Biology of Sex Differences

Article	Citations
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin	100
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors	94
Correction to: Consideration of sex and gender differences in addiction medication response	73
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities	68
Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females	66
Psychosocial and clinical characteristics in Takotsubo syndrome	64
In search of sex-related mediators of affective illness	47
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis	46
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice	43
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics	41
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review	36
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies	36
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice	35
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus	33
Sex and gender correlates of sexually polymorphic cognition	33
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”	32
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance	32
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males	31
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity	30
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice	29
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis	28
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus	27
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations	27
Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	26
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas	26

Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma	25
The influence of sex on neuroimmune communication, pain, and physiology	22
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic	22
Sex-based differences in remote monitoring of biometric, psychometric and biomarker indices in stable ischemic heart disease	21
Sex differences in the human brain related to visual motion perception	21
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice	21
Sex and gender differences in adverse events following influenza and COVID-19 vaccination	21
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study	20
H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads	20
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries	20
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort	19
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring	19
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain	19
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients	19
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains	18
Sex dimorphism and tissue specificity of gene expression changes in aging mice	18
Sex differences in mitochondrial gene expression during viral myocarditis	17
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome	17
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring	17
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers	17
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta	17
Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort	16
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women	16
Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey	16
The mixed legacy of the rat estrous cycle	16
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study	16
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain	16
Breast cancer: the first comparative evaluation of oncobiome composition between males and females	15
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years	14
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice	14
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner	14
Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen’S chest pain rEgistry (KoROSE)	14
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics	14
Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension	14
Sex-related associations between body height and cognitive impairment among low-income elderly adults in rural China: a population-based cross-sectional study	14
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats	14
Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood	13
Sex-specific association of hair cortisol concentration with stress-related psychological factors in healthy young adults	13
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats	13
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice	13
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome	13
Sex-specific differences in zebrafish brains	13
Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers	13
Nk3R blockade has sex-divergent effects on memory in mice	12
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms	12
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	12
Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study	12
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	12
Remembering the null hypothesis when searching for brain sex differences	11
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank	11

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease	11
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury	11
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex	11
Sex-specific response to A1BG loss results in female dilated cardiomyopathy	10
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis	10
Sex and gender differences in drug treatment: experiences from the knowledge database Janusmed Sex and Gender	10
Different mechanisms underlie compulsive alcohol self-administration in male and female rats	10
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study	10
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns	10
The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women	10
Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition	10
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study	10
Treating sex and gender differences as a continuous variable can improve precision cancer treatments	10
Sex-specific role of galectin-3 in aortic stenosis	10
Influences of sex and gender on the associations between risk and protective factors, brain, and behavior	10
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia	10
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise	10
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea	10
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?	10
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination	10
Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study	10
Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice	10
Correction: Variability of temperature measurements recorded by a wearable device by biological sex	10
Sex differences in recovery of motor function in a rhesus monkey model of cortical injury	10
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review	10
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only	10
Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neu	10
Correction to: Sex differences in a cohort of COVID-19 Italian patients hospitalized during the first and second pandemic waves	9
Sex differences in type 2 diabetes: an opportunity for personalized medicine	9
Prospective paired crossover evaluation of potential impact of investigator gender on perceived pain intensity early after acute or scheduled surgery	9
Correction: Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	9
Associations of social determinants of health on likelihood of systemic hormone therapy use in midlife women	9
TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$-dependent in adult mice following neonatal hypoxia ischemia	9
Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress	9
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment	9
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease	9
Chromosomal and gonadal sex have differing effects on social motivation in mice	9
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity	9
Sex differences in fetal intracranial volumes assessed by in utero MR imaging	9
Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study	9
Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats	9
Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats	9
Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury	9
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocamp	9
Sex modifies the association between urinary albumin-to-creatinine ratio and diabetes among adults in the United States (NHANES 2011–2018)	8
Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?	8
Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background	8
Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner	8
Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review	8
Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis	8
Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities	8
Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking	8
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance	8
Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women	8
Sex differences in the rapid detection of neutral faces associated with emotional value	8
Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang	8
The role of microRNAs in understanding sex-based differences in Alzheimer’s disease	8
Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fi	8
Sex differences in subjective cognitive impairment and clinical correlates in Chinese patients with subthreshold depression	7
Sex differences in contextual pattern separation, neurogenesis, and functional connectivity within the limbic system	7
KDM6A facilitates Xist upregulation at the onset of X inactivation	7
Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomes	7
Why the estrous cycle matters for neuroscience	7
Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia	7
Consideration of sex as a biological variable in diabetes research across twenty years	7
Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model	7
Consideration of sex and gender differences in addiction medication response	7
Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records	7
Sex differences in symptoms following the administration of BNT162b2 mRNA COVID-19 vaccine in children below 5 years of age in Germany (CoVacU5): a retrospective cohort study	7
Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function	7
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank	7
Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia	7
Sex differences in bladder cancer: understanding biological and clinical implications	7
A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model	7
Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position	6
Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers	6
Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes	6
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses	6
Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes	6
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes	6

TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells	6
A call for inclusive research, policies, and leadership to close the global women’s health gap	6
Own-gender bias in facial feature recognition yields sex differences in holistic face processing	6
Glycogen depletion in astrocytes induces sex-dimorphic remodeling of astrocytic and synaptic structures with concomitant anxiety-like behaviors and maternal care deficits	6
Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis	6
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments	6
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases	6
SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers	6
Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner	6
MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis	6
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy	5
Sex-dependent effects of a high-fat diet on the hypothalamic response in mice	5
Aerobic exercise improves executive functions in females, but not males, without the BDNF Val66Met polymorphism	5
Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health	5
Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development	5
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer	5
Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals	5
Sulcal pits as potential markers of early sex-related human brain differences in healthy adults	5
Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure	5
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex	5
A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala	5
Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex	5
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome	5
Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions	5
Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas	5
Coronary artery calcification and aortic valve calcification in patients with kidney failure: a sex-disaggregated study	5
A cross-species analysis of neuroanatomical covariance sex differences in humans and mice	5
Sex-specific associations between diabetes and dementia: the role of age at onset of disease, insulin use and complications	5