ACS Medicinal Chemistry Letters

Article	Citations
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	101
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	98
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	91
Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols	59
Clozapine as an E3 Ligand for PROTAC Technology	51
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	49
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	48
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	47
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	45
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors	45
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	43
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	41
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	41
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	37
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	37
Discovery of a Novel sp3-Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	36
Issue Editorial Masthead	34
Issue Publication Information	34
Issue Publication Information	34
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	33
Targeting the “Undruggable” Driver Protein, KRASG12D, as Potential Therapy in Prostate Cancer	31
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	30
In This Issue, Volume 14, Issue 5	30
Novel Phosphorylpurinone Compounds for Treating Cancer	29
Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors	29

Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	29
Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”	29
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	29
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain	28
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	27
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	27
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	26
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	26
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	26
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	26
Contemporary Computational Applications and Tools in Drug Discovery	26
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	25
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	25
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	25
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	25
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	24
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	24
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	24
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	23
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	23
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	23
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	22
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	22
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	22
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	21
Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones	21
Advancing New Chemical Modalities into Clinical Studies	20
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	20
Synthesis and In Vitro/In Silico α-Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole	20
Thermal Stability and Utility of Dienes as Protecting Groups for Acrylamides	20
Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment	20
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	20
Tricyclic and Novel Chemotypes as Selective WRN Helicase Inhibitors for MSI-H Cancer Therapy	19
Fragment Ligands of the m6A-RNA Reader YTHDF2	19
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	19
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	19
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	18
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	18
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	18
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	17
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	17
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	17
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	17
Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold	17
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	17
Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents	17
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	17
Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics	16
Synthesis and Preclinical Evaluation of Novel 68Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	16
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction	16

Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	16
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	16
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	16
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	16
Thermal Degradation Kinetics and pH–Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles	16
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	16
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry	15
Issue Editorial Masthead	15
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	15
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	15
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists	15
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	15
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	15
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	15
The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate	14
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist	14
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	14
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	14
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	14
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties	14
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	14
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	14
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	14
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2	14
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	14
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	14
Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy	14
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	14
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	14
Identification and In Silico Binding Study of a Highly Potent DENV NS2B-NS3 Covalent Inhibitor	14
Issue Publication Information	13
SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity	13
Issue Publication Information	13
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids	13
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D2 Receptors	13
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition	13
Issue Publication Information	13
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	13
Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications	13
Design, Synthesis, and Biological Activity of l-1′-Homologated Adenosine Derivatives	13
2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii	13
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer	13
Issue Editorial Masthead	13
Issue Editorial Masthead	13
Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids	13
Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	13
Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke	13
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	13
Issue Editorial Masthead	12
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups	12
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	12
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	12
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	12
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	12
Issue Publication Information	12
Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization	12
Issue Publication Information	12
In this Issue, Volume 16, Issue 5	12
Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	12
Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	12
Novel Nonpeptide as Oxytocin Receptor Agonist	12
Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	12
Novel Fused Heterocycles as 5-HT2A Receptor Agonists for Treating Neurological Diseases, Namely, Depression, Anxiety, Substance Abuse, and Headaches	12
Fragment-Based Discovery of Drug-like LRH-1 Agonists	12
Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro	12
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	12
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen	11
Pyrroloquinolone-Based Compounds as a Novel Antimycobacterial Chemotype	11
Tetrazole Derivatives as TRPA1 Inhibitors for Treating Idiopathic Lung Disease or Cough	11
Targeting KRAS G12D Mutant for the Potential Treatment of Pancreatic Cancer	11
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	11
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders	11
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	11
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	11
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors	11
Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist	11
Application of Rapidly Accelerating Fibrosarcoma Protein Degraders in Drug Discovery	11
Novel Substituted Pyrazoles as 5-HT1A Agonists for Treating Neuropsychiatric Diseases	11
In This Issue, Volume 13, Issue 1	11

Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11
Potentiometric Determination of Acid Dissociation Constants (pKa) for an Anticancer Pyrrole-Imidazole Polyamide	11
Issue Publication Information	10
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants	10
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	10
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	10
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	10
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations	10
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	10
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	10
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	10
Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds	10
Issue Editorial Masthead	10
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	10
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	10
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	10
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	10
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	10
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	10
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	10
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	10
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	10
Issue Publication Information	10
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	10
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	10
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	10
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity	10
Structure-Guided Virtual Screening of Small Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy	10
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	10
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	10
Biological Effects of Modifications of the Englerin A Glycolate	10
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	10
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors	9
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	9
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	9
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	9
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	9
NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex	9
How a Blockchain Approach Can Improve Data Reliability in the COVID-19 Pandemic	9
In This Issue, Volume 12, Issue 11	9
Inhibitors of Nav1.7 for the Treatment of Pain	9
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	9
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	9
Intramolecular Ring-Opening Decomposition of Aryl Azetidines	9
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	9
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	9
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir	9
Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes	9
Modulation of KRAS Mutant by Inhibiting PLK1 Kinase in Cancer Therapeutics	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	9
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	9
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor	9
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	9
Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090	9
ACS Medicinal Chemistry Letters: An Innovation Ten Years in the Making	9
Novel Aminocyclobutanes as Monoacylglycerol Lipase Modulators	9
Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in Cancer	9
Novel AHR Agonists for Treating Psoriasis	8
Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy	8
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders	8
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity	8
Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors	8
Addition to “The Death of the Strategy of Classical Chiral Switches Is an Exaggeration”	8
Investigation of Isobactin Analogues of Teixobactin	8
Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B	8
Allostery Illuminated: Harnessing AI and Machine Learning for Drug Discovery	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode	8
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation	8
Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators	8
Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies	8
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	8
BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis	8
Synthesis and Antifungal Evaluation of New Azole Derivatives against Candida albicans	8
Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors	8
In This Issue, Volume 15, Issue 4	8
Application of Compositions Comprising a KRAS G12C Inhibitor and an EGFR Inhibitor for the Potential Treatment of Cancer	8
Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors	8
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery	8
Total Synthesis as Training for Medicinal Chemistry	8
Structure–Activity Relationship of Anti-Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Targeting the Inhibition of B-Cell Lymphoma 2 Protein for the Treatment of Cancer	7
Imidazopyridine Compounds as ERK5 Inhibitors for Treating Cancer	7
Novel Pyrazolopyrazine Compounds as SHP2 Inhibitors for Treating Glioblastoma	7
Novel Phenylpiperidine Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer or Fibrotic Diseases	7
Bespoke Drug Discovery Training for Low-Middle Income Countries	7
Lipid Tales: Optimizing Arylomycin Membrane Anchors	7
Design, Synthesis, and Biological Evaluation of 3-Amino-pyrazine-2-carboxamide Derivatives as Novel FGFR Inhibitors	7
Unraveling Psychedelic Responses: Targeted Protein Degradation and Genetic Diversity	7