OOIR: Observatory of International Research

Papers

(The TQCC of Cancer & Metabolism is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study	88
A role of arginase-1-expressing myeloid cells in cachexia	63
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition	37
GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation	35
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma	35
Ketomimetic nutrients remodel the glycocalyx and trigger a metabolic defense in breast cancer cells	33
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	31
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival	31
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	27
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma	27
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis	26
Circulating metabolome landscape in Lynch syndrome	22
Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes	22
Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer	22
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells	21
CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function	20
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors	20
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages	20
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress	19
Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling	18
Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo	17
Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics	16
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging	16
Pharmacological inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) imparts selective leukemia cell death	16
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma	15

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles	14
Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states	14
Correction: STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	14
Lactate metabolism in clonal plasma cells and its therapeutic implications in multiple myeloma patients with elevated serum LDH levels	13
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1	13
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells	13
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment	13
The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer	13
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells	12
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	12