Cell Death & Disease

Article	Citations
Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib)	424
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis	332
Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway	310
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment	281
Retraction Note: Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma	271
Retraction Note: miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt/β-catenin signaling through targeting BCL9	264
RAB33A promotes metastasis via RhoC accumulation through non-canonical autophagy in cervical cancer	263
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells	200
Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles	196
Hypoxia-induced ATF3 escalates breast cancer invasion by increasing collagen deposition via P4HA1	195
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma	192
Correction: Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling	191
Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer	179
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma	169
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD	161
MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma	159
C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression	149
POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1	149
Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment	149
Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury	144
ADT-OH exhibits anti-metastatic activity on triple-negative breast cancer by combinatorial targeting of autophagy and mitochondrial fission	138
Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α	137
MESH1 knockdown triggers proliferation arrest through TAZ repression	137
Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells	135
JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis	135

Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk	134
Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression	132
CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1	131
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis	131
Oxidative phosphorylation promotes vascular calcification in chronic kidney disease	129
Roles of tRNA metabolism in aging and lifespan	128
PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis	128
The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling	127
Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway	126
FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2	126
Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease	125
Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway	124
ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis	122
Retraction Note: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation	122
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling	120
Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects	119
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea	118
Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6	116
Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling	115
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia	114
CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy	112
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases	109
LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway	107
SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C	107
Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway	107
Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis	104
PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression	103
Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast	103
Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKβ/NF-κB signaling	102
Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhi	100
POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway	100
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression	100
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker	99
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma	99
Correction: Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization	98
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation	98
HIF2α drives ccRCC metastasis through transcriptional activation of methylation-controlled J protein and enhanced prolegumain secretion	95
LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer	94
WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway	92
PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner	92
Endurance exercise remodels skeletal muscle by suppressing Ythdf1-mediated myostatin expression	92
METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression	92
Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner	90
Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis	90
Histocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway	89
The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects	88
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila	88
SARS-CoV-2 infection and COVID-19 vaccination in cancer patients undergoing immune checkpoint inhibitors	87
The crosstalk between mitochondrial quality control and metal-dependent cell death	86
RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma	86

WWOX promotes osteosarcoma development via upregulation of Myc	86
STAT3/miR-135b/NF-κB axis confers aggressiveness and unfavorable prognosis in non-small-cell lung cancer	85
Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis	83
Increased MCL-1 synthesis promotes irradiation-induced nasopharyngeal carcinoma radioresistance via regulation of the ROS/AKT loop	83
PTBP2 promotes cell survival and autophagy in chronic myeloid leukemia by stabilizing BNIP3	83
Senataxin prevents replicative stress induced by the Myc oncogene	82
MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1	81
Why Bax detection in >1400 publications might be flawed	81
Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1	80
GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease	80
Correction: NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90	80
Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells	80
Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML	80
Correction: Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition	80
Linc01133 contributes to gastric cancer growth by enhancing YES1-dependent YAP1 nuclear translocation via sponging miR-145-5p	80
KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma	79
CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription	78
Targeting ERBB3 and AKT to overcome adaptive resistance in EML4-ALK-driven non-small cell lung cancer	77
REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis	76
Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation	75
Targeting PPARγ via SIAH1/2-mediated ubiquitin-proteasomal degradation as a new therapeutic approach in luminal-type bladder cancer	75
LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex	75
Correction: Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates	75
Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells	75
Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish	74
Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA	74
An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma	72
TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis	72
Correction to: HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas	72
Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface	71
Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells	71
GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma	71
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model	70
Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence	70
Cellular fractionation reveals transcriptome responses of human fibroblasts to UV-C irradiation	70
Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib	69
The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis	69
Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer	69
Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer	68
The role of SPATA2 in TNF signaling, cancer, and spermatogenesis	68
Filamentous nuclear actin regulation of PML NBs during the DNA damage response is deregulated by prelamin A	67
RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression	67
Correction: MELK promotes HCC carcinogenesis through modulating cuproptosis-related gene DLAT-mediated mitochondrial function	66
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis	66
Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells	66
BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy	66
Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A	66
GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling	66
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog	65
Genome-wide screening in the haploid system reveals Slc25a43 as a target gene of oxidative toxicity	65
Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis	65
SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52	65
SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm	64
HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma	64
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function	64
The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors	64
Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression	64
UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963	64
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation	63
Glucocorticoid activates STAT3 and NF-κB synergistically with inflammatory cytokines to enhance the anti-inflammatory factor TSG6 expression in mesenchymal stem/stromal cells	63
RETRACTED ARTICLE: Hepatic stellate cell mediates transcription of TNFSF14 in hepatocellular carcinoma cells via H2S/CSE-JNK/JunB signaling pathway	63
Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis	63
Impact of AMPK on cervical carcinoma progression and metastasis	62
Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial–mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer	62
Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells	62
Correction: HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis	62
SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters	61
Longitudinal efficacy and toxicity of SARS-CoV-2 vaccination in cancer patients treated with immunotherapy	61
Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma	61
Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain	61
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7	61
Modulations of the neuronal trafficking of tissue-type plasminogen activator (tPA) influences glutamate release	61
Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop	60
AMTB, a TRPM8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the TGFβ signaling pathway	60
Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway	60
Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma	59
Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR	59
Identification of G protein subunit alpha i2 as a promising therapeutic target of hepatocellular carcinoma	59
BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma	59
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)	59

The dual role of mesenchymal stem cells in apoptosis regulation	58
Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells	58
The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation	58
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α	58
A first-in-class TIMM44 blocker inhibits bladder cancer cell growth	58
The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2	58
The MITF/mir-579-3p regulatory axis dictates BRAF-mutated melanoma cell fate in response to MAPK inhibitors	58
p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence	57
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons	57
Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells	57
10th International Multithematic Scientific Bio-Medical Congress (IMBMC), Nicosia, Cyprus, 2022	56
ANXA9 facilitates S100A4 and promotes breast cancer progression through modulating STAT3 pathway	56
The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system	55
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis	54
A novel tumour enhancer function of Insulin-like growth factor II mRNA-binding protein 3 in colorectal cancer	54
Mature neurons from iPSCs unveil neurodegeneration-related pathways in mucopolysaccharidosis type II: GSK-3β inhibition for therapeutic potential	54
HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury	54
Hepatic Sirt6 activation abrogates acute liver failure	54
Retraction Note: miR-381 modulates human bone mesenchymal stromal cells (BMSCs) osteogenesis via suppressing Wnt signaling pathway during atrophic nonunion development	53
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3	53
PQR309, a dual PI3K/mTOR inhibitor, synergizes with gemcitabine by impairing the GSK-3β and STAT3/HSP60 signaling pathways to treat nasopharyngeal carcinoma	53
Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers	53
Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes	53
A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer	53
HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice	53
Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations	52
ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice	52
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer	52
Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages	52
PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer	52
The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling	52
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury	52
Genetic influence on vascular smooth muscle cell apoptosis	52
Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status	52
Origin recognition complex 6 overexpression promotes growth of glioma cells	51
CRISPR screen identifies the role of RBBP8 in mediating unfolded protein response induced liver damage through regulating protein synthesis	51
DEF6(differentially exprehomolog) exacerbates pathological cardiac hypertrophy via RAC1	51
PXDN reduces autophagic flux in insulin-resistant cardiomyocytes via modulating FoxO1	51
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC	51
Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila	51
CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator	51
Noncanonical formation of SNX5 gene-derived circular RNA regulates cancer growth	51
TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7	51
Correction: Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease	51
CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3	51
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC	51
Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells	51
The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease	50
Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib	50
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism	50
Aberrantly reduced expression of miR-342-5p contributes to CCND1-associated chronic myeloid leukemia progression and imatinib resistance	50
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway	49
Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity	49
Role of GALNT4 in protecting against cardiac hypertrophy through ASK1 signaling pathway	49
EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities	49
p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway	49
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats	49
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α	49
A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis	49
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK	49
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression	49
The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway	49
ZBTB38 suppresses prostate cancer cell proliferation and migration via directly promoting DKK1 expression	49
MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3	49
Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features	48
The histone chaperone function of Daxx is dispensable for embryonic development	48
Effect of Sortilin1 on promoting angiogenesis and systemic metastasis in hepatocellular carcinoma via the Notch signaling pathway and CD133	48
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m6A-YTHDF2-dependent manner	48
ErbB2/Her2-dependent downregulation of a cell death-promoting protein BLNK in breast cancer cells is required for 3D breast tumor growth	48
Mast cell heparanase promotes breast cancer stem-like features via MUC1/estrogen receptor axis	48
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma	48
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3	47
NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance	47
MAT2B regulates the protein level of MAT2A to preserve RNA N6-methyladenosine	47
The NRF2-CARM1 axis links glucose sensing to transcriptional and epigenetic regulation of the pentose phosphate pathway in gastric cancer	47
miR-497-5p/SALL4 axis promotes stemness phenotype of choriocarcinoma and forms a feedback loop with DNMT-mediated epigenetic regulation	47
Mucosa-like differentiation of head and neck cancer cells is inducible and drives the epigenetic loss of cell malignancy	47
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma	47
The m6A “reader” YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839	46
Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2	46
TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake	46
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma	46
IL-17A injury to retinal ganglion cells is mediated by retinal Müller cells in diabetic retinopathy	46
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle	46
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation	46
Hearing loss and vestibular schwannoma: new insights into Schwann cells implication	46
Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin	46
Identification of the mitochondrial protein POLRMT as a potential therapeutic target of prostate cancer	45
Heparin-binding EGF-like growth factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers	45
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma	45
Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation	45
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis	45
β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis	45
Author Correction: EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer	45
ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells	45