OOIR: Observatory of International Research

Papers

(The median citation count of Biomaterials Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Inside front cover	116
Front cover	103
Injectable leonurine nanocrystal-loaded microspheres for long-term hyperlipidemia management	101
Albumin-coated pH-responsive dimeric prodrug-based nano-assemblies with high biofilm eradication capacity	87
Bioactive additives from the dorsal dermis of mice for enhanced vascularization in 3D bioprinting	85
Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma	83
A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72	80
Fetuin A functionalisation of biodegradable PLLA-co-PEG nonwovens towards enhanced biomineralisation and osteoblastic growth behaviour	77
Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions	77
Fluorinated poly(aryl ether)/polypropylene composite patch for prevention of abdominal adhesions after hernia repairs	74
Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy	68
A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization	68
Transtympanic delivery of V₂O₅ nanowires with a tympanic-membrane penetrating peptide	65
Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency	63
Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway	63
Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers	62
Does mechanobiology drive respiratory disease? Biomechanical induction of mucus hypersecretion in human bronchial organoids using a photocontrolled biomaterial gel	61
Contents list	61
Microwave-triggered organic sensitizer for synergistic dynamic/thermal therapy of osteosarcoma	60
Site-selective post-modification of short α/γ hybrid foldamers: a powerful approach for molecular diversification towards biomedical applications	60
Principles of nucleic acid toehold mediated strand displacement (TMSD) reaction model and its applications in cell environment	56
Tuning molecular assembly behavior to amplify the sonodynamic activity of porphyrins for efficient antibacterial therapy	56
Therapeutic effects of tea polyphenol-loaded nanoparticles coated with platelet membranes on LPS-induced lung injury	55
NIR-II imaging-guided photothermal cancer therapy combined with enhanced immunogenic death	55
Biocompatible recombinant type III collagen enhancing skin repair and anti-wrinkle effects	55

Lung-targeting lipid nanoparticle-mediated sparstolonin B delivery improves acute lung injury	55
A novel donor–acceptor structured diketopyrrolopyrrole-based conjugated polymer synthesized by direct arylation polycondensation (DArP) for highly efficient antimicrobial photothermal therapy	54
Rapid neurostimulation at the micron scale with an optically controlled thermal-capture technique	53
Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes	52
Exploring therapy transport from implantable medical devices using experimentally informed computational methods	51
Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation	50
Advances in the application of hydrogel adhesives for wound closure and repair in abdominal digestive organs	49
Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds	49
An intrinsically semi-permeable PDMS nanosheet encapsulating adipose tissue-derived stem cells for enhanced angiogenesis	48
Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights	48
Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration	48
Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering	48
Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation	47
Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair	46
Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications	46
Red blood cell-derived extracellular vesicles as biomaterials: the opportunity of freezing-induced accelerated aging	46
Soft tissue-mimicking hydrogel stiffness modulates polarisation of human monocyte-derived macrophages	45
Leveraging microtopography to pattern multi-oriented muscle actuators	45
Influence of lung extracellular matrix from non-IPF and IPF donors on primary human lung fibroblast biology	45
Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases	44
Hemp sprout-derived exosome-like nanovesicles as hepatoprotective agents attenuate liver fibrosis	44
Silk fibroin-based piezoelectric nanofibrous scaffolds for rapid wound healing	43
Contents list	43
Inside front cover	42
Back cover	41
Contents list	41
Microstructured silk fiber scaffolds with enhanced stretchability	40
Modulation of the inflammatory microenvironment after SCI to achieve enhanced nerve regeneration using pteryxin-releasing methylacrylated hyaluronic acid	40
The marriage of nanozymes and phages promotes pathogenic bacteria detection and elimination: a review	39
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes	39
Fucoidan based hydrogel biomaterials for tissue engineering	39
Front cover	39
Engineering goat milk-derived extracellular vesicles for multiple bioimaging-guided and photothermal-enhanced therapy of colon cancer	38
Trends in protein derived materials for wound care applications	38
Multiscale design strategies for high-performance hemostatic bioadhesives	38
Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents	38
All-in-one CoFe₂O₄@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy	38
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting	38
Nanostructured lipopeptide-based membranomimetics for stabilizing bacteriorhodopsin	38
Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery	37
Carboxylated gelatin-based instant dissolvable microneedles with robust mechanical properties and biomolecule stabilization for biomedical applications	36
A magnetic mucus-penetrating nanoagent boosting phlegm elimination for inhalation injury treatment	36
Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	36
Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules	36
Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review	36
Impact of material characteristics on nanoparticle penetration and retention in thrombi: implications for thrombolysis	36
Immunogenic dead cells engineered by the sequential treatment of ultraviolet irradiation/cryo-shocking for lung-targeting delivery and tumor vaccination	36
Antibacterial sponge for rapid noncompressible hemostatic treatment: spatiotemporal studies using a noninvasive model	36
LAPONITE® nano-silicates potentiate the angiogenic effects of FG-4592 and osteogenic effects of BMP-2	35
Fe₃O₄/MnCO₃ microbubbles for efficient elimination of bacterial biofilms by mechanical/sonodynamic effects under ultrasound irradiation and magnetic field targeting	35

Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases	35
Reactive oxygen species-scavenging biomaterials for neural regenerative medicine	35
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance	34
The olfactory epithelium as a gateway for bloodborne nanoparticles to the central nervous system	34
Dendritic systems for bacterial outer membrane disruption as a method of overcoming bacterial multidrug resistance	34
Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy	34
A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alka	34
Blood–brain barrier-crossing dendrimers for glioma theranostics	33
Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication	33
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels	33
Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease	33
Construction strategies of whole tumor cell vaccines	33
Ir(iv) and Ir(iii) in situ transition promotes ROS generation for eradicating multidrug-resistant bacterial infection	33
Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors	32
Biofabricated tissue model for determining biocompatibility of metallic coatings	32
Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies	32
Electrical hydrogel: electrophysiological-based strategy for wound healing	32
Thermo-sensitive poly( l -methionine) hydrogel facilitates regenerative repair of diabetic wounds by modulating immune microenvironments	32
Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis	32
Indocyanine green-based nanomedicine for theranostic applications	32
Effects of chain lengths and backbone chirality on the bone-targeting ability of poly(glutamic acid)s	32
Contents list	31
Recent advances in responsive antibacterial materials: design and application scenarios	31
Back cover	31
Biomimetic organomineral layers with antibacterial properties based on di/tetrahydroquinolinediol and nanocrystalline hydroxyapatite deposited on enamel surface	31
Biocompatibility and wound-healing prospect of KAPs-depleted residual hair biomaterial	30
Front cover	30
Front cover	30
Contents list	30
A tissue-engineered endothelial cell – smooth muscle cell arteriole-like model	30
Front cover	30
Contents list	30
Outstanding Reviewers for Biomaterials Science in 2024	29
Cell-free and cytokine-free self-assembling peptide hydrogel-polycaprolactone composite scaffolds for segmental bone defects	29
Mesopore-encaged active MnOx in nano-silica selectively suppresses lung cancer cells by inducing autophagy	29
Ligand free FeSn₂ alloy nanoparticles for safe T₂-weighted MR imaging of in vivo lung tumors	29
Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low-density lipoprotein in atherosclerotic plaques	29
A novel exopolysaccharide (p-CY01) from the Antarctic bacterium Pseudoalteromonas sp. strain CY01 cryopreserves human red blood cells	29
Emerging innovations in 3D and 4D bioprinting	29
Front cover	28
Quercetin alleviates nanoparticle-induced osteolysis via deactivating pyroptosis	28
Base-modified factor VIII mRNA delivery with galactosylated lipid nanoparticles as a protein replacement therapy for haemophilia A	28
Multi-functional intelligent drug-loaded microalgae for the repair of diabetic wounds: oxygen supply, cell proliferation promotion, and hypoglycemic effect	28
Synthetic and biological nanoparticles for cancer immunotherapy	28
An antibacterial and healing-promoting collagen fibril constructed by the simultaneous strategy of fibril reconstitution and ε-polylysine anchoring for infected wound repair	28
Enabling global access to potent subunit vaccines with a simple and scalable injectable hydrogel platform	27
Ultra-low attachment surface enabling 3D co-culture of human B cells with CD40L-expressing stromal cells for in vitro mimicry of secondary lymphoid organ	27
3D printing microporous scaffolds from modular bioinks containing sacrificial, cell-encapsulating microgels	27
Design of a quinoxalinone-based AIE probe for the detection of ROS in in vitro and in vivo sepsis models	27
Drug carrier-assisted combined chemo- and radionuclide therapy for tumors of diverse origins: effects of therapeutic schemes on tumor responses	27
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis	27
Extended siponimod release via low-porosity PLGA fibres: a comprehensive three-month in vitro evaluation for neovascular ocular diseases	27
Cationic PPC liposomes with dual targeting modules for enhanced liver fibrosis therapy via the extracellular matrix barrier	27
Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer	27
Correction: Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	27
Calotropis procera flower extracts: a green approach to zinc oxide with a pineapple-like nanoleaf morphology for biological applications	27
Liposomal MRI probes containing encapsulated or amphiphilic Fe( iii ) coordination complexes	27
Inhibition and eradication of bacterial biofilm using polymeric materials	26
Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment	26
3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence	26
Composite microspheres of bioactive glass and hydrophilic biodegradable polymers to accelerate infected wound healing	26
Polyaspartic acid coatings for blood-contacting surfaces: Promising antithrombotic and antibacterial properties under static and dynamic conditions	26
Glutathione-triggered release of SO₂gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy	26
Enhanced corneal retention of hyaluronic acid via a metabolic glycoengineering-based in vivo bioorthogonal	26
Engineering of an in-cell protein crystal for fastening a metastable conformation of a target miniprotein	26
Ultra-small NIR J-aggregates of BODIPY for potent phototheranostics	26
Construction of strontium-loaded injectable lubricating hydrogel and its role in promoting repair of cartilage defects	25
Restoring endothelial function: shedding light on cardiovascular stent development	25
Biofabrication of 3D-printed fibrous scaffolds for large muscle tissue engineering: enhancing scalability, myotube formation and surgical handling	25
Back cover	25
Multifunctional antibacterial hydrogels for chronic wound management	25
Microencapsulation system for scalable differentiation of peripheral motor neurons from human induced pluripotent stem cells	25
Bioactive chitosan scaffolds reinforced with hydroxyapatite and nickel tungstate for bone tissue engineering	25
4D-printed multifunctional hydrogels as flexible strain sensors and nerve conduits	25
Chitosan-based multifunctional oxygenating antibiotic hydrogel dressings for managing chronic infection in diabetic wounds	25
Silver nanoclusters with near-infrared-II emission: synthesis, properties, and biomedical applications	25
3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes	25
Melatonin and the nervous system: nanomedicine perspectives	25
Recent advances in functional polyurethane elastomers: from structural design to biomedical applications	25
In-depth chiral sensing capability of C-dots in a biomimetic protein-based hydrogel: a probe for chiral recognition applications	24

Front cover	24
Expanding opportunities to engineer mucosal vaccination with biomaterials	24
Micro/nanomotors for active inflammatory disease therapy	24
Front cover	24
Wound-healing biodegradable microparticles: an in vitro investigation	24
Research progress in nucleus-targeted tumor therapy	24
Back cover	24
Front cover	24
Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties	24
Aptamers in dentistry: diagnosis, therapeutics, and future perspectives	23
Correction: Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging	23
P407 hydrogel loaded with nitric oxide microbubbles promotes angiogenesis and functional improvement in testicular transplantation	23
Harnessing the potential of oxygen-generating materials and their utilization in organ-specific delivery of oxygen	23
Effects of the aspect ratio of plasmonic gold nanorods on the inhibition of lysozyme amyloid formation	23
Correction: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis	23
Correction: Bioactivity of cerium dioxide nanoparticles as a function of size and surface features	23
Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid	23
PET image-guided kidney injury theranostics enabled by a bipyramidal DNA framework	23
Magnetic nanoparticle-facilitated rapid mass production of high affinity polymeric materials (nanoMIPs) for protein recognition and biosensing	23
Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels	23
A nanoparticle reinforced microporous methacrylated silk fibroin hydrogel to promote bone regeneration	23
Correction: Synergetic osteogenesis of extracellular vesicles and loading RGD colonized on 3D-printed titanium implants	23
Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration	22
Nanomedicine-mediated co-expression of a PD-1 blockade agent and CXCL9 synergizes T cell infiltration and activation in solid tumors	22
Single atom nanozymes for bacterial infection therapy	22
MOF-reinforced NIR-responsive composite hydrogel with photothermal antibacterial and antioxidant activities for diabetic wound healing	22
Flexible use of commercial rhenium disulfide for various theranostic applications	22
Ultrasound-enhanced cascade chemodynamic tumor nanotherapy with lactic acid-enabled hydrogen peroxide self-production	22
Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens	22
Correction: Optimized synthesis of biphasic calcium phosphate: enhancing bone regeneration with a tailored β-tricalcium phosphate/hydroxyapatite ratio	22
Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy	22
Casein microparticles filled with cellulase to enzymatically degrade nanocellulose for cell growth	22
Bridging the gap between visualization and reality: integrating degradation and metabolism data to elucidate recombinant collagen behavior	22
Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy	21
Optimized synthesis of biphasic calcium phosphate: enhancing bone regeneration with a tailored β-tricalcium phosphate/hydroxyapatite ratio	21
Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers	21
One-pot synthesis of dynamically cross-linked polymers for serum-resistant nucleic acid delivery	21
A self-assembled HSA–ICG nanoprobe enables accurate photoacoustic thermometry and feedback-controlled tumor photothermal therapy	21
The engineering and application of extracellular matrix hydrogels: a review	21
Bioinspired scaffold design using a custom Voronoi path generator for extrusion-based 3D printing	21
Injectable hybrid hydrogel-mediated calcium-sensing receptor (CaSR) activation for enhanced osteogenesis and bone remodeling	21
Stimulus-responsive hydrogels for diabetic wound management via microenvironment modulation	21
Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance	21
Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection	21
Integrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms	21
A sugar modified amphiphilic cationic nano-adjuvant ceased tumor immune suppression and rejuvenated peptide vaccine induced antitumor immunity in cervical cancer	21
Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting	21
Development of organic photosensitizers for antimicrobial photodynamic therapy	21
Deconstructing culture media reveals a key role of oxyanion salts on the physicochemical properties of ortho -aminomethyl-phenylboronic acid/glucamine hy	21
Contents list	20
Front cover	20
Contents list	20
Color-coded galectin fusion proteins as novel tools in biomaterial science	20
Preparation and characterization of tildipirosin-loaded solid lipid nanoparticles for the treatment of intracellular Staphylococcus aureus infections	20
Branched silver–iron oxide nanoparticles enabling highly effective targeted and localised drug-free thrombolysis	20
Back cover	20
Contents list	20
Front cover	20
Front cover	20
Assessing the influence of small structural modifications in simple DNA-based nanostructures on their role as drug nanocarriers	20
Cellulose acetate/metal–organic framework composite beads with macroporous adsorption channels as a novel hemoadsorbent for effective virus capture	20
Dimethysiloxane polymer for the effective transdermal delivery of donepezil in Alzheimer's disease treatment	20
Reversible transformation of peptide assembly between densified-polysarcosine-driven kinetically and helix-orientation-driven thermodynamically stable morphologies	20
SiO₂/hyaluronic acid nanoparticles carry CaO₂, DOX and p53 plasmid to effectively achieve ion interference/chemical/gene multimodal therapy of lung cancer	20
Contents list	20
Front cover	20
Contents list	20
Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications	20
Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma	20
In situ modified mesoporous silica nanoparticles: synthesis, properties and theranostic applications	20
Enhancing the tumor penetration of multiarm polymers by collagenase modification	20
Modified chitosan-fabricated antifungal transdermal array for dermatophytosis therapy	20
Contents list	20
A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury	19
Image-based single-cell isolation in high-density seeded cells using photoactivatable surfaces	19
Improvement of the effectiveness of sonodynamic therapy: by optimizing components and combination with other treatments	19
Controlled degradation of polycaprolactone-based micropillar arrays	19
Vaginal reconstruction with a double-sided biomembrane—a preclinical experimental study on large animals	19
Design considerations for photoinitiator selection in cell-laden gelatin methacryloyl hydrogels	19
Elasticity of mesoporous nanocapsules regulates cellular uptake, blood circulation, and intratumoral distribution	19
Front cover	19
Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer	19
A self-assembling CXCR4-targeted pyroptosis nanotoxin for melanoma therapy	19
A manganese-phenolic network platform amplifying STING activation to potentiate MRI guided cancer chemo-/chemodynamic/immune therapy	19
From bone to nacre – development of biomimetic materials for bone implants: a review	18
Programmable bionanomaterials for revolutionizing cancer immunotherapy	18
Photothermal self-adjuvant porous microneedles for self-healing encapsulation and sustained release of antigens to improve adaptive immunity	18
Renal tissue engineering for regenerative medicine using polymers and hydrogels	18
Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration	18
Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy	18
Multifluid electrospinning for multi-drug delivery systems: pros and cons, challenges, and future directions	18
Near-infrared light activatable niosomes loaded with indocyanine green and plasmonic gold nanorods for theranostic applications	18
Reaching new lights: a review on photo-controlled nanomedicines and theirin vivoevaluation	18
Platelet membrane encapsulated curcumin nanomaterial-mediated specific thrombolysis and anti-thrombotic treatment among pregnant women	18
Potent intrinsic bactericidal activity of novel copper telluride nano-grape clusters with facile preparation	18