OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Neuroscience is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Issue Publication Information	99
Molecular and Cellular Mechanisms of Neuropathic Pain in Aging	96
Virtual Issue: Neurotoxicology	92
Issue Publication Information	91
Unique Glycans in Synaptic Glycoproteins in Mouse Brain	78
Imaging Glucose Metabolism and Dopaminergic Dysfunction in Sheep (Ovis aries) Brain Using Positron Emission Tomography Imaging Reveals Abnormalities in OVT73 Huntington’s Disease Sheep	77
Propionate Decreases Microglial Activation but Impairs Phagocytic Capacity in Response to Aggregated Fibrillar Amyloid Beta Protein	75
Bile Acids as Modulators of α-Synuclein Aggregation: Implications for Parkinson’s Therapy	72
Structure–Activity Relationships of the Fentanyl Scaffold: Identification of Antagonists as Potential Opioid Overdose Reversal Agents	64
Issue Editorial Masthead	58
Discovery of VU0467319: an M₁ Positive Allosteric Modulator Candidate That Advanced into Clinical Trials	53
Element Changes Occurring in Brain Point at the White Matter Abnormalities in Rats Exposed to the Ketogenic Diet During Prenatal Life	52
Neurochemical and Morphological Comparisons of Motor Nerve Organoids and Spinal-Cord Explants	51
Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity	51
Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders	50
Machine Learned Classification of Ligand Intrinsic Activities at Human μ-Opioid Receptor	49
Activation of Cellular Antioxidant Defense System by Naturally Occurring Dibenzopyrone Derivatives Confers Neuroprotection against Oxidative Insults	48
Abnormal Insulin-like Growth Factor 1 Signaling Regulates Neuropathic Pain by Mediating the Mechanistic Target of Rapamycin-Related Autophagy and Neuroinflammation in Mice	46
Issue Editorial Masthead	45
Novel Dual-Functional Half-Curcumin Analogues as a Fluorescent and PET Probe for β-Amyloid Imaging in the Alzheimer’s Disease APP/PS1 Model	44
Issue Publication Information	44
Issue Publication Information	44
Targeting Neuroinvasion by SARS-CoV-2: Emerging Trends in Drug and Antibody Delivery to Combat COVID-19	44
Serotonergic Mechanisms in Proteinoid-Based Protocells	43
Enhanced Analgesic Efficacy and Reduced Side Effects of Morphine by Combination with PD-1 Agonist	42

Subventricular Accumulation of Cu in the Aging Mouse Brain Does Not Associate with Anticipated Increases in Markers of Oxidative Stress	42
Issue Publication Information	39
Issue Editorial Masthead	39
Issue Editorial Masthead	39
Issue Publication Information	37
GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF	37
Issue Publication Information	36
Issue Publication Information	35
Issue Editorial Masthead	35
Scan-Find-Scan-Model: Discrete Site-Targeted Suppressor Design Strategy for Amyloid-β	34
Issue Publication Information	34
Amyotrophic Lateral Sclerosis-Associated Persistent Organic Pollutant cis-Chlordane Causes GABA_A-Independent Toxicity to Motor Neurons, Providing Evidence toward an Environmental Com	33
Aquaporin-4 Mediated Aggregation of Alzheimer’s Amyloid β-Peptide	33
Pharmacokinetic Approach to Combat the Synthetic Cannabinoid PB-22	32
Issue Editorial Masthead	32
Chronic Light-Distorted Glutamate-Cortisol Signaling, Behavioral and Histological Markers, and Induced Oxidative Stress and Dementia: An Amelioration by Melatonin	31
Issue Editorial Masthead	31
Issue Publication Information	31
Issue Editorial Masthead	31
Issue Publication Information	31
Issue Publication Information	31
Issue Editorial Masthead	30
Anticonvulsant Classes and Possible Mechanism of Actions	30
Naturally Occurring HMGB1 Inhibitor, Glycyrrhizin, Modulates Chronic Seizures-Induced Memory Dysfunction in Zebrafish Model	30
Issue Editorial Masthead	30
Issue Editorial Masthead	30
Issue Publication Information	30
Issue Editorial Masthead	30
Issue Publication Information	29
Issue Publication Information	29
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer’s Disease Therapy	29
Issue Publication Information	29
Mass Spectrometric Analysis of Urinary N-Glycosylation Changes in Patients with Parkinson’s Disease	29
Issue Publication Information	29
Issue Editorial Masthead	29
Issue Editorial Masthead	29
Electrochemical Sensing of Dopamine with an Implantable Microelectrode Array Microprobe Including an On-Probe Iridium Oxide Reference Electrode	28
Synthesis and Neuroprotective Evaluation of Substituted Indanone/Benzofuranone and Piperidine Hybrids	28
HINT1 Inhibitors as Selective Modulators of MOR–NMDAR Cross-Regulation and Non-Opioid Analgesia	28
Binding Sites and the Mechanism of Action of Propofol and a Photoreactive Analogue in Prokaryotic Voltage-Gated Sodium Channels	28
Synthesis and Evaluation of Benzylic ¹⁸F-Labeled N-Biphenylalkynyl Nipecotic Acid Derivatives for PET Imaging of GABA Transporter 1	28
Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target	27
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease	27
Quantitative Analysis of Neuropeptide Y (NPY) and C-Terminal Glycine-Extended NPY by Mass Spectrometry and Their Localization in the Developing and Sexual Adult Mouse Brains	27
JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding	26
Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones	26
Patent Review of Novel Biologics Targeting Opioid Use Disorder (2018–2024)	25
Procognitive Potential of Neuroprotective Triazine 5-HT₆ Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on th	25
Imidazo[2,1-b][1,3]thiazine Derivatives as Potential Modulators of Alpha-Synuclein Amyloid Aggregation	25
Acridine Benzimidazolium Derivatives Induced Protective Microglia Polarization and In Silico TDP-43 Interaction─Potential Implications for Amyotrophic Lateral Sclerosis	25

Chrysin-Loaded Chitosan Nanoparticle-Mediated Neuroprotection in Aβ_1–42-Induced Neurodegenerative Conditions in Zebrafish	25
Oroxylin A Attenuates Homocysteine-Induced Blood–Brain Barrier (BBB) Dysfunction by Reducing Endothelial Permeability and Activating the CREB/Claudin-5 Signaling Pathway	25
Neuroprotective Effects of Fluoxetine on Molecular Markers of Circadian Rhythm, Cognitive Deficits, Oxidative Damage, and Biomarkers of Alzheimer’s Disease-Like Pathology Induced under Chronic Constan	25
Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis	24
Spectral Fluorescence Pathology of Protein Misfolding Disorders	24
Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist	24
Intranasal Route: A Nasocerebral Approach against SARS-CoV-2 in NeuroCOVID	24
Rimota-Gd: Paramagnetic Probe for In Vivo MRI Studies of the Cannabinoid 1 Receptor Distribution in the Mouse Brain	23
Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex	23
Blood Biomarkers in Alzheimer’s Disease	23
Role of NLRP3 Inflammasome in Post-Spinal-Cord-Injury Anxiety and Depression: Molecular Mechanisms and Therapeutic Implications	23
Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D	23
PolyQ-Expanded Mutant Huntingtin Forms Inclusion Body Following Transient Cold Shock in a Two-Step Aggregation Mechanism	23
Accumulation of Prion and Abnormal Prion Protein Induces Hyperphosphorylation of α-Synuclein in the Brain Tissues from Prion Diseases and in the Cultured Cells	23
Stoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics	22
Correlation between Cerebrospinal Fluid Core Alzheimer’s Disease Biomarkers and β-Amyloid PET in Chinese Dementia Population	22
An Antidote Screening System for Organophosphorus Poisoning Using Zebrafish Larvae	21
Kinetic Properties of Glutamate Carboxypeptidase II Partially Purified from Leukodystrophy Patient’s Serum	21
Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils	21
Correction to “PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure”	21
Issue Editorial Masthead	21
Role of Bmal1 and Gut Microbiota in Alzheimer’s Disease and Parkinson’s Disease Pathophysiology: The Probable Effect of Melatonin on Their Association	21
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein–Ligand Complexes	21
Issue Publication Information	21
Issue Publication Information	21
Plantamajoside Alleviates Substantia Nigra Damage in Parkinson’s Disease Mice by Inhibiting HDAC2/MAPK Signaling and Reducing Microglia Polarization	20
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder	20
Cross-Seeded Fibrillation Induced by Pyroglutamate-3 and Truncated Aβ₄₀ Variants Leads to Aβ₄₀ Structural Polymorphism Modulation and Elevated Toxicity	20
Length and Unsaturation of Fatty Acids of Phosphatidic Acid Determines the Aggregation Rate of Insulin and Modifies the Structure and Toxicity of Insulin Aggregates	20
ALS Variants of Annexin A11’s Proline-Rich Domain Impair Its S100A6-Mediated Fibril Dissolution	20
Molecular Dynamics Activation of γ-Secretase for Cleavage of the Notch1 Substrate	20
Validation of Dexamethasone-Enhanced Continuous-Online Microdialysis for Monitoring Glucose for 10 Days after Brain Injury	20
Defining Steric Requirements at CB₁ and CB₂ Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and Their Analogue	20
Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress	20
Attenuation of Stimulated Accumbal Dopamine Release by NMDA Is Mediated through Metabotropic Glutamate Receptors	20
Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkinson’s Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy	20
Study on the Difference of Protective Efficacy and Mechanism of Radix Aconiti Coreani and Rhizoma Typhonii in Gerbils with Ischemic Stroke	20
miR-29a/b1 Regulates BACE1 in Aluminum-Induced Aβ Deposition in Vitro	20
Synthesis and Functional Evaluation of Synthetic Cannabinoid Receptor Agonists Related to ADB-HEXINACA	19
Functionalized Allopurinols Targeting Amyloid-Binding Alcohol Dehydrogenase Rescue Aβ-Induced Mitochondrial Dysfunction	19
Unraveling the Interplay of Dopamine, Carbon Monoxide, and Heme Oxygenase in Neuromodulation and Cognition	19
Optimizing Epitope Conformational Ensembles Using α-Synuclein Cyclic Peptide “Glycindel” Scaffolds: A Customized Immunogen Method for Generating Oligomer-Selective Antibodies for Parkinson’s Disease	19
Correction to “Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo”	19
Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment	19
Characterization of Hair Metabolome in 5xFAD Mice and Patients with Alzheimer’s Disease Using Mass Spectrometry-Based Metabolomics	19
Sleep–Wake Disorders in Alzheimer’s Disease: A Review	19
Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light	19
Defining the Spatial Resolution of Analyte Recovery during Microperfusion-Based Sampling of Brain Parenchyma	19
Tolcapone Derivative (Tol-D) Inhibits Aβ42 Fibrillogenesis and Ameliorates Aβ42-Induced Cytotoxicity and Cognitive Impairment	19
Brain Glucose Metabolism as a Readout of the Central Nervous System Impact of Cigarette Smoke Exposure and Withdrawal and the Effects of NFL-101, as an Immune-Based Drug Candidate for Smoking Cessatio	18
Radiocaine: An Imaging Marker of Neuropathic Injury	18
Repurposing Anakinra for Alzheimer’s Disease: The In Vitro and In Vivo Effects of Anakinra on LPS- and AC-Induced Neuroinflammation	18
Dynamics of the Multipathway Regulation of the Vasodilator Bold Effect Induced by a Nerve Impulse: A Kinetic Model of the Neurovascular Coupling Process	18
Effects of the Synthetic Cathinone α-Pyrrolidinobutiothiophenone (α-PBT) on Discriminative Stimulus Effects and Intracranial Self-Stimulation Thresholds in Male Rats	18
Radiosynthesis and In Vivo Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors	18
Structural Insights into Dopamine Receptor–Ligand Interactions: From Agonists to Antagonists	18
Impaired Dopamine Release and Latent Learning in Alzheimer’s Disease Model Zebrafish	18
Prophylactic Administration of Gut Microbiome Metabolites Abrogated Microglial Activation and Subsequent Neuroinflammation in an Experimental Model of Japanese Encephalitis	18
Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of O₂ after Brain Injury	18
Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome	18
Pathological Mutations D169G and P112H Electrostatically Aggravate the Amyloidogenicity of the Functional Domain of TDP-43	18
Targeting Microglial Immunoproteasome: A Novel Approach in Neuroinflammatory-Related Disorders	17
O-GlcNAc Modification of α-Synuclein Can Alter Monomer Dynamics to Control Aggregation Kinetics	17
Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT_2A/C Receptors	17
Influence of Cigarette Aerosol in Alpha-Synuclein Oligomerization and Cell Viability in SH-SY5Y: Implications for Parkinson’s Disease	17
Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays	17
Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance	17
Mutation-Dependent Refolding of Prion Protein Unveils Amyloidogenic-Related Structural Ramifications: Insights from Molecular Dynamics Simulations	17
Evaluating the Neuroprotective Potential of Novel Benzodioxole Derivatives in Parkinson’s Disease via AMPA Receptor Modulation	17
Targeting MicroRNA-144/451-AKT-GSK3β Axis Affects the Proliferation and Differentiation of Radial Glial Cells in the Mouse Hippocampal Dentate Gyrus	17
β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson’s Disease	17
Vertebrates on a Chip: Noninvasive Electrical and Optical Mapping of Whole Brain Activity Associated with Pharmacological Treatments	17
Targeting Two-Pore-Domain Potassium Channels by Mechanical Stretch Instantaneously Modulates Action Potential Transmission in Mouse Sciatic Nerves	17
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid	17
Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition	17
Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus	17
A Novel Stereospecific Bioluminescent Assay for Detection of Endogenous d-Cysteine	17
Identification of Potential Antiseizure Agents in Boswellia sacra using In Vivo Zebrafish and Mouse Epilepsy Models	17
Repeated Endomorphin Analogue MEL-0614 Reduces Tolerance and Improves Chronic Postoperative Pain without Modulating the P2X7R Signaling Pathway	17
Unveiling the Journey from the Gut to the Brain: Decoding Neurodegeneration–Gut Connection in Parkinson’s Disease	17

Low-Dose Radiation Induces Alterations in Fatty Acid and Tyrosine Metabolism in the Mouse Hippocampus: Insights from Integrated Multiomics	16
Rational Design, Synthesis, and Evaluation of Rofecoxib-Based Photosensitizers for the NIR Imaging and Photo-Oxidization of Aβ Aggregates	16
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents	16
Molecular Characterization of Two Wamide Neuropeptide Signaling Systems in Mollusk Aplysia	16
Stimulus-Specific Adaptation in Auditory Thalamus Is Modulated by the Thalamic Reticular Nucleus	16
HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood–Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke	16
Multiple Actions of H₂S-Releasing Peptides in Human β-Amyloid Expressing C. elegans	16
Pulsed Hydrogen–Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer’s Disease Mutants	16
Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer’s Disease	16
Marine-Derived Xyloketal Compound Ameliorates MPP⁺-Induced Neuronal Injury through Regulating of the IRE1/XBP1 Signaling Pathway	16
All Hands on Deck: We Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis	16
Binding Mode of Human Norepinephrine Transporter Interacting with HIV-1 Tat	16
Neuroprotective Effect of Propolis Polyphenol-Based Nanosheets in Cellular and Animal Models of Rotenone-Induced Parkinson’s Disease	16
FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT_1A, 5-HT_1B, and 5-HT_1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Kn	16
Probing Cerebral Metabolism with Hyperpolarized ¹³C Imaging after Opening the Blood–Brain Barrier with Focused Ultrasound	16
ALS-Linked A315T and A315E Mutations Enhance β-Barrel Formation of the TDP-43_307–319 Hexamer: A REST2 Simulation Study	16
Noncoding RNAs: Novel Insights into Postoperative Neurocognitive Disorders	16
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors	16
κ-Carrageenan Oligosaccharides Protect Nerves by Regulating Microglial Autophagy in Alzheimer’s Disease	16
Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation	15
Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser¹²⁹ in Biological Samples	15
Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/β-Catenin Signaling Pathway	15
Structure–Activity Relationships, Deuteration, and Fluorination of Synthetic Cannabinoid Receptor Agonists Related to AKB48, 5F-AKB-48, and AFUBIATA	15
Atomic Insights into Amyloid-Induced Membrane Damage	15
Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model	15
Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke	15
Discovery of VU6007496: Challenges in the Development of an M₁ Positive Allosteric Modulator Backup Candidate	15
SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck	15
4-Acyl-3,4-dihydropyrrolo[1,2-a]pyrazine Derivative Rescued the Hippocampal-Dependent Cognitive Decline of 5XFAD Transgenic Mice by Dissociating Soluble and Insoluble Aβ Aggregates	15
Repetitive Thoughts and Behaviors in Autism Spectrum Disorder: A Symptom-Based Framework for Novel Therapeutics	15
Concise and Scalable Radiosynthesis of (+)-[¹⁸F]MDL100907 as a Serotonin 5-HT_2A Receptor Antagonist for PET	14
Translational Significance of GMF-β Inhibition by Indazole-4-yl-methanol in Enteric Glial Cells for Treating Multiple Sclerosis	14
Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System	14
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion	14
Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation	14
Thrsp Gene and the ADHD Predominantly Inattentive Presentation	14
Lipidomics of Serum and Hippocampus Reveal the Protective Effects of Fermented Soybean Lipid on Rats of Microwave-Induced Cognitive Damage	14
Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines	14
Mechanistic Insights Behind the Self-Assembly of Human Insulin under the Influence of Surface-Engineered Gold Nanoparticles	14
Caged Zn²⁺ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake	14
Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo	14
Cross-Interactions of Aβ Peptides Implicated in Alzheimer’s Disease Shape Amyloid Oligomer Structures and Aggregation	14
Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation	14
Emerging Frontiers in Conformational Exploration of Disordered Proteins: Integrating Autoencoder and Molecular Simulations	14
Inhibition of the ERK1/2 Phosphorylation by Dextromethorphan Protects against Core Autistic Symptoms in VPA Induced Autistic Rats: In Silico and in Vivo Drug Repurposition Study	14
Alzheimer’s Disease Prevention through Natural Compounds: Cell-Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity	14
Roflumilast, a Phosphodiesterase-4 Inhibitor, Ameliorates Sleep Deprivation-Induced Cognitive Dysfunction in C57BL/6J Mice	14
Binding and Activation of Serotonergic G-Protein Coupled Receptors by the Multimodal Antidepressant Vortioxetine	14
Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling	14
De Novo Design of a β-Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer’s Disease	14
Effects of Charged Polyelectrolytes on Amyloid Fibril Formation of a Tau Fragment	14
Evidence that GIRK Channels Mediate the DREADD-hM4Di Receptor Activation-Induced Reduction in Membrane Excitability of Striatal Medium Spiny Neurons	14
Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise	14
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement	14
Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase	14
Rapid FRET Assay for the Early Detection of Alpha-Synuclein Aggregation in Parkinson’s Disease	14
Isolation and Identification of the High-Affinity DNA Aptamer Target to the Brain-Derived Neurotrophic Factor (BDNF)	14
Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis	13
Unlocking the Molecular Variations of a Micron-Scale Amyloid Plaque in an Early Stage Alzheimer’s Disease by a Cellular-Resolution Mass Spectrometry Imaging Platform	13
5-HT_2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics	13
Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential	13
Synthesis and Development of a Novel First-in-Class Cofilin Inhibitor for Neuroinflammation in Hemorrhagic Brain Injury	13
Discrimination between Alpha-Synuclein Protein Variants with a Single Nanometer-Scale Pore	13
New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System	13
Multitracer Approach to Understanding the Complexity of Reactive Astrogliosis in Alzheimer’s Brains	13
Site of Cholesterol Oxidation Impacts Its Localization and Domain Formation in the Neuronal Plasma Membrane	13
Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice	13
Specific Peptide from the Novel W-Tau Isoform Inhibits Tau and Amyloid β Peptide Aggregation In Vitro	13
Small Molecule Decoys of Aggregation for Elimination of Aβ-Peptide Toxicity	13
Competitive Antagonism of Xylazine on α7 Nicotinic Acetylcholine Receptors and Reversal by Curcuminoids	13
Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin	13
ΔFOSB: A Potentially Druggable Master Orchestrator of Activity-Dependent Gene Expression	13
Structure–Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP)	13
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca²⁺Channels and Pain	13
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke	13
Indication of Neurodegenerative Cascade Initiation by Amyloid-like Aggregate-Forming EBV Proteins and Peptide in Alzheimer’s Disease	13
Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro	13
JNK Activation in Alzheimer’s Disease Is Driven by Amyloid β and Is Associated with Tau Pathology	13
Lateral Habenula and Its Potential Roles in Pain and Related Behaviors	13
Neuromicrobiology Comes of Age: The Multifaceted Interactions between the Microbiome and the Nervous System	13
Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids	13
Identifying Substructures That Facilitate Compounds to Penetrate the Blood–Brain Barrier via Passive Transport Using Machine Learning Explainer Models	13
Mass Spectrometric Imaging of Anionic Phospholipids Desorbed from Human Hippocampal Sections: Discrimination between Temporal and Nontemporal Lobe Epilepsies	13
Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils	13
Schizophrenia, Bipolar and Major Depressive Disorders: Overview of Clinical Features, Neurotransmitter Alterations, Pharmacological Interventions, and Impact of Oxidative Stress in the Disease Process	13
Ferroptosis, Pyroptosis, and Cuproptosis in Alzheimer’s Disease	13
“Photo-Rimonabant”: Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar “Cis-On” CB₁R Antagonist	13
The Pharmacological Activity of Garlic (Allium sativum) in Parkinson’s Disease: From Molecular Mechanisms to the Therapeutic Potential	13
Molecular Simulations Reveal Distinct Energetic and Kinetic Binding Properties of [¹⁸F]PI-2620 on Tau Filaments from 3R/4R and 4R Tauopathies	13
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Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo	12
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