OOIR: Observatory of International Research

Papers

(The TQCC of Open Biology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Wound healing: cellular mechanisms and pathological outcomes	585
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines	230
Anti-cancer peptides: classification, mechanism of action, reconstruction and modification	132
Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses	108
Hallmarks of cancer—the new testament	104
Higher-order organization of biomolecular condensates	102
The rise and rise of mitochondrial DNA mutations	90
Metarhizium: jack of all trades, master of many	88
Bacterial chromosome segregation by the ParABS system	80
Satellite cells in ageing: use it or lose it	69
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition	69
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease	69
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester	68
The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle	65
To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease	62
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine	61
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential	60
Molecular mechanisms of olfactory detection in insects: beyond receptors	59
Black box of phage–bacterium interactions: exploring alternative phage infection strategies	55
SARS-CoV-2 envelope protein topology in eukaryotic membranes	55
An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease	52
Senescent cells and macrophages: key players for regeneration?	51
Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin	50
Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases	48
Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy	47

ADAMTS proteases in cardiovascular physiology and disease	45
Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease	42
A duplicated amh is the master sex-determining gene for Sebastes rockfish in the Northwest Pacific	41
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains	41
Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones	40
Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues	40
Role of antioxidants and a nutrient rich diet in Alzheimer's disease	39
Substrate recruitment by zDHHC protein acyltransferases	39
Adipose tissue in health and disease	39
Pathways shaping the mitochondrial inner membrane	37
The evolutionary origins of the vertebrate olfactory system	35
The intrinsically disorderly story of Ki-67	34
Brain and testis: more alike than previously thought?	32
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs	31
Syndecan receptors: pericellular regulators in development and inflammatory disease	31
The role of disorder in RNA binding affinity and specificity	30
Modulators of calcium signalling at fertilization	30
Molecular mechanisms behind mRNA localization in axons	29
Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories	29
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea	29
Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?	29
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders	28
Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture	28
How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?	28
Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?	28
A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n–3) exists in the marine Harpacticoida copepod Tigriopus californicus	27
Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida	27
Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions	27
Darwin's bark spider shares a spidroin repertoire with Caerostris extrusa but achieves extraordinary silk toughness through gene expression	27
Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate	26
Unravelling the mystery of female meiotic drive: where we are	26
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead	26
Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle	26
Protein S -palmitoylation in immunity	25
Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate	25
Reversible bacteriophage resistance by shedding the bacterial cell wall	25
The structure and function of deubiquitinases: lessons from budding yeast	25
A centriole's subdistal appendages: contributions to cell division, ciliogenesis and differentiation	25
Ultrastructure expansion microscopy in Trypanosoma brucei	24
Insight into m ⁶ A methylation from occurrence to functions	24
Prader-Willi syndrome: reflections on seminal studies and future therapies	24
Notch signalling in healthy and diseased vasculature	24
Signalling through cerebral cavernous malformation protein networks	24
Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders	24
Temperature modulates immune gene expression in mosquitoes during arbovirus infection	23
Molecular insights into the powerful mucus-based adhesion of limpets ( Patella vulgata L.)	23
SIRT7: a sentinel of genome stability	23
TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases	23
Viral pathogenesis of SARS-CoV-2 infection and male reproductive health	23
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers	22

Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer	22
Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder	22
Non-apoptotic roles of apoptotic proteases: new tricks for an old dog	21
Vascular underpinning of COVID-19	21
Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19	21
Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells	21
RNA polymerase II pausing in development: orchestrating transcription	21
Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system	21
The FBXL family of F-box proteins: variations on a theme	21
SUMOylation modification-mediated cell death	20
The role of Wnt signalling in development of coronary artery disease and its risk factors	20
The contribution of non-coding regulatory elements to cardiovascular disease	20
Ferroptosis in myocardial infarction: not a marker but a maker	20
What determines eukaryotic translation elongation: recent molecular and quantitative analyses of protein synthesis	20
The impact of autophagy during the development and survival of glioblastoma	20
HIV Rev-isited	20
Long non-coding RNA-polycomb intimate rendezvous	19
The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways	19
Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase	19
Controlling the topology of mammalian mitochondrial DNA	19
The plastic cell: mechanical deformation of cells and tissues	19
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections	19
Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis	18
Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research	18
Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies	18
RETRACTED: Long non-coding RNA LINC00346 contributes to cisplatin resistance in nasopharyngeal carcinoma by repressing miR-342-5p	18
Centrosome-centric view of asymmetric stem cell division	18
Capturing crop adaptation to abiotic stress using image-based technologies	18
Metabolomics of human fasting: new insights about old questions	18
Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer	18
Cellular and molecular mechanisms that regulate mammalian digit tip regeneration	17
The aerobic mitochondrial ATP synthesis from a comprehensive point of view	17
The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation	17
An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development	17
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis	17
Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature	16
Haloferax volcanii —a model archaeon for studying DNA replication and repair	16
Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration	16
Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth	16
Proteolytic activity of the proteasome is required for female insect reproduction	16
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression	16
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27	16
Neutrophil interactions with the sexually transmitted parasite Trichomonas vaginalis: implications for immunity and pathogenesis	15
Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology	15
Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer	15
Development of the mammalian cortical hem and its derivatives: the choroid plexus, Cajal–Retzius cells and hippocampus	15
Diversity from similarity: cellular strategies for assigning particular identities to actin filaments and networks	15
ANGPTL8 in metabolic homeostasis: more friend than foe?	15
Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites	15
Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms	15
Lysosomal positioning diseases: beyond substrate storage	15
Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective	15
The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer	14
Patterning principles of morphogen gradients	14
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease	14
Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer	14
Aspirin and cancer: biological mechanisms and clinical outcomes	14
PGE ₂ upregulates gene expression of dual oxidase in a lepidopteran insect midgut via cAMP signalling pathway	14
SUMOylation in the control of cholesterol homeostasis	14
Iron-sulfur flavoenzymes: the added value of making the most ancient redox cofactors and the versatile flavins work together	14
Mechanism and regulation of P element transposition	14
Human intestinal models to study interactions between intestine and microbes	14
Secondary cell wall patterning—connecting the dots, pits and helices	14
Establishment and function of chromatin modification at enhancers	13
Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation	13
Ghrelin octanoylation by ghrelin O -acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling	13
Role of amylopectin synthesis in Toxoplasma gondii and its implication in vaccine development against toxoplasmosis	13
TRIM family proteins: roles in proteostasis and neurodegenerative diseases	13
The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis	13
Driving forces in the origins of life	13
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics	13
Reconstitution of the recombinant human γ-tubulin ring complex	13