OOIR: Observatory of International Research

Papers

(The median citation count of Toxicological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	30
Effect of CTMP1 gene on pulmonary fibrosis	28
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	25
Policosanol suppresses tumor progression in a gastric cancer xenograft model	20
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	16
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	13
In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice	13
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	13
Efficiency of pharmaceutical toxicity prediction in computational toxicology	12
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	12
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	12
Exposure and health effects follow-up study of residents near a former smelter site	11
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	11
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	10
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	10
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	10
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	10
Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells	9
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	9
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	9
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	9
Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay	8
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	8
Acute toxicity assessment of nine organic UV filters using a set of biotests	8
Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats	8

Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	8
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	8
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	8
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	8
In vitro toxicological assessment of PhSeZnCl in human liver cells	8
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	8
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	7
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	7
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	7
Exploring the various functions of PHD finger protein 20: beyond the unknown	7
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	7
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	7
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis	7
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	7
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	6
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	6
Integrative roles of sphingosine kinase in liver pathophysiology	6
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	6
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	6
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	6
Quantification and visualization of metastatic lung tumors in mice	6
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	5
Current status and future prospects of toxicity assessment using organoids	5
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	5
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	5
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	5
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	5
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	5
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	5
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	4
Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell	4
Unveiling the intriguing potential of Bacopa monnieri extract in alleviating cypermethrin-induced hypothyroidism and oxidative stress in female mice	4
Is salsolinol a friend or foe? Revisiting its roles in neurotoxicity and cellular protection	4
HEBP2 affects sensitivity to cisplatin and BCNU but not to paclitaxel in MDA-MB-231 breast cancer cells	4
Correction: Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	4
Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma	4
Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats	4
Enhancement of renal fibrosis in PHF20 transgenic mice	4
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption	4
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	4
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1	4
Mechanism of endoplasmic reticulum stress-induced endothelial cell ferroptosis in trichloroethylene-induced mouse kidney injury	4
Induction of synergistic apoptosis by tetramethoxystilbene and nutlin-3a in human cervical cancer cells	4
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	4
Steroidogenic cytochrome P450 enzymes as drug target	4
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes	4
Anthraquinone as emerging contaminant: technological, toxicological, regulatory and analytical aspects	4
Acute toxicity of aqueous extract of Ambrosia arborescens Mill. on biochemical and histopathological parameters in rats	4
Correction to: No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period	4
The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression	4

Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane	3
Effect of 3-caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea on endothelial nitric oxide synthase activation via calcium signaling pathway	3
YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells	3
Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma	3
Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats	3
Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation	3
miR-143-3p mediates mercury chloride-induced neurotoxicity by targeting LMO4 and the Akt/GSK3β/mTOR pathway in vitro	3
Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition	3
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination	3
Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential	3
Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats	3
Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases	3
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration	3
Metal arsenic mediated enhancement of type-2 immunity in brains with altered locomotive activities in mice with autism-like behavioral characteristics	3
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes	3
Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling	3
Changes in gut microbiota and metabolites of mice with intravenous graphene oxide-induced embryo toxicity	3
Validation study of spectrophotometric direct peptide reactivity assay (spectro-DPRA), a newly modified in chemico skin sensitization test method	3
Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice	3
Toxicity of diclofenac sodium salt after two weeks of daily intramuscular administration in cynomolgus monkeys	3
Quinine inhibits myogenic differentiation by disrupting AKT signaling pathway	2
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells	2
Regulatory frameworks for fragrance safety in cosmetics: a global overview	2
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone)	2
The impact of manganese on vascular endothelium	2
Case study on the evaluation of skin sensitization for 23 selected fragrance ingredients using a defined approach based on OECD Guideline 497	2
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma	2
Genotoxicity evaluation of fucoidan-rich Undaria pinnatifida sporophyll	2
Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locusta migratoria (Orthoptera: Acrididae) as a novel food source	2
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes	2
A curcumin analog CA-5f inhibits urokinase-type plasminogen activator and invasive phenotype of triple-negative breast cancer cells	2
Oxidative stress and NRF2 signaling in kidney injury	2
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study	2
Cytotoxicity evaluation and mechanism of endocrine-disrupting chemicals by the embryoid body test	2
Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid	2
Effect of daflon-500®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats	2
Chitooligosaccharides as a potential immune modulator for reducing particulate matter 10-induced inflammation in pulmonary damage models	2
Chemerin/CMKLR1 pathway exacerbates cisplatin-induced spiral ganglion neuron injury	2
Toxicity assessment using neural organoids: innovative approaches and challenges	2
Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats	2
Bisphenol A and reproductive health: a comprehensive overview of toxicological effect	2