OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Bridging regional neurovascular unit heterogeneity and cognitive function: a review	212
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	185
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	113
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	104
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	85
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	83
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	80
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	78
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	75
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	63
Translational biomarkers of hypoxic brain injury uncovered in CSF secreting human choroid plexus organoids	56
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	56
Effect of intracerebral infusion rate on optic nerve tissue pressure and diurnal intracranial pressure in rats	55
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	54
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	51
White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus	50
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	47
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	47
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	45
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	44
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study	42
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	41
Evidence for reduced choroid plexus volume in the aged brain	41
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	40
Neutrophil extracellular traps aggravate blood-brain barrier disruption via ZBP1/FSP1-mediated ferroptosis after traumatic brain injury	39

Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	39
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	36
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	36
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	35
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	35
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	34
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep	34
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study	34
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients	32
Occludin: a gatekeeper of brain Infection by HIV-1	32
Active CNS delivery of oxycodone in healthy and endotoxemic pigs	32
Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders	32
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	32
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	31
Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging	31
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability	30
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	30
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis	30
The relationship between CSF/serum immunoglobulin and albumin ratio across laboratories: a retrospective, multi-center study	29
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies	29
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury	29
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"	27
Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults	27
VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy	27
Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus	27
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production	27
Intracranial pressure following surgery of an unruptured intracranial aneurysm—a model for normal intracranial pressure in humans	27
Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection	26
Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method	25
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	25
Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus	25
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders	25
Novel localization of folate transport systems in the murine central nervous system	25
ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain	24
A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice	24
The choroid plexus and its role in the pathogenesis of neurological infections	24
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	24
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	24
Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus	23
Navigating the blood–brain barrier to blood–brain tumor barrier transition: microvascular P-glycoprotein and CD146 potentially contribute to glioma grading	23
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain	23
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody	22
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line	22
Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus	22
Relevance of choroid plexus volumes in multiple sclerosis	22
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	21
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport	21
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	21
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults	21
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus	21

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	21
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17	21
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	20
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	19
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	19
Eppur si muove: the dynamic brain pericyte	19
Glucocorticoids modify intracranial pressure in freely moving rats	19
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	19
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	19
A retrospective longitudinal analysis of risk factors, treatment outcomes and imaging parameters of ventricular collapse in idiopathic intracranial hypertension	19
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	19
Brain fluid physiology in ischaemic stroke; more than just oedema	18
Functions of the basal lamina and ApoE in cerebral amyloid angiopathy	18
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	18
Mucopolysaccharidoses and the blood–brain barrier	17
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	17
Research priorities for non-invasive therapies to improve hydrocephalus outcomes	17
Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration	17
Imaging the distribution and drainage of fluid in the human olfactory regions using intravenous Gadolinium-based contrast agents (GBCA) enhanced MRI	16
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	16
VHHs as tools for therapeutic protein delivery to the central nervous system	16
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model	16
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	16
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord	16
Blinded gait assessment in idiopathic normal pressure hydrocephalus: reliability and correlation with clinical and patient-reported outcomes	16
Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis	16
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	16
Correction: impact of sex differences on thrombin‑induced hydrocephalus and white matter injury: the role of neutrophils	16
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	16
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al	16
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients	15
Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice	15
Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption	15
The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus	15
Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve	15
Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF)	15
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	15
Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis	15
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	15