OOIR: Observatory of International Research

Papers

(The H4-Index of Fluids and Barriers of the Cns is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	198
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	177
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	104
Bridging regional neurovascular unit heterogeneity and cognitive function: a review	81
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	80
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	78
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	75
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	71
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	67
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	60
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	56
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study	55
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	54
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	51
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	50
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	47
Effect of intracerebral infusion rate on optic nerve tissue pressure and diurnal intracranial pressure in rats	44
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	43
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	41
White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus	40
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	39
Evidence for reduced choroid plexus volume in the aged brain	39
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	38
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus	38
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	37

Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	36
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	36
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	34
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	34
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	32
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	32
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study	32
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury	32
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	32