OOIR: Observatory of International Research

Papers

(The TQCC of Translational Neurodegeneration is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Retraction Note: Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease	323
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice	292
Life and disease status of patients with Parkinson’s disease during and after zero-COVID in China: an online survey	185
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model	173
N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease	141
The C. elegans gba-3 gene encodes a glucocerebrosidase that exacerbates α-synuclein-mediated impairments in deletion mutants	118
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy	108
Retraction Note: Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism	92
Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients	90
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis	86
Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application	86
Role of dopamine in the pathophysiology of Parkinson’s disease	85
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors	82
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease	78
Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology	73
Correction: A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau	69
A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease	68
Aquaporin-4 as a cerebrospinal fluid biomarker of Alzheimer’s disease	67
Defective mitophagy and the etiopathogenesis of Alzheimer’s disease	66
Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer’s disease: a comprehensive review of the characteristics and therapeutic strategies	64
Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies	63
Correction: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease	60
Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai, China	58
NMDAR-dependent somatic potentiation of synaptic inputs is correlated with β amyloid-mediated neuronal hyperactivity	58
Hybrid nanostructures for neurodegenerative disease theranostics: the art in the combination of biomembrane and non-biomembrane nanostructures	57

Nose-to-brain drug delivery: from bench to bedside	55
Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta	55
Inflammasomes in neurodegenerative diseases	53
Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity	53
ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein	50
Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside	48
Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease	48
Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study	45
Peripheral proteinopathy in neurodegenerative diseases	45
Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease	44
Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease	43
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Cav3.2 calcium signaling in astrocytes	43
Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson’s disease	43
Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology	42
Mitochondrial links between brain aging and Alzheimer’s disease	41
The emerging role of furin in neurodegenerative and neuropsychiatric diseases	41
A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter	40
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis	40
Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory	40
Perivascular spaces relate to the course and cognition of Huntington’s disease	40
Multidimensional biomarkers for multiple system atrophy: an update and future directions	40
An AARS1 variant identified to cause adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia	40
Genetic spectrum and clinical features in a cohort of Chinese patients with autosomal recessive cerebellar ataxias	39
Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model	37
Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease	36
SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system	35
Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease	35
Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβ plaques and brain rhythms in 5×FAD mice	34
Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease	34
Cerebrospinal fluid cyclase-associated protein 2 is increased in Alzheimer’s disease and correlates with tau pathology	34
Impact of seed amplification assay and surface-enhanced Raman spectroscopy combined approach on the clinical diagnosis of Alzheimer’s disease	33
TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis	32
Role of extracellular vesicle-carried ncRNAs in the interactive ‘dialogue’ within the brain and beyond: emerging theranostic epigenetic modifiers in brain-derived nanoplatforms	31
Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model	31
Plasma proteomic signatures as predictors of dementia risk in individuals with sleep apnea: a cohort study	30
In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use	30
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease	30
Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity	30