OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Science is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Introduction to the 31^st Annual Conference of the European Society for Biomaterials (ESB 2021)	154
Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency	150
Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications	129
An intrinsically semi-permeable PDMS nanosheet encapsulating adipose tissue-derived stem cells for enhanced angiogenesis	111
Albumin-coated pH-responsive dimeric prodrug-based nano-assemblies with high biofilm eradication capacity	108
A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization	107
Influence of lung extracellular matrix from non-IPF and IPF donors on primary human lung fibroblast biology	105
Front cover	86
Inside front cover	85
Bioactive additives from the dorsal dermis of mice for enhanced vascularization in 3D bioprinting	81
Fluorinated poly(aryl ether)/polypropylene composite patch for prevention of abdominal adhesions after hernia repairs	80
Rapid neurostimulation at the micron scale with an optically controlled thermal-capture technique	76
Injectable leonurine nanocrystal-loaded microspheres for long-term hyperlipidemia management	74
NIR-II imaging-guided photothermal cancer therapy combined with enhanced immunogenic death	73
A universal biocompatible coating for enhanced lubrication and bacterial inhibition	72
Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions	72
Exploring therapy transport from implantable medical devices using experimentally informed computational methods	72
Transtympanic delivery of V₂O₅ nanowires with a tympanic-membrane penetrating peptide	66
Mechanical behavior of biomimetic oriented cell sheets from a perspective of living materials	66
Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy	65
Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes	62
A chiral microenvironment promotes retinal progenitor cell proliferation by activating the Akt and ERK pathways	60
Advances in the application of hydrogel adhesives for wound closure and repair in abdominal digestive organs	57
Microporous surface containing flower-like molybdenum disulfide submicro-spheres of sulfonated polyimide with antibacterial effect and promoting bone regeneration and osteointegration	57
Principles of nucleic acid toehold mediated strand displacement (TMSD) reaction model and its applications in cell environment	56

Site-selective post-modification of short α/γ hybrid foldamers: a powerful approach for molecular diversification towards biomedical applications	55
Fetuin A functionalisation of biodegradable PLLA-co-PEG nonwovens towards enhanced biomineralisation and osteoblastic growth behaviour	55
A multifunctional theranostics nanosystem featuring self-assembly of alcohol-abuse drug and photosensitizers for synergistic cancer therapy	54
Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma	53
Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights	52
Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering	52
Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers	51
Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair	50
Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration	50
Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway	49
Therapeutic effects of tea polyphenol-loaded nanoparticles coated with platelet membranes on LPS-induced lung injury	48
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1	48
Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation	48
Biocompatible recombinant type III collagen enhancing skin repair and anti-wrinkle effects	48
Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds	47
Advances in biomaterials for the treatment of retinoblastoma	46
A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy	46
Silk fibroin-based piezoelectric nanofibrous scaffolds for rapid wound healing	46
Hemp sprout-derived exosome-like nanovesicles as hepatoprotective agents attenuate liver fibrosis	46
A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72	45
Lung-targeting lipid nanoparticle-mediated sparstolonin B delivery improves acute lung injury	45
Tuning molecular assembly behavior to amplify the sonodynamic activity of porphyrins for efficient antibacterial therapy	45
Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation	45
Gram-selective antibacterial peptide hydrogels	45
Artesunate drug-loaded 2D nano-shuttle landing on RBCs infected with malaria parasites	44
Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases	44
Leveraging microtopography to pattern multi-oriented muscle actuators	44
Inside front cover	43
Contents list	43
A novel donor–acceptor structured diketopyrrolopyrrole-based conjugated polymer synthesized by direct arylation polycondensation (DArP) for highly efficient antimicrobial photothermal therapy	43
Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies	42
Back cover	42
A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alka	42
Efficient CRISPR-Cas9-based knockdown of RUNX2 to induce chondrogenic differentiation of stem cells	42
Front cover	42
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance	41
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels	41
Thiadiazoloquinoxaline derivative-based NIR-II organic molecules for NIR-II fluorescence imaging and photothermal therapy	41
Engineering goat milk-derived extracellular vesicles for multiple bioimaging-guided and photothermal-enhanced therapy of colon cancer	41
Molecular weight tuning optimizes poly(2-methoxyethyl acrylate) dispersion to enhance the aging resistance and anti-fouling behavior of denture base resin	41
Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases	41
Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers	41
Biomimetic organomineral layers with antibacterial properties based on di/tetrahydroquinolinediol and nanocrystalline hydroxyapatite deposited on enamel surface	41
A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin	40
Recent advances in responsive antibacterial materials: design and application scenarios	40
Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors	40
Nanostructured lipopeptide-based membranomimetics for stabilizing bacteriorhodopsin	40
Reactive oxygen species-scavenging biomaterials for neural regenerative medicine	40
Blood–brain barrier-crossing dendrimers for glioma theranostics	39
Electrical hydrogel: electrophysiological-based strategy for wound healing	39

Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents	38
pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss	38
Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication	38
Substrate-independent adsorption of nanoparticles as anti-biofilm coatings	38
Antibacterial sponge for rapid noncompressible hemostatic treatment: spatiotemporal studies using a noninvasive model	37
All-in-one CoFe₂O₄@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy	37
Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	37
Fe₃O₄/MnCO₃ microbubbles for efficient elimination of bacterial biofilms by mechanical/sonodynamic effects under ultrasound irradiation and magnetic field targeting	37
Effects of chain lengths and backbone chirality on the bone-targeting ability of poly(glutamic acid)s	36
Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review	36
A magnetic mucus-penetrating nanoagent boosting phlegm elimination for inhalation injury treatment	36
Indocyanine green-based nanomedicine for theranostic applications	36
Biofabricated tissue model for determining biocompatibility of metallic coatings	35
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes	35
Construction strategies of whole tumor cell vaccines	35
Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy	35
LAPONITE® nano-silicates potentiate the angiogenic effects of FG-4592 and osteogenic effects of BMP-2	35
Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery	35
Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules	34
Redox chemistry-enabled stepwise surface dual nanoparticle engineering of 2D MXenes for tumor-sensitive T₁ and T₂ MRI-guided photonic breast-cancer hyperthermia in	33
Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications	33
Magnetic nanocluster-mediated photothermal effect and macrophage modulation for synergistic photothermal immunotherapy of cancer	33
Dendritic systems for bacterial outer membrane disruption as a method of overcoming bacterial multidrug resistance	33
A self-assembling peptidic platform to boost the cellular uptake and nuclear delivery of oligonucleotides	33
A polydopamine-based photodynamic coating on the intraocular lens surface for safer posterior capsule opacification conquering	33
Trends in protein derived materials for wound care applications	33
Microstructured silk fiber scaffolds with enhanced stretchability	33
In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy	33
Ir(iv) and Ir(iii) in situ transition promotes ROS generation for eradicating multidrug-resistant bacterial infection	33
Immunogenic dead cells engineered by the sequential treatment of ultraviolet irradiation/cryo-shocking for lung-targeting delivery and tumor vaccination	33
Correction: Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	32
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting	32
Mesopore-encaged active MnOx in nano-silica selectively suppresses lung cancer cells by inducing autophagy	32
Recent advances in functional polyurethane elastomers: from structural design to biomedical applications	32
Design of a quinoxalinone-based AIE probe for the detection of ROS in in vitro and in vivo sepsis models	32
MnO₂ coated nanotheranostic LDH for synergistic cascade chemo/chemodynamic cancer therapy under the guidance of MRI-targeted diagnosis	32
Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis	32
Liposomal MRI probes containing encapsulated or amphiphilic Fe(iii) coordination complexes	32
Contents list	32
Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease	32
Glutathione-triggered release of SO₂gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy	32
Extended siponimod release via low-porosity PLGA fibres: a comprehensive three-month in vitro evaluation for neovascular ocular diseases	32
Back cover	31
Front cover	31
Contents list	31
Cell-free and cytokine-free self-assembling peptide hydrogel-polycaprolactone composite scaffolds for segmental bone defects	31
Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low-density lipoprotein in atherosclerotic plaques	31
Front cover	31
Front cover	31
Front cover	31
Contents list	31
Contents list	31
A novel exopolysaccharide (p-CY01) from the Antarctic bacterium Pseudoalteromonas sp. strain CY01 cryopreserves human red blood cells	31
The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid	31
Front cover	31
Back cover	31
Drug carrier-assisted combined chemo- and radionuclide therapy for tumors of diverse origins: effects of therapeutic schemes on tumor responses	31
Base-modified factor VIII mRNA delivery with galactosylated lipid nanoparticles as a protein replacement therapy for haemophilia A	31
An antibacterial and healing-promoting collagen fibril constructed by the simultaneous strategy of fibril reconstitution and ε-polylysine anchoring for infected wound repair	31
Tissue engineered scaffolds for corneal endothelial regeneration: a material's perspective	31
Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment	30
Biocompatibility and wound-healing prospect of KAPs-depleted residual hair biomaterial	30
Ligand free FeSn₂ alloy nanoparticles for safe T₂-weighted MR imaging of in vivo lung tumors	30
Engineering of an in-cell protein crystal for fastening a metastable conformation of a target miniprotein	30
Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI)	30
Safe magnetic resonance imaging on biocompatible nanoformulations	30
Multifunctional FeS₂@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy	30
Melatonin and the nervous system: nanomedicine perspectives	30
Inhibition and eradication of bacterial biofilm using polymeric materials	29
Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements	29
3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes	29
4D-printed multifunctional hydrogels as flexible strain sensors and nerve conduits	29
Sequentially Unlockable Prodrug Nanoparticles Enable Spatiotemporal Coordination of Chemotherapy and Tumor Microenvironment Regulation for Metastasis Prevention in Breast Cancer	29
Chitosan-based multifunctional oxygenating antibiotic hydrogel dressings for managing chronic infection in diabetic wounds	28
Restoring endothelial function: shedding light on cardiovascular stent development	28
3D printing microporous scaffolds from modular bioinks containing sacrificial, cell-encapsulating microgels	28
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis	28
Outstanding Reviewers for Biomaterials Science in 2024	28
Microencapsulation system for scalable differentiation of peripheral motor neurons from human induced pluripotent stem cells	28
Quercetin alleviates nanoparticle-induced osteolysis via deactivating pyroptosis	27

Improved survival rate and minimal side effects of doxorubicin for lung metastasis using engineered discoidal polymeric particles	27
Back cover	27
Front cover	27
Analysis of the potential role of photocurable hydrogel in patient-derived glioblastoma organoid culture through RNA sequencing	27
Multifunctional antibacterial hydrogels for chronic wound management	27
Polyaspartic Acid Coatings for Blood-Contacting Medical Devices: Antithrombotic and Antibacterial Properties under Static and Dynamic Conditions	27
Back cover	27
Synthetic and biological nanoparticles for cancer immunotherapy	27
Ultra-small NIR J-aggregates of BODIPY for potent phototheranostics	27
Construction of strontium-loaded injectable lubricating hydrogel and its role in promoting repair of cartilage defects	27
3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence	27
Correction: Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging	27
Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy	26
Aptamers in dentistry: diagnosis, therapeutics, and future perspectives	26
Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties	26
Front cover	26
Front cover	26
Contents list	26
Correction: Bioactivity of cerium dioxide nanoparticles as a function of size and surface features	26
Bisphosphonate type-dependent cell viability suppressive effects of carbon nanohorn–calcium phosphate–bisphosphonate nanocomposites	26
Casein microparticles filled with cellulase to enzymatically degrade nanocellulose for cell growth	26
Expanding opportunities to engineer mucosal vaccination with biomaterials	26
Correction: Synergetic osteogenesis of extracellular vesicles and loading RGD colonized on 3D-printed titanium implants	26
Magnetic nanoparticle-facilitated rapid mass production of high affinity polymeric materials (nanoMIPs) for protein recognition and biosensing	26
Effects of the aspect ratio of plasmonic gold nanorods on the inhibition of lysozyme amyloid formation	26
Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors	26
PNJ scaffolds promote microenvironmental regulation of glioblastoma stem-like cell enrichment and radioresistance	26
Front cover	26
A sugar modified amphiphilic cationic nano-adjuvant ceased tumor immune suppression and rejuvenated peptide vaccine induced antitumor immunity in cervical cancer	25
Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy	25
Stimulus-responsive hydrogels for diabetic wound management via microenvironment modulation	25
Correction: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis	25
BSA-templated ultrasmall Ag/Gd₂O₃ as a self-enabled nanotheranostic for MR/CT/PA tri-modality imaging and photothermal therapy	25
Smart erythrocyte-hitchhiking insulin delivery system for prolonged automatic blood glucose control	25
Harnessing the potential of oxygen-generating materials and their utilization in organ-specific delivery of oxygen	25
Integrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms	25
mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency	24
Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid	24
Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels	24
Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers	24
Flexible use of commercial rhenium disulfide for various theranostic applications	24
Improved osseointegration of strontium-modified titanium implants by regulating angiogenesis and macrophage polarization	24
Research progress in nucleus-targeted tumor therapy	24
Front cover	24
Micro/nanomotors for active inflammatory disease therapy	24
P407 hydrogel loaded with nitric oxide microbubbles promotes angiogenesis and functional improvement in testicular transplantation	24
Development of non-viral vectors for neuronal-targeted delivery of CRISPR-Cas9 RNA-proteins as a therapeutic strategy for neurological disorders	24
Development of organic photosensitizers for antimicrobial photodynamic therapy	24
The engineering and application of extracellular matrix hydrogels: a review	24
Ultrasound-enhanced cascade chemodynamic tumor nanotherapy with lactic acid-enabled hydrogen peroxide self-production	24
A ratiometric theranostic system for visualization of ONOO⁻ species and reduction of drug-induced hepatotoxicity	24
Single atom nanozymes for bacterial infection therapy	24
Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens	24
A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor	24
Cationic porphyrin-based nanoparticles for photodynamic inactivation and identification of bacteria strains	24
Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting	23
The molecular design of performance-enhanced intraocular lens composites	23
Injectable hybrid hydrogel-mediated calcium-sensing receptor (CaSR) activation for enhanced osteogenesis and bone remodeling	23
Wound-healing biodegradable microparticles: an in vitro investigation	23
A nanoparticle reinforced microporous methacrylated silk fibroin hydrogel to promote bone regeneration	23
PET image-guided kidney injury theranostics enabled by a bipyramidal DNA framework	23
Mesoporous silica nanoparticle-supported nanocarriers with enhanced drug loading, encapsulation stability, and targeting efficiency	23
Cascade nanozymes based on the “butterfly effect” for enhanced starvation therapy through the regulation of autophagy	23
Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration	23
The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation	23
Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection	23
Optimized synthesis of biphasic calcium phosphate: enhancing bone regeneration with a tailored β-tricalcium phosphate/hydroxyapatite ratio	23
One-pot synthesis of dynamically cross-linked polymers for serum-resistant nucleic acid delivery	23
Magnetic alignment of injectable hydrogel scaffolds for spinal cord injury repair	23
Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance	23
Therapeutic effect of indirubin-loaded bovine serum albumin nanoparticules on ulcerative colitis	22
Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma	22
Back cover	22
Contents list	22
Front cover	22
Controlled degradation of polycaprolactone-based micropillar arrays	22
Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis	22
Light-responsive nanodrugs co-self-assembled from a PEG-Pt(iv) prodrug and doxorubicin for reversing multidrug resistance in the chemotherapy process of hypoxic solid tumors	22
Contents list	22
Contents list	22
Thermoresponsive degradable hydrogels with renewable surfaces for protein removal	22
SiO₂/hyaluronic acid nanoparticles carry CaO₂, DOX and p53 plasmid to effectively achieve ion interference/chemical/gene multimodal therapy of lung cancer	22
Front cover	22
Front cover	22
Back cover	22
Contents list	21
Contents list	21
Reversible transformation of peptide assembly between densified-polysarcosine-driven kinetically and helix-orientation-driven thermodynamically stable morphologies	21
Retraction: NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway	21
Front cover	21
Enhanced anticancer efficacy of primed natural killer cellsviacoacervate-mediated exogenous interleukin-15 delivery	21
Front cover	21
Correction: Implantation of a functional TEMPO-hydrogel induces recovery from rat spinal cord transection through promoting nerve regeneration and protecting bladder tissue	21
Dual-responsive and NIR-driven free radical nanoamplifier with glutathione depletion for enhanced tumor-specific photothermal/thermodynamic/chemodynamic synergistic Therapy	21
Contents list	21