Cell and Bioscience

Article	Citations
The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience	197
Retraction Note: Growth inhibition and apoptosis in colorectal cancer cells induced by vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways	147
Retraction Note to: Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b	131
Enhanced exosome secretion regulated by microglial P2X7R in the medullary dorsal horn contributes to pulpitis-induced pain	119
Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: exploring sphingolipids in MASH-HCC progression	111
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning	103
FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2	94
Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation	78
From nasal to basal: single-cell sequencing of the bursa of Fabricius highlights the IBDV infection mechanism in chickens	78
Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway	77
Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis	73
Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers	73
Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids	72
TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC	67
Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1−/−) gain less body weight during adolescence and adulthood	66
CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma	62
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation	59
Stress granules: functions and mechanisms in cancer	56
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor	55
GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis	53
Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas	53
The lncRNA MIR181A1HG in extracellular vesicles derived from highly metastatic colorectal cancer cells promotes liver metastasis by remodeling the extracellular matrix and recruiting myeloid-derived s	52
Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities	50
Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes	46
N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo	44

Transcriptome-scale spatial gene expression in rat arcuate nucleus during puberty	43
Evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis	41
Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire	39
The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1	39
SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis	38
Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells	38
β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer	38
Slit-Robo expression in the leech nervous system: insights into eyespot evolution	37
A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet	37
HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA	37
Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves	36
TSA-PACT: a method for tissue clearing and immunofluorescence staining on zebrafish brain with improved sensitivity, specificity and stability	36
Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patients	36
scMTD: a statistical multidimensional imputation method for single-cell RNA-seq data leveraging transcriptome dynamic information	36
Aging aggravates acetaminophen-induced acute liver injury and inflammation through inordinate C/EBPα-BMP9 crosstalk	36
The role of goblet cells in Crohn’ s disease	35
Clinical biomarkers for Lewy body diseases	34
Employment of diverse in vitro systems for analyzing multiple aspects of disease, hereditary hemorrhagic telangiectasia (HHT)	34
Menin orchestrates hepatic glucose and fatty acid uptake via deploying the cellular translocation of SIRT1 and PPARγ	33
Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology	33
Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier	32
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma	32
Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis	32
Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches	32
Multiple responses contribute to the enhanced drought tolerance of the autotetraploid Ziziphus jujuba Mill. var. spinosa	32
CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells	31
Retraction Note: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p	31
The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance	30
Metabolomics of blood reveals age-dependent pathways in Parkinson’s Disease	30
YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy	29
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes	29
AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer	29
Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets	29
A ribonucleoprotein transfection strategy for CRISPR/Cas9‐mediated gene editing and single cell cloning in rainbow trout cells	29
Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease	29
E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin	29
Tick-borne encephalitis affects sleep–wake behavior and locomotion in infant rats	28
EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes	28
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star	28
Mxc, a Drosophila homolog of mental retardation-associated gene NPAT, maintains neural stem cell fate	28
Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells	27
Integrative analysis of bulk and single-cell RNA sequencing reveals the gene expression profile and the critical signaling pathways of type II CPAM	27
CD44 fucosylation on bone marrow-derived mesenchymal stem cells enhances homing and promotes enteric nervous system remodeling in diabetic mice	27
PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis	26
CDKN2AIP is critical for spermiogenesis and germ cell development	26
Metabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy	26
Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy	26
METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis	26
Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation	26
Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties	25

Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney	25
SARS-CoV-2 and COVID-19: revisiting the most important research questions	25
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor	25
Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2	25
CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome	25
Modulation of foraging-like behaviors by cholesterol-FGF19 axis	25
Reduction of eEF2 kinase alleviates the learning and memory impairment caused by acrylamide	25
Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways	25
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease	24
Myelin basic protein enhances axonal regeneration from neural progenitor cells	24
TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation	24
Correction to: Mettl14-mediated m6A modification modulates neuron apoptosis during the repair of spinal cord injury by regulating the transformation from pri‐mir‐375 to miR-375	24
N6-methyladenosine-mediated CELF2 regulates CD44 alternative splicing affecting tumorigenesis via ERAD pathway in pancreatic cancer	24
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers	24
A translational perspective of the malignant hematopoietic proteoglycome	24
AQP4-dependent glioma cell features affect the phenotype of surrounding cells via extracellular vesicles	23
Correction: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma	23
Correction to: The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data	23
Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota	23
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis	23
Correction: Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease	23
New insights into the important roles of phase seperation in the targeted therapy of lung cancer	23
Correction: l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway	23
Correction to: Upregulation of IL-15 in the placenta alters trophoblasts behavior contributing to gestational diabetes mellitus	23
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression	23
Brain nuclear receptors and cardiovascular function	22
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease	22
A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development	22
Unconventional protein post-translational modifications: the helmsmen in breast cancer	22
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3	22
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions	22
Vacuolin-1 enhances RA-induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP-76 axis subject to endosomal regulation that drives late differenti	22
Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19	22
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose	21
The emerging studies on mesenchymal progenitors in the long bone	21
Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection	21
Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax	21
Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice	21
Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion	21
Single-cell RNA sequencing reveals the potential mechanism of heterogeneity of immunomodulatory properties of foreskin and umbilical cord mesenchymal stromal cells	21
Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models	21
The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives	20
Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer’s disease by inhibiting neuroinflammation and neuronal necroptosis	20
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression	20
Microglia and macrophage metabolism: a regulator of cerebral gliomas	20
FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagy	20
Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology	20
Metabolic reprogramming in colorectal cancer: regulatory networks and therapy	20
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer	20
MiR-181a targets STING to drive PARP inhibitor resistance in BRCA- mutated triple-negative breast cancer and ovarian cancer	20
Reliable assessment of telomere maintenance mechanisms in neuroblastoma	20
Astaxanthin attenuates cognitive deficits in Alzheimer’s disease models by reducing oxidative stress via the SIRT1/PGC-1α signaling pathway	20
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma	19
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components	19
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma	19
Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms	19
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia	19
The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies	19
Multi-omics in thoracic aortic aneurysm: the complex road to the simplification	19
Comparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis	19
Single-cell analysis of mouse uterus at the invasion phase of embryo implantation	18
Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα	18
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level	18
Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases	18
The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes	18
RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer	18
The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo	18
The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer	18
Correction to: Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism	18
Roles of bile acids signaling in neuromodulation under physiological and pathological conditions	18
Advances in predictive biomarkers associated with immunotherapy in extensive-stage small cell lung cancer	17
Sbno1 mediates cell–cell communication between neural stem cells and microglia through small extracellular vesicles	17
Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients	17
Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics	16
Precision nephrotoxicity testing using 3D in vitro models	16
SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo	16
Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells	16
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction	16
Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation	16
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment	16

VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α	16
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations	16
Correction to: Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective	16
Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder	16
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders	16
β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions	16
Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury	16
Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis	16
Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson’s disease model	16
Advances in the allostery of angiotensin II type 1 receptor	16
APP family member dimeric complexes are formed predominantly in synaptic compartments	15
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells	15
BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1	15
Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis	15
Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction	15
Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis	15
Role of ammonia for brain abnormal protein glycosylation during the development of hepatitis B virus-related liver diseases	15
An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation	15
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration	15
Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling	15
Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma	15
Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP	15
Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation	15
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1	15
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth	14
GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors	14
Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity	14
Amelioration of olfactory dysfunction in a mouse model of Parkinson’s disease via enhancing GABAergic signaling	14
Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models	14
Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior	14
Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression	14
A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses	14
Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy	14
Transcriptionally imprinted glycomic signatures of acute myeloid leukemia	14
Association of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study	14
Dihydroartemisinin restores the immunogenicity and enhances the anticancer immunosurveillance of cisplatin by activating the PERK/eIF2α pathway	14
Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail	14
RNA methylations in hepatic fibrosis, a gradually emerging new treatment strategy	13
Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes	13
RETRACTED ARTICLE: Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer	13
The function of LncRNA-H19 in cardiac hypertrophy	13
Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing	13
Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids	13
Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms	13
Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants	13
The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway	13
Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review	13
MIR210HG promotes breast cancer progression by IGF2BP1 mediated m6A modification	13
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer’s disease	13
Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies	13
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts	13
NF-κB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis	13
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice	13
LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer	13
Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition	13
Defb19 regulates the migration of germ cell and is involved in male fertility	13