Computational and Structural Biotechnology Journal

Article	Citations
UPIMAPI, reCOGnizer and KEGGCharter: Bioinformatics tools for functional annotation and visualization of (meta)-omics datasets	175
A DICOM-based standard for quantitative physical rehabilitation	166
Transcriptomic investigations of polymyxins and colistin/sulbactam combination against carbapenem-resistant Acinetobacter baumannii	142
A shared mechanism for TNP-ATP recognition by members of the P2X receptor family	117
VIBES: A consensus subtyping of the vaginal microbiota reveals novel classification criteria	109
Genome-wide analysis reveals the contributors to fast molecular evolution of the Chinese hook snout carp (Opsariichthys bidens)	109
The molecular subtypes of autoimmune diseases	91
Deep-HPI-pred: An R-Shiny applet for network-based classification and prediction of Host-Pathogen protein-protein interactions	90
Enhancing prediction of short linear protein motifs with Wregex 3.0	84
cPEPmatch Webserver: A comprehensive tool and database to aid rational design of cyclic peptides for drug discovery	74
Network-based analysis of heterogeneous patient-matched brain and extracranial melanoma metastasis pairs reveals three homogeneous subgroups	72
Comprehensive integration of single-cell RNA and transcriptome RNA sequencing to establish a pyroptosis-related signature for improving prognostic prediction of gastric cancer	67
Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface	63
RCDdb: A manually curated database and analysis platform for regulated cell death	61
Personalized analysis of human cancer multi-omics for precision oncology	58
Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet	53
Discovery of a novel marine Bacteroidetes with a rich repertoire of carbohydrate-active enzymes	51
Curvature-enhanced graph convolutional network for biomolecular interaction prediction	50
Transnational learning and teaching activities: Smart Healthcare Engineering	48
Revealing SARS-CoV-2 Mpro mutation cold and hot spots: Dynamic residue network analysis meets machine learning	47
TCMM: A unified database for traditional Chinese medicine modernization and therapeutic innovations	47
Cell-to-cell distance that combines gene expression and gene embeddings	46
InTiCAR: Network-based identification of significant inter-tissue communicators for autoimmune diseases	46
Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors	45
ppHiC: Interactive exploration of Hi-C results on the ProteinPaint web portal	45

Landscape of intrinsically disordered proteins in mental disorder diseases	45
Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus	45
Rapid profiling of carcinogenic types of Helicobacter pylori infection via deep learning analysis of label-free SERS spectra of human serum	44
Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies	42
Nanopore sequencing of protozoa: Decoding biological information on a string of biochemical molecules into human-readable signals	42
Structure-based protein and small molecule generation using EGNN and diffusion models: A comprehensive review	41
A heterogeneous information network learning model with neighborhood-level structural representation for predicting lncRNA-miRNA interactions	39
Free energy landscape of the PI3Kα C-terminal activation	38
Cultivation driven transcriptomic changes in the wild-type and mutant strains of Rhodospirillum rubrum	38
WUREN: Whole-modal union representation for epitope prediction	37
Insulin-related traits and prostate cancer: A Mendelian randomization study	36
AFSC: A self-supervised augmentation-free spatial clustering method based on contrastive learning for identifying spatial domains	36
Unsupervised machine learning for risk stratification and identification of relevant subgroups of ascending aorta dimensions using cardiac CT and clinical data	36
Physical-aware model accuracy estimation for protein complex using deep learning method	36
Identification and biophysical characterization of epitope atlas of Porcine Reproductive and Respiratory Syndrome Virus	36
Development of a new data management system for the study of the gut microbiome of children who are small for their gestational age	36
The complement C3a/C3aR pathway is associated with treatment resistance to gemcitabine-based neoadjuvant therapy in pancreatic cancer	35
HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state	35
DeepFusion: A deep bimodal information fusion network for unraveling protein-RNA interactions using in vivo RNA structures	34
BrainCellR: A precise cell type nomenclature pipeline for comparative analysis across brain single-cell datasets	34
Prolonged premature rupture of membranes with increased risk of infection is associated with gut accumulation of Pseudomonas from the environment	34
C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability	33
Predictive dynamic control accurately maps the design space for 2,3-butanediol production	32
The variegated canalized-1 tomato mutant is linked to photosystem assembly	32
Deep5mC: Predicting 5-methylcytosine (5mC) methylation status using a deep learning transformer approach	32
Artificial intelligence in skeletal metastasis imaging	31
MMRT: MultiMut Recursive Tree for predicting functional effects of high-order protein variants from low-order variants	31
Deep learning-based characterization of neutrophil activation phenotypes in ex vivo human Candida blood infections	30
NeuralBeds: Neural embeddings for efficient DNA data compression and optimized similarity search	30
Cysteine hyperoxidation rewires communication pathways in the nucleosome and destabilizes the dyad	30
Unraveling membrane properties at the organelle-level with LipidDyn	29
PIMMS-Dash: Accessible analysis, interrogation, and visualisation of high-throughput transposon insertion sequencing (TIS) data	29
Path to normality: Assessing the level of social-distancing measures relaxation against antibody-resistant SARS-CoV-2 variants in a partially-vaccinated population	29
Corrigendum to “Cryo-EM reveals architectural diversity in active rotavirus particles” [Comput. Struct. Biotechnol. J. 17 (2019) 1178–1183]	29
Structural insight into the macrocyclic inhibitor TPX-0022 of c-Met and c-Src	28
Confronting the data deluge: How artificial intelligence can be used in the study of plant stress	28
Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders	28
TWN-FS method: A novel fragment screening method for drug discovery	27
Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies	27
Identification of feature genes and key biological pathways in immune-mediated necrotizing myopathy: High-throughput sequencing and bioinformatics analysis	27
An integrated protein structure fitness scoring approach for identifying native-like model structures	26
Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist	26
Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants	26
Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68	26
Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects	26
Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations	25
PeakCNV: A multi-feature ranking algorithm-based tool for genome-wide copy number variation-association study	25
The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines	25
A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway	25
BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure	25

Identification of new head and neck squamous cell carcinoma subtypes and development of a novel score system (PGSscore) based on variations in pathway activity between tumor and adjacent non-tumor sam	25
Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA	25
Optimizing the Illumina COVIDSeq laboratorial and bioinformatics pipeline on thousands of samples for SARS-CoV-2 Variants of Concern tracking	24
Modeling the effect of rRNA-mRNA interactions and mRNA folding on mRNA translation in chloroplasts	24
Can we infer tumor presence of single cell transcriptomes and their tumor of origin from bulk transcriptomes by machine learning?	24
Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany	24
Novelty detection for metabolic dynamics established on breast cancer tissue using 2D NMR TOCSY spectra	24
LncRNA functional annotation with improved false discovery rate achieved by disease associations	23
What remains from living cells in bacterial lysate-based cell-free systems	23
Electron density is not spherical: the many applications of the transferable aspherical atom model	23
Rapid intraoperative amplicon sequencing of CNS tumor markers	23
Hepatic encephalopathy post-TIPS: Current status and prospects in predictive assessment	23
Deciphering and designing microbial communities by genome-scale metabolic modelling	23
Computational identification of differentially-expressed genes as suggested novel COVID-19 biomarkers: A bioinformatics analysis of expression profiles	23
Designing CITOBOT: A portable device for cervical cancer screening using human-centered design, smart prototyping, and artificial intelligence	23
Automated machine learning in nanotoxicity assessment: A comparative study of predictive model performance	23
Agreement and disagreement in pediatric functional neurological symptom disorders: Comparing patient reported outcome measures (PROMs) and clinician assessments	23
NanoConstruct: A web application builder of ellipsoidal nanoparticles for the investigation of their crystal growth, stability, and the calculation of atomistic descriptors	23
BioVisReport: A Markdown-based lightweight website builder for reproducible and interactive visualization of results from peer-reviewed publications	23
Keep it accurate and robust: An enhanced nuclei analysis framework	23
Structural elucidation of four fungal hydrophobins belonging to classes I and II: Results from Alphafold and accelerated molecular dynamics simulations	22
Critical assessment of structure-based approaches to improve protein resistance in aqueous ionic liquids by enzyme-wide saturation mutagenesis	22
Machine learning for predicting Plasmodium liver stage development in vitro using microscopy imaging	22
scCCTR: An iterative selection-based semi-supervised clustering model for single-cell RNA-seq data	22
Towards advanced bioprocess optimization: A multiscale modelling approach	22
Genomic evidence for divergent co-infections of co-circulating SARS-CoV-2 lineages	22
Biomarker discovery process at binomial decision point (2BDP): Analytical pipeline to construct biomarker panel	22
Stability of human gut microbiome: Comparison of ecological modelling and observational approaches	21
Comparative evaluation of AlphaFold2 and disorder predictors for prediction of intrinsic disorder, disorder content and fully disordered proteins	21
Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein	21
Multiple transcription auto regulatory loops can act as robust oscillators and decision-making motifs	21
NanoBioAccumulate: Modelling the uptake and bioaccumulation of nanomaterials in soil and aquatic invertebrates via the Enalos DIAGONAL Cloud Platform	20
Machine learning-assisted medium optimization revealed the discriminated strategies for improved production of the foreign and native metabolites	20
D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1	20
Predicting the effects of cultivation condition on gene regulation in Escherichia coli by using deep learning	20
Multiscale modeling of drug resistance in glioblastoma with gene mutations and angiogenesis	20
Towards mechanistic models of mutational effects: Deep learning on Alzheimer’s Aβ peptide	20
Histone modification in Saccharomyces cerevisiae: A review of the current status	20
Critical evaluation of the use of artificial data for machine learning based de novo peptide identification	20
Automated sample annotation for diabetes mellitus in healthcare integrated biobanking	20
A pathway-based mutation signature to predict the clinical outcomes and response to CTLA-4 inhibitors in melanoma	20
Epigenomic signatures on paralogous genes reveal underappreciated universality of active histone codes adopted across animals	20
Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies	19
Prediction of protein-ligand binding affinity with deep learning	19
DeepMC-iNABP: Deep learning for multiclass identification and classification of nucleic acid-binding proteins	19
Assessing comparative importance of DNA sequence and epigenetic modifications on gene expression using a deep convolutional neural network	19
Flow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate Amphidinium carterae	19
A novel integrative computational framework for breast cancer radiogenomic biomarker discovery	19
Multi-omics landscape and clinical significance of a SMAD4-driven immune signature: Implications for risk stratification and frontline therapies in pancreatic cancer	19
Network-based prioritization of cancer biomarkers by phenotype-driven module detection and ranking	19
Beta-diversity distance matrices for microbiome sample size and power calculations — How to obtain good estimates	19
Sequence variety in the CC’ loop of Siglec-8/9/3 determines the recognitions to sulfated oligosaccharides	19
SRIQ clustering: A fusion of Random Forest, QT clustering, and KNN concepts	19
Classification of lung adenocarcinoma based on stemness scores in bulk and single cell transcriptomes	19
Artificial intelligence and deep learning: New tools for histopathological diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis	18
Comprehensive exploration of JQ1 and GSK2801 targets in breast cancer using network pharmacology and molecular modeling approaches	18
Clinical Decision Support systems: A step forward in establishing the clinical laboratory as a decision maker hub - A CDS system protocol implementation in the clinical laboratory	18
First thermostable CLIP-tag by rational design applied to an archaeal O-alkyl-guanine-DNA-alkyl-transferase	18
Beyond sequence: Structure-based machine learning	18
In silico analyses of isoniazid and streptomycin resistance-associated mutations in Mycobacterium tuberculosis	18
IHGA: An interactive web server for large-scale and comprehensive discovery of genes of interest in hepatocellular carcinoma	18
Predicting zeta potential of liposomes from their structure: A nano-QSPR model for DOPE, DC-Chol, DOTAP, and EPC formulations	18
TF-COMB – Discovering grammar of transcription factor binding sites	18
IMFSegNet: Cost-effective and objective quantification of intramuscular fat in histological sections by deep learning	18
Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells	18
Consistencies and contradictions in different polymer models of chromatin architecture	18
Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule	18
dsCellNet: A new computational tool to infer cell–cell communication networks in the developing and aging brain	18
Recognition of the ligand-induced spatiotemporal residue pair pattern of β2-adrenergic receptors using 3-D residual networks trained by the time series of protein distance maps	17
Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier	17
Molecular rationale for the impairment of the MexAB-OprM efflux pump by a single mutation in MexA	17
Light-sheet laser speckle imaging for cilia motility assessment	17
Comprehensive characterization of human–virus protein-protein interactions reveals disease comorbidities and potential antiviral drugs	17
The impact of noise and missing fragmentation cleavages on de novo peptide identification algorithms	17
In silico screening of phenylethanoid glycosides, a class of pharmacologically active compounds as natural inhibitors of SARS-CoV-2 proteases	17
Using patient-generated health data more efficient and effectively to facilitate the implementation of value-based healthcare in the EU – Innovation report	17
Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders	17
Highly effective batch effect correction method for RNA-seq count data	17
Functional convergence of Yunnan snub-nosed monkey and bamboo-eating panda gut microbiomes revealing the driving by dietary flexibility on mammal gut microbiome	17
Hybrid computational models of multicellular tumour growth considering glucose metabolism	16

The NPR/Hal family of protein kinases in yeasts: biological role, phylogeny and regulation under environmental challenges	16
TWN-RENCOD: A novel method for protein binding site comparison	16
SARS-CoV-2 virus classification based on stacked sparse autoencoder	16
CCLHunter: An efficient toolkit for cancer cell line authentication	16
NGS allele counts versus called genotypes for testing genetic association	16
Unravelling hierarchical levels of structure in lipid membranes	16
Open quantum systems theory of ultraweak ultraviolet photon emissions: Revisiting Gurwitsch's onion experiment as a prototype for quantum biology	16
LibGENiE – A bioinformatic pipeline for the design of information-enriched enzyme libraries	16
The chromatin remodeling factors EP300 and TRRAP are novel SMYD3 interactors involved in the emerging ‘nonmutational epigenetic reprogramming’ cancer hallmark	16
CRISPR-surfaceome: An online tool for designing highly efficient sgRNAs targeting cell surface proteins	16
Wordom update 2: A user-friendly program for the analysis of molecular structures and conformational ensembles	16
Exploring the patient-microbiome interaction patterns for pan-cancer	16
A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness	16
The second intracellular loop of the yeast Trk1 potassium transporter is involved in regulation of activity, and interaction with 14–3-3 proteins	16
Methods to mechanically perturb and characterize GUV-based minimal cell models	16
Dynamic alternative polyadenylation during iPSC differentiation into cardiomyocytes	16
Classifying breast cancer and fibroadenoma tissue biopsies from paraffined stain-free slides by fractal biomarkers in Fourier Ptychographic Microscopy	16
GSPHI: A novel deep learning model for predicting phage-host interactions via multiple biological information	15
Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1	15
Exploring the landscape of tools and resources for the analysis of long non-coding RNAs	15
Exploring chemical space for lead identification by propagating on chemical similarity network	15
Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo	15
Databases and prospects of dynamic gene regulation in eukaryotes: A mini review	15
Unitig level assembly graph based metagenome-assembled genome refiner (UGMAGrefiner): A tool to increase completeness and resolution of metagenome-assembled genomes	15
The impact of pathogenic and artificial mutations on Claudin-5 selectivity from molecular dynamics simulations	15
Genetically predicted telomere length and its relationship with neurodegenerative diseases and life expectancy	15
Epigenetic modifications: Allusive clues of lncRNA functions in plants	15
Monomeric and dimeric states of human ZO1-PDZ2 are functional partners of the SARS-CoV-2 E protein	15
The evolutionary diversification and antimicrobial potential of MPEG1 in Metazoa	15
Computation-aided studies related to the induction of specialized metabolite biosynthesis in microbial co-cultures: An introductory overview	15
Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study	15
Discovery of a highly efficient TylF methyltransferase via random mutagenesis for improving tylosin production	15
Exploring long non-coding RNA networks from single cell omics data	15
Extensive characterization of 28 complete chloroplast genomes of Hydrangea species: A perspective view of their organization and phylogenetic and evolutionary relationships	15
In silico and in vitro approaches allow the identification of the Prosystemin molecular network	15
A drug repurposing method based on inhibition effect on gene regulatory network	15
Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096	15
MUG: A mutation overview of GPCR subfamily A17 receptors	14
OrganelX web server for sub-peroxisomal and sub-mitochondrial protein localization and peroxisomal target signal detection	14
Comprehensive genomic analysis of Bacillus paralicheniformis strain BP9, pan-genomic and genetic basis of biocontrol mechanism	14
Entropy-extreme model for predicting the development of cyber epidemics at early stages	14
ProFeatX: A parallelized protein feature extraction suite for machine learning	14
ProxyBind: A compendium of binding sites for proximity-induced pharmacology	14
Improved inter-residue contact prediction via a hybrid generative model and dynamic loss function	14
Integration of transcriptomics data into agent-based models of solid tumor metastasis	14
Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes	14
Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of Paracoccidioides brasiliensis as a benchmark study	14
Computational Analysis of the Gut Microbiota-Mediated Drug Metabolism	14
Targeted protein degradation in mammalian cells: A promising avenue toward future	14
Genome mining of metabolic gene clusters in the Rubiaceae family	14
Metabolomics and biochemical assays reveal the metabolic responses to hypo-salinity stress and osmoregulatory role of cAMP-PKA pathway in Mercenaria mercenaria	14
Corrigendum to “AI-driven multi-omics integration for multi-scale predictive modeling of genotype-environment-phenotype relationships” [Comput Struct Biotechnol J 27 (2025) 265–277]	14
Network Proximity-based computational pipeline identifies drug candidates for different pathological stages of Alzheimer's disease	14
VTAM: A robust pipeline for validating metabarcoding data using controls	14
Cell segmentation and representation with shape priors	14
Integrated metabolomics and network analysis reveal changes in lipid metabolisms of tripterygium glycosides tablets in rats with collagen-induced arthritis	14
Altered heme metabolism and hemoglobin concentration due to empirical antibiotics-induced gut dysbiosis in preterm infants	14
Design rules applied to silver nanoparticles synthesis: A practical example of machine learning application.	14
Exploring the universal healthy human gut microbiota around the World	14
Computational modelling of bone growth and mineralization surrounding biodegradable Mg-based and permanent Ti implants	14
Corrigendum to “In silico and in vitro approaches allow the identification of the Prosystemin molecular network” [Comput Struct Biotechnol J 21 (2023) 212–223]	14
Landscape of the intratumroal microenvironment in bladder cancer: Implications for prognosis and immunotherapy	14
Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations	13
EccBase: A high-quality database for exploration and characterization of extrachromosomal circular DNAs in cancer	13
Language models can identify enzymatic binding sites in protein sequences	13
RNAME: A comprehensive database of RNA modification enzymes	13
Network-based identification and mechanism exploration of active ingredients against Alzheimer’s disease via targeting endoplasmic reticulum stress from traditional chinese medicine	13
Cross-kingdom analyses of transmembrane protein kinases show their functional diversity and distinct origins in protists	13
Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor	13
From sequence to function through structure: Deep learning for protein design	13
Richness estimation in microbiome data obtained from denoising pipelines	13
SoluProtMutDB: A manually curated database of protein solubility changes upon mutations	13
Computational modeling for deciphering tissue microenvironment heterogeneity from spatially resolved transcriptomics	13
A guide to multi-omics data collection and integration for translational medicine	13
A roadmap towards safe and sustainable by design nanotechnology: Implementation for nano-silver-based antimicrobial textile coatings production by ASINA project	13
MLSP: A bioinformatics tool for predicting molecular subtypes and prognosis in patients with breast cancer	13
Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer’s disease	13
A novel exosome-derived prognostic signature and risk stratification for breast cancer based on multi-omics and systematic biological heterogeneity	13
Using molecular dynamics simulations to interrogate T cell receptor non-equilibrium kinetics	13
Quantifying fecal and plasma short-chain fatty acids in healthy Thai individuals	13
Predicting the location of coordinated metal ion-ligand binding sites using geometry-aware graph neural networks	13
Advances in multi-omics study of biomarkers of glycolipid metabolism disorder	13
Nanopore sequencing enables novel detection of deuterium incorporation in DNA	13
Using metagenomic data to boost protein structure prediction and discovery	13
Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants	13
TetraRNA, a tetra-class machine learning model for deciphering the coding potential derivation of RNA world	12
An ecological and stochastic perspective on persisters resuscitation	12
CHAPERONg: A tool for automated GROMACS-based molecular dynamics simulations and trajectory analyses	12
Soil under stress: The importance of soil life and how it is influenced by (micro)plastic pollution	12
Biotic interactions and environmental modifications determine symbiotic microbial diversity and stability	12
Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity	12
Advanced biokinetic and hydrodynamic modelling to support and optimize the design of full-scale high rate algal ponds	12
Challenges and opportunities in processing NanoString nCounter data	12
Improving generalization capability of deep learning-based nuclei instance segmentation by non-deterministic train time and deterministic test time stain normalization	12
Fever temperatures modulate intraprotein dynamics and enhance the binding affinity between monoclonal antibodies and the spike protein from SARS-CoV-2	12