OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Extracellular Vesicles is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
	1100
Inflammasome‐induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses	302
A secretory form of Parkin‐independent mitophagy contributes to the repertoire of extracellular vesicles released into the tumour interstitial fluid in vivo	259
Erratum: Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer	258
	252
	219
EV‐Elute: A universal platform for the enrichment of functional surface marker‐defined extracellular vesicle subpopulations	213
Microglial activation induces nitric oxide signalling and alters protein S‐nitrosylation patterns in extracellular vesicles	210
	176
Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation	165
Characterisation of LPS+ bacterial extracellular vesicles along the gut‐hepatic portal vein‐liver axis	142
Extracellular vesicle‐associated cholesterol supports the regenerative functions of macrophages in the brain	136
Neuropathogenic role of astrocyte‐derived extracellular vesicles in HIV‐associated neurocognitive disorders	133
ISEV2021 Abstract Book	131
Extracellular vesicles from retinal pigment epithelial cells expressing R345W‐Fibulin‐3 induce epithelial‐mesenchymal transition in recipient cells	131
Biodistribution of unmodified cardiosphere‐derived cell extracellular vesicles using single RNA tracing	129
	125
Extracellular vesicles derived from melanoma cells induce carcinoma‐associated fibroblasts via miR‐92b‐3p mediated downregulation of PTEN	123
Correction to “ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia‐driven hematopoiesis & inflammation via extracellular vesicles”	119
	116
Correction to “Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies”	110
Erratum	109
	108
Early prediction of COVID‐19 severity using extracellular vesicle COPB2	107
Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS‐induced colitis in a murine model	103

Small extracellular vesicles derived from human adipose‐derived mesenchymal stromal cells cultured in a new chemically‐defined contaminate‐free media exhibit enhanced biological and therapeutic effect	102
Ascorbate peroxidase‐mediated in situ labelling of proteins in secreted exosomes	102
Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases	101
MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti‐tumour immunity	100
Beyond basic characterization and omics: Immunomodulatory roles of platelet‐derived extracellular vesicles unveiled by functional testing	99
Anti‐SARS‐CoV‐2 effect of extracellular vesicles released from mesenchymal stem cells	98
	94
Extracellular vesicles synchronize cellular phenotypes of differentiating cells	93
WNT3A‐loaded exosomes enable cartilage repair	91
Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy	90
Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages	87
Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion	84
Extracellular vesicles containing SARS‐CoV‐2 proteins are associated with multi‐organ dysfunction and worse outcomes in patients with severe COVID‐19	83
Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis	83
Extracellular vesicles from organoid‐derived human retinal progenitor cells prevent lipid overload‐induced retinal pigment epithelium injury by regulating fatty acid metabolism	82
Clathrin light chain A‐enriched small extracellular vesicles remodel microvascular niche to induce hepatocellular carcinoma metastasis	81
TGFβ⁺ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype	80
Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation	80
Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise	79
Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity	77
Untouched isolation enables targeted functional analysis of tumour‐cell‐derived extracellular vesicles from tumour tissues	75
Membranes on the move: The functional role of the extracellular vesicle membrane for contact‐dependent cellular signalling	74
Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx	73
The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis	71
β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis	71
High TSPAN8 expression in epithelial cancer cell‐derived small extracellular vesicles promote confined diffusion and pronounced uptake	71
Endothelial extracellular vesicles promote tumour growth by tumour‐associated macrophage reprogramming	71
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk	69
Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles	68
Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EV^ISF) reveals sex‐dependent changes in microglial EV proteome in response to Aβ pathology	68
Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer	68
Nanoscopic Profiling of Small Extracellular Vesicles via High‐Speed Atomic Force Microscopy (HS‐AFM) Videography	66
Circulating extracellular vesicles in healthy and pathological pregnancies: A scoping review of methodology, rigour and results	66
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform	62
Dr. Eberhard Trams—The man who coined the name “exosomes”—A prescient but largely forgotten pioneer	59
Metabolic labelling of a subpopulation of small extracellular vesicles using a fluorescent palmitic acid analogue	56
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles	53
Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling	53
A new subtype of artificial cell‐derived vesicles from dental pulp stem cells with the bioequivalence and higher acquisition efficiency compared to extracellular vesicles	52
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo	52
The immunomodulatory ballet of tumour‐derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD‐L1 pathway in cancer	51
Extracellular vesicles derived from nasopharyngeal carcinoma induce the emergence of mature regulatory dendritic cells using a galectin‐9 dependent mechanism	51
Quantitative assessment of lipophilic membrane dye‐based labelling of extracellular vesicles by nano‐flow cytometry	50
Synthetic biology‐based bacterial extracellular vesicles displaying BMP‐2 and CXCR4 to ameliorate osteoporosis	49
Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting	49
Neuron‐derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB‐mediated signalling and preserve neuronal complexity	48
A compendium of single extracellular vesicle flow cytometry	48
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia	47
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms	46
Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma	46

Roles of extracellular vesicles in the aging microenvironment and age‐related diseases	45
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation	44
Extracellular vesicles in the development of organ‐specific metastasis	44
Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis	44
Proteomic analysis of MSC‐derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions	43
Single Extracellular VEsicle Nanoscopy	43
	41
Helminth extracellular vesicles co‐opt host monocytes to drive T cell anergy	41
Intercellular Epigenomic Signalling via Extracellular Vesicles During B Cell Maturation	41
Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia	40
Extracellular Vesicles From Bone Marrow‐Derived Macrophages Enriched in ARG1 Enhance Microglial Phagocytosis and Haematoma Clearance Following Intracerebral Haemorrhage	40
Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α	40
Proteomic comparison between non‐purified cerebrospinal fluid and cerebrospinal fluid‐derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia	39
Cell dehydration enables massive production of engineered membrane vesicles with therapeutic functions	38
	38
Androgens alter the heterogeneity of small extracellular vesicles and the small RNA cargo in prostate cancer	37
Gut Microbiota‐Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats	36
Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production	35
Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina	34
	34
The importance of activated TMPRSS2 in the proviral role of small extracellular vesicles in SARS‐CoV‐2 infection	34
HIV‐1 Nef is carried on the surface of extracellular vesicles	33
Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T‐cells	33
Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis	33
Erratum to “Non‐invasive imaging of extracellular vesicles: Quo vaditis in vivo?”	33
First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles	33
	33
	33
Erratum: Exogenous loading of miRNAs into small extracellular vesicles	32
Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in‐depth proteomic analysis	32
	32
Monocyte‐derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1	32
Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma	32
A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer	32
Publishing the MISEV guidelines; The editorial process	31
Correction to article pagination in the Journal of Extracellular Vesicles	31
Erratum: Arrdc4‐dependent extracellular vesicle biogenesis is required for sperm maturation	31
Advancing research on parasitic infections: Standardized extracellular vesicle guideline	30
Correction to “Beyond basic characterization and omics: Immunomodulatory roles of platelet‐derived extracellular vesicles unveiled by functional testing”	30
Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model	30
Practical advice for extracellular vesicle isolation in plant–microbe interactions: Concerns, considerations, and conclusions	30
EVAnalyzer: High content imaging for rigorous characterisation of single extracellular vesicles using standard laboratory equipment and a new open‐source ImageJ/Fiji plugin	30
Biopotency and surrogate assays to validate the immunomodulatory potency of extracellular vesicles derived from mesenchymal stem/stromal cells for the treatment of experimental autoimmune uveitis	29
Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression	29
A Predictive Model for Initial Platinum‐Based Chemotherapy Efficacy in Patients with Postoperative Epithelial Ovarian Cancer Using Tissue‐Derived Small Extracellular Vesicles	29
An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood	29
Extracellular vesicles carry transcriptional ‘dark matter’ revealing tissue‐specific information	29
	29
The quick reference card “Storage of urinary EVs” – A practical guideline tool for research and clinical laboratories	29
Asymmetric depth‐filtration: A versatile and scalable method for high‐yield isolation of extracellular vesicles with low contamination	28
PD‐L1 on large extracellular vesicles is a predictive biomarker for therapy response in tissue PD‐L1‐low and ‐negative patients with non‐small cell lung cancer	28
An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth	28
Multiomic integration reveals neuronal‐extracellular vesicle coordination of gliotic responses in degeneration	28
Neoantigen‐based cancer vaccination using chimeric RNA‐loaded dendritic cell‐derived extracellular vesicles	27
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases	27
Plant exosomes fused with engineered mesenchymal stem cell‐derived nanovesicles for synergistic therapy of autoimmune skin disorders	27
Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis	27
The polysaccharide chitosan facilitates the isolation of small extracellular vesicles from multiple biofluids	26
Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing	26
Isolation of CD63‐positive epididymosomes from human semen and its application in improving sperm function	26
STAM transports STING oligomers into extracellular vesicles, down‐regulating the innate immune response	26
The emerging role of bacterial extracellular vesicles in human cancers	26