Biology of Sex Differences

Article	Citations
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin	122
Correction to: Consideration of sex and gender differences in addiction medication response	112
Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression	101
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors	83
Psychosocial and clinical characteristics in Takotsubo syndrome	73
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis	69
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics	51
Fundamental sex differences in cocaine-induced plasticity of D1R- and D2R-MSNs in the mouse nucleus accumbens core	48
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review	47
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities	46
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice	41
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males	39
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies	39
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”	37
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus	37
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice	36
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity	35
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice	35
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance	35
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis	33
Sex and gender correlates of sexually polymorphic cognition	33
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma	32
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas	30
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic	29
Sex differences in the association between cardiovascular risk factors and coronary artery calcification progression among individuals without coronary artery calcium	28

Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics	27
Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	27
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus	27
The influence of sex on neuroimmune communication, pain, and physiology	26
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations	24
Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome	24
Impact of gender and side of surgery on cognition, affectivity, and quality of life in patients undergoing temporal lobe epilepsy surgery: a prospective cohort study	23
Sex-based differences in remote monitoring of biometric, psychometric and biomarker indices in stable ischemic heart disease	23
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model	23
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice	22
Sex and gender differences in adverse events following influenza and COVID-19 vaccination	22
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study	22
Sex differences in the human brain related to visual motion perception	22
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients	21
Perinatal citalopram exposure alters the gut composition and microbial metabolic profiles of Sprague-Dawley rat dams and female offspring but not male offspring	21
H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads	21
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring	21
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries	21
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort	21
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain	20
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta	20
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains	18
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome	18
Sex dimorphism and tissue specificity of gene expression changes in aging mice	18
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women	17
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain	17
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study	17
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring	17
Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension	17
The mixed legacy of the rat estrous cycle	17
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years	16
Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen’S chest pain rEgistry (KoROSE)	16
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers	16
Sex differences in mitochondrial gene expression during viral myocarditis	16
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice	16
Breast cancer: the first comparative evaluation of oncobiome composition between males and females	16
Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model	15
Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers	15
Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey	15
Explaining sex: contrast between social and sexual selection	15
Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort	15
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats	15
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats	14
Sex-specific differences in zebrafish brains	14
Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure	14
Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood	14
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome	14
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice	13
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics	13
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	13

Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms	13
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner	13
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank	12
Remembering the null hypothesis when searching for brain sex differences	12
The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women	12
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex	12
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury	12
Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice	12
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease	12
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis	12
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	12
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination	12
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?	12
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study	12
Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study	12
Nk3R blockade has sex-divergent effects on memory in mice	12
Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neu	11
Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study	11
Sex-specific response to A1BG loss results in female dilated cardiomyopathy	11
Influences of sex and gender on the associations between risk and protective factors, brain, and behavior	11
Different mechanisms underlie compulsive alcohol self-administration in male and female rats	11
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study	11
Sex differences in the blood metabolome of extremely preterm infants: a pilot study on the impact of antibiotic therapy	11
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review	11
Treating sex and gender differences as a continuous variable can improve precision cancer treatments	11
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia	11
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise	11
Sex-specific role of galectin-3 in aortic stenosis	11
Correction: Variability of temperature measurements recorded by a wearable device by biological sex	11
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea	11
Social stress, cortisol awakening response and sex: association with hippocampus and amygdala volume	11
Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury	10
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease	10
Associations of social determinants of health on likelihood of systemic hormone therapy use in midlife women	10
Sex-related differences in phenotype and nigro-striatal degeneration of c-rel-/- mouse model of Parkinson’s disease	10
βeta-2 glycoprotein I is a novel regulator of Apolipoprotein E containing HDL particles in females	10
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns	10
Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats	10
Sex differences in fetal intracranial volumes assessed by in utero MR imaging	10
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity	10
Correction: Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	10
Sex and gender differences in drug treatment: experiences from the knowledge database Janusmed Sex and Gender	10
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment	10
Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress	10
The effects of sex and gender attributes on clinical outcomes: a systematic review	10
Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner	10
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance	10
Prospective paired crossover evaluation of potential impact of investigator gender on perceived pain intensity early after acute or scheduled surgery	10
Sex differences in type 2 diabetes: an opportunity for personalized medicine	10
Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice	10
Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study	10
Electrocardiographic sex index: a continuous representation of sex	10
Chromosomal and gonadal sex have differing effects on social motivation in mice	10
The role of microRNAs in understanding sex-based differences in Alzheimer’s disease	9
Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking	9
Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis	9
Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review	9
Loss of ovarian hormones is detrimental in early disease stages of mouse models of Alzheimer’s disease and multi-etiology dementia	9
The role of visual experience in haptic spatial perception: evidence from early blind, late blind, and sighted individuals	9
Paradoxical sex differences in a hamster model of angiotensin II-dependent hypertension and associated renal injury	9
Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background	9
TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$-dependent in adult mice following neonatal hypoxia ischemia	9
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocamp	9
Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess	9
Sex modifies the association between urinary albumin-to-creatinine ratio and diabetes among adults in the United States (NHANES 2011–2018)	9
Sex differences in the rapid detection of neutral faces associated with emotional value	8
Sex differences in symptoms following the administration of BNT162b2 mRNA COVID-19 vaccine in children below 5 years of age in Germany (CoVacU5): a retrospective cohort study	8
Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fi	8
Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function	8
Sex differences in the effects of 10 Hz and 40 Hz transcranial alternating current stimulation on spatial cognition in mice	8
Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women	8
Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities	8
Sex differences in subjective cognitive impairment and clinical correlates in Chinese patients with subthreshold depression	8
Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang	8
Sex differences in contextual pattern separation, neurogenesis, and functional connectivity within the limbic system	7
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank	7
Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model	7
Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records	7
Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomes	7
MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis	7

Understanding sex and gender disparities in COVID-19 mortality: a narrative review beyond biology	7
Cell line-specific estrogen responses uncover functional sex differences in murine macrophages	7
Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia	7
A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model	7
Consideration of sex and gender differences in addiction medication response	7
KDM6A facilitates Xist upregulation at the onset of X inactivation	7
Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences	7
Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?	7
Women’s health research funding in Canada across 15 years suggests low funding levels with a narrow focus	7
Consideration of sex as a biological variable in diabetes research across twenty years	7
Sex differences in bladder cancer: understanding biological and clinical implications	7
Why the estrous cycle matters for neuroscience	7
Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner	7
Sex/gender differences in the association between behavioural factors and cancers: an umbrella review of systematic reviews with quantitative synthesis	6
Sex-specific associations between diabetes and dementia: the role of age at onset of disease, insulin use and complications	6
Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes	6
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells	6
Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position	6
Glycogen depletion in astrocytes induces sex-dimorphic remodeling of astrocytic and synaptic structures with concomitant anxiety-like behaviors and maternal care deficits	6
Own-gender bias in facial feature recognition yields sex differences in holistic face processing	6
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer	6
Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex	6
Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers	6
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases	6
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes	6
Sexual dimorphism in the serum metabolome following acute exhaustive exercise	6
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments	6
Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward	6
SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers	6
Genotype-by-environment interactive effects and conflict solving during gonadal sex differentiation of pejerrey Odontesthes bonariensis, a fish with dual genotypic/environmental sex determination	6
A cross-species analysis of neuroanatomical covariance sex differences in humans and mice	6
Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis	6
Three maxims for countering sex essentialism in scientific research	6
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses	6
Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes	6
Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development	5
A call for inclusive research, policies, and leadership to close the global women’s health gap	5
Global sex disparities in lifetime risk of alopecia areata: a systematic analysis from the global burden of disease study, 1990 to 2021	5
Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas	5
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome	5
Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure	5
A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala	5
Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology	5
Sex-based associations between neighborhood disadvantage and brain–gut alterations in individuals with irritable bowel syndrome	5
Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions	5
The mechanism study of targeting DPP4 in regulating ferroptosis and its influence on endometrial receptivity in PCOS	5
Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health	5
Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals	5
Aerobic exercise improves executive functions in females, but not males, without the BDNF Val66Met polymorphism	5
Sulcal pits as potential markers of early sex-related human brain differences in healthy adults	5
Research trends in estrogen and rheumatoid arthritis: a systematic bibliometric approach	5
The importance of sex dimorphism in liver metabolism and progressive liver diseases	5