OOIR: Observatory of International Research

Papers

(The TQCC of Therapeutic Advances in Chronic Disease is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Chronotherapy of cardiovascular pathologies: a hopeful strategy	189
Development of the ESEx index: a tool for predicting risk of recurrent severe COPD exacerbations	55
Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient	40
The impact of choline supplementation on oxidative stress and clinical outcomes among patients with non-alcoholic fatty liver disease: a randomized controlled study	38
Impact of cytomegalovirus on outcomes in acute severe ulcerative colitis: a retrospective observational study	36
Association of Barrett’s esophagus with Helicobacter pylori infection: a meta-analysis	35
Association between non-alcoholic fatty liver disease and risk of incident heart failure: a meta-analysis of observational studies	33
Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases	32
Effect of short-term cardiac function changes after cardiac resynchronization therapy on long-term prognosis in heart failure patients with and without diabetes	31
Blood pressure measurement in the elderly with atrial fibrillation: an observational study comparing different noninvasive sphygmomanometers	29
‘When Cryptococcus strikes and lupus is found’: a unique covert unveiling of systemic lupus erythematosus presenting as subacute meningitis	28
The impact of body mass index on periodontitis: a cross-sectional study	25
AES-CSFS: an automatic evaluation system for corneal sodium fluorescein staining based on deep learning	24
The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly	24
An analysis report on the application of immune checkpoint inhibitors after liver transplantation	22
Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules	22
HCV-positive kidney transplant patients treated with direct-acting antivirals maintain stable medium-term graft function despite persistent reduction in tacrolimus trough levels	22
Improving diagnosis of primary aldosteronism through education: a modified Delphi study to identify key learning points	21
Mineralocorticoid receptor antagonist treatment improved arterial stiffness in patients with primary aldosteronism: a cohort study compared with adrenalectomy	21
Increased IL-31 expression in serum and tissue protein in prurigo nodularis	20
The relationship between MAFLD and CVD in a health check-up Chinese population: a prospective cohort study	20
Optical coherence tomography biomarkers as predictors of transition to chronic central serous chorioretinopathy after retinal laser photocoagulation	20
A new dual function dorsal root ganglion stimulation in pain management: a technical note and case report	20
Elevated activating Fc gamma receptors levels correlated with susceptibility and severity of IgA nephropathy	18
The comparative effectiveness of antidepressants for youths with major depressive disorder: a nationwide population-based study in Taiwan	18

State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus	18
Auricular erythermalgia showing excellent response to itraconazole: a case report	17
Hepatitis and periodontal health: an emerging oral-liver axis	17
Golimumab and certolizumab pegol for the treatment of hidradenitis suppurativa: a literature review and future perspective	16
Evidence of nonsurgical treatment for polycystic liver disease	16
Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study	16
Granulomatous hepatitis in a Saudi child with IL2RA defect: a case report and literature review	16
Preservation of ovarian endocrine function in patients with lymphoma: a systematic review	15
Distinguishing bronchoscopically observed anatomical positions of airway under by convolutional neural network	15
Predicting cardiovascular risk in a Chinese primary Sjögren’s syndrome population: development and assessment of a predictive nomogram	14
Comparative short-term risks of infection and serious infection in patients receiving biologic and small-molecule therapies for psoriasis and psoriatic arthritis: a systemic review and network meta-an	14
Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism	14
Blood pressure change and cognition in childhood and early adulthood: a systematic review	14
Patterns of use and dose optimization of renin-angiotensin system modulators among chronic heart failure patients with reduced ejection fraction in resource-limited settings: a multicenter cohort stud	13
A model for predicting high BMI of people living with HIV after receiving antiretroviral therapy	13
Biological pathways and mechanisms linking COPD and cardiovascular disease	13
Practitioner’s perception of myasthenia gravis management recommendations in clinical practice: a cross-sectional survey study	13
First-line therapeutic strategy for patients with advanced non–small cell lung cancer with Leu858Arg epidermal growth factor receptor mutations: a Bayesian network meta-analysis	12
Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials	12
New drugs in cystic fibrosis: what has changed in the last decade?	12
Real-world safety and effectiveness of secukinumab in adult patients with moderate to severe plaque psoriasis: results from postmarketing surveillance in Korea	11
Pharmacotherapeutic perspectives on nutraceuticals in the treatment of MASLD and MASH	11
Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea	11
Corrigendum to air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea	11
Tenofovir is superior to entecavir in reducing HCC for patients with HBV-related compensated cirrhosis at high HCC risk scores	11
Characteristics of myeloproliferative neoplasm-associated portal hypertension and endoscopic management of variceal bleeding	11
Establishment of a preliminary FRAX®-based intervention threshold for rheumatoid arthritis–associated fragility fracture: a 3-year longitudinal, observational, cohort study	11
Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator	11
Remission and relapses of myasthenia gravis on long-term tacrolimus: a retrospective cross-sectional study of a Chinese cohort	11
Lifetime risk, life expectancy, loss-of-life expectancy, and lifetime healthcare expenditures for psoriasis in Taiwan: a nationwide cohort followed from 2000 to 2017	10
Clinical scenarios-based guide for tofacitinib in rheumatoid arthritis	10
Staging and markers in Parkinson’s disease and Lewy body disorders: narrative review	10
Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients	10
The efficacy of telemedicine for pain management in patients with cancer: a systematic review and meta-analysis	10
Relationship of sKlotho with hemoglobin level in patients undergoing maintenance hemodialysis: a case–control study	9
Risk factors of significant relapse and appropriate maintenance therapy strategy in SLE-associated immune thrombocytopenia	9
The optimal percutaneous coronary intervention strategy for patients with ST-segment elevation myocardial infarction and multivessel disease: a pairwise and network meta-analysis	9
Eosinophilia attention, diagnosis, treatment, and awareness in physicians: a cross-sectional survey	9
Endoscopic treatment as secondary prophylaxis ameliorates short-term mortality for acute esophagogastric variceal bleeding in older patients with cirrhotic hepatocellular carcinoma	9
Resective surgery for patients with frontal lobe diffuse low-grade glioma-related epilepsy: predictors of seizure outcomes	9
Author response to comment on: Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants	9
Trends in mortality from infection among patients with hematologic malignancies: differences according to hematologic malignancy subtype	9
Advancements in prevention and intervention of sensorineural hearing loss	9
Efficacy and safety of intravenous immunoglobulin for treating refractory livedoid vasculopathy: a systematic review	8
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia: rationale and description	8
Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy	8
Comparison of the efficacy and safety of leflunomide versus placebo combined with basic prednisone therapy in patients with active disease phase of Takayasu arteritis: study protocol for a randomized,	8
Shall we start? Ready, set, go! Toward early intervention in infants with unilateral cerebral palsy. A randomized clinical trial protocol	8
Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach	8
The evidence for ketamine treatment in older adults with psychiatric illness: a scoping review	8

Long-term outcomes and associated factors of Crohn’s disease patients achieving transmural healing based on magnetic resonance enterography: a Chinese retrospective cohort study	8
Metformin and the risk of dementia based on an analysis of 396,332 participants	8
Effectiveness and safety of low-dose interferon alpha-2a treatment in Behçet’s Syndrome with refractory vascular or neurological involvement: a case series	8
Association of NAFLD with cardiovascular disease and all-cause mortality: a large-scale prospective cohort study based on UK Biobank	8
Prevalence and determinants of metabolic syndrome among adults living with HIV on first-line antiretroviral treatment in southern Ethiopia: a cross-sectional study	8