OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	587
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila	461
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea	458
Correction: Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis	427
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7	407
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α	320
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons	304
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function	278
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation	254
KLF13 promotes esophageal cancer progression and regulates triacylglyceride and free fatty acid metabolism through GPIHBP1	253
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker	250
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation	228
KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma	225
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication	214
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model	209
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling	204
Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC	195
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation	190
FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12	189
ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation	187
TRAIL protects the immature lung from hyperoxic injury	184
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3	173
Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects	166
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival	162
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation	157

PD-L1 induces autophagy and primary resistance to EGFR–TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway	155
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response	150
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1	147
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression	146
Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity	144
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α	142
Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2	142
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications	142
p63, a key regulator of Ago2, links to the microRNA-144 cluster	141
Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia	137
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma	135
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis	132
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle	132
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway	132
PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis	130
MESH1 knockdown triggers proliferation arrest through TAZ repression	129
Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders	127
CAR-T therapy dilemma and innovative design strategies for next generation	126
Targeting FAM111B attenuates mitophagy and increases the sensitivity to lenvatinib treatment by increasing MFN2 stability in hepatocellular carcinoma	125
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer	122
CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma	122
ATRA upregulates OTUD6B to recruit CD8+ T cells to suppress colorectal liver metastasis by stabilizing DDX5/STAT3/CXCL11 axis	120
Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1	119
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition	118
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3	116
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma	116
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition	116
α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation	116
Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer	116
TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway	115
Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish	113
m5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization	110
Underlying mechanisms of glucocorticoid-induced β-cell death and dysfunction: a new role for glycogen synthase kinase 3	109
In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy	109
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma	109
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis	109
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury	106
NADH:ubiquinone oxidoreductase core subunit S8 expression and functional significance in non-small cell lung cancer	105
Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs	104
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence	104
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice	104
Knockdown of Porf-2 restores visual function after optic nerve crush injury	103
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction	102
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma	100
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop	99
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation	99
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma	97
Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review	96
Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor	95
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer	94

Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma	94
Regulatory T cells in skeletal muscle repair and regeneration: recent insights	94
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma	93
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD	92
BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury	91
SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF24	90
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats	90
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment	89
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis	88
UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963	85
Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice	85
JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis	85