Computational and Structural Biotechnology Journal

Article	Citations
Agreement and disagreement in pediatric functional neurological symptom disorders: Comparing patient reported outcome measures (PROMs) and clinician assessments	288
Corrigendum to “Cryo-EM reveals architectural diversity in active rotavirus particles” [Comput. Struct. Biotechnol. J. 17 (2019) 1178–1183]	268
In silico and in vitro approaches allow the identification of the Prosystemin molecular network	189
The balance between photosynthesis and respiration explains the niche differentiation between Crocosphaera and Cyanothece	164
Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects	161
NGS allele counts versus called genotypes for testing genetic association	159
dsCellNet: A new computational tool to infer cell–cell communication networks in the developing and aging brain	148
Network-based prioritization of cancer biomarkers by phenotype-driven module detection and ranking	131
Biomarker discovery process at binomial decision point (2BDP): Analytical pipeline to construct biomarker panel	119
An integrated protein structure fitness scoring approach for identifying native-like model structures	119
Cell segmentation and representation with shape priors	116
Comprehensive exploration of JQ1 and GSK2801 targets in breast cancer using network pharmacology and molecular modeling approaches	100
Optimizing the Illumina COVIDSeq laboratorial and bioinformatics pipeline on thousands of samples for SARS-CoV-2 Variants of Concern tracking	96
VTAM: A robust pipeline for validating metabarcoding data using controls	95
Prediction of protein-ligand binding affinity with deep learning	93
Identification and biophysical characterization of epitope atlas of Porcine Reproductive and Respiratory Syndrome Virus	92
Entropy-extreme model for predicting the development of cyber epidemics at early stages	90
MUG: A mutation overview of GPCR subfamily A17 receptors	83
Artificial intelligence predictive system of individual survival rate for lung adenocarcinoma	82
A novel exosome-derived prognostic signature and risk stratification for breast cancer based on multi-omics and systematic biological heterogeneity	79
Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA	75
Predictive dynamic control accurately maps the design space for 2,3-butanediol production	72
Computation-aided studies related to the induction of specialized metabolite biosynthesis in microbial co-cultures: An introductory overview	71
Free energy landscape of the PI3Kα C-terminal activation	70
Discovery of a novel marine Bacteroidetes with a rich repertoire of carbohydrate-active enzymes	69

Integrated metabolomics and network analysis reveal changes in lipid metabolisms of tripterygium glycosides tablets in rats with collagen-induced arthritis	68
The second intracellular loop of the yeast Trk1 potassium transporter is involved in regulation of activity, and interaction with 14–3-3 proteins	67
Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies	66
CKATool: A clinical kinematic analysis toolbox for upper limb rehabilitation	65
Advanced biokinetic and hydrodynamic modelling to support and optimize the design of full-scale high rate algal ponds	64
Nextcast: A software suite to analyse and model toxicogenomics data	64
Multi-omics landscape and clinical significance of a SMAD4-driven immune signature: Implications for risk stratification and frontline therapies in pancreatic cancer	63
Using molecular dynamics simulations to interrogate T cell receptor non-equilibrium kinetics	62
Structural elucidation of four fungal hydrophobins belonging to classes I and II: Results from Alphafold and accelerated molecular dynamics simulations	61
cPEPmatch Webserver: A comprehensive tool and database to aid rational design of cyclic peptides for drug discovery	60
The influence of HIV sense and antisense transcripts on stochastic HIV transcription and reactivation	60
What remains from living cells in bacterial lysate-based cell-free systems	58
UPIMAPI, reCOGnizer and KEGGCharter: Bioinformatics tools for functional annotation and visualization of (meta)-omics datasets	58
Phylogenetic tree-based amino acid sequence generation for proteomics data analysis of unknown species	57
Towards predicting implant-induced fibrosis: A standardized network model of macrophage-fibroblast interactions	57
Altered heme metabolism and hemoglobin concentration due to empirical antibiotics-induced gut dysbiosis in preterm infants	56
Evolution is in the details: Regulatory differences in modern human and Neanderthal	55
Deep5mC: Predicting 5-methylcytosine (5mC) methylation status using a deep learning transformer approach	54
MMRT: MultiMut Recursive Tree for predicting functional effects of high-order protein variants from low-order variants	54
A miRNA signature linked to high lipoprotein (a) and coronary calcification in familial hypercholesterolaemia	54
macpie: Scalable workflow for high-throughput transcriptomic profiling	53
Gut microbiome enterotypes and temporal variations during a six-month inulin-supplemented weight loss randomized controlled trial in Thai children with obesity	52
Radiomic clustering using graph network techniques coupled with unbalanced optimal transport	52
DiabetesOmic: A comprehensive multi-omics diabetes database	52
DIPAN: Detecting personalized intronic polyadenylation derived neoantigens from RNA sequencing data	51
Corrigendum to “Maternal Clostridium butyricum supplementation during late gestation and lactation enhances gut bacterial communities, milk quality, and reduces piglet diarrhea” [Comput Struct Biotech	51
Consistencies and contradictions in different polymer models of chromatin architecture	50
Computational fluid dynamics modeling and simulation of nanoparticle-tumor interaction: Systematic literature review	50
A drug repurposing method based on inhibition effect on gene regulatory network	49
From latent dynamics to data geometry: Nonlinear diffusion modelling for protein structures	48
WUREN: Whole-modal union representation for epitope prediction	47
Predicting zeta potential of liposomes from their structure: A nano-QSPR model for DOPE, DC-Chol, DOTAP, and EPC formulations	46
Design rules applied to silver nanoparticles synthesis: A practical example of machine learning application.	46
Improved inter-residue contact prediction via a hybrid generative model and dynamic loss function	46
Ranking pre-trained speech embeddings in Parkinson's disease detection: Does Wav2Vec 2.0 outperform its 1.0 version across speech modes and languages?	45
From sequence to function through structure: Deep learning for protein design	45
CRUSADE project: Recycling technologies for ELV components to create a sustainable source of market grade materials for EU applications	44
Towards accurate and efficient diagnoses in nephropathology: An AI-based approach for assessing kidney transplant rejection	44
Data pre-processing for analyzing microbiome data – A mini review	43
Automated machine learning in nanotoxicity assessment: A comparative study of predictive model performance	43
Predicting cellular adaptation proteins dependent on eIF2α regulation under stress conditions: Physiological and pathophysiological implications in neuronal function	42
Identification of genetic basis of brain imaging by group sparse multi-task learning leveraging summary statistics	42
EthnoHERBS: Harnessing traditional herbal knowledge for biodiversity conservation and innovative health solutions	42
Statistical methods for Mendelian randomization in genome-wide association studies: A review	42
Contagious infection-free medical interaction system with machine vision controlled by remote hand gesture during an operation	41
Prognostic iron-metabolism signature robustly stratifies single-cell characteristics of hepatocellular carcinoma	41
PS-GO parametric protein search engine	41
ECGA: A web server to explore and analyze extrachromosomal gene in cancer	40
Genome-scale models as a vehicle for knowledge transfer from microbial to mammalian cell systems	40
Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos	39

Survival estimation in patients with stomach and esophageal carcinoma using miRNA expression profiles	39
The World of GPCR dimers – Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements	39
Literature-based translation from synthetic lethality screening into therapeutics targets: CD82 is a novel target for KRAS mutation in colon cancer	39
Inference of essential genes in Brugia malayi and Onchocerca volvulus by machine learning and the implications for discovering new interventions	39
Identifying novel SMYD3 interactors on the trail of cancer hallmarks	39
SbD4Skin by EosCloud: Integrating multi-view molecular representation for predicting skin sensitization, irritation, and acute dermal toxicity	38
Pleiotropic expression quantitative trait loci are enriched in enhancers and transcription factor binding sites and impact more genes	38
Population genomic analyses reveal evidence for limited recombination in the superbug Candida auris in nature	38
Performance of a HER2 testing algorithm tailored for urothelial bladder cancer: A Bi-centre study	38
Multicopper oxidases with laccase-ferroxidase activity: Classification and study of ferroxidase activity determinants in a member from Heterobasidion annosum s. l.	38
Drug repurposing in psoriasis, performed by reversal of disease-associated gene expression profiles	38
PCLDA: An interpretable cell annotation tool for single-cell RNA-sequencing data based on simple statistical methods	37
Protein design accelerates the development and application of optogenetic tools	37
Augusta: From RNA‐Seq to gene regulatory networks and Boolean models	37
Structural studies of protein–nucleic acid complexes: A brief overview of the selected techniques	37
PLO3S: Protein LOcal Surficial Similarity Screening	37
Co-expression of immune checkpoints in glioblastoma revealed by single-nucleus RNA sequencing and spatial transcriptomics	37
Cat-E: A comprehensive web tool for exploring cancer targeting strategies	36
YTLR: Extracting yeast transcription factor-gene associations from the literature using automated literature readers	36
A cellulose-degrading Bacillus altitudinis from Tibetan pigs improved the in vitro fermentation characteristics of wheat bran	36
IsomiRome analysis reveals dysregulation of 5’ isomiRs during SARS-CoV-2 infection	35
Public Omics Explorer (POE): Enabling integrative semantic search across GEO omics datasets based on PubMed publications	35
Single-cell multiome characterizing intercellular communication and intracellular regulation of epithelium and mesenchymal during secondary palate development in mice	35
Review of protein structure-based analyses that illuminate plant stress mechanisms	35
Over time analysis of the codon usage of SARS-CoV-2 and its variants	35
ImmiR: A database of microRNAs associated with immune checkpoints and infiltrates	35
Mutation density analyses on long noncoding RNA reveal comparable patterns to protein-coding RNA and prognostic value	35
A universal pipeline MosaicProt enables large-scale modeling and detection of chimeric protein sequences for studies on programmed ribosomal frameshifting	34
Dual guide RNA-mediated concurrent C&G-to-T&A and A&T-to-G&C conversions using CRISPR base editors	34
Self-supervised domain adaptation of protein language model based solely on positive enzyme-reaction pairs	34
Whole-genome analysis of carbapenem-resistant Acinetobacter baumannii from clinical isolates in Southern Thailand	34
OncoProExp: An interactive shiny web application for comprehensive cancer proteomics and phosphoproteomics analysis	34
Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants	33
SSRTool: A web tool for evaluating RNA secondary structure predictions based on species-specific functional interpretability	33
Strengths and limitations of web servers for the modeling of TCRpMHC complexes	33
Thresholding Gini variable importance with a single-trained random forest: An empirical Bayes approach	33
Scale bar of aging trajectories for screening personal rejuvenation treatments	33
Machine learning in metastatic cancer research: Potentials, possibilities, and prospects	33
Empirical comparison and recent advances of computational prediction of hormone binding proteins using machine learning methods	33
NaCTR: Natural product-derived compound-based drug discovery pipeline from traditional oriental medicine by search space reduction	33
Bacillus subtilis spores displaying RBD domain of SARS-CoV-2 spike protein	33
Prediction of HER2-positive breast cancer recurrence and metastasis risk from histopathological images and clinical information via multimodal deep learning	32
Computational approaches in rheumatic diseases – Deciphering complex spatio-temporal cell interactions	32
The discovery of hidden guanylate cyclases (GCs) in the Homo sapiens proteome	31
A DNA-based non-infectious replicon system to study SARS-CoV-2 RNA synthesis	31
TRRAP-mediated acetylation on Sp1 regulates adult neurogenesis	31
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression	31
HELLS modulates the stemness of intrahepatic cholangiocarcinoma through promoting senescence-associated secretory phenotype	31
Beyond the Scalpel: Assessing ChatGPT's potential as an auxiliary intelligent virtual assistant in oral surgery	31
Optimizing fountain codes for DNA data storage	31
SARS-CoV-2 mutations acquired during serial passage in human cell lines are consistent with several of those found in recent natural SARS-CoV-2 variants	31
Corrigendum to “TREAT: Therapeutic RNAs exploration inspired by artificial intelligence technology” [Comput Struct Biotechnol J 20 (2022) 5680–5689]	30
Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism	30
Corrigendum to “Coupling the endophytic microbiome with the host transcriptome in olive roots” [Comput. Struct. Biotechnol. J. 19 (2021) 4777–4789]	30
SPARC: Structural properties associated with residue constraints	30
Alterations in 3D chromatin organization contribute to tumorigenesis of EGFR-amplified glioblastoma	30
Generic and queryable data integration schema for transcriptomics and epigenomics studies	30
Mechanistic insights into P-glycoprotein ligand transport and inhibition revealed by enhanced molecular dynamics simulations	30
Concentration-dependent thermodynamic analysis of the partition process of small ligands into proteins	30
Proteome-wide prediction and analysis of the Cryptosporidium parvum protein–protein interaction network through integrative methods	30
Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells	30
The structural integrity of the membrane-embedded bacterial division complex FtsQBL studied with molecular dynamics simulations	30
Detecting differentially expressed circular RNAs from multiple quantification methods using a generalized linear mixed model	30
MSPJ: Discovering potential biomarkers in small gene expression datasets via ensemble learning	30
The seen and the unseen: Molecular classification and image based-analysis of gastrointestinal cancers	30
Protposer: The web server that readily proposes protein stabilizing mutations with high PPV	29
Deep learning of antibody epitopes using positional permutation vectors	29
Role of Bmal1 in mediating the cholinergic system to regulate the behavioral rhythm of nocturnal marine molluscs	29
Mysteries of gene regulation: Promoters are not the sole triggers of gene expression	29
Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia	29
scDemultiplex: An iterative beta-binomial model-based method for accurate demultiplexing with hashtag oligos	29
PgxSAVy: A tool for comprehensive evaluation of variant peptide quality in proteogenomics – catching the (un)usual suspects	29
Claudin-10b cation channels in tight junction strands: Octameric-interlocked pore barrels constitute paracellular channels with low water permeability	29
Comparative analysis of amino acid auxotrophies and peptidase profiles in non-dysbiotic and dysbiotic small intestinal microbiomes	28
Structure analysis of human gut microbiota associated with single-celled gut protists using Next-Generation Sequencing of 16S and 18S rRNA genes	28
Enhancing glucose level prediction of ICU patients through hierarchical modeling of irregular time-series	28
In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation	28
Advances in gut microbiota functions in inflammatory bowel disease: Dysbiosis, management, cytotoxicity assessment, and therapeutic perspectives	28
Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases	28
Post-processing enhances protein secondary structure prediction with second order deep learning and embeddings	28

HIV infection detection using CRISPR/Cas systems: Present and future prospects	27
Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation	27
EquiRank: Improved protein-protein interface quality estimation using protein language-model-informed equivariant graph neural networks	27
Ion and water permeation through claudin-10b and claudin-15 paracellular channels	27
Optimization of regulatory DNA with active learning	27
Structure-based identification of HNF4α agonists: Rosmarinic acid as a promising candidate for NAFLD treatment	27
Fantastic genes and where to find them expressed in CHO	27
Analyzing the human gut mycobiome – A short guide for beginners	27
Integrative geno-metabolomics of tenasserim turmeric (Curcuma candida (Wall.) Techapr. & Škorničk.) with insights into volatile biosynthesis across the turmeric genus	27
Enhancing detection of epileptic seizures using transfer learning and EEG brain activity signals	27
INSIGHT: An integrated framework for safe and sustainable chemical and material assessment	26
Modeling approaches for probing cross-feeding interactions in the human gut microbiome	26
Discovery of C-12 dithiocarbamate andrographolide analogues as inhibitors of SARS-CoV-2 main protease: In vitro and in silico studies	26
The potential of Real-Time volume-rendered 3D Imaging in immersive virtual-reality (VR) for surgical planning in infants with congenital thoracic malformation (CTM)	26
BioLogical: a universal analysis framework for biosystem logical dynamics	26
Population-scale genotyping of structural variation in the era of long-read sequencing	25
Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins	25
Reprogramming landscape highlighted by dynamic transcriptomes in therapy-induced neuroendocrine differentiation	25
Targeted removal of mitochondrial DNA from mouse and human extrachromosomal circular DNA with CRISPR-Cas9	25
A novel deep learning method for large-scale analysis of bone marrow adiposity using UK Biobank Dixon MRI data	25
Molecular dynamics analysis of the structural properties of the transglutaminases of Kutzneria albida and Streptomyces mobaraensis	25
New insights empowered by single-cell sequencing: From neural crest to enteric nervous system	25
Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane	25
Histone variants and chromatin structure, update of advances	25
CNN6mA: Interpretable neural network model based on position-specific CNN and cross-interactive network for 6mA site prediction	25
A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics	25
Structural insights into apoptotic regulation of human Bfk as a novel Bcl-2 family member	25
Easy-MODA: Simplifying standardised registration of scientific simulation workflows through MODA template guidelines powered by the Enalos Cloud Platform	24
Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases	24
Oxidative Stress-Driven Transcriptomic Remodeling in Human Astrocytes Reveals Network Signatures Associated with Neurodegenerative and Cardiovascular Processes	24
TOAST: A novel method for identifying topologically associated domains based on graph auto-encoders and clustering	24
MNNMDA: Predicting human microbe-disease association via a method to minimize matrix nuclear norm	24
Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains	24
Targeting non-structural proteins of Hepatitis C virus for predicting repurposed drugs using QSAR and machine learning approaches	24
EpiCas-DL: Predicting sgRNA activity for CRISPR-mediated epigenome editing by deep learning	24
A gap analysis of UK biobank publications reveals SNPs associated with intrinsic subtypes of breast cancer	24
Downregulation of ABLIM3 confers to the metastasis of neuroblastoma via regulating the cell adhesion molecules pathway	24
New targets for the treatment of ulcerative colitis: Gut microbiota and its metabolites	24
Evaluation of the impact of printing and embroidery parameters in the process of obtaining utility comfort sensors used in protective clothing dedicated to premature babies	24
CNNSplice: Robust models for splice site prediction using convolutional neural networks	24
Interplay of starch debranching enzyme and its inhibitor is mediated by Redox-Activated SPL transcription factor	24
BioPrediction-RPI: Democratizing the prediction of interaction between non-coding RNA and protein with end-to-end machine learning	23
Reference-based read clustering improves the de novo genome assembly of microbial strains	23
Aggregating amyloid resources: A comprehensive review of databases on amyloid-like aggregation	23
Structural and functional mapping of ars gene cluster in Deinococcus indicus DR1	23
Unleashing high content screening in hit detection – Benchmarking AI workflows including novelty detection	23
Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics	23
Overcoming the cognition-reality gap in robot-to-human handovers with anisotropic variable force guidance	23
IBPred: A sequence-based predictor for identifying ion binding protein in phage	23
Bacterial low-abundant taxa are key determinants of a healthy airway metagenome in the early years of human life	23
Binding modes of prothrombin cleavage site sequences to the factor Xa catalytic triad: Insights from atomistic simulations	23
Recognition of immune-related tumor antigens and immune subtypes for mRNA vaccine development in lung adenocarcinoma	23
Evaluation of protein descriptors in computer-aided rational protein engineering tasks and its application in property prediction in SARS-CoV-2 spike glycoprotein	23
Shared and divergent contribution of vitamin A and oxytocin to the aetiology of autism spectrum disorder	23
Linkage and association analyses reveal that hub genes in energy-flow and lipid biosynthesis pathways form a cluster in upland cotton	23
Relative flux trade-offs and optimization of metabolic network functionalities	23
Pan-genomic and comparative analysis of Pediococcus pentosaceus focused on the in silico assessment of pediocin-like bacteriocins	23
iKcr_CNN: A novel computational tool for imbalance classification of human nonhistone crotonylation sites based on convolutional neural networks with focal loss	22
Non-coding antisense transcripts: fine regulation of gene expression in cancer	22
Design, proof-of-concept of single robotic hair transplant mechanisms for both harvest and implant of hair grafts	22
HELENA project: Driving innovation in high energy density Li-metal halide solid-state batteries for electric vehicles and aircrafts	22
MOVIS: A multi-omics software solution for multi-modal time-series clustering, embedding, and visualizing tasks	22
Detection and prioritization of COVID-19 infected patients from CXR images: Analysis of AI-assisted diagnosis in clinical settings	22
A method for analyzing the ERP associated with high frequency ANT DBS offset	22
Data recovery methods for DNA storage based on fountain codes	22
MACRAMÉ – Advanced characterisation methodologies to assess and predict the health and environmental risks of advanced materials	22
Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction	22
iResNetDM: An interpretable deep learning approach for four types of DNA methylation modification prediction	22
Noninvasive detection and interpretation of gastrointestinal diseases by collaborative serum metabolite and magnetically controlled capsule endoscopy	22
Family-wide analysis of integrin structures predicted by AlphaFold2	22
Prediction and validation of host-pathogen interactions by a versatile inference approach using Aspergillus fumigatus as a case study	22
fRNC: Uncovering the dynamic and condition-specific RBP-ncRNA circuits from multi-omics data	22
ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis	22
CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies	22
MM-DRPNet: A multimodal dynamic radial partitioning network for enhanced protein–ligand binding affinity prediction	22
A Nano Risk Governance Portal supporting risk governance of nanomaterials and nano-enabled products	22
Deep learning frameworks for protein–protein interaction prediction	21
Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection	21
Metabolomic and lipidomic insights into the impact of Euglena gracilis-derived β-glucan supplementation on sow colostrum and milk composition	21
Improving doublet cell removal efficiency through multiple algorithm runs	21
Dynamics of spindle assembly and position checkpoints: Integrating molecular mechanisms with computational models	21
Tevenvirinae phages encode a family of LSm-like fold proteins	21
Osmolyte-induced protein stability changes explained by graph theory	21
Low-calorie diet intervention ameliorates gut microbiota dysbiosis and metabolic changes in obese patients with type 2 diabetes under standard care	21
Pathway-guided architectures for interpretable AI in biological research	21
CPRCSdb: A comprehensive phenotype-associated single-cell transcriptomic database for human cancer	21
SpatialPPIv2: Enhancing protein–protein interaction prediction through graph neural networks with protein language models	21
Intraline genomic heterogeneity of the triple-negative breast cancer MDA-MB-231-luc-GFP cell line	21
A potent nonapeptide inhibitor for the CXCL12/HMGB1 heterocomplex: A computational and experimental approach	21
Deep learning based deconvolution methods: A systematic review	21
Identifying the risk of Kawasaki disease based solely on routine blood test features through novel construction of machine learning models	21
Quercetin: A promising drug candidate against the potential SARS-CoV-2-Spike mutants with high viral infectivity	20
Exploring the role of plant lysin motif receptor-like kinases in regulating plant-microbe interactions in the bioenergy crop Populus	20
Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review	20
Machine learning for metabolic pathway optimization: A review	20