OOIR: Observatory of International Research

Papers

(The TQCC of Toxicological Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	58
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	56
Policosanol suppresses tumor progression in a gastric cancer xenograft model	31
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	23
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	18
Effect of CTMP1 gene on pulmonary fibrosis	18
Punicalagin mitigates benzo[α]pyrene induced epithelial-mesenchymal transition and migration in triple‑negative breast cancer cells	16
Exposure and health effects follow-up study of residents near a former smelter site	16
Esculetin alleviates IgA nephropathy in rats by improving intestinal mucosal function through the IL-17/NF-κB signaling	15
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	14
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	13
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	13
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	13
Efficiency of pharmaceutical toxicity prediction in computational toxicology	13
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	12
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist	12
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	12
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	11
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	11
Acute toxicity assessment of nine organic UV filters using a set of biotests	11
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	11
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	11
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	11
In vitro toxicological assessment of PhSeZnCl in human liver cells	11
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	11

Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	11
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	11
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	11
PK/PD interactions of antiarrhythmic drugs and oral anticoagulants in atrial fibrillation patients: clinical implications for stroke and dementia prevention	10
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	10
Exploring the various functions of PHD finger protein 20: beyond the unknown	10
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	10
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	10
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	10
Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	10
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	9
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	9
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	9
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	9
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	8
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	8
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	8
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	8
Integrative roles of sphingosine kinase in liver pathophysiology	8
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	8
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	8
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	8
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	7
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	7
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats	7
Disinfection’s impact on the environment, molecular cross-resistance with antibiotics, and modern reduction approaches	7
In silico cardiac safety assessment using a multi-biomarker approach based on an electrophysiological model of hiPSC-derived cardiomyocytes	7
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	7
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	7
Current status and future prospects of toxicity assessment using organoids	6
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	6
Steroidogenic cytochrome P450 enzymes as drug target	6
Unveiling the intriguing potential of Bacopa monnieri extract in alleviating cypermethrin-induced hypothyroidism and oxidative stress in female mice	6
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	6
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats	6
Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell	6
Enhancement of renal fibrosis in PHF20 transgenic mice	6
Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats	6
The resveratrol-induced apoptosis and/or necroptosis of lung cancer cells is dependent on the activation status of PARP-1 and MLKL under oxidative stress	6
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes	6
Methylmercury causes pain disorders by disrupting the neuronal function of spinal dorsal horn neurons in mice	6