OOIR: Observatory of International Research

Papers

(The TQCC of Biology of Sex Differences is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression	139
Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications	137
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies	126
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin	99
Psychosocial and clinical characteristics in Takotsubo syndrome	82
Correction to: Consideration of sex and gender differences in addiction medication response	57
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors	54
Fundamental sex differences in cocaine-induced plasticity of D1R- and D2R-MSNs in the mouse nucleus accumbens core	52
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics	50
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice	47
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis	44
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities	44
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review	41
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity	40
Sex and gender correlates of sexually polymorphic cognition	39
Sex-specific hypothalamic PVN transcriptomic signatures of blood pressure autonomic regulation and neuroinflammation in hypertension	39
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice	39
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”	38
Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more	36
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males	36
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance	33
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis	31
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma	30
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice	30
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus	30

Sex differences in primary Sjögren’s disease: prognostic impact on mortality and cancer	29
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas	28
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic	28
A hypomorphic SRD5A2 haplotype with a potential founder effect: composed of common variants in individuals with 5α-reductase type 2 deficiency from South China	27
Sex-specific gonadal transcriptome during early development of Siberian sturgeon	27
The influence of sex on neuroimmune communication, pain, and physiology	27
Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics	27
Integrative microRNA and transcriptome analysis reveals sex-specific molecular divergence in human bladder cancer	27
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus	26
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations	25
Sex differences in the association between cardiovascular risk factors and coronary artery calcification progression among individuals without coronary artery calcium	24
Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	24
Sex differences in the human brain related to visual motion perception	23
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model	23
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study	23
Impact of gender and side of surgery on cognition, affectivity, and quality of life in patients undergoing temporal lobe epilepsy surgery: a prospective cohort study	23
Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives	23
Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome	23
Hormonal regulation of cochlear gene expression: effects of the estrous cycle, ovariectomy, and estradiol treatment	22
The persisting presence of absence in female sex development: a critical interdisciplinary reflection	22
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice	22
Sex and gender differences in adverse events following influenza and COVID-19 vaccination	22
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains	21
Perinatal citalopram exposure alters the gut composition and microbial metabolic profiles of Sprague-Dawley rat dams and female offspring but not male offspring	21
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients	20
Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies	20
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain	20
Sex dimorphism and tissue specificity of gene expression changes in aging mice	20
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort	20
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta	19
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring	19
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries	19
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome	18
Explaining sex: contrast between social and sexual selection	18
Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort	18
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers	18
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain	18
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring	18
Breast cancer: the first comparative evaluation of oncobiome composition between males and females	18
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice	17
Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension	17
The mixed legacy of the rat estrous cycle	17
Sex-related differences in Huntington‘s disease: a scoping review	17
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years	17
Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system	17
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study	17
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women	16
Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood	16
Sex differences in the strategies of haptic object memory in early adulthood	16
Sex differences in mitochondrial gene expression during viral myocarditis	16

Sex differences in immune modulation: implications for infection, inflammation, and nutritional supplementation	15
Sex-specific differences in zebrafish brains	15
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner	15
No impact of sex or testosterone treatment on wheel running in a rat model of inflammatory bowel disease	15
Nk3R blockade has sex-divergent effects on memory in mice	14
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice	14
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	14
Sex and gender effects on incidence of migraine and stroke: a longitudinal observational study based on the german socio-economic panel	14
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics	14
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats	14
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	14
Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model	14
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms	14
Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure	14
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats	14
The cognitive connectome of men and women: a study on sex differences across three cohorts	14
Mind the “CRP gender gap”! sex differences in CRP evolution over time in neonatal sepsis: a monocentric retrospective cohort study	14
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease	13
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank	13
Walking to protect against cognitive decline: the role of APOE genotype and sex	13
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury	13
Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice	13
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination	12
Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice	12
Sex-specific neural responses to smartphone cues in young adults	12
Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response	12
Decoding sex and gender effects on health: evidence from a nationwide cohort	12
Remembering the null hypothesis when searching for brain sex differences	12
The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women	12
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex	12
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study	12
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis	12
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?	12
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise	12
Sex differences in the blood metabolome of extremely preterm infants: a pilot study on the impact of antibiotic therapy	12
Menstrual cycle modulates the effect of BDNF Val66Met variant on category learning	12
Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neu	12
Sex-specific role of galectin-3 in aortic stenosis	11
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study	11
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns	11
Social stress, cortisol awakening response and sex: association with hippocampus and amygdala volume	11
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review	11
Correction: Variability of temperature measurements recorded by a wearable device by biological sex	11
Dynamic transcriptome analysis highlights collagen-integrin-mediated extracellular matrix remodeling underlying sexual dimorphism in the amplexus muscle of Bufo gargarizans	11
Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study	11
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea	11
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia	11
Sex and gender differences in drug treatment: experiences from the knowledge database Janusmed Sex and Gender	11