Technology	32
Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids	31
Design and Synthesis of a Structurally Stabilized B-Chain Antagonist Targeting Relaxin Family Peptide Receptor 3 (RXFP3)	31

Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	31
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	30
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	30
Discovery of a Novel sp3-Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	29
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	29
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	29
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	28
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	28
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	27
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	27
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	26
Contemporary Computational Applications and Tools in Drug Discovery	26
Tricyclic and Novel Chemotypes as Selective WRN Helicase Inhibitors for MSI-H Cancer Therapy	25
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	25
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	25
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction	24
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	23
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	23
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	23
Issue Editorial Masthead	23
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry	22
Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	22
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	22
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	22
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	21
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	21
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	21
Synthesis and Preclinical Evaluation of Novel 68Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	20
Thermal Stability and Utility of Dienes as Protecting Groups for Acrylamides	20
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	20
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	20
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	19
Synthesis and In Vitro/In Silico α-Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole	19
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	19
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	19
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	19
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	18
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	18
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	18
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	18
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	18
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	18
Thermal Degradation Kinetics and pH–Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles	18
Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold	18
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	18
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	18
Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones	18
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	17
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists	17
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	17

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	17
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	17
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	17
Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group	16
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	16
Fragment Ligands of the m6A-RNA Reader YTHDF2	16
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	16
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	16
Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase	16
Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment	16
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	16
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	16
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	16
Advancing New Chemical Modalities into Clinical Studies	16
A Novel Peptide-Based PD-L1 PET Tracer: Design, Synthesis, and Preclinical Imaging Validation	16
Novel Compounds as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity	16
First-in-Class Potent, Dual HDAC6/Proteasome Inhibitors Lacking a Hydroxamic Acid Motif: Discovery of Novel Anti-Multiple Myeloma Agents	16
Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications	15
Issue Publication Information	15
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	15
2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii	15
Structure-Guided Temporin L Analogs Development to Inhibit the Main Protease of SARS-CoV-2	15
Issue Editorial Masthead	15
Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	15
Issue Editorial Masthead	15
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D2 Receptors	15
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2	15
Issue Editorial Masthead	15
Issue Publication Information	15
Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids	14
Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics	14
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	14
Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy	14
Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke	14
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist	14
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	14
SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity	14
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids	14
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	14
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties	14
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	13
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	13
Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	13
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	13
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	13
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	13
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	13
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer	13
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	13
In this Issue, Volume 16, Issue 5	13
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	13
Identification and In Silico Binding Study of a Highly Potent DENV NS2B-NS3 Covalent Inhibitor	13
Design, Synthesis, and Biological Activity of l-1′-Homologated Adenosine Derivatives	13
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	13
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	13
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	13
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition	13
Novel Fused Heterocycles as 5-HT2A Receptor Agonists for Treating Neurological Diseases, Namely, Depression, Anxiety, Substance Abuse, and Headaches	12
Application of Rapidly Accelerating Fibrosarcoma Protein Degraders in Drug Discovery	12
Issue Publication Information	12
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen	12
Novel Substituted Pyrazoles as 5-HT1A Agonists for Treating Neuropsychiatric Diseases	12
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations	12
Tetrazole Derivatives as TRPA1 Inhibitors for Treating Idiopathic Lung Disease or Cough	12
Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	12
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders	12
Pyrroloquinolone-Based Compounds as a Novel Antimycobacterial Chemotype	12
In This Issue, Volume 13, Issue 1	12
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	12
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	12
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity	12
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants	11
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	11
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	11
Next-Generation GLUT Inhibitors: Lactone to Lactam Conversion in Rapaglutin A Confers Resistance to Plasma Esterases	11
Potentiometric Determination of Acid Dissociation Constants (pKa) for an Anticancer Pyrrole-Imidazole Polyamide	11
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	11
Issue Editorial Masthead	11
Novel Nonpeptide as Oxytocin Receptor Agonist	11
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11

Issue Editorial Masthead	11
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	11
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11
Novel Compounds for Treating Hemoglobinopathies, Namely, Anemia, Sickle Cell Disease, or Thalassemia	11
Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist	11
Novel 2 H -Pyrazolo[3,4- d ]thiazole Compounds Targeting NLRP3 for the Treatment of Neurodegenerative Dise	11
Targeted Degradation of EGFR and PKC Isoforms: Emerging Bifunctional and Peptidic Modalities in Oncology and Immune Regulation	11
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	11
Issue Publication Information	10
Issue Editorial Masthead	10
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	10
Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	10
Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes	10
Fragment-Based Discovery of Drug-like LRH-1 Agonists	10
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	10
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	10
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	10
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups	10
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	10
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	10
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	10
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	10
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	10
Issue Publication Information	10
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	10
Tambjamines as Promising Leads for the Development of Next-Generation Antifungals against Candida auris	10
Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro	10
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	10
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	10
Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	10
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	10
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	10
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	10
Novel Substituted Aryl Sulfonamides and Sulfuric Diamides As Transglutaminase 2 Inhibitors	10
Structure-Guided Virtual Screening of Small Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy	10
NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex	9
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement	9
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir	9
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	9
Novel Substituted Spiro-Ureas as Monoacylglycerol Lipase Inhibitors	9
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	9
Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Inhibitors of Nav1.7 for the Treatment of Pain	9
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	9
How a Blockchain Approach Can Improve Data Reliability in the COVID-19 Pandemic	9
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	9
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	9
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery	9
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	9
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	9
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	9
Engineering the Next Generation of Psychedelic Therapeutics through Serotonergic Precision and Pharmacokinetic Control	9
ACS Medicinal Chemistry Letters: An Innovation Ten Years in the Making	9
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	9
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	9
Biological Effects of Modifications of the Englerin A Glycolate	9
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	9
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor	9
Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090	9
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	9
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	9
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	9
Design, Synthesis, and Biological Evaluation of Tetrazol-2-yl-acetamides as Novel Antitubercular Agents	9
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators	9
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	9
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation	8
Inhibitors of Interleukin 4 Induced Protein 1 (IL4I1) as Potential Treatment for Cancer	8
Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors	8
Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases	8
Novel 6-Substituted-3-Phenylisoindolin-1-ones as Cbl-B Inhibitors for Treating Cancer	8
Novel Cyanotriazole Compounds for Treating Kinetoplastid Diseases, Particularly, Chagas Disease, Leishmaniasis, and Human African Trypanosomiasis	8
Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies	8
Total Synthesis as Training for Medicinal Chemistry	8
Novel AHR Agonists for Treating Psoriasis	8
Issue Publication Information	8
Readily Accessible High-Throughput Experimentation: A General Protocol for the Preparation of ChemBeads and EnzyBeads	8
BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis	8
Advances in the Quest for Safe and Effective Drugs That Target the Cannabinoid Receptor Type 1 (CB1)	8
Application of Compositions Comprising a KRAS G12C Inhibitor and an EGFR Inhibitor for the Potential Treatment of Cancer	8
Investigation of Isobactin Analogues of Teixobactin	8
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity	8
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders	8
Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Allostery Illuminated: Harnessing AI and Machine Learning for Drug Discovery	8
Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Structure–Activity Relationship of Anti-Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors	8
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging	8
Issue Publication Information	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors	8