OOIR: Observatory of International Research

Papers

(The TQCC of Biomolecules & Therapeutics is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation	61
Lipid Metabolism, Disorders and Therapeutic Drugs - Review	55
Diabetic Nephropathy - a Review of Risk Factors, Progression, Mechanism, and Dietary Management	44
COVID-19 Vaccine: Critical Questions with Complicated Answers	38
Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection	38
Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit	30
Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells	29
The Role of Leptin in the Association between Obesity and Psoriasis	29
Chronicles of EGFR Tyrosine Kinase Inhibitors: Targeting EGFR C797S Containing Triple Mutations	28
Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway	28
Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders	25
Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease	24
Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae	21
Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury	20
Bioactive Lipids and Their Derivatives in Biomedical Applications	19
Inhibition of Cytochrome P450 Enzymes by Drugs-Molecular Basis and Practical Applications	19
Imipramine Ameliorates Depressive Symptoms by Blocking Differential Alteration of Dendritic Spine Structure in Amygdala and Prefrontal Cortex of Chronic Stress-Induced Mice	19
Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma	18
Dasatinib Inhibits Lyn and Fyn Src-Family Kinases in Mast Cells to Suppress Type I Hypersensitivity in Mice	18
Topical Application of S1P₂ Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice	18
Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science	17
Epithelial-Mesenchymal Transition-Inducing Factors Involved in the Progression of Lung Cancers	17
Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells	17
Gentiopicroside Ameliorates the Progression from Hepatic Steatosis to Fibrosis Induced by Chronic Alcohol Intake	17
Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells	17

Dual Roles of Autophagy and Their Potential Drugs for Improving Cancer Therapeutics	16
Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers	16
Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation	16
Spinosin Inhibits Aβ_1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway	16
Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology	15
Alternative Methods for Testing Botulinum Toxin: Current Status and Future Perspectives	15
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption	15
Interruption of Helicobacter pylori-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives	14
Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway	14
Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus	14
AR-mTOR-SRF Axis Regulates HMMR Expression in Human Prostate Cancer Cells	14
Effects of Diabetes Mellitus on the Disposition of Tofacitinib, a Janus Kinase Inhibitor, in Rats	13
Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells	13
Immune Responses to Plant-Derived Recombinant Colorectal Cancer Glycoprotein EpCAM-FcK Fusion Protein in Mice	13
Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model	12
Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress	12
Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome	12
Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells	12
Toluene Inhalation Causes Early Anxiety and Delayed Depression with Regulation of Dopamine Turnover, 5-HT_1AReceptor, and Adult Neurogenesis in Mice	12
Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators	12
Diosmetin and Its Glycoside, Diosmin, Improve Atopic Dermatitis- Like Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models	11
Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling	11
Metabolic Bone Diseases and New Drug Developments	11
Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction	11
Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells	11
Antineuroinflammatory Effects of 7,3’,4’-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression	11
Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation	11
Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation	11
Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging	11
Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine	11
Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice	11
Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS	11
Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo	11
Cell Autonomous Circadian Systems and Their Relation to Inflammation	10
Transcriptome Analysis of Long-Term Exposure to Blue Light in Retinal Pigment Epithelial Cells	10
Luteolin Promotes Apoptosis of Endometriotic Cells and Inhibits the Alternative Activation of Endometriosis-Associated Macrophages	10
Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3	10
Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease	10
Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance	10
KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure	9
KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells	9
Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes	9
FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice	9
Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia	9
Anti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells	9
Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells	9
KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice	9
Drug Discovery Perspectives of Antisense Oligonucleotides	9
Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426	9
Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and ErkMediated Nrf2/Ogg1 Signaling Pathways	9

Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene