OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Genomics is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Striate palmoplantar keratoderma: a novel DSG1 mutation, combined with an LDLR mutation	64
Correction to: A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity	23
Lactate released by lung adenocarcinoma (LUAD) cells promotes M2 macrophage polarization via the GPR132/cAMP/PKA pathway	21
Clinical report and genetic analysis of a novel variant in ZMIZ1 causing neurodevelopmental disorder with dysmorphic factors and distal skeletal anomalies in a Chinese family	20
miR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells	20
Comprehensive assessment of the significance of cellular senescence-associated genes in neuroblastoma	19
Genomic survey of high-throughput RNA-Seq data implicates involvement of long intergenic non-coding RNAs (lincRNAs) in cytoplasmic male-sterility and fertility restoration in pigeon pea	19
Plant cross-fertilization for production of dual-specific antibodies targeting both Ebola virus–like particles and HER2 protein in F1 plants	18
Identification and validation of an ECM organization-related gene signature as a prognostic biomarker and therapeutic target for glioma patients	17
Comparative genomic analysis of Mycoplasma anatis strains	16
Characterization of the B cell receptor repertoire of patients with acute coronary syndrome	15
METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression	14
Alleles disrupting LBD37-like gene by an 136 bp insertion show different distributions between green and purple cabbages (Brassica oleracea var. capitata)	14
Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population	14
PIM3 regulates myocardial ischemia/reperfusion injury via ferroptosis	14
Comparative analysis of human facial skin microbiome between topical sites compared to entire face	13
Transcriptome-wide characterization of the WRKY family genes in Lonicera macranthoides and the role of LmWRKY16 in plant senescence	13
Comparative analysis of allele variation using allele frequencies according to sample size in Korean population	13
RPTOR methylation in the peripheral blood and breast cancer in the Chinese population	12
YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44	12
Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population	11
Epigenetic reorganization during early embryonic lineage specification	11
missForest with feature selection using binary particle swarm optimization improves the imputation accuracy of continuous data	10
HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway	10
Genotype–environment interaction for milk production of Gyr cattle in Brazil and Colombia	10

Identification of Saccharum CaM gene family and function characterization of ScCaM1 during cold and oxidant exposure in Pichia pastoris	10
SmGDB: genome database of Salvia miltiorrhiza, an important TCM Plant	10
Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line	10
PKC-β modulates Ca2+ mobilization through Stim1 phosphorylation	10
Expression profiles of TNF-Alpha and HERV-K Env proteins in multiple types of colon and lung disease	9
Differential expression and functional analysis of circRNA in the ovaries of Yili geese at different egg-laying stages	9
Physiological and omics analysis of maize inbred lines during late grain development	9
Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia	9
Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion	9
Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma	9
Transcriptome analysis reveals key defense-related genes upon SA induction in Cocos nucifera L.	9
Genomic and transcriptomic analysis of Korean colorectal cancer patients	9
Genetically predicted physical activity is associated with lower serum urate concentrations	9
MicroRNA 429 regulates MMPs expression by modulating TIMP2 expression in colon cancer cells and inflammatory colitis	8
Genome-wide identification of drought-responsive microRNAs and their target genes in Chinese jujube by deep sequencing	8
CDK1 promotes the proliferation of melanocytes in Rex rabbits	8
RelCurator: a text mining-based curation system for extracting gene–phenotype relationships specific to neurodegenerative disorders	8
Identification of ulcerative colitis-specific immune cell signatures from public single-cell RNA-seq data	8
Association mapping analysis (AMA) for morpho-agronomic traits and leaf aromatic compounds using SSR markers in three types of Perilla crop collected from South Korea	8
Clinical and genetic analyses in syndromic intellectual disability with primary microcephaly reveal biallelic and de novo variants in patients with parental consanguinity	8
DNA methylome profiling of blood to identify individuals in a pair of monozygotic twins	8
Effect of human endogenous retrovirus-K env gene knockout on proliferation of ovarian cancer cells	8
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment	8
Gut bacteria-derived 3-phenylpropionylglycine mitigates adipocyte differentiation of 3T3-L1 cells by inhibiting adiponectin-PPAR pathway	8
ceRNA network of lncRNA MIR210HG/miR-377-3p/LMX1A in malignant proliferation of glioma cells	8
Postoperative circulating tumor DNA detection and CBLB mutations are prognostic biomarkers for gastric cancer	8
Transcriptome analysis of flower colour reveals the correlation between SNP and differential expression genes in Phalaenopsis	7
Genomic analyses of intricate interaction of TE-lncRNA overlapping genes with miRNAs in human diseases	7
MiR-122, miR-133a, and miR-206 as potential biomarkers for post-mortem interval estimation	7
Association between TGF-β/BMP signaling pathway polymorphisms and the risk of primary ovarian insufficiency in Korean women	7
Profiling of testis-specific or testis-predominant genes expressed in mouse male germ cell lines GC-1 and GC-2	7
Genetic specificity study using next-generation sequencing (NGS) of peritoneal metastatic colorectal cancer compared to primary colorectal cancer	7
Histone methyltransferase KMT2D inhibits ENKTL carcinogenesis by epigenetically activating SGK1 and SOCS1	7
Construction of methylation driver gene-related prognostic signature and development of a new prognostic stratification strategy in neuroblastoma	7
A novel role of the cotton calcium sensor CBL3 was involved in Verticillium wilt resistance in cotton	7
Prognostic and immunological role of LASP2 in clear cell renal cell carcinoma	7
DNA methylation of GDF-9 and GHR genes as epigenetic regulator of milk production in Egyptian Zaraibi goat	7
FOXK1 regulates epithelial-mesenchymal transition and radiation sensitivity in nasopharyngeal carcinoma via the JAK/STAT3 signaling pathway	7
A rare TNNT1 gene variant causing creatine kinase elevation in nemaline myopathy: c.271_273del (p.Lys91del)	7
Transcriptome analysis of East Asian common octopus, Octopus sinensis, paralarvae	7
Transcriptome-based screening and validation of key genes for wool color in cashmere goats	7
Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells	7
Single-cell transcriptomic analysis reveals transcriptional and cell subpopulation differences between human and pig immune cells	7
Repurposing existing drugs for monkeypox: applications of virtual screening methods	7
Regulation of UHRF1 acetylation by TIP60 is important for colon cancer cell proliferation	6
LncRNA KTN1-AS1 facilitates esophageal squamous cell carcinoma progression via miR-885-5p/STRN3 axis	6
Ectopic expression of AtMYB115 and AtMYB118 induces green tissue formation in non-green organs of Arabidopsis thaliana	6
MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7	6
Comparative analysis of genome-based CAZyme cassette in Antarctic Microbacterium sp. PAMC28756 with 31 other Microbacterium species	6
IDO promotes the proliferation and invasion of prostate cancer cells through KYNU	6

Harnessing epigenetic variability for crop improvement: current status and future prospects	6
Bidirectional two-sample mendelian randomization analysis identifies causal associations between age at menarche and sarcopenia-related traits	6
Suppression of TBCK enhances TRAIL-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma Caki-1 cells	6
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology	6
Correction to: Comprehensive analysis the diagnosis, malignant progression and immune infiltrate of ANXA6 in prostate cancer	6
DJ-1 protects cell death from a mitochondrial oxidative stress due to GBA1 deficiency	6
Puerarin alleviates chronic renal failure-induced pyroptosis in renal tubular epithelial cells by targeting miR-342-3p/TGF-β/SMAD axis	6
Exploring the role of alternative splicing in the pathogenesis of Sjögren’s syndrome: identification of novel isoforms associated with salivary gland immune infiltration	6
A novel study on CXXC5: unraveling its regulatory mechanisms in hematopoietic stem cell biology through proteomics and gene editing	6
The effect of canagliflozin on gut microbiota and metabolites in type 2 diabetic mice	6
Dual-specificity phosphatase 23 functions as a promising prognostic biomarker in non-small cell lung cancer	6
Mir-326 potentiates radiosensitivity of cervical squamous cell carcinoma through downregulating SMO expression in the Hedgehog signaling pathway	6
Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells	6
Gene expression profile in ulcerative colitis patients: FOXO4, ALDOB, SLC26A3, SOD2 genes as potential biomarkers	6
MED1 induces M2 polarization of tumor-associated macrophages to aggravate breast cancer	6
RepID depletion enhances TWS119-induced erythropoiesis through chromatin reprogramming and transcription factor recruitment	6
Analysing glycolysis-related genes reveals the prognostic and diagnostic relevance of IER3 and AGRN in colorectal cancer	6
Integrated analysis of single-cell RNA-seq and bulk RNA-seq revealed key genes for bone metastasis and chemoresistance in prostate cancer	5
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells	5
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin	5
Trait − driven analysis of the 2p15p16.1 microdeletion syndrome suggests a complex pattern of interactions between candidate genes	5
Transcriptome sequencing of the endangered land snail Karaftohelix adamsi from the Island Ulleung: De novo assembly, annotation, valuation of fitness genes and SSR markers	5
Characterization of the complete mitochondrial genome of a newly discovered torrent catfish, Liobagrus geumgangensis, and their phylogenetic relationships	5
Bacterial profile-based body fluid identification using a machine learning approach	5
Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced acute lung injury by regulating miR-424-5p/MAPK14 axis	5
High expression of HOXC6 predicts a poor prognosis and induces proliferation and inflammation in multiple myeloma cells	5
MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of gastric cancer by targeting ARF6	5
LncRNA SNHG20 promotes cell proliferation and invasion by suppressing miR-217 in ovarian cancer	5
Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis	5
A pan-cancer analysis unveiling the function of NR4A family genes in tumor immune microenvironment, prognosis, and drug response	5
Comparative whole genome analysis of face-derived Streptococcus infantis CX-4 unravels the functions related to skin barrier	5
Relative synonymous codon usage of ORF1ab in SARS-CoV-2 and SARS-CoV	5
GVAF: generalized, flexible filtering software for annotated variant files	5
UBE2C regulating the lung carcinoma progression via inhibiting ubiquitin-proteasomal degradation to increase MMP9 protein stability	5
NEDD4L suppresses PD-L1 expression and enhances anti-tumor immune response in A549 cells	5
Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling	5
Phylogeography of the Korean endemic Coreoleuciscus (Cypriniformes: Gobionidae): the genetic evidence of colonization through Eurasian continent to the Korean Peninsula during Late Plio-Pleistocene	5
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer	5
Discovery and genome-wide characterization of a novel miniature inverted repeat transposable element reveal genome-specific distribution in Glycine	5
Genomic analysis of nuclear receptors and miRNAs identifies a role for the NR3C1/miR-200 axis in colon cancer	5
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis	5
A novel approach of kinship determination based on the physical length of genetically shared regions of chromosomes	5
Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis	5
1, 25-(OH)2D3 protects against ER stress and miRNA dysregulation in Mus musculus neurons	5
Rare minisatellite alleles of MUC2-MS8 influence susceptibility to rectal carcinoma	4
Immune micro-environment analysis and drug screening for ovarian endometriosis	4
Phosphorylation of BIK1 is critical for interaction with downstream signaling components	4
Transcriptomic analysis reveal the responses of dendritic cells to VDBP	4
P14.5 functions to inhibit cell migration and can be used as a prognostic marker in hepatocellular carcinoma	4
Biallelic mutations in pakistani families with autosomal recessive prelingual nonsyndromic hearing loss	4
Application of RapidHIT™ ID for cell authentication by fast and convenient STR profiling	4
Effects of TLR9/NF-κB on oxidative stress and inflammation in IPEC-J2 cells	4
Characteristics of circRNAs expression profiles in the piglets intestine induced by oxidative stress	4
RETRACTED ARTICLE: Long non-coding RNA H19X promotes tumorigenesis and metastasis of colorectal cancer through regulating the miR-503-5p/KANK1 axis	4
Spreading-dependent or independent Sir2-mediated gene silencing in budding yeast	4
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin	4
Distinct granzyme k expression in immune cells: a single-cell rna-seq meta-analysis	4
ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages	4
Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome	4
Gene expression profiling and in vitro functional studies reveal RAD54L as a potential therapeutic target in multiple myeloma	4
Transcriptional induction of TGF-β1 and endothelial-to-mesenchymal transition cell markers in human umbilical vein endothelial cells by Ebola virus infection	4
Causal relationship between smoking status, smoking frequency and bladder cancer: a Mendelian randomization study	4
Insignificant effects of loss of heterozygosity in HLA in the efficacy of immune checkpoint blockade treatment	4
Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy	4
RBBP4 plays a vital role in the malignant progression of triple-negative breast cancer by regulating epithelial-mesenchymal transition	4
Prognostic significance of three endothelial nitric oxide synthase (eNOS) polymorphisms and metabolic syndrome (MetS) in patients with colorectal cancer	4
Development of markers using microsatellite loci of two rove beetle species, Paederus fuscipes Curtis and Aleochara (Aleochara) curtula Goeze (Coleoptera: Staphylinidae), followed by analyses of genet	4
Expression of lncRNA NEAT1 in endometriosis and its biological functions in ectopic endometrial cells as mediated via miR-124-3p	4
LncRNA expression profile analysis of Mg2+-induced osteogenesis by RNA-seq and bioinformatics	4
Purposive breeding strategies drive genetic differentiation in Thai fighting cock breeds	4
ICT1 deficiency leads to reduced oxygen resistance due to the cell wall damage in S. cerevisiae	4
Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia	4
Correlation between obstructive sleep apnea and cerebral small vessel disease: a mendelian randomization study	4
Methyltransferase-like 3 (METTL3) mediated N6-methyladenosine (m6A) modifications facilitate mir-25-3p maturation to promote gastrointestinal stromal tumors (GISTs) progression	4
TissueSpace: a web tool for rank-based transcriptome representation and its applications in molecular medicine	4
MiR-200c-3p inhibits LPS-induced M1 polarization of BV2 cells by targeting RIP2	4
Epigenome editing: targeted manipulation of epigenetic modifications in plants	4
The effect of the PLIN1 gene on the metabolism and mitochondria of porcine skeletal muscle satellite cells	4
The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China	4
Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis	4