OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	27
Effect of CTMP1 gene on pulmonary fibrosis	23
Policosanol suppresses tumor progression in a gastric cancer xenograft model	20
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	20
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	16
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	13
In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice	13
Efficiency of pharmaceutical toxicity prediction in computational toxicology	12
Sub-lethal effects of organophosphates and synthetic pyrethroid insecticides on muscle tissue transaminases of Oreochromis niloticus in vivo	12
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	11
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	11
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	11
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	10
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	10
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	9
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	9
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	9
Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells	9
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	9
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	8
Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats	8
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	8
Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay	8
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	7
Acute toxicity assessment of nine organic UV filters using a set of biotests	7

CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	7
In vitro toxicological assessment of PhSeZnCl in human liver cells	7
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	7
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	7
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	7
Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	7
Exploring the various functions of PHD finger protein 20: beyond the unknown	7
Quantification and visualization of metastatic lung tumors in mice	6
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	6
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	6
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	6
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	6
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	6
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis	6
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	6
Integrative roles of sphingosine kinase in liver pathophysiology	6
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	6
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	5
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	5
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	5
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	5
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	5
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	5
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	5
Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell	4
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	4
Steroidogenic cytochrome P450 enzymes as drug target	4
HEBP2 affects sensitivity to cisplatin and BCNU but not to paclitaxel in MDA-MB-231 breast cancer cells	4
Induction of synergistic apoptosis by tetramethoxystilbene and nutlin-3a in human cervical cancer cells	4
Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma	4
Enhancement of renal fibrosis in PHF20 transgenic mice	4
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	4
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption	4
Acute toxicity of aqueous extract of Ambrosia arborescens Mill. on biochemical and histopathological parameters in rats	4
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1	4
Correction: Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	4
Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats	4
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	4
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes	4
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	4
Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects	4
Correction to: No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period	4
Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid	3
Toxicity of diclofenac sodium salt after two weeks of daily intramuscular administration in cynomolgus monkeys	3
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes	3
Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane	3
Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition	3
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice	3
Effect of 3-caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea on endothelial nitric oxide synthase activation via calcium signaling pathway	3
Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats	3

Quinine inhibits myogenic differentiation by disrupting AKT signaling pathway	3
YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells	3
Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma	3
Changes in gut microbiota and metabolites of mice with intravenous graphene oxide-induced embryo toxicity	3
Metal arsenic mediated enhancement of type-2 immunity in brains with altered locomotive activities in mice with autism-like behavioral characteristics	3
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration	3
Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential	3
Genotoxicity evaluation of fucoidan-rich Undaria pinnatifida sporophyll	3
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	3
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	3
Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation	3
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases	3
Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats	3
Validation study of spectrophotometric direct peptide reactivity assay (spectro-DPRA), a newly modified in chemico skin sensitization test method	3
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	3
Chemerin/CMKLR1 pathway exacerbates cisplatin-induced spiral ganglion neuron injury	2
Regulatory frameworks for fragrance safety in cosmetics: a global overview	2
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells	2
Oxidative stress and NRF2 signaling in kidney injury	2
Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats	2
Two weeks dose range-finding and four weeks repeated dose oral toxicity study of a novel reversible monoamine oxidase B inhibitor KDS2010 in cynomolgus monkeys	2
Naringenin suppresses aluminum-induced experimental hepato-nephrotoxicity in mice through modulation of oxidative stress and inflammation	2
Grading criteria of histopathological evaluation in BCOP assay by various staining methods	2
Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locusta migratoria (Orthoptera: Acrididae) as a novel food source	2
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)	2
Cytotoxicity evaluation and mechanism of endocrine-disrupting chemicals by the embryoid body test	2
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study	2
Zinc and selenium attenuate quaternary heavy metal mixture-induced testicular damage via amplification of the antioxidant system, reduction in metal accumulation, inflammatory and apoptotic biomarkers	2
Toxicity assessment using neural organoids: innovative approaches and challenges	2
A curcumin analog CA-5f inhibits urokinase-type plasminogen activator and invasive phenotype of triple-negative breast cancer cells	2
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes	2
Effect of daflon-500®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats	2
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma	2
The impact of manganese on vascular endothelium	2
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice	2