OOIR: Observatory of International Research

Papers

(The median citation count of Biomaterials Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Introduction to the 31^st Annual Conference of the European Society for Biomaterials (ESB 2021)	146
Artesunate drug-loaded 2D nano-shuttle landing on RBCs infected with malaria parasites	143
A novel donor–acceptor structured diketopyrrolopyrrole-based conjugated polymer synthesized by direct arylation polycondensation (DArP) for highly efficient antimicrobial photothermal therapy	123
Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency	108
Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications	105
An intrinsically semi-permeable PDMS nanosheet encapsulating adipose tissue-derived stem cells for enhanced angiogenesis	103
Albumin-coated pH-responsive dimeric prodrug-based nano-assemblies with high biofilm eradication capacity	100
Bioactive additives from the dorsal dermis of mice for enhanced vascularization in 3D bioprinting	84
Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma	82
Influence of lung extracellular matrix from non-IPF and IPF donors on primary human lung fibroblast biology	78
A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization	78
Front cover	74
Inside front cover	69
NIR-II imaging-guided photothermal cancer therapy combined with enhanced immunogenic death	68
Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions	68
Exploring therapy transport from implantable medical devices using experimentally informed computational methods	67
A universal biocompatible coating for enhanced lubrication and bacterial inhibition	67
Principles of nucleic acid toehold mediated strand displacement (TMSD) reaction model and its applications in cell environment	66
Injectable leonurine nanocrystal-loaded microspheres for long-term hyperlipidemia management	65
Fluorinated poly(aryl ether)/polypropylene composite patch for prevention of abdominal adhesions after hernia repairs	64
Silk fibroin-based piezoelectric nanofibrous scaffolds for rapid wound healing	60
Leveraging microtopography to pattern multi-oriented muscle actuators	59
Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration	56
Rapid neurostimulation at the micron scale with an optically controlled thermal-capture technique	55
Hemp sprout-derived exosome-like nanovesicles as hepatoprotective agents attenuate liver fibrosis	54

Transtympanic delivery of V₂O₅ nanowires with a tympanic-membrane penetrating peptide	53
Mechanical behavior of biomimetic oriented cell sheets from a perspective of living materials	51
Tuning molecular assembly behavior to amplify the sonodynamic activity of porphyrins for efficient antibacterial therapy	51
Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy	51
Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes	50
A chiral microenvironment promotes retinal progenitor cell proliferation by activating the Akt and ERK pathways	50
A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy	50
Advances in the application of hydrogel adhesives for wound closure and repair in abdominal digestive organs	49
Microporous surface containing flower-like molybdenum disulfide submicro-spheres of sulfonated polyimide with antibacterial effect and promoting bone regeneration and osteointegration	49
Biocompatible recombinant type III collagen enhancing skin repair and anti-wrinkle effects	48
Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases	48
Advances in biomaterials for the treatment of retinoblastoma	47
Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers	46
A multifunctional theranostics nanosystem featuring self-assembly of alcohol-abuse drug and photosensitizers for synergistic cancer therapy	46
Fetuin A functionalisation of biodegradable PLLA-co-PEG nonwovens towards enhanced biomineralisation and osteoblastic growth behaviour	45
Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation	45
Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds	44
Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation	43
Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway	43
Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights	43
Site-selective post-modification of short α/γ hybrid foldamers: a powerful approach for molecular diversification towards biomedical applications	43
Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering	43
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1	43
Gram-selective antibacterial peptide hydrogels	43
Therapeutic effects of tea polyphenol-loaded nanoparticles coated with platelet membranes on LPS-induced lung injury	42
Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair	42
Contents list	41
Efficient CRISPR-Cas9-based knockdown of RUNX2 to induce chondrogenic differentiation of stem cells	41
Inside front cover	41
Back cover	41
Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies	40
A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alka	40
Nanostructured lipopeptide-based membranomimetics for stabilizing bacteriorhodopsin	40
Front cover	40
Biomimetic organomineral layers with antibacterial properties based on di/tetrahydroquinolinediol and nanocrystalline hydroxyapatite deposited on enamel surface	40
Electrical hydrogel: electrophysiological-based strategy for wound healing	40
Effects of chain lengths and backbone chirality on the bone-targeting ability of poly(glutamic acid)s	39
Ir(iv) and Ir(iii) in situ transition promotes ROS generation for eradicating multidrug-resistant bacterial infection	39
Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers	39
Engineering goat milk-derived extracellular vesicles for multiple bioimaging-guided and photothermal-enhanced therapy of colon cancer	39
Molecular weight tuning optimizes poly(2-methoxyethyl acrylate) dispersion to enhance the aging resistance and anti-fouling behavior of denture base resin	39
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels	39
Magnetic nanocluster-mediated photothermal effect and macrophage modulation for synergistic photothermal immunotherapy of cancer	38
Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents	38
pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss	38
MnO₂ coated nanotheranostic LDH for synergistic cascade chemo/chemodynamic cancer therapy under the guidance of MRI-targeted diagnosis	38
All-in-one CoFe₂O₄@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy	38
Substrate-independent adsorption of nanoparticles as anti-biofilm coatings	38
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance	37
Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	37

Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery	37
Fe₃O₄/MnCO₃ microbubbles for efficient elimination of bacterial biofilms by mechanical/sonodynamic effects under ultrasound irradiation and magnetic field targeting	37
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes	37
Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy	36
Biofabricated tissue model for determining biocompatibility of metallic coatings	36
Dendritic systems for bacterial outer membrane disruption as a method of overcoming bacterial multidrug resistance	36
A self-assembling peptidic platform to boost the cellular uptake and nuclear delivery of oligonucleotides	35
Blood–brain barrier-crossing dendrimers for glioma theranostics	35
Redox chemistry-enabled stepwise surface dual nanoparticle engineering of 2D MXenes for tumor-sensitive T₁ and T₂ MRI-guided photonic breast-cancer hyperthermia in	35
Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis	35
Indocyanine green-based nanomedicine for theranostic applications	35
Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules	35
LAPONITE® nano-silicates potentiate the angiogenic effects of FG-4592 and osteogenic effects of BMP-2	35
Reactive oxygen species-scavenging biomaterials for neural regenerative medicine	35
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting	34
Trends in protein derived materials for wound care applications	34
Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications	33
A polydopamine-based photodynamic coating on the intraocular lens surface for safer posterior capsule opacification conquering	33
In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy	33
Microstructured silk fiber scaffolds with enhanced stretchability	33
Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors	32
Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease	32
Antibacterial sponge for rapid noncompressible hemostatic treatment: spatiotemporal studies using a noninvasive model	32
Thiadiazoloquinoxaline derivative-based NIR-II organic molecules for NIR-II fluorescence imaging and photothermal therapy	32
Immunogenic dead cells engineered by the sequential treatment of ultraviolet irradiation/cryo-shocking for lung-targeting delivery and tumor vaccination	32
Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review	32
A magnetic mucus-penetrating nanoagent boosting phlegm elimination for inhalation injury treatment	32
Recent advances in responsive antibacterial materials: design and application scenarios	32
Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication	31
Glutathione-triggered release of SO₂gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy	31
Multifunctional FeS₂@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy	31
Chitosan-based multifunctional oxygenating antibiotic hydrogel dressings for managing chronic infection in diabetic wounds	31
Contents list	31
Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases	31
Design of a quinoxalinone-based AIE probe for the detection of ROS in in vitro and in vivo sepsis models	31
3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes	31
Inhibition and eradication of bacterial biofilm using polymeric materials	31
Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment	31
A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin	31
Liposomal MRI probes containing encapsulated or amphiphilic Fe(iii) coordination complexes	31
Construction of strontium-loaded injectable lubricating hydrogel and its role in promoting repair of cartilage defects	31
3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence	31
Extended siponimod release via low-porosity PLGA fibres: a comprehensive three-month in vitro evaluation for neovascular ocular diseases	31
Back cover	30
An antibacterial and healing-promoting collagen fibril constructed by the simultaneous strategy of fibril reconstitution and ε-polylysine anchoring for infected wound repair	30
Front cover	30
A novel exopolysaccharide (p-CY01) from the Antarctic bacterium Pseudoalteromonas sp. strain CY01 cryopreserves human red blood cells	30
Back cover	30
Contents list	30
Front cover	30
Drug carrier-assisted combined chemo- and radionuclide therapy for tumors of diverse origins: effects of therapeutic schemes on tumor responses	30
Base-modified factor VIII mRNA delivery with galactosylated lipid nanoparticles as a protein replacement therapy for haemophilia A	30
Contents list	30
Correction: Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	30
Front cover	30
Front cover	30
Contents list	30
Cell-free and cytokine-free self-assembling peptide hydrogel-polycaprolactone composite scaffolds for segmental bone defects	30
Front cover	30
The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid	29
Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low-density lipoprotein in atherosclerotic plaques	29
Ligand free FeSn₂ alloy nanoparticles for safe T₂-weighted MR imaging of in vivo lung tumors	28
Safe magnetic resonance imaging on biocompatible nanoformulations	28
Quercetin alleviates nanoparticle-induced osteolysis via deactivating pyroptosis	28
Mesopore-encaged active MnOx in nano-silica selectively suppresses lung cancer cells by inducing autophagy	28
Improved survival rate and minimal side effects of doxorubicin for lung metastasis using engineered discoidal polymeric particles	28
Ultra-small NIR J-aggregates of BODIPY for potent phototheranostics	28
Microencapsulation system for scalable differentiation of peripheral motor neurons from human induced pluripotent stem cells	28
Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI)	28
Melatonin and the nervous system: nanomedicine perspectives	28
Biocompatibility and wound-healing prospect of KAPs-depleted residual hair biomaterial	28
Engineering of an in-cell protein crystal for fastening a metastable conformation of a target miniprotein	27
Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements	27
Synthetic and biological nanoparticles for cancer immunotherapy	27
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis	27
4D-printed multifunctional hydrogels as flexible strain sensors and nerve conduits	27
Recent advances in functional polyurethane elastomers: from structural design to biomedical applications	27
Multifunctional antibacterial hydrogels for chronic wound management	27
Tissue engineered scaffolds for corneal endothelial regeneration: a material's perspective	27
3D printing microporous scaffolds from modular bioinks containing sacrificial, cell-encapsulating microgels	27

Restoring endothelial function: shedding light on cardiovascular stent development	27
Analysis of the potential role of photocurable hydrogel in patient-derived glioblastoma organoid culture through RNA sequencing	27
Front cover	26
Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties	26
Bisphosphonate type-dependent cell viability suppressive effects of carbon nanohorn–calcium phosphate–bisphosphonate nanocomposites	26
Front cover	26
Effects of the aspect ratio of plasmonic gold nanorods on the inhibition of lysozyme amyloid formation	26
Aptamers in dentistry: diagnosis, therapeutics, and future perspectives	26
Back cover	26
PNJ scaffolds promote microenvironmental regulation of glioblastoma stem-like cell enrichment and radioresistance	26
Expanding opportunities to engineer mucosal vaccination with biomaterials	26
Contents list	26
Correction: Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging	26
Back cover	26
Harnessing the potential of oxygen-generating materials and their utilization in organ-specific delivery of oxygen	25
Correction: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis	25
Front cover	25
Magnetic nanoparticle-facilitated rapid mass production of high affinity polymeric materials (nanoMIPs) for protein recognition and biosensing	25
Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors	25
Stimulus-responsive hydrogels for diabetic wound management via microenvironment modulation	25
PET image-guided kidney injury theranostics enabled by a bipyramidal DNA framework	25
Correction: Bioactivity of cerium dioxide nanoparticles as a function of size and surface features	25
Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy	25
A sugar modified amphiphilic cationic nano-adjuvant ceased tumor immune suppression and rejuvenated peptide vaccine induced antitumor immunity in cervical cancer	25
Casein microparticles filled with cellulase to enzymatically degrade nanocellulose for cell growth	25
Front cover	25
Correction: Synergetic osteogenesis of extracellular vesicles and loading RGD colonized on 3D-printed titanium implants	25
Ultrasound-enhanced cascade chemodynamic tumor nanotherapy with lactic acid-enabled hydrogen peroxide self-production	24
Single atom nanozymes for bacterial infection therapy	24
Front cover	24
Development of organic photosensitizers for antimicrobial photodynamic therapy	24
Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels	24
The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation	24
A ratiometric theranostic system for visualization of ONOO⁻ species and reduction of drug-induced hepatotoxicity	24
Micro/nanomotors for active inflammatory disease therapy	24
Cascade nanozymes based on the “butterfly effect” for enhanced starvation therapy through the regulation of autophagy	24
Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid	24
Optimized synthesis of biphasic calcium phosphate: enhancing bone regeneration with a tailored β-tricalcium phosphate/hydroxyapatite ratio	24
Injectable hybrid hydrogel-mediated calcium-sensing receptor (CaSR) activation for enhanced osteogenesis and bone remodeling	24
Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance	24
One-pot synthesis of dynamically cross-linked polymers for serum-resistant nucleic acid delivery	23
Flexible use of commercial rhenium disulfide for various theranostic applications	23
The engineering and application of extracellular matrix hydrogels: a review	23
A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor	23
Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration	23
P407 hydrogel loaded with nitric oxide microbubbles promotes angiogenesis and functional improvement in testicular transplantation	23
Development of non-viral vectors for neuronal-targeted delivery of CRISPR-Cas9 RNA-proteins as a therapeutic strategy for neurological disorders	23
Improved osseointegration of strontium-modified titanium implants by regulating angiogenesis and macrophage polarization	23
Research progress in nucleus-targeted tumor therapy	23
Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers	23
Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens	23
Cationic porphyrin-based nanoparticles for photodynamic inactivation and identification of bacteria strains	23
Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting	23
Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection	23
BSA-templated ultrasmall Ag/Gd₂O₃ as a self-enabled nanotheranostic for MR/CT/PA tri-modality imaging and photothermal therapy	22
A nanoparticle reinforced microporous methacrylated silk fibroin hydrogel to promote bone regeneration	22
Mesoporous silica nanoparticle-supported nanocarriers with enhanced drug loading, encapsulation stability, and targeting efficiency	22
Therapeutic effect of indirubin-loaded bovine serum albumin nanoparticules on ulcerative colitis	22
Enhancing the tumor penetration of multiarm polymers by collagenase modification	22
Front cover	22
Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy	22
Integrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms	22
Magnetic alignment of injectable hydrogel scaffolds for spinal cord injury repair	22
Thermoresponsive degradable hydrogels with renewable surfaces for protein removal	22
Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis	22
Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma	22
Front cover	22
The molecular design of performance-enhanced intraocular lens composites	22
mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency	22
Smart erythrocyte-hitchhiking insulin delivery system for prolonged automatic blood glucose control	22
Controlled degradation of polycaprolactone-based micropillar arrays	22
SiO₂/hyaluronic acid nanoparticles carry CaO₂, DOX and p53 plasmid to effectively achieve ion interference/chemical/gene multimodal therapy of lung cancer	22
Light-responsive nanodrugs co-self-assembled from a PEG-Pt(iv) prodrug and doxorubicin for reversing multidrug resistance in the chemotherapy process of hypoxic solid tumors	22
Contents list	22
Contents list	21
Contents list	21
Front cover	21
Correction: Implantation of a functional TEMPO-hydrogel induces recovery from rat spinal cord transection through promoting nerve regeneration and protecting bladder tissue	21
Back cover	21
Contents list	21
Contents list	21
Contents list	21
Front cover	21
Back cover	21
Retraction: NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway	21
Front cover	21
Near-infrared light activatable niosomes loaded with indocyanine green and plasmonic gold nanorods for theranostic applications	20
From bone to nacre – development of biomimetic materials for bone implants: a review	20
“Spear and shield in one” nanochaperone enables protein to navigate multiple biological barriers for enhanced tumor synergistic therapy	20
Design considerations for photoinitiator selection in cell-laden gelatin methacryloyl hydrogels	20
Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes	20
Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration	20
A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury	20
Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy	20
Multifluid electrospinning for multi-drug delivery systems: pros and cons, challenges, and future directions	20