ACS Medicinal Chemistry Letters

Article	Citations
Psychiatric Treatments with Short-Duration Psychedelics and AI-Driven Behavioral Monitoring	139
Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine	130
Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket	130
From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3	81
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain	65
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport	59
Issue Editorial Masthead	57
Issue Publication Information	50
Issue Publication Information	49
Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes	46
Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates	46
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome	46
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation	44
Contemporary Computational Applications and Tools in Drug Discovery	42
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation	40
Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2	39
Novel Heterocyclic Pyrimidine Derivatives as GSK3α Inhibitors	36
Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders	35
Targeting the “Undruggable” Driver Protein, KRASG12D, as Potential Therapy in Prostate Cancer	35
In This Issue, Volume 14, Issue 5	34
Call for Papers: Fungal Pathogens – Life Cycle, Infection, Host Immunity and Drug Discovery	33
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology	33
Novel Phosphorylpurinone Compounds for Treating Cancer	33
Discovery of Quinazolinone Derivatives as Potent PARP1 Inhibitors	32
Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids	32

Design and Synthesis of a Structurally Stabilized B-Chain Antagonist Targeting Relaxin Family Peptide Receptor 3 (RXFP3)	32
Clozapine as an E3 Ligand for PROTAC Technology	31
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach	31
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential	31
Novel PSMA-Targeting Radionuclide Peptidomimetics for Treating Prostate Cancer	31
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor	31
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors	30
Introducing the Potential Binding Interface between the TRAIL-Mimicking Peptide and DR5 via Alanine Scan	29
Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity	29
Discovery of Pyridopyrazine Inverse Agonists Targeting G Protein-Coupled Receptor 6	28
Modulation of Cancer Networks through Protein Degradation, DNA Repair Inhibition, and Quantitative Interactomics	27
Multimodal Control of STAT6 Signaling through Small-Molecule Modulation and Targeted Degradation	27
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes	26
Application of Deuterated N,N-Dimethyltryptamine in the Potential Treatment of Psychiatric and Neurological Disorders	25
Discovery of a Novel sp3-Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping	25
Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation	24
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases	24
Tricyclic and Novel Chemotypes as Selective WRN Helicase Inhibitors for MSI-H Cancer Therapy	23
Announcing the Early Career Board of ACS Medicinal Chemistry Letters	22
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction	22
Issue Editorial Masthead	21
In Retrospect: Root-Cause Analysis of Structure–Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)	21
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in Particular Coronavirus Infections	21
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	21
ACS Medicinal Chemistry Letters Patent Highlights: A Look Back	20
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA	20
Novel 3-Cycloaminoindole Compounds as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	20
Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors	20
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning	20
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases	19
Novel Indazole Compounds as PKMYT1 Kinase Inhibitors for Treating Cancer	19
Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics	19
Optimized Parenteral and Intranasal Formulations of Tryptamine Psychedelics for Rapid-Acting Antidepressant Therapy	19
N -Myristoyltransferase Inhibitors as a Potential Starting Point for the Development of Antischistosomal Agents	19
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis	19
Neuropharmacological Advances: Harnessing 5-HT2A Receptor Modulators and Psychoplastogens	19
An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis	19
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations	19
Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones	19
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization	19
SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity	19
Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold	19
Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes	18
Novel Compounds as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity	18
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors	18
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health	18
(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase	18
Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group	18
Thermal Degradation Kinetics and pH–Rate Profile of Verbascoside and Stability Improvement by Solid Lipid Nanoparticles	18
Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment	17

Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase	17
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists	17
Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer	17
First-in-Class Potent, Dual HDAC6/Proteasome Inhibitors Lacking a Hydroxamic Acid Motif: Discovery of Novel Anti-Multiple Myeloma Agents	17
Synthesis and Preclinical Evaluation of Novel 68Ga-DOTA-RBB as Potential PET Radiotracer for Imaging CDK4/6 in Tumors	17
Synthesis and Biological Evaluation of 3,5-Diaryl-Substituted 1,2,4-Oxadiazole Sulfamates as Potent Steroid Sulfatase Inhibitors	17
Novel Compounds as 5-HT2A Receptor Modulators for Treating Psychiatric and Neurological Disorders	17
Issue Publication Information	17
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry	17
Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20	16
A Novel Peptide-Based PD-L1 PET Tracer: Design, Synthesis, and Preclinical Imaging Validation	16
Mechanistic Insights from Differences in the Aggregate Morphologies of Amphotericin B and Its Less Toxic Variant Am-2-19 (Turletricin)	16
Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies	16
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2	16
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2	16
6,7-Dihalo-Benzothiadiazines as Potent and Selective AMPA Receptor Modulators for Cognitive Enhancement and Neuroprotection	16
Fragment Ligands of the m6A-RNA Reader YTHDF2	16
In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity	16
Synthesis and In Vitro/In Silico α-Glucosidase Inhibitory Study of Novel Ethanones Containing Naphthalene-Linked 1,2,4-Triazole	16
Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies	15
Heparan Sulfate-Mimicking Glycopolymers Bind SARS-CoV-2 Spike Protein in a Length- and Sulfation Pattern-Dependent Manner	15
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease	15
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers	15
Advancing New Chemical Modalities into Clinical Studies	15
N-Arylsulfonylated C-Homoaporphines as a New Class of Antiplatelet and Antimicrobial Agents	15
Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	14
Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study	14
Issue Publication Information	14
Issue Publication Information	14
DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site	14
N -Alkyl and N -Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable P	14
Issue Editorial Masthead	14
Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics	14
Novel Compounds for Treating Huntington’s Disease	14
Issue Editorial Masthead	14
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience	14
Design, Synthesis, and Biological Activity of l-1′-Homologated Adenosine Derivatives	14
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist	13
Targeted Degradation of Androgen Receptor for the Potential Treatment of Prostate Cancer	13
Issue Editorial Masthead	13
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties	13
Novel Furopyridine and Furopyrimidine Compounds as PI4K Inhibitors for Treating Malaria and Viral Infection	13
Novel Plasma Kallikrein Inhibitors for Treating Hereditary Angioedema, Diabetic Macular Edema, and Diabetic Retinopathy	13
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents	13
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids	13
Structure-Guided Temporin L Analogs Development to Inhibit the Main Protease of SARS-CoV-2	13
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders	13
Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders	12
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D 2 Receptors	12
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055	12
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators	12
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors	12
Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics	12
Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization	12
From Solid-State Control to Predictive Precision: Building a Deployable Ecosystem for Psychedelic Therapeutics	12
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity	12
Chemical Design and Pharmacokinetics Enable Precision Psychedelic Therapeutics	12
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma	12
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2	12
Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications	12
Targeting the Glucokinase–Glucokinase Regulatory Protein Axis: Pharmacophore-Based Identification of Novel Antidiabetic Small Molecules	12
Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis	12
2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii	12
Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase	11
Novel Nonpeptide as Oxytocin Receptor Agonist	11
Novel Fused Heterocycles as 5-HT2A Receptor Agonists for Treating Neurological Diseases, Namely, Depression, Anxiety, Substance Abuse, and Headaches	11
Issue Publication Information	11
Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders	11
Novel Substituted Aryl Sulfonamides and Sulfuric Diamides As Transglutaminase 2 Inhibitors	11
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations	11
Targeted Degradation of EGFR and PKC Isoforms: Emerging Bifunctional and Peptidic Modalities in Oncology and Immune Regulation	11
In this Issue, Volume 16, Issue 5	11
Application of Rapidly Accelerating Fibrosarcoma Protein Degraders in Drug Discovery	11
Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders	11
Issue Editorial Masthead	11
Tambjamines as Promising Leads for the Development of Next-Generation Antifungals against Candida auris	11
Synthesis and Evaluation of Novel meso-Tetraphenyltetrabenzoporphyrins for Photodynamic Therapy	11
Structure-Guided Virtual Screening of Small Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy	11
Novel Substituted Pyrazoles as 5-HT1A Agonists for Treating Neuropsychiatric Diseases	11
Pyrroloquinolone-Based Compounds as a Novel Antimycobacterial Chemotype	11

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics	11
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases	11
Tetrazole Derivatives as TRPA1 Inhibitors for Treating Idiopathic Lung Disease or Cough	11
Issue Publication Information	10
Next-Generation GLUT Inhibitors: Lactone to Lactam Conversion in Rapaglutin A Confers Resistance to Plasma Esterases	10
Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors	10
Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C	10
Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists	10
The Value of Academic and Industrial Collaborations in Drug Discovery	10
Novel 2 H -Pyrazolo[3,4- d ]thiazole Compounds Targeting NLRP3 for the Treatment of Neurodegenerative Dise	10
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists	10
Novel Compounds as MALT1 Inhibitors for Treating Cancer	10
Potentiometric Determination of Acid Dissociation Constants (pKa) for an Anticancer Pyrrole-Imidazole Polyamide	10
Issue Editorial Masthead	10
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery	10
Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups	10
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment	10
Fragment-Based Discovery of Drug-like LRH-1 Agonists	10
Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders	10
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field	10
Issue Editorial Masthead	10
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba	10
Fentanyl-Rewired: A 2-Azaspiro[3.3]heptane Core Preserves μ-Opioid Function	10
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders	10
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry	10
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones	10
Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs)	10
Novel Compounds for Treating Hemoglobinopathies, Namely, Anemia, Sickle Cell Disease, or Thalassemia	10
Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity	10
Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections	10
N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction	10
Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist	10
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design	10
Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening	10
Correction to “Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain”	10
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen	10
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor	9
Novel Substituted Spiro-Ureas as Monoacylglycerol Lipase Inhibitors	9
Design, Synthesis, and Biological Evaluation of Tetrazol-2-yl-acetamides as Novel Antitubercular Agents	9
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases	9
Recent Discovery of PARP7 Inhibitors as Anticancer Agents	9
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors	9
Novel Piperidine Substituted Pyrazolopyrimidine Derivatives as SGK1 Inhibitors for Treating Cardiovascular Diseases	9
A Neutral Flavin–Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments	9
Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer	9
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement	9
Pioneering Changes in Psychiatry: Biomarkers, Psychedelics, and AI	9
Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors	9
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries	9
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases	9
Novel Pyridine Derivatives as 5-HT2A Agonists for Treating Psychiatric Disorders	9
Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid)	9
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation	9
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors	9
Issue Publication Information	9
Biological Effects of Modifications of the Englerin A Glycolate	9
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery	9
4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL	9
Engineering the Next Generation of Psychedelic Therapeutics through Serotonergic Precision and Pharmacokinetic Control	9
Novel 2-Pyrrolidone Derivatives as Negative Allosteric Modulators of GluN2B-Containing NMDA Receptors	9
Synthesis and Determination of Anticancer Activity of Dicobalt Hexacarbonyl 2′-Deoxy-5-alkynylfuropyrimidines	9
MALT1 Inhibitors for Treating Cancer and Immunological Diseases	9
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression	9
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach	9
Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090	9
NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex	9
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions	8
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging	8
Total Synthesis as Training for Medicinal Chemistry	8
A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir	8
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release	8
Novel Compounds as NLRP3 Inhibitors for Treating Asthma or COPD	8
Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy	8
Application of Compositions Comprising a KRAS G12C Inhibitor and an EGFR Inhibitor for the Potential Treatment of Cancer	8
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists	8
Innovations in Precision Oncology: Biomarker-Driven Approaches for Enhanced Cancer Therapy	8
Novel AHR Agonists for Treating Psoriasis	8
Identification of 5-Thiocyanatothiazol-2-amines Disrupting WDR5-MYC Protein–Protein Interactions	8
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders	8
Novel Lactams as Cbl-b Inhibitors for Treating Cancer	8
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity	8
Integrated Advancements in Neuroplasticity, Psychedelic Therapeutics, and AI-Driven Innovations for Precision Medicine	8
Novel Cyanotriazole Compounds for Treating Kinetoplastid Diseases, Particularly, Chagas Disease, Leishmaniasis, and Human African Trypanosomiasis	8
Addition to “The Death of the Strategy of Classical Chiral Switches Is an Exaggeration”	8
Novel 6-Substituted-3-Phenylisoindolin-1-ones as Cbl-B Inhibitors for Treating Cancer	8
Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery	8
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode	8
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation	8
Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors	8
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor	8
Issue Publication Information	8
Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies	8
Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases	8
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors	8
In This Issue, Volume 15, Issue 4	8