OOIR: Observatory of International Research

Papers

(The H4-Index of Fluids and Barriers of the Cns is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	169
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	167
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	98
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	71
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	69
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study	68
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	68
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	59
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	52
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	51
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	50
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	49
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	49
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	42
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	42
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	40
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	40
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	39
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	39
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	38
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	38
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	35
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	35
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	34
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus	33

Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	33
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	33
Active CNS delivery of oxycodone in healthy and endotoxemic pigs	32
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	31
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep	31
Occludin: a gatekeeper of brain Infection by HIV-1	31
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis	31
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	31