OOIR: Observatory of International Research

Papers

(The TQCC of Biology of Sex Differences is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin	116
Correction to: Consideration of sex and gender differences in addiction medication response	105
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies	88
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors	74
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review	73
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis	69
Psychosocial and clinical characteristics in Takotsubo syndrome	56
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics	47
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities	46
Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression	46
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity	40
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice	40
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus	38
Sex and gender correlates of sexually polymorphic cognition	36
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance	36
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis	35
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice	34
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”	32
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma	32
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice	32
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males	32
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus	32
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas	30
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic	29
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations	29

Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	28
The influence of sex on neuroimmune communication, pain, and physiology	27
Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome	26
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice	25
Sex differences in the human brain related to visual motion perception	24
Sex and gender differences in adverse events following influenza and COVID-19 vaccination	23
Sex-based differences in remote monitoring of biometric, psychometric and biomarker indices in stable ischemic heart disease	23
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring	22
Sex dimorphism and tissue specificity of gene expression changes in aging mice	22
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries	22
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study	22
H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads	21
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta	21
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain	21
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome	20
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains	20
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients	20
Sex-related associations between body height and cognitive impairment among low-income elderly adults in rural China: a population-based cross-sectional study	19
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort	19
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years	19
The mixed legacy of the rat estrous cycle	19
Breast cancer: the first comparative evaluation of oncobiome composition between males and females	18
Sex differences in mitochondrial gene expression during viral myocarditis	18
Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey	17
Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen’S chest pain rEgistry (KoROSE)	17
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study	16
Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort	16
Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension	16
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice	16
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring	16
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome	15
Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model	15
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women	15
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats	15
Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers	15
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats	15
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain	15
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	15
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms	15
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers	15
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics	15
Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood	14
Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure	14
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice	14
Nk3R blockade has sex-divergent effects on memory in mice	13
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	13
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner	13
Sex-specific differences in zebrafish brains	13
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank	12
Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study	12

Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex	12
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?	12
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury	12
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination	12
Remembering the null hypothesis when searching for brain sex differences	12
Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neu	11
Sex-specific role of galectin-3 in aortic stenosis	11
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study	11
Correction: Variability of temperature measurements recorded by a wearable device by biological sex	11
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis	11
The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women	11
Different mechanisms underlie compulsive alcohol self-administration in male and female rats	11
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review	11
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea	11
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease	11
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise	11
Sex-specific response to A1BG loss results in female dilated cardiomyopathy	11
Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study	11
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study	11