OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity	602
Choroid plexus and the blood–cerebrospinal fluid barrier in disease	148
The glymphatic hypothesis: the theory and the evidence	98
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human	82
Measuring intracranial pressure by invasive, less invasive or non-invasive means: limitations and avenues for improvement	80
Commentary on human pluripotent stem cell-based blood–brain barrier models	72
Extracellular vesicles through the blood–brain barrier: a review	64
Review: pathophysiology of intracranial hypertension and noninvasive intracranial pressure monitoring	62
The regulatory roles of motile cilia in CSF circulation and hydrocephalus	51
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited	50
Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion	46
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease	43
SARS-CoV-2: is there neuroinvasion?	43
Functional hyperemia drives fluid exchange in the paravascular space	43
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	39
Modeling blood–brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms	38
Identification and in vivo characterization of a brain-penetrating nanobody	37
Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells	34
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size	33
Modeling ischemic stroke in a triculture neurovascular unit on-a-chip	33
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging	32
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases	31
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review	30
Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance	28
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review	28

Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia	27
Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro	26
Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1	26
Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure	25
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays	25
The relationship between cerebral blood flow and venous sinus pressure: can hyperemia induce idiopathic intracranial hypertension?	24
Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas	24
The choroid plexus and its role in the pathogenesis of neurological infections	24
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders	24
Epigenetics in blood–brain barrier disruption	23
Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states	22
Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling	21
The CLDN5 gene at the blood-brain barrier in health and disease	21
Expression and functions of adenylyl cyclases in the CNS	21
Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema	20
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure	20
Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model	19
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model	19
Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells	19
Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders	19
LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose	19
The potential role of microvascular pathology in the neurological manifestations of coronavirus infection	19
Preterm intraventricular hemorrhage in vitro: modeling the cytopathology of the ventricular zone	18
Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism	18
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	18
A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood–brain barrier models for drug transport studies	18
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients	18
Sex difference in cerebrospinal fluid/blood albumin quotients in patients with schizophreniform and affective psychosis	18
Experimental approaches for manipulating choroid plexus epithelial cells	18
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	18
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters	18
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains	17
CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis	17
Chemically defined human vascular laminins for biologically relevant culture of hiPSC-derived brain microvascular endothelial cells	17
Quantitative analysis of macroscopic solute transport in the murine brain	16
Brain endothelial LRP1 maintains blood–brain barrier integrity	16
The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)	16
Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice	16
Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury	16
Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders	16
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo	16
In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces	15
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	15
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging	15
Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter	15
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics	15
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults	14
Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology	14
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies	14
Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers	14

Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses	14
Variations in the cerebrospinal fluid dynamics of the American alligator (Alligator mississippiensis)	14
The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF	14
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping	13
Cerebrospinal fluid biomarkers of neuroinflammation in children with hydrocephalus and shunt malfunction	13
Upright versus supine MRI: effects of body position on craniocervical CSF flow	13
Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus	13
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using smal	13
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	13
The incidence of obesity, venous sinus stenosis and cerebral hyperaemia in children referred for MRI to rule out idiopathic intracranial hypertension at a tertiary referral hospital: a 10 year review	13
Structural disruption of the blood–brain barrier in repetitive primary blast injury	13