OOIR: Observatory of International Research

Papers

(The median citation count of Cancer & Metabolism is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study	108
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma	74
A role of arginase-1-expressing myeloid cells in cachexia	51
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition	46
GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation	38
Ketomimetic nutrients remodel the glycocalyx and trigger a metabolic defense in breast cancer cells	35
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma	30
Measurement of mitochondria amount and clearance using flow cytometry: effect of mitophagy inhibitors in leukemia cells	29
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival	28
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages	26
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	26
Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes	26
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells	25
Circulating metabolome landscape in Lynch syndrome	24
Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer	23
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	23
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis	23
In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T	22
Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer	22
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors	21
Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling	19
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress	19
POU2F1 drives cholesterol biosynthesis and lipid remodeling through the DHCR24/ELOVL2 axis in endometrial cancer	18
CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function	17
Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells	17

Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo	16
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging	16
Pharmacological inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) imparts selective leukemia cell death	16
Correction: STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	15
The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer	12
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma	12
Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states	11
PFKFB4 promotes M2 polarization of tumor-associated macrophages through aerobic glycolysis-mediated modification of histone H3K18 lactylation in hepatocellular carcinoma	11
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells	11
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells	10
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment	10
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1	10
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles	10
Lactate metabolism in clonal plasma cells and its therapeutic implications in multiple myeloma patients with elevated serum LDH levels	10
Fatty acid synthase-derived lipid stores support breast cancer metastasis	9
METTL16 regulates the mRNA stability of FBXO5 via m6A modification to facilitate the malignant behavior of breast cancer	9
Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus	9
Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer	9
Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRafV600E/Pten−/− mice	9
RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition	9
Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation	9
Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo	9
Tumor-intrinsic metabolic pathways essential for tumorigenesis and resistance to anti-PD1 in oncogenic Kras-driven lung adenocarcinoma	9
Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation	9
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	9
The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition	9
A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells	8
Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effect	8
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines	8
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells	8
Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer	8
Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression	8
Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma	8
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia	7
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer	7
Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases	7
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis	7
SENP1 drives de novo cholesterogenesis via disrupting SUMOylation-mediated SREBP2-FBXW7 interaction	7
Correction: A role of arginase-1-expressing myeloid cells in cachexia	7
Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study	7
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	6
Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells	6
Metabolic alterations and cellular responses to β-Hydroxybutyrate treatment in breast cancer cells	6
GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway	6
CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells	6
Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway	5
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH	5
Unraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors	5
Cdk5 regulates glutamine metabolism in colorectal cancer via the EZH2-GLS1 axis	5
The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells	5

Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability	4
Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in fumarate hydratase-deficient renal cell carcinoma cells	4
Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer	4
WTAP contributes to platinum resistance in high-grade serous ovarian cancer by up-regulating malic acid: insights from liquid chromatography and mass spectrometry analysis	4
Correction to: Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	4
High-fat diet promotes prostate cancer metastasis via RPS27	4
The FGL1-LAG-3 axis attenuates melanoma-induced cachexia in mice	4
Scaffold-mediated switching of lymphoma metabolism in culture	4
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling	4
S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer	4
Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer	4
Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism	4