Cell and Bioscience

Article	Citations
SARS-CoV-2: from its discovery to genome structure, transcription, and replication	144
Treatment of spinal cord injury with mesenchymal stem cells	110
Structure, kinetic properties and biological function of mechanosensitive Piezo channels	101
Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells	97
BIRC3 and BIRC5: multi‐faceted inhibitors in cancer	95
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor	93
Extracellular matrix: an important regulator of cell functions and skeletal muscle development	92
The role of lysosomes in cancer development and progression	83
ACE2: the molecular doorway to SARS-CoV-2	83
Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential	81
Three-dimensional in vitro culture models in oncology research	79
Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls	78
Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect	68
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor	65
Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice	65
The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases	64
Mesenchymal stem cell therapy for liver disease: full of chances and challenges	62
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases	61
The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application	60
Targeting tumor-associated macrophages for cancer treatment	60
Exosomal cargos modulate autophagy in recipient cells via different signaling pathways	58
Potential roles and prognostic significance of exosomes in cancer drug resistance	56
CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?	55
Thymidine kinase 1 through the ages: a comprehensive review	54
Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review	53

Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma	49
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease	47
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases	47
Post-translational modifications of EZH2 in cancer	47
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner	45
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood–brain barrier destruction in Alzheimer’s disease	44
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases	44
DNA in extracellular vesicles: from evolution to its current application in health and disease	43
Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity	43
Two-step generation of mesenchymal stem/stromal cells from human pluripotent stem cells with reinforced efficacy upon osteoarthritis rabbits by HA hydrogel	41
An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer	38
New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction	37
Unfolded protein response in colorectal cancer	37
YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy	37
Critical steps to tumor metastasis: alterations of tumor microenvironment and extracellular matrix in the formation of pre-metastatic and metastatic niche	37
CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2	37
Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing	36
Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma	36
Research models and mesenchymal/epithelial plasticity of osteosarcoma	34
Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation	34
MicroRNA-7: expression and function in brain physiological and pathological processes	34
The functions and mechanisms of prefoldin complex and prefoldin-subunits	34
Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases	34
AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathway	33
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities	33
Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis	33
Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases	33
Mechanism of mesenchymal stem cells in spinal cord injury repair through macrophage polarization	32
Biological functions of m6A methyltransferases	31
KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis	31
Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications	31
Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury	30
Multiple functions of autophagy in vascular calcification	30
Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines	30
SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1	29
RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma	29
Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health	29
Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients	29
DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination	28
Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease	28
How to reprogram human fibroblasts to neurons	28
The role of CPEB family proteins in the nervous system function in the norm and pathology	27
The crucial roles of N6-methyladenosine (m6A) modification in the carcinogenesis and progression of colorectal cancer	27
Tissue-specific role and associated downstream signaling pathways of adiponectin	27
Why do poxviruses still matter?	27
Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice	26
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer	26
UBIAD1 alleviates ferroptotic neuronal death by enhancing antioxidative capacity by cooperatively restoring impaired mitochondria and Golgi apparatus upon cerebral ischemic/reperfusion insult	26
Low-dose Diosbulbin-B (DB) activates tumor-intrinsic PD-L1/NLRP3 signaling pathway mediated pyroptotic cell death to increase cisplatin-sensitivity in gastric cancer (GC)	26
Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis	26

Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors	25
In vivo interactome profiling by enzyme‐catalyzed proximity labeling	25
Long non‐coding RNA NEAT1 transported by extracellular vesicles contributes to breast cancer development by sponging microRNA-141-3p and regulating KLF12	25
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression	25
Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma	25
Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence	25
Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions	25
Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen	25
Emerging functions and clinical applications of exosomes in human oral diseases	24
Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review	23
Turning the tide on Alzheimer’s disease: modulation of γ-secretase	23
ApoE4 (Δ272–299) induces mitochondrial‐associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron	23
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level	23
Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia	23
SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury	23
SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages	23
The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation	23
Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression	23
The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages	23
The cGAS–STING pathway: more than fighting against viruses and cancer	23
Golgi-associated Rab GTPases implicated in autophagy	23
Single‐cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between genders	23
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer	22
Mitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor	22
Multiple responses contribute to the enhanced drought tolerance of the autotetraploid Ziziphus jujuba Mill. var. spinosa	22
Botulinum toxin type A alleviates neuropathic pain and suppresses inflammatory cytokines release from microglia by targeting TLR2/MyD88 and SNAP23	22
Perspective of placenta derived mesenchymal stem cells in acute liver failure	22
Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment	22
Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy	21
Significant transcriptomic changes are associated with differentiation of bone marrow-derived mesenchymal stem cells into neural progenitor-like cells in the presence of bFGF and EGF	21
Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1	21
The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway	21
Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells	20
Aging and respiratory viral infection: from acute morbidity to chronic sequelae	20
Emerging roles of N6-methyladenosine (m6A) modification in breast cancer	20
MIR210HG promotes breast cancer progression by IGF2BP1 mediated m6A modification	20
FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2	20
Dapagliflozin attenuates hypoxia/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK	19
MicroRNAs: emerging driver of cancer perineural invasion	19
YAP1 protects against septic liver injury via ferroptosis resistance	19
Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: “alliance” or “war” in intercellular signals	19
The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior	19
Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway	19
Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation	19
SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study	19
Autophagy deficiency in neurodevelopmental disorders	19
Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication	18
rpoS-mutation variants are selected in Pseudomonas aeruginosa biofilms under imipenem pressure	18
The functions of long non-coding RNAs in neural stem cell proliferation and differentiation	18
Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication	18
Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis	18
Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells	18
Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors	18
MicroRNA-320d regulates tumor growth and invasion by promoting FoxM1 and predicts poor outcome in gastric cardiac adenocarcinoma	17
The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons	17
Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway	17
Neurohormonal activation induces intracellular iron deficiency and mitochondrial dysfunction in cardiac cells	17
PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner	17
The function of LncRNA-H19 in cardiac hypertrophy	17
EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway	17
Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment	17
The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis	17
ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12	17
Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy	17
Mettl14-mediated m6A modification modulates neuron apoptosis during the repair of spinal cord injury by regulating the transformation from pri‐mir‐375 to miR-375	17
Genome editing of CCR5 by AsCpf1 renders CD4+T cells resistance to HIV-1 infection	17
Neural stemness contributes to cell tumorigenicity	17
Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury	17
Neddylation regulation of mitochondrial structure and functions	16
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis	16
Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy	16
Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation	16
Irradiated mesenchymal stem cells support stemness maintenance of hepatocellular carcinoma stem cells through Wnt/β-catenin signaling pathway	16
Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma	16
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges	16
The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure	16
KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway	16
Advances in the role of m6A RNA modification in cancer metabolic reprogramming	16
The dual role of p62 in ferroptosis of glioblastoma according to p53 status	16
Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review	15

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake	15
Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes	15
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation	15
Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans	15
Genetically modified large animal models for investigating neurodegenerative diseases	15
Unconventional protein post-translational modifications: the helmsmen in breast cancer	15
Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome	15
Generation of macrophage containing alveolar organoids derived from human pluripotent stem cells for pulmonary fibrosis modeling and drug efficacy testing	15
Comparative evaluation of methods for isolating small extracellular vesicles derived from pancreatic cancer cells	15
Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases	15
Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches	15
The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis	15
Bile acid-mediated signaling in cholestatic liver diseases	14
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy	14
RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer	14
Liver organoids: an in vitro 3D model for liver cancer study	14
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3	14
Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2	14
Emerging roles of non-histone protein crotonylation in biomedicine	14
Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses	14
Cardiac effects and clinical applications of MG53	14
Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology	14
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation	14
Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank	14
Autophagy in the control and pathogenesis of parasitic infections	14
Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors	14
Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices	14
Exosomes from oral tissue stem cells: biological effects and applications	14
The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives	14
The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles	13
Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling	13
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture	13
Intestinal homeostasis: a communication between life and death	13
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A	13
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression	13
MicroRNA let-7b inhibits cell proliferation via upregulation of p21 in hepatocellular carcinoma	13
RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway	13
Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function	13
Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail	13
From nasal to basal: single-cell sequencing of the bursa of Fabricius highlights the IBDV infection mechanism in chickens	13
TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes	13
Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature	13
Ubiquitinated AIF is a major mediator of hypoxia-induced mitochondrial dysfunction and pulmonary artery smooth muscle cell proliferation	13
Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse	13
Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells	13
Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms	13
Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease	13
Comparative transcriptome analysis revealed differential gene expression in multiple signaling pathways at flowering in polyploid Brassica rapa	13