OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity	149
Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model	132
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	78
The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown	74
Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1	70
Retirement of Dr. Hazel Jones as Co-Editor-in-Chief of Fluids and Barriers of the CNS. Dr. Mark Hamilton becomes Co-Editor-in-Chief	60
Abstracts from Hydrocephalus 2021: The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders	59
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies	57
Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis	56
Blood-spinal cord barrier disruption in degenerative cervical myelopathy	53
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	50
Exploring ITM2A as a new potential target for brain delivery	49
Expression and functions of adenylyl cyclases in the CNS	48
Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model	47
The influence of upright posture on craniospinal, arteriovenous, and abdominal pressures in a chronic ovine in-vivo trial	44
The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure	44
Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow	40
A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease	39
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B	37
Physical exercise and goal attainment after shunt surgery in idiopathic normal pressure hydrocephalus: a randomised clinical trial	37
Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull	35
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	33
Modeling cerebrospinal fluid dynamics across the entire intracranial space through integration of four-dimensional flow and intravoxel incoherent motion magnetic resonance imaging	33
White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery	31
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	30

Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model	30
A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer	30
Brain barriers virtual: an interim solution or future opportunity?	29
Choroid plexus aging: structural and vascular insights from the HCP-aging dataset	29
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	29
Methodological and analytical considerations for intra-operative microdialysis	28
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	28
Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis	28
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	28
Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus	27
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains	27
Glucocorticoids modify intracranial pressure in freely moving rats	26
Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid	26
Response to Commentary on “Structural characterization of SLYM – a 4th meningeal membrane” by Julie Siegenthaler and Christer Betsholtz	26
Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia	26
The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study	25
Resting-state functional-MRI in iNPH: can default mode and motor networks changes improve patient selection and outcome? Preliminary report	25
Correction: Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier	25
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	24
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function	23
Abstracts from Hydrocephalus 2024: The 16th Meeting of the Hydrocephalus Society	23
Correction to: Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells	23
Blood-brain barrier disruption: a culprit of cognitive decline?	22
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	22
The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF	21
Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?	21
The neurovascular unit in leukodystrophies: towards solving the puzzle	20
Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models	20
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	20
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review	20
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	20
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses	20
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	20
Ventricular volume in relation to lumbar CSF levels of amyloid-β 1–42, tau and phosphorylated tau in iNPH, is there a dilution effect?	20
A year in review: brain barriers and brain fluids research in 2022	19
Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers	19
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells	19
Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance	19
Abstracts from the Virtual Symposium “Signal Transduction at the Blood–Brain Barriers”	18
Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood–brain barrier and neurovascular unit	18
A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs	18
Gait apraxia evaluation in normal pressure hydrocephalus using inertial sensors. Clinical correlates, ventriculoperitoneal shunt outcomes, and tap-test predictive capacity	18
Role of aquaporin-4 polarization in extracellular solute clearance	18
Hypoxemia exerts detrimental effects on the choroid plexuses and cerebrospinal fluid system in rats	18
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	17
Intercompartmental communication between the cerebrospinal and adjacent spaces during intrathecal infusions in an acute ovine in-vivo model	17
Research priorities for non-invasive therapies to improve hydrocephalus outcomes	17
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	17
Mucopolysaccharidoses and the blood–brain barrier	16
Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse® platform	16

The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact	16
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	16
Correction to: Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	15
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	15
Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis	14
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	14
Effects of fasudil on blood–brain barrier integrity	14
Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia	14
Cerebral arterial flow dynamics during systole and diastole phases in young and older healthy adults	14
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	14
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	14
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	14
Evaluating the cerebrospinal fluid tap test with the Hellström iNPH scale for patients with idiopathic normal pressure hydrocephalus	14
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	14
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	13
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	13
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	13
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	13
Coupled pulsatile vascular and paravascular fluid dynamics in the human brain	13
Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells	13
Analysis of ischemic stroke-mediated effects on blood–brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging	13
Response to the letter, entitled “Role of hemagglutinin esterase protein in neurological manifestation of COVID-19”	12
Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model	12
Blood–brain barrier breakdown in dementia with Lewy bodies	12
Microglia-derived CCL2 has a prime role in neocortex neuroinflammation	12
Proteomic interrogation of the meninges reveals the molecular identities of structural components and regional distinctions along the CNS axis	12
Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1	12
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein	12
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord	12
Serial Tap Test of patients with idiopathic normal pressure hydrocephalus: impact on cognitive function and its meaning	12
Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines	12
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo	12
A multicenter retrospective study of heterogeneous tissue aggregates obstructing ventricular catheters explanted from patients with hydrocephalus	12