OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Tissue Engineering is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated nanoparticles with hydrogel	88
Decellularization for the retention of tissue niches	80
Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing	67
Additively manufactured bioceramic scaffolds based on triply periodic minimal surfaces for bone regeneration	62
Advanced 3D bioprinted liver models with human-induced hepatocytes for personalized toxicity screening	61
An organotypic oral mucosal infection model to study host-pathogen interactions	60
Soft substrates direct stem cell differentiation into the chondrogenic lineage without the use of growth factors	49
Construction of a pancreatic cancer nerve invasion system using brain and pancreatic cancer organoids	48
Continuous nutrient supply culture strategy controls multivesicular endosomes pathway and anti-photo-aging miRNA cargo loading of extracellular vesicles	43
Advances in tissue engineering of peripheral nerve and tissue innervation – a systematic review	39
Generation of a tendon-like tissue from human iPS cells	33
Steering the multipotent mesenchymal cells towards an anti-inflammatory and osteogenic bias via photobiomodulation therapy: How to kill two birds with one stone	30
Tissue-engineered composite tracheal grafts create mechanically stable and biocompatible airway replacements	30
Vascularized characteristics and functional regeneration of three-dimensional cell reconstruction of oral mucosa equivalents based on vascular homeostasis phenotypic modification	29
Enhanced effects of antagomiR-3074-3p-conjugated PEI-AuNPs on the odontogenic differentiation by targeting FKBP9	28
In vitro elastic cartilage reconstruction using human auricular perichondrial chondroprogenitor cell–derived micro 3D spheroids	28
Regeneration of articular cartilage defects: Therapeutic strategies and perspectives	28
Microvessels derived from hiPSCs are a novel source for angiogenesis and tissue regeneration	27
Advanced lung organoids for respiratory system and pulmonary disease modeling	26
Gum-on-a-Chip Exploring Host-Microbe Interactions: Periodontal Disease Modeling and Drug Discovery	26
Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review	25
Nanodrug delivery systems for regulating microglial polarization in ischemic stroke treatment: A review	24
High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing	24
Emerging strategies for tissue engineering in vascularized composite allotransplantation: A review	23
Development of an iPSC-derived immunocompetent skin model for identification of skin sensitizing substances	23

Exosomal non-coding RNAs: Emerging insights into therapeutic potential and mechanisms in bone healing	22
Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels	22
Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization	22
Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products	22
Expanding tubular microvessels on stiff substrates with endothelial cells and pericytes from the same adult tissue	21
Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems	21
A global bibliometric and visualized analysis in the status and trends of corneal tissue engineering research from 1991 to 2021	20
A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles	20
Tendon tissue engineering: An overview of biologics to promote tendon healing and repair	20
In situ regeneration of nasal septal defects using acellular cartilage enhanced with platelet-derived growth factor	20
Non-hypertrophic chondrogenesis of mesenchymal stem cells through mechano-hypoxia programing	19
Advances in hydrogels for capturing and neutralizing inflammatory cytokines	19
Liver scaffolds obtained by decellularization: A transplant perspective in liver bioengineering	19
RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model	19
Two-dimensional vascularized liver organoid on extracellular matrix with defined stiffness for modeling fibrotic and normal tissues	18
Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head	17
Extracellular vesicles delivering nuclear factor I/C for hard tissue engineering: Treatment of apical periodontitis and dentin regeneration	17
Unlocking the regenerative key: Targeting stem cell factors for bone renewal	16
SP7 gene silencing dampens bone marrow stromal cell hypertrophy, but it also dampens chondrogenesis	16
Peptide nanogels as a scaffold for fabricating dermal grafts and 3D vascularized skin models	16
Retraction: Estradiol-17β [E2] stimulates wound healing in a 3D in vitro tissue-engineered vaginal wound model	16
Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases	15
SPI1 facilitates microfracture-mediated cartilage regeneration in the elderly by enhancing bone marrow stromal cells stemness	15
GDF15 promotes osteogenic differentiation of human dental pulp stem cells by activating the TGF-β/SMAD signaling pathway	15
Position Paper Progress in the development of biomimetic engineered human tissues	15
Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanism	15
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia	14
Bioactivated scaffolds promote angiogenesis and lymphangiogenesis for dermal regeneration in vivo	14
Hamster organotypic kidney culture model of early-stage SARS-CoV-2 infection highlights a two-step renal susceptibility	14
Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs^®) in an ovine bone model	14
Decellularized extracellular matrix for organoid and engineered organ culture	14
Repairing a critical cranial defect using WISP1-pretreated chondrocyte scaffolds	14
Developing human upper, lower, and deep lung airway models: Combining different scaffolds and developing complex co-cultures	14
3-D tissue-engineered epidermis against human primary keratinocytes apoptosis via relieving mitochondrial oxidative stress in wound healing	13
Rat liver extracellular matrix and perfusion bioreactor culture promote human amnion epithelial cell differentiation towards hepatocyte-like cells	13
New insights into balancing wound healing and scarless skin repair	13
Enhanced interaction between genome-edited mesenchymal stem cells and platelets improves wound healing in mice	12
Revolutionizing digestive system tumor organoids research: Exploring the potential of tumor organoids	12
Osteoarthritis models: From animals to tissue engineering	11
Epigenetics: Novel crucial approach for osteogenesis of mesenchymal stem cells	11
Synthetic injectable and porous hydrogels for the formation of skeletal muscle fibers: Novel perspectives for the acellular repair of substantial volumetric muscle loss	11
Construction of artificial lung tissue structure with 3D-inkjet bioprinting core for pulmonary disease evaluation	11
Development of a reliable method for human triple-negative breast cancer organotypic culture: Improving imaging and genomic studies in 3D cultures	11
Cell shape characteristics of human skeletal muscle cells as a predictor of myogenic competency: A new paradigm towards precision cell therapy	10
Differential immune responses of 3D gingival and periodontal connective tissue equivalents to microbial colonization	10
Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies	10
Enhancement structural and signaling microenvironment of artificial tumor extracellular matrix for enhanced drug screening	10
Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells	10
From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease	10
Engineering transplantable human lymphatic and blood capillary networks in a porous scaffold	10

Development of human salivary gland cell lines for modeling radiation-induced damage in three-dimensional spheroid cultures	10
Disc regeneration by injectable fucoidan-methacrylated dextran hydrogels through mechanical transduction and macrophage immunomodulation	10
Novel 3D printed TPMS scaffolds: microstructure, characteristics and applications in bone regeneration	9
Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal	9
Precision-engineered niche for directed differentiation of MSCs to lineage-restricted mineralized tissues	9
Bio-electrospraying assessment toward in situ chondrocyte-laden electrospun scaffold fabrication	9
Method for manufacture and cryopreservation of cartilage microtissues	8
Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues	8
Fibrous hydrogels by electrospinning: Novel platforms for biomedical applications	8
Restoration of olfactory dysfunctions by nanomaterials and stem cells-based therapies: Current status and future perspectives	8
Decellularization of tumours: A new frontier in tissue engineering	8
In vitro maturation and in vivo stability of bioprinted human nasal cartilage	7
Efficient generation of human cerebral organoids directly from adherent cultures of pluripotent stem cells	7
Collagenase treatment appears to improve cartilage tissue integration but damage to collagen networks is likely permanent	7
Toward 3D-bioprinting of an endocrine pancreas: A building-block concept for bioartificial insulin-secreting tissue	7
In vivo vascularized scaffold with different shear-exposed models for lymphatic tissue regeneration	7
Mesenchymal stem cells overexpressing XIST induce macrophage M2 polarization and improve neural stem cell homeostatic microenvironment, alleviating spinal cord injury	7
Strain-induced bands of Büngner formation promotes axon growth in 3D tissue-engineered constructs	7
Oral delivery of pH-sensitive nanoparticles loaded Celastrol targeting the inflammatory colons to treat ulcerative colitis	7
Construction of functional tissue-engineered microvasculatures using circulating fibrocytes as mural cells	7
A gastruloid model of the interaction between embryonic and extra-embryonic cell types	7
Meta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design	7
Single-cell RNA-sequence analysis of human bone marrow reveals new targets for isolation of skeletal stem cells using spherical nucleic acids	7
Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush	7