OOIR: Observatory of International Research

Papers

(The median citation count of Cancer & Metabolism is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study	93
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma	67
A role of arginase-1-expressing myeloid cells in cachexia	42
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition	40
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival	37
GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation	37
Ketomimetic nutrients remodel the glycocalyx and trigger a metabolic defense in breast cancer cells	27
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	27
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma	26
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	25
Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes	24
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis	24
Circulating metabolome landscape in Lynch syndrome	23
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages	23
Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer	22
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells	22
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors	21
CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function	21
Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics	20
Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling	20
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress	20
Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells	18
Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo	17
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging	17
Pharmacological inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) imparts selective leukemia cell death	17

Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states	16
Correction: STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	16
The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer	15
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma	15
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles	14
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells	14
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment	13
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells	12
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	12
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1	11
Lactate metabolism in clonal plasma cells and its therapeutic implications in multiple myeloma patients with elevated serum LDH levels	10
Fatty acid synthase-derived lipid stores support breast cancer metastasis	9
Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus	9
Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effect	8
Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation	8
Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo	8
RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition	8
METTL16 regulates the mRNA stability of FBXO5 via m6A modification to facilitate the malignant behavior of breast cancer	8
Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation	8
Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRafV600E/Pten−/− mice	8
The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition	8
Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer	7
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines	7
Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas	7
Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma	7
Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression	7
A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells	7
Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells	7
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia	6
Correction: A role of arginase-1-expressing myeloid cells in cachexia	6
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer	6
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis	6
Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study	6
Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases	5
Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells	5
Unraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors	5
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	5
CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells	5
GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway	5
Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway	5
Metabolic alterations and cellular responses to β-Hydroxybutyrate treatment in breast cancer cells	5
Cdk5 regulates glutamine metabolism in colorectal cancer via the EZH2-GLS1 axis	5
Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish	5
Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer	4
The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells	4
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH	4
Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer	4
S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer	4
Scaffold-mediated switching of lymphoma metabolism in culture	4
Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer	4

Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability	4
High-fat diet promotes prostate cancer metastasis via RPS27	4
Correction to: Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	4
Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism	4
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling	4