OOIR: Observatory of International Research

Papers

(The median citation count of ACS Medicinal Chemistry Letters is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	85
Novel Pyrazolopyrazine Compounds as SHP2 Inhibitors for Treating Glioblastoma	84
Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain	68
When Cofactors Aren’t X Factors: Functional Groups That Are Labile in Human Liver Microsomes in the Absence of NADPH	49
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists	49
Issue Editorial Masthead	48
Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders	46
Issue Editorial Masthead	44
In This Issue, Volume 14, Issue 5	43
1,2,4-Triazine Derivatives as NLRP3 Inhibitors for Treating Diseases	39
Issue Editorial Masthead	39
Pyridazine Derivatives as NLRP3 Inhibitors for Treating Asthma, COPD, Parkinson’s Disease, and Alzheimer’s Disease	33
Effective Combination Therapies for the Treatment of HER2 Cancer	33
Novel Tricyclic Compounds as KRAS Inhibitors for Treating Cancer	33
Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets	33
Unraveling Psychedelic Responses: Targeted Protein Degradation and Genetic Diversity	32
Issue Publication Information	32
Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders	31
Novel PARP1 Inhibitors for Treating Cancer	31
Novel Phosphorylpurinone Compounds for Treating Cancer	30
Targeting the “Undruggable” Driver Protein, KRAS^G12D, as Potential Therapy in Prostate Cancer	28
Orally Active Forms of DMT, 5-MeO-DMT, and Long-Acting MDMA for the Treatment of Neuropsychiatric Disorders	28
Issue Editorial Masthead	27
Unveiling New KRAS^G12D Inhibitors: A Promising Approach for Pancreatic Cancer Therapy	27
Emopamil-Binding Protein Inhibitors for Treating Multiple Sclerosis	26

Molecular Biology Clues Portray SARS-CoV-2 as a Gain-of-Function Laboratory Manipulation of Bat CoV RaTG13	25
Neurosteroids and Postpartum Depression: The Mechanism, Efficacy, and Approval of Brexanolone and Zurzuvae	25
Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α)	25
Novel Histone Acetyltransferase (HAT) Inhibitors for Treating Diseases	24
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	24
Virtual Special Issue: Epigenetics 2022	24
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	24
Small Molecule Inhibitors of KRAS Mutant as a Therapeutic Strategy for the Treatment of Cancer	23
Boron-Containing Pyrazole Compounds as JAK Inhibitors for Treating Inflammation, Autoimmune Diseases, and Cancer	23
Issue Publication Information	23
Resisting Clinical Translation from Bench to Bedside: The China Case of Liver Cancer Therapeutic Revolution	23
Substituted 6,7-Dihydro-5H-Benzo[7]annulene Compounds as Selective Estrogen Receptor Degraders for Treating Cancer	23
Fragment-Based Discovery of Novel MUS81 Inhibitors	22
Novel Compounds for Treating Malaria	22
Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction	22
Potent PROTACs Targeting EGFR Mutants in Drug Discovery	22
In This Issue, Volume 14, Issue 12	21
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	21
Targeting the Inhibition of B-Cell Lymphoma 2 Protein for the Treatment of Cancer	21
Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19	21
Empowering Women in Organic Chemistry (EWOC) at Five Years: Giving Back and Getting Back	21
Nitrogen-Containing 2,3-Dihydroquinazolinone Compounds as Na_v1.8 Inhibitors for Treating Pain and Cardiovascular Diseases	21
Call for Papers: The Many Faces of Medicinal Chemistry	21
The Promiscuity of Disulfiram in Medicinal Research	20
Novel RIPK1 Inhibitors for Treating Neurodegenerative, Autoimmune, and Inflammatory Diseases	20
In This Issue, Volume 13, Issue 3	20
Spiro-naphthyridine Antagonists of the Melanocortin Receptor 4 for the Treatment of Cachexia Associated with Chronic Illness	20
Application of Degradation of Cyclic-AMP Response Element Binding Protein for the Potential Treatment of Cancer	19
Novel Spiropiperidine Allosteric Modulators of Nicotinic Acetylcholine Receptors for Treating Central Nervous System Disorders	19
3-Pyrrolidine-indole Derivatives as 5-HT2-Selective Receptor Modulators for the Potential Treatment of Mental Disorders	19
Issue Editorial Masthead	18
Novel CD73 Inhibitors for Treating Cancer	18
Expression of Concern for “Molecular Biology Clues Portray SARS-CoV-2 as a Gain-of-Function Laboratory Manipulation of Bat CoV RaTG13”	18
Issue Editorial Masthead	18
Issue Editorial Masthead	18
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors	17
Advancements in Predictive Medicine: NLRP3 Inflammasome Inhibitors and AI-Driven Predictive Health Analytics	17
Psychedelic-Assisted Neuroplasticity for the Treatment of Mental Health Disorders	16
Novel Substituted Heterocyclic Carboxamides as Adrenoreceptor ADRAC2 Inhibitors for Treating Diseases	16
Potential Therapeutic Transdermal Psychoactive Drug Delivery Technology	16
Call for Papers: Academic and Industrial Collaborations in Drug Discovery	16
Sulfonamide Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, Namely, Narcolepsy and Hypersomnia	16
Novel KRAS Inhibitors for Treating Non-Small-Cell Lung Cancer	16
Issue Editorial Masthead	16
In This Issue, Volume 15, Issue 10	16
Novel Heterocyclic Compounds as Delta-5-Desaturase Inhibitors for Treating Metabolic and Cardiovascular Diseases	16
In This Issue, Volume 12, Issue 9	16
Mining for Ligandable Cavities in RNA	16
Discovery of Novel Nonpeptidic Proteasome Inhibitors Using Covalent Virtual Screening and Biological Evaluation	16
Carboxamide-Bearing Panobinostat Analogues Designed To Interact with E103-D104 at the Cavity Opening of Class I HDAC Isoforms	15

Novel Cyclopentathiophene Carboxamide Derivatives as PAFR Antagonists for Treating Ocular Diseases, Allergies, and Inflammation-Related Diseases	15
Issue Editorial Masthead	15
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR	15
Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors	15
Novel Tricyclic KRAS Inhibitors for the Treatment of Cancer	15
Clozapine as an E3 Ligand for PROTAC Technology	15
Redefining Cancer Therapy: Toward BCL-XL/BCL-2 Dual Inhibitors with Diminished Platelet Toxicity	15
Novel Compounds for Preventing SARS-CoV-2 Viral Replication and Treating COVID-19	15
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	15
Novel Indoline Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness and CNS Disorders	15
Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria	15
Enhancing the Stability of ²¹¹At Radiopharmaceuticals: Insights from Ortho-Substituent Strategies	14
Novel Approaches in Biotechnology: Microbial Genetic Modifications and Metabolic Disease Therapies	14
Novel 3-Pyrrolidineindole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis and Mental Illnesses Such as Depression and Post-Traumatic Stress Disorder	14
Novel PARP7 Inhibitors for Treating Cancer	14
Novel Bicyclic Heterocyclic Compounds as CD73 Inhibitors for Treating Cancer	14
New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein–Protein Interaction	14
Targeted Therapeutics in Oncology and Neurology: Advances in Kinase Inhibition and Biomarkers for Brain Injury	14
Issue Publication Information	14
In This Issue	14
A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition	13
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	13
Unveiling Reality: Psychedelics, Neural Filtering, and the Future of Psychiatric Medicine	13
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors	13
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	13
Synthesis and Preclinical Evaluation of a Bispecific PSMA-617/RM2 Heterodimer Targeting Prostate Cancer	13
Issue Editorial Masthead	13
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo	13
Imidazopyridine Compounds as ERK5 Inhibitors for Treating Cancer	13
YMCC and YSN: An Opportunity for Scientific and Cultural Exchange	13
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding	13
Issue Publication Information	13
Pyrazolopyridine and Triazolopyridine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases	13
Heterocyclic Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML)	13
Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free–Wilson Analysis for Improved In Vivo Efficacy	13
In This Issue, Volume 15, Issue 6	13
Lipid Tales: Optimizing Arylomycin Membrane Anchors	13
Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space	13
Design, Synthesis, and Biological Evaluation of 3-Amino-pyrazine-2-carboxamide Derivatives as Novel FGFR Inhibitors	13
Novel Aminopyrazole Inhibitors of PDE11A for the Treatment of Alzheimer’s Disease and Other Types of Dementia	13
Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase	12
Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1	12
Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy	12
Fueling the Pipeline via Innovations in Organic Synthesis	12
Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay	12
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors	12
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer	12
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	12
Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles	12
Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors	12
RIBOTACs: Small Molecules Selectively Destroy Cancer-Associated RNA	12
Discovery of Arylsulfonamide Na_v1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile	12
Synthesis and Preclinical Evaluation of [⁶⁸Ga]SP94 for Micro-PET Imaging of GRP78 Expression in Hepatocellular Carcinoma	12
Design of Coibamide A Mimetics with Improved Cellular Bioactivity	12
Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization	12
Design, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors	12
Piperazinyl Bicyclic Derivatives as Selective Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels	12
Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs	12
Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 M^pro Inhibitors	12
On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein	12
Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation	11
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	11
Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors	11
2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint	11
Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1	11
Examination of the Impact of Triazole Position within Linkers on Solubility and Lipophilicity of a CDK9 Degrader Series	11
Binding versus Enzymatic Processing of ε-Trimethyllysine Dioxygenase Substrate Analogues	11
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	11
Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells	11
Novel CA(1–7)M(2–9) Analogs: Synthesis, Characterization, and Antibacterial Evaluation	11
Stereoisomers of an Aryl Pyrazole Glucocorticoid Receptor Agonist Scaffold Elicit Differing Anti-inflammatory Responses	11
Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability	11
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator	11
Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity	11
Using Imidazo[2,1-b][1,3,4]thiadiazol Skeleton to Design and Synthesize Novel MNK Inhibitors	11
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline	11
Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer	11
Development of Esterase-Resistant and Highly Active Ghrelin Analogs via Thiol–Ene Click Chemistry	11
Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use	11
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes	11

A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis	10
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	10
Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors	10
Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance	10
Correction to “Bespoke Drug Discovery Training for Low-Middle Income Countries”	10
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	10
Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function	10
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	10
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors	10
Bespoke Drug Discovery Training for Low-Middle Income Countries	10
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	10
PEG: The Magic Bullet for Biophysical Analysis of Highly Aggregating Small Molecules in Aqueous Solutions	10
Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands	10
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	10
Forgotten Natural Products: Semisynthetic Development of Blasticidin S As an Antibiotic Lead	10
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress	10
2-Aminopyridines as Potent and Selective Na_v1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model	10
Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers	10
Development of Allosteric NIK Ligands from Fragment-Based NMR Screening	10
ATP Mimetic Attack on the Nucleotide-Binding Domain to Overcome ABC Transporter Mediated Chemoresistance	10
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions	10
Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library	10
SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme	10
Selective Recognition of c-KIT 1 G-Quadruplex by Structural Tuning of Heteroaromatic Scaffolds and Side Chains	10
Dose–Response Activity-Based DNA-Encoded Library Screening	10
Structural Aspects of Mycobacterium tuberculosis DNA Gyrase Targeted by Novel Bacterial Topoisomerase Inhibitors	9
Novel Thienopyrimidines as Acetyl-CoA Carboxylase Inhibitors for Treating Liver Diseases	9
Structure–Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile	9
Predictive Modeling and Drug Repurposing for Type-II Diabetes	9
Neuroprotective Effect of 2-(Benzyloxy)arylureas Is Not Related to CypD Inhibition nor Suppression of mPTP Opening	9
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	9
Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer	9
Discovery of Ring-Annulated Analogues of Cannabidiol as Potential Anticancer Agents: Synthesis and Biological Evaluation	9
Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists	9
A Putative Single-Photon Emission CT Imaging Tracer for Erythropoietin-Producing Hepatocellular A2 Receptor	9
In Silico Targeting of the Long Noncoding RNA MALAT1	9
PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase as a Therapeutic Strategy for Cancer	9
In This Issue, Volume 12, Issue 4	9
Systematical Mutational Analysis of FRATtide against Osteoclast Differentiation by Alanine Scanning	9
2′-O-Alkyl-N³-Methyluridine Functionalized Passenger Strand Improves RNAi Activity by Modulating the Thermal Stability	9
Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen	9
ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells	9
Improving Activity of New Arylurea Agents against Multidrug-Resistant and Biofilm-Producing Staphylococcus epidermidis	9
Synthesis and Biological Evaluation of 5′-Deoxy-adenosine Derivatives as A₃ Adenosine Receptor Ligands	9
Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules	9
In This Issue, Volume 12, Issue 5	9
Radiosynthesis and Biological Evaluation of [¹⁸F]R91150, a Selective 5-HT_2A Receptor Antagonist for PET-Imaging	9
Expanding the Chemical Space of Reverse Fosmidomycin Analogs	9
Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening	9
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	9
Chemical Space Profiling of SARS-CoV-2 PL^pro Using DNA-Encoded Focused Libraries	9
New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies	9
Correction to “An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline”	9
Asymmetric Synthesis and Biological Evaluation of Both Enantiomers of 5- and 6-Boronotryptophan as Potential Boron Delivery Agents for Boron Neutron Capture Therapy	9
Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity	9
Dual Targeting of Function–Structure for Effective Killing of Pathogenic Free-Living Amoebae	9
Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y₂ Receptor	8
Retraction of “Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists”	8
Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2	8
Pyrrolidines as Main Protease Inhibitors for Treating Viral Infections, in Particular, Coronavirus Infections	8
Novel Substituted Thiadiazoles as Splicing Modulators for Modulating Splicing of mRNA and Uses Thereof for Treating Diseases	8
Design and Implementation of Synthetic RNA Binders for the Inhibition of miR-21 Biogenesis	8
Correction to “Discovery of l-Lysine Dioxalate (LH1513) as a Novel Inhibitor of Calcium Oxalate Crystallization for Hyperoxaluria”	8
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity	8
Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction Mixtures	8
Discovery and Development of Cyclic Peptide Inhibitors of CIB1	8
Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity	8
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	8
The Inhibitors of Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2) as Potential Enhancers of Cancer Immunotherapy and Type 1 (PTPN1) as Treatment of Metabolic Diseases	8
Novel Pyrrolidinone Urea Compounds as FPR2 Agonists for Treating Atherosclerosis and Heart Failure	8
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2	8
Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of ¹¹C-Labeled ALK2 Inhibitors	8
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers	8
Discovery of a Novel Class of ERRα Agonists	8
Development of Oligomeric Mannose-6-phosphonate Conjugates for Targeted Protein Degradation	8
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	8
Structure–Activity Relationship Study of Splicing Modulators on Hsh155/SF3B1 through Chemical Synthesis and Yeast Genetics	8
In This Issue, Volume 15, Issue 12	8
Advanced Delivery Systems and Novel Psilocin Derivatives for Enhanced Therapeutic Applications	8
Novel Fragment-Based Screening Method to Identify Small Molecules That Selectively Bind RNA	8
Discovery and Characterization of a Rapidly Fungicidal and Minimally Toxic Peptoid against Cryptococcus neoformans	8
Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs	8
Linker-Determined Folding and Hydrophobic Interactions Explain a Major Difference in PROTAC Cell Permeability	8
Morita–Baylis–Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands	7
Identification of Indazole- and Azaindazole-Substituted Cyclopentapyrroles as G2019S Leucine-Rich Repeat Kinase 2 Inhibitors for the Treatment of CNS Disorders	7
Structure–Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α	7
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	7
A Hybrid Energy-Based and AI-Based Screening Approach for the Discovery of Novel Inhibitors of AXL	7
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	7
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	7
Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis	7
Derivatives of Aristoquinoline Accessed through a Ritter-like Reaction	7
Novel Cyclic Peptides Inhibiting Tumor Necrosis Factor Receptor 1 Activity	7
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	7
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	7