OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Extracellular Vesicles is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Correction to "DetectEV: a Functional Enzymatic Assay to Assess Integrity and Bioactivity of Extracellular Vesicles"	1371
Helminth extracellular vesicles co‐opt host monocytes to drive T cell anergy	331
Inflammasome‐induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses	273
Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia	265
Metabolic labelling of a subpopulation of small extracellular vesicles using a fluorescent palmitic acid analogue	239
Beyond basic characterization and omics: Immunomodulatory roles of platelet‐derived extracellular vesicles unveiled by functional testing	232
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases	220
Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation	191
Nanoscopic Profiling of Small Extracellular Vesicles via High‐Speed Atomic Force Microscopy (HS‐AFM) Videography	190
Synthetic biology‐based bacterial extracellular vesicles displaying BMP‐2 and CXCR4 to ameliorate osteoporosis	154
Circulating extracellular vesicles in healthy and pathological pregnancies: A scoping review of methodology, rigour and results	151
Arabidopsis Produces Distinct Subpopulations of Extracellular Vesicles That Respond Differentially to Biotic Stress, Altering Growth and Infectivity of a Fungal Pathogen	147
A new subtype of artificial cell‐derived vesicles from dental pulp stem cells with the bioequivalence and higher acquisition efficiency compared to extracellular vesicles	141
Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis	139
Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma	126
Neuropathogenic role of astrocyte‐derived extracellular vesicles in HIV‐associated neurocognitive disorders	124
The immunomodulatory ballet of tumour‐derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD‐L1 pathway in cancer	119
A multiantigenic antibacterial nanovaccine utilizing hybrid membrane vesicles for combating Pseudomonas aeruginosa infections	119
	118
Gut Microbiota‐Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats	116
Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography	115
Breast Cancer‐Derived Extracellular Vesicles Modulate the Cytoplasmic and Cytoskeletal Dynamics of Blood‐Brain Barrier Endothelial Cells	114
Engineered Cas9 extracellular vesicles as a novel gene editing tool	113
Imaging of surface microdomains on individual extracellular vesicles in 3‐D	113
A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy	110

	102
Dynamic Change of PD‐L2 on Circulating Plasma Extracellular Vesicles as a Predictor of Treatment Response in Melanoma Patients Receiving Anti‐PD‐1 Therapy	97
Correction to “Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation”	97
Hyaluronic acid: An overlooked extracellular vesicle contaminant	94
Phloem sap from melon plants contains extracellular vesicles that carry active proteasomes which increase in response to aphid infestation	94
	90
	89
ISEV2023 Abstract Book	88
TGF‐β regulates the release of breast cancer cell‐derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression	88
Extracellular vesicles and high‐density lipoproteins: Exercise and oestrogen‐responsive small RNA carriers	86
Bacterial outer membrane vesicles induce a transcriptional shift in arabidopsis towards immune system activation leading to suppression of pathogen growth in planta	86
	86
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles	85
Extracellular Vesicle (EV) Targeted Cells Release Secondary Effector EVs: Indication of How To Account for Histocompatibility and Disease Specificity of EV Treatments	84
Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity	82
MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research	80
A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta variants	78
Correction to “Cell‐engineered virus‐mimetic nanovesicles for vaccination against enveloped viruses”	74
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models	74
Corrigendum	74
	74
HTLV‐1 infected T cells cause bone loss via small extracellular vesicles	73
Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease	72
Quantitative imaging of vesicle–protein interactions reveals close cooperation among proteins	71
Metastatic prostate cancer‐derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein	70
Cell‐engineered virus‐mimetic nanovesicles for vaccination against enveloped viruses	66
Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes	65
Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility	64
	60
Small Extracellular Vesicles Engineered Using Click Chemistry to Express Chimeric Antigen Receptors Show Enhanced Efficacy in Acute Liver Failure	60
	58
Homosalate boosts the release of tumour‐derived extracellular vesicles with protection against anchorage‐loss property	57
Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia	57
Late Breaking Orals	56
The trajectory of vesicular proteomic signatures from HBV‐HCC by chitosan‐magnetic bead‐based separation and DIA‐proteomic analysis	55
Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data	54
RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release	54
Unraveling multilayered extracellular vesicles: Speculation on cause	53
Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers	53
A beginner's guide to study extracellular vesicles in human blood plasma and serum	52
Formation of a protein corona on the surface of extracellular vesicles in blood plasma	51
Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes	51
Correction to Heat inactivation of foetal bovine serum performed after EV‐depletion influences the proteome of cell‐derived extracellular vesicles	50
	49
	49
Direct delivery of immune modulators to tumour‐infiltrating lymphocytes using engineered extracellular vesicles	48
Transfer of photothermal nanoparticles using stem cell derived small extracellular vesicles for in vivo treatment of primary and multinodular tumours	48
Cocaine perturbs mitovesicle biology in the brain	47
Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles	47
Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification	47

Lipid profile of circulating placental extracellular vesicles during pregnancy identifies foetal growth restriction risk	46
Non‐Invasive imaging of extracellular vesicles: Quo vaditis in vivo?	44
Scalable production of siRNA‐encapsulated extracellular vesicles for the inhibition of KRAS‐mutant cancer using acoustic shock waves	44
Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion	44
EV‐COMM: A database of interspecies and intercellular interactions mediated by extracellular vesicles	43
Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model	40
Extracellular vesicle‐bound DNA in urine is indicative of kidney allograft injury	40
Light‐induced high‐efficient cellular production of immune functional extracellular vesicles	39
Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions	39
Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles	38
The activity of the quorum sensing regulator HapR is modulated by the bacterial extracellular vesicle (BEV)‐associated protein ObfA of Vibrio cholerae	38
An immunogold single extracellular vesicular RNA and protein (^AuSERP) biochip to predict responses to immunotherapy in non‐small cell lung cancer patients	37
Differential temporal release and lipoprotein loading in B. thetaiotaomicron bacterial extracellular vesicles	37
Tumour tissue‐derived small extracellular vesicles reflect molecular subtypes of bladder cancer	37
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS‐CoV‐2 infection	37
Surface protein profiling and subtyping of extracellular vesicles in body fluids reveals non‐CSF biomarkers of Alzheimer's disease	37
Anti‐SARS‐CoV‐2 effect of extracellular vesicles released from mesenchymal stem cells	36
Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis	36
Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS‐induced colitis in a murine model	36
	36
Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise	36
Fusobacterium nucleatum‐Derived Outer Membrane Vesicles Promote Immunotherapy Resistance via Changes in Tryptophan Metabolism in Tumour‐Associated Macrophages	36
	36
	36
Extracellular vesicles derived from nasopharyngeal carcinoma induce the emergence of mature regulatory dendritic cells using a galectin‐9 dependent mechanism	36
Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles	35
Endothelial extracellular vesicles promote tumour growth by tumour‐associated macrophage reprogramming	35
Untouched isolation enables targeted functional analysis of tumour‐cell‐derived extracellular vesicles from tumour tissues	34
Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion	34
EVAnalyzer: High content imaging for rigorous characterisation of single extracellular vesicles using standard laboratory equipment and a new open‐source ImageJ/Fiji plugin	33
A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer	33
Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells	33
Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression	33
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform	33
Release of VAMP5‐positive extracellular vesicles by retinal Müller glia in vivo	33
Erratum: Arrdc4‐dependent extracellular vesicle biogenesis is required for sperm maturation	33
Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing	32
Establishment of a simplified dichotomic size‐exclusion chromatography for isolating extracellular vesicles toward clinical applications	32
An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood	32
A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles	32
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases	32
Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis	31
Proviral role of human respiratory epithelial cell‐derived small extracellular vesicles in SARS‐CoV‐2 infection	31
Extracellular vesicles as human therapeutics: A scoping review of the literature	31
	31
An aptamer‐guided fluorescence polarisation platform for extracellular vesicle liquid biopsy	31
Potential Role of Menstrual Fluid‐Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesis	30
From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment	30
Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery	30
Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles in SARS‐CoV‐2 and H1N1 influenza‐induced acute lung injury	30
The importance of controlled clinical trials with extracellular vesicles	29
Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model o	29
The dark side of foetal bovine serum in extracellular vesicle studies	29
Defining Biological Variability, Analytical Precision and Quantitative Biophysiochemical Characterization of Human Urinary Extracellular Vesicles	29
Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment	29
Profiling extracellular vesicle surface proteins with 10 µL peripheral plasma within 4 h	28
Adult cardiomyocytes‐derived EVs for the treatment of cardiac fibrosis	28
Single vesicle analysis of CD47 association with integrins and tetraspanins on extracellular vesicles released by T lymphoblast and prostate carcinoma cells	28
Intranasal Delivery of Brain‐Derived Neurotrophic Factor (BDNF)‐Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys	28
Stress‐induced Rab11a‐exosomes induce amphiregulin‐mediated cetuximab resistance in colorectal cancer	28
Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles	28
Correction to “Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α”	28
Single‐extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron‐derived EVs	27
Lipid A in outer membrane vesicles shields bacteria from polymyxins	27
Extracellular vesicles enclosed‐miR‐421 suppresses air pollution (PM_2.5)‐induced cardiac dysfunction via ACE2 signalling	27