OOIR: Observatory of International Research

Papers

(The median citation count of Therapeutic Advances in Chronic Disease is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases	179
Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient	48
Development of the ESEx index: a tool for predicting risk of recurrent severe COPD exacerbations	39
Impact of cytomegalovirus on outcomes in acute severe ulcerative colitis: a retrospective observational study	32
Association between non-alcoholic fatty liver disease and risk of incident heart failure: a meta-analysis of observational studies	30
Association of Barrett’s esophagus with Helicobacter pylori infection: a meta-analysis	29
Effect of short-term cardiac function changes after cardiac resynchronization therapy on long-term prognosis in heart failure patients with and without diabetes	27
Chronotherapy of cardiovascular pathologies: a hopeful strategy	27
An analysis report on the application of immune checkpoint inhibitors after liver transplantation	27
Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules	24
AES-CSFS: an automatic evaluation system for corneal sodium fluorescein staining based on deep learning	23
Blood pressure measurement in the elderly with atrial fibrillation: an observational study comparing different noninvasive sphygmomanometers	23
‘When Cryptococcus strikes and lupus is found’: a unique covert unveiling of systemic lupus erythematosus presenting as subacute meningitis	22
HCV-positive kidney transplant patients treated with direct-acting antivirals maintain stable medium-term graft function despite persistent reduction in tacrolimus trough levels	21
The comparative effectiveness of antidepressants for youths with major depressive disorder: a nationwide population-based study in Taiwan	21
The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly	21
Optical coherence tomography biomarkers as predictors of transition to chronic central serous chorioretinopathy after retinal laser photocoagulation	20
Elevated activating Fc gamma receptors levels correlated with susceptibility and severity of IgA nephropathy	20
State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus	20
Increased IL-31 expression in serum and tissue protein in prurigo nodularis	19
Improving diagnosis of primary aldosteronism through education: a modified Delphi study to identify key learning points	19
Mineralocorticoid receptor antagonist treatment improved arterial stiffness in patients with primary aldosteronism: a cohort study compared with adrenalectomy	18
Auricular erythermalgia showing excellent response to itraconazole: a case report	16
Preservation of ovarian endocrine function in patients with lymphoma: a systematic review	16
A new dual function dorsal root ganglion stimulation in pain management: a technical note and case report	16

Evidence of nonsurgical treatment for polycystic liver disease	15
Predicting cardiovascular risk in a Chinese primary Sjögren’s syndrome population: development and assessment of a predictive nomogram	15
Granulomatous hepatitis in a Saudi child with IL2RA defect: a case report and literature review	15
Distinguishing bronchoscopically observed anatomical positions of airway under by convolutional neural network	14
Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study	14
Golimumab and certolizumab pegol for the treatment of hidradenitis suppurativa: a literature review and future perspective	14
A model for predicting high BMI of people living with HIV after receiving antiretroviral therapy	13
Blood pressure change and cognition in childhood and early adulthood: a systematic review	13
New drugs in cystic fibrosis: what has changed in the last decade?	13
First-line therapeutic strategy for patients with advanced non–small cell lung cancer with Leu858Arg epidermal growth factor receptor mutations: a Bayesian network meta-analysis	12
Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism	12
Biological pathways and mechanisms linking COPD and cardiovascular disease	12
Comparative short-term risks of infection and serious infection in patients receiving biologic and small-molecule therapies for psoriasis and psoriatic arthritis: a systemic review and network meta-an	12
Real-world safety and effectiveness of secukinumab in adult patients with moderate to severe plaque psoriasis: results from postmarketing surveillance in Korea	11
Establishment of a preliminary FRAX®-based intervention threshold for rheumatoid arthritis–associated fragility fracture: a 3-year longitudinal, observational, cohort study	11
Corrigendum to air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea	11
Tenofovir is superior to entecavir in reducing HCC for patients with HBV-related compensated cirrhosis at high HCC risk scores	11
Pharmacotherapeutic perspectives on nutraceuticals in the treatment of MASLD and MASH	11
The optimal percutaneous coronary intervention strategy for patients with ST-segment elevation myocardial infarction and multivessel disease: a pairwise and network meta-analysis	10
Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea	10
Eosinophilia attention, diagnosis, treatment, and awareness in physicians: a cross-sectional survey	10
Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials	10
Remission and relapses of myasthenia gravis on long-term tacrolimus: a retrospective cross-sectional study of a Chinese cohort	10
Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator	9
Characteristics of myeloproliferative neoplasm-associated portal hypertension and endoscopic management of variceal bleeding	9
The efficacy of telemedicine for pain management in patients with cancer: a systematic review and meta-analysis	9
Clinical scenarios-based guide for tofacitinib in rheumatoid arthritis	9
Lifetime risk, life expectancy, loss-of-life expectancy, and lifetime healthcare expenditures for psoriasis in Taiwan: a nationwide cohort followed from 2000 to 2017	9
Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach	9
Resective surgery for patients with frontal lobe diffuse low-grade glioma-related epilepsy: predictors of seizure outcomes	9
Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients	9
Advancements in prevention and intervention of sensorineural hearing loss	9
Risk factors of significant relapse and appropriate maintenance therapy strategy in SLE-associated immune thrombocytopenia	9
Author response to comment on: Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants	8
Endoscopic treatment as secondary prophylaxis ameliorates short-term mortality for acute esophagogastric variceal bleeding in older patients with cirrhotic hepatocellular carcinoma	8
Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy	8
Prevalence and determinants of metabolic syndrome among adults living with HIV on first-line antiretroviral treatment in southern Ethiopia: a cross-sectional study	8
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia: rationale and description	8
Comparison of the efficacy and safety of leflunomide versus placebo combined with basic prednisone therapy in patients with active disease phase of Takayasu arteritis: study protocol for a randomized,	8
Association of NAFLD with cardiovascular disease and all-cause mortality: a large-scale prospective cohort study based on UK Biobank	8
Effectiveness and safety of low-dose interferon alpha-2a treatment in Behçet’s Syndrome with refractory vascular or neurological involvement: a case series	8
Trends in mortality from infection among patients with hematologic malignancies: differences according to hematologic malignancy subtype	8
Relationship of sKlotho with hemoglobin level in patients undergoing maintenance hemodialysis: a case–control study	8
Efficacy and safety of intravenous immunoglobulin for treating refractory livedoid vasculopathy: a systematic review	8
Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?	7
Emerging roles of macrophages in heart failure and associated treatment approaches	7
Long-term outcomes and associated factors of Crohn’s disease patients achieving transmural healing based on magnetic resonance enterography: a Chinese retrospective cohort study	7
How do phytocannabinoids affect cardiovascular health? An update on the most common cardiovascular diseases	7
The profound implications of mitochondrial myopathy on activities of daily living: an observational qualitative study of standardized structured and semi-structured patient interviews	7
Short- and long-term effects of whole-body photobiomodulation on pain, functionality, tissue quality, central sensitisation and psychological factors in a population suffering from fibromyalgia: proto	7

Shall we start? Ready, set, go! Toward early intervention in infants with unilateral cerebral palsy. A randomized clinical trial protocol	7
Socioeconomic and lifestyle factors associated with chronic musculoskeletal disorders in Brazil: a network analysis of a population-based study involving 87,648 Brazilian adults	7
Untimely surgery for stent-fracture-related death after transjugular intrahepatic portosystemic shunt: a case report	7
Preoperative malnutrition as an independent risk factor for the postoperative mortality in elderly Chinese individuals undergoing hip surgery: a single-center observational study	7
Predictors of seizure outcomes in stereo-electroencephalography-guided radio-frequency thermocoagulation for MRI-negative epilepsy	7
Metformin and the risk of dementia based on an analysis of 396,332 participants	7
Predialysis trajectories of estimated GFR and concurrent trends of Chronic Kidney Disease-relevant biomarkers	7
Joint effects of sodium intake and circadian rhythm of urinary sodium excretion on prognosis of chronic kidney disease: a prospective study	6
Periprocedural, short-term, and long-term outcomes following transcatheter tricuspid valve repair: a systemic review and meta-analysis	6
Take vedolizumab home: transition from intravenous to subcutaneous treatment	6
Sailing the ship of life: scurvy and autoimmunity . . .	6
Fecal microbiota transplantation treatment for type 1 diabetes mellitus with malnutrition: a case report	6
Associations between age-related hearing loss, cognitive decline, and depression in Chinese centenarians and oldest-old adults	6
Aortic arch calcification increases major adverse cardiac event risk, modifiable by echocardiographic left ventricular hypertrophy, in end-stage kidney disease patients	6
Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants	6
Willingness to start insulin therapy among insulin-naïve persons with type 2 diabetes mellitus at Gulu Regional Referral Hospital, Gulu City, Uganda	6
Prevalence of major non-communicable diseases and their associated risk factors in Afghanistan: a systematic review and meta-analysis	6
Inheritance and innovation of the diagnosis of peripheral pulmonary lesions	6
Sarcopenia and frailty combined increases the risk of mortality in patients with decompensated cirrhosis	6
Strongyloidiasis: what every gastroenterologist needs to know	6
Synchronized application of closed-loop NMES and precision tACS in post-stroke hand rehabilitation: a protocol of neurorehabilitation trial	5
Hip BMD is associated with visceral fat change: a registry study of osteoporosis and sarcopenia	5
Rosacea and treatment with retinoids: a systematic review and meta-analysis	5
Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study	5
Changes of circulating biomarkers of inflammation and glycolipid metabolism by CPAP in OSA patients: a meta-analysis of time-dependent profiles	5
Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial	5
Effect of postoperative radiotherapy on survival in patients with completely resected and pathologically confirmed stage N2 non-small-cell lung cancer: a systematic review and meta-analysis	5
Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?	5
Cyclosporin A as an adjunct may enhance the therapeutic effect of interferon alpha-2a in patients with refractory Behcet’s uveitis: a retrospective cohort study	5
Bimekizumab for the treatment of moderate-to-severe plaque psoriasis: a meta-analysis of randomized clinical trials	5
The emerging role of digital health in the management of asthma	5
Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis	5
Italian validation of the credibility/expectancy questionnaire in spinal pain: a useful tool for clinicians and physiotherapist (CEQ-I)	5
Relationship between vascular access and angulation of vena cava filter at placement and retrieval: a multicenter retrospective cohort study	5
Effects of non-invasive brain stimulation in multiple sclerosis: systematic review and meta-analysis	5
Exploring the risk factors and prognosis of transverse myelitis in systemic lupus erythematosus	5
The dynamics of the general practitioner-nephrologist collaboration for the management of patients with chronic kidney disease before and after dialysis initiation: a mixed-methods study	4
Synergistic effect of albuminuria on atherosclerosis in patients with primary aldosteronism	4
Associations between bone mineral density and coronary artery calcification: a systematic review and meta-analysis	4
Morphological alterations of the hypothalamus in idiopathic intracranial hypertension	4
Two-year real-world outcome data from a single tertiary centre shows reduced ustekinumab persistence in a non-bio-naïve Crohn’s disease cohort with penetrating disease, -ostomies and sarcopenia	4
Application and observation of artificial intelligence in clinical practice of fundus screening for diabetic retinopathy with non-mydriatic fundus photography: a retrospective observational study of T	4
Comment on: Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants	4
Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis	4
The early diagnostic value of serum renalase level in diabetic kidney disease and diabetic macroangiopathy: a retrospective case–control study	4
The early diagnostic value of optical coherence tomography (OCT) and OCT angiography in thyroid-associated ophthalmopathy	4
Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis complicated with macrophage activation syndrome	4
Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China	4
Medication adherence in Medicare-enrolled older adults with asthma and chronic obstructive pulmonary disease before and during COVID-19 pandemic	4
Is Helicobacter pylori infection associated with pancreatic cancer? A systematic review and meta-analysis of observational studies	4
Non-inferiority of 1 month versus longer dual antiplatelet therapy in patients undergoing PCI with drug-eluting stents: a systematic review and meta-analysis of randomized clinical trials	4
Patient preferences for active ulcerative colitis treatments and fecal microbiota transplantation	4
Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs	4
Physical activity and the ‘pediatric inactivity triad’ in children living with chronic kidney disease: a narrative review	4
Comparative risk of herpes zoster in patients with psoriatic disease on systemic treatments: a systematic review and network meta-analysis	4
Comparison of the profiles of first-line PD-1/PD-L1 inhibitors for advanced NSCLC lacking driver gene mutations: a systematic review and Bayesian network meta-analysis	4
One-year outcomes and predictive factors for primary patency after stent placement for treatment of central venous occlusive disease in hemodialysis patients	4
Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury	4
Relaxation-weighted ²³Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis	4
Association between galectin-3 and hepatosteatosis in a community-based cross-sectional study	4
Periodontal inflammation is associated with increased circulating levels of endothelial progenitor cells: a retrospective cohort study in a high vascular risk population	4
Thanks to Reviewers	4
Comparative efficacy of different noninvasive brain stimulation therapies for recovery of global cognitive function, attention, memory, and executive function after stroke: a network meta-analysis of	4
Tafamidis improves myocardial longitudinal strain in A97S transthyretin cardiac amyloidosis	4
Deep learning-based classification of infectious keratitis on slit-lamp images	4