Fluids and Barriers of the Cns

Article	Citations
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	169
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	167
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	98
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	71
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	69
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study	68
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	68
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	59
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	52
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	51
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	50
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	49
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	49
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	42
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	42
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	40
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	40
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	39
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	39
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	38
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	38
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	35
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	35
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	34
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	33

Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	33
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus	33
Active CNS delivery of oxycodone in healthy and endotoxemic pigs	32
Occludin: a gatekeeper of brain Infection by HIV-1	31
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis	31
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	31
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	31
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep	31
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study	30
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	29
Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging	28
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies	28
Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders	28
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients	28
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability	27
Intracranial pressure following surgery of an unruptured intracranial aneurysm—a model for normal intracranial pressure in humans	27
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury	27
Novel localization of folate transport systems in the murine central nervous system	26
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	25
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	24
Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method	24
Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults	24
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production	23
VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy	23
Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus	23
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"	23
Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection	22
Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus	22
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders	22
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	22
ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain	22
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays	22
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain	21
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line	21
The choroid plexus and its role in the pathogenesis of neurological infections	21
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport	21
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus	20
Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus	20
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults	20
Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline	20
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody	20
Relevance of choroid plexus volumes in multiple sclerosis	20
A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice	20
Abstracts from Hydrocephalus 2021: The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders	19
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	19
Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus	19
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17	19
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	18
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	18
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	18

Glucocorticoids modify intracranial pressure in freely moving rats	18
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	18
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	18
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	17
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	17
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	17
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	17
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	16
Mucopolysaccharidoses and the blood–brain barrier	16
Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration	16
VHHs as tools for therapeutic protein delivery to the central nervous system	16
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	16
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	16
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord	15
Brain fluid physiology in ischaemic stroke; more than just oedema	15
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	15
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model	15
Research priorities for non-invasive therapies to improve hydrocephalus outcomes	15
Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines	15
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients	15
Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice	15
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	15
Correction: impact of sex differences on thrombin‑induced hydrocephalus and white matter injury: the role of neutrophils	15
Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve	15
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al	15
Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis	14
Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-we	14
Significant individual variation in cardiac-cycle-linked cerebrospinal fluid production following subarachnoid hemorrhage	14
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	14
Microfluidic models of the neurovascular unit: a translational view	14
Cerebrospinal fluid dynamics and subarachnoid space occlusion following traumatic spinal cord injury in the pig: an investigation using magnetic resonance imaging	14
Immunohistochemical visualization of lymphatic vessels in human dura mater: methodological perspectives	14
Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF)	14
Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation	14
Choroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage	14
The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus	14
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	14
Transient intracranial pressure elevations (B waves) are associated with sleep apnea	13
Breaking boundaries: role of the brain barriers in metastatic process	13
Correction: Effects of aging on hydrocephalus after intraventricular hemorrhage	13
Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus	13
Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique	13
Relationship between brain iron dynamics and blood-brain barrier function during childhood: a quantitative magnetic resonance imaging study	13
Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients	13
Human intracranial pulsatility during the cardiac cycle: a computational modelling framework	13
Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures	12
C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity	12
Idiopathic normal pressure hydrocephalus: associations between CSF biomarkers, clinical symptoms, and outcome after shunt surgery	12
NX210c drug candidate peptide strengthens mouse and human blood-brain barriers	12
Capsule-dependent impact of MAPK signalling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis	12
Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer’s model	12
Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice	12
Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival	12
Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins	12
[1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects	12
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping	12
The impact of genetic manipulation of laminin and integrins at the blood–brain barrier	11
Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier	11
SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity	11
Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus	11
Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia	11
Single-cell analysis of mesenchymal cells in permeable neural vasculature reveals novel diverse subpopulations of fibroblasts	11
The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator	11
Movement of cerebrospinal fluid tracer into brain parenchyma and outflow to nasal mucosa is reduced at 24 h but not 2 weeks post-stroke in mice	11
Commentary on “Transient intracranial pressure elevations (B waves) associated with sleep apnea”: the neglected role of cyclic alternating pattern	11
Exploring ITM2A as a new potential target for brain delivery	10
Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures	10
Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull	10
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure	10
Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure	10
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan	10
CSF outflow from the human spinal canal: preliminary results from an anatomical specimen-based model	10
Correction to: Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells	10
The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown	9
Blood-brain barrier disruption: a culprit of cognitive decline?	9
Abstracts from the Virtual Symposium “Signal Transduction at the Blood–Brain Barriers”	9
The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure	9
Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model	9
The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF	9
Intercompartmental communication between the cerebrospinal and adjacent spaces during intrathecal infusions in an acute ovine in-vivo model	9

Abstracts from Hydrocephalus 2024: The 16th Meeting of the Hydrocephalus Society	9
A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer	9
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells	9
A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery	9
Cerebral arterial flow dynamics during systole and diastole phases in young and older healthy adults	8
Characteristics of patients with idiopathic normal pressure hydrocephalus for whom neurosurgeons hesitate to perform shunt surgery: a nationwide hospital-based survey in Japan	8
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity	8
Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in idiopathic intracranial hypertension	8
Unique features of the arterial blood–brain barrier	8
Review of the lumbar infusion test use in pediatric populations: state-of-the-art and future perspectives	8
Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse® platform	8
In response to Mutti et al. 2024 commentary on “Transient intracranial pressure elevations (B waves) associated with sleep apnea: the neglected role of cyclic alternating pattern”	8
Role of aging in Blood–Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19	8
Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro	8
Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases	8
BBB proteomic analysis reveals that complex febrile seizures in infancy enhance susceptibility to epilepsy in adulthood through dysregulation of ECM-receptor interaction signaling pathway	8
Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit	8
Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells	8
Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics	8
Ventriculosagittal sinus shunt for treating hydrocephalus with elevated cerebrospinal fluid protein	8
Choroid plexus organoids reveal mechanisms of Streptococcus suis translocation at the blood-cerebrospinal fluid barrier	8
Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance	8
Postnatal meningeal CSF transport is primarily mediated by the arachnoid and pia maters and is not altered after intraventricular hemorrhage-posthemorrhagic hydrocephalus	7
iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta	7
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability	7
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes	7
Rutin ameliorates stress–induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin–5 axis	7
Deformation of brain in normal pressure hydrocephalus is more readily associated with slow vasomotion rather than heartbeat related pulsations of intracranial pressure	7
A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption	7
CSF dynamics throughout the ventricular system using 4D flow MRI: associations to arterial pulsatility, ventricular volumes, and age	7
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein	7
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model	7
Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways	7
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors	7
CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis	7
Transient but not chronic hyperglycemia accelerates ocular glymphatic transport	7
Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier	7
Quantitative analysis of macroscopic solute transport in the murine brain	6
In vitro investigation of the effect of proinflammatory cytokines on mouse choroid plexus membrane transporters Ncbe and NKCC1	6
Alterations in brain fluid physiology during the early stages of development of ischaemic oedema	6
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease	6
Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data	6
Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries	6
Sizes and shapes of perivascular spaces surrounding murine pial arteries	6
Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier	6
Distinct volumetric features of cerebrospinal fluid distribution in idiopathic normal-pressure hydrocephalus and Alzheimer’s disease	6
Involvement of the choroid plexus in Alzheimer’s disease pathophysiology: findings from mouse and human proteomic studies	6
Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity	6
Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus	6
Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice	6
The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis	6
The influence of upright posture on craniospinal, arteriovenous, and abdominal pressures in a chronic ovine in-vivo trial	6
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review	6
Brain barriers virtual: an interim solution or future opportunity?	6