OOIR: Observatory of International Research

Papers

(The TQCC of Toxicological Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora	40
Atg5 knockout induces alternative autophagy via the downregulation of Akt expression	38
Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies	28
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague–Dawley rats	16
Effect of CTMP1 gene on pulmonary fibrosis	15
Policosanol suppresses tumor progression in a gastric cancer xenograft model	15
Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes	13
Exposure and health effects follow-up study of residents near a former smelter site	13
Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist	12
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism	12
Efficiency of pharmaceutical toxicity prediction in computational toxicology	12
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora	11
Radioactive Iodine-induced hypothyroidism interferes with the maturation of reproductive organs during puberty in immature female rats	10
Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors	10
Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells	10
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells	10
Metabolic effects of diclofenac on the aquatic food chain – 1 H-NMR study of water flea-zebrafish system	10
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis	10
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human microvascular endothelial cells (HMEC-1)	10
Establishment of a platform for measuring mitochondrial oxygen consumption rate for cardiac mitochondrial toxicity	9
Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats	9
Oral toxicity evaluation of freeze-dried honeybee pupa powder (HDPp) in ICR mice: single-dose and 4-week repeated-dose studies	9
Acute toxicity assessment of nine organic UV filters using a set of biotests	9
Therapeutic strategies for colorectal cancer: antitumor efficacy of dopamine D2 receptor antagonists	9
In vitro toxicological assessment of PhSeZnCl in human liver cells	9

Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020	9
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method	9
Silencing circPalm2 inhibits sepsis-induced acute lung injury by sponging miR-376b-3p and targeting MAP3K1	8
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico	8
CKD-516 potentiates the anti-cancer activity of docetaxel against epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer	8
Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes	8
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization	8
Exploring the various functions of PHD finger protein 20: beyond the unknown	8
Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens	8
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis	8
Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact	7
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs	7
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells	7
Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice	7
Quantification and visualization of metastatic lung tumors in mice	7
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis	7
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model	7
Exposure to China dust exacerbates testicular toxicity induced by cyclophosphamide in mice	7
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer	7
Integrative roles of sphingosine kinase in liver pathophysiology	7
Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice	7
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs	6
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period	6
Current status and future prospects of toxicity assessment using organoids	6
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model	6
Roundup® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation	6
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics	6
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure	6
A decrease in Atp8a2 expression in Purkinje cells mediated acrylamide-induced cerebellar pathology in rats	6
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver	6