eLife

Article	Citations
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability	591
Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes	387
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing	321
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	312
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	311
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation	301
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	289
Patterns of interdivision time correlations reveal hidden cell cycle factors	286
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	259
Intrinsic excitability mechanisms of neuronal ensemble formation	244
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state	243
A meta-analysis of the association between male dimorphism and fitness outcomes in humans	242
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	222
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	219
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	215
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	212
Serial attentional resource allocation during parallel feature value tracking	192
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	184
High-grade serous ovarian carcinoma organoids as models of chromosomal instability	175
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	173
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children	167
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	163
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	161
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	158
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	155

Cingulate cortex shapes early postnatal development of social vocalizations	146
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	142
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	141
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	141
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	138
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	135
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	134
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	134
Variation in the basal immune state and implications for disease	132
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	128
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	127
Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange	125
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	123
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	122
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	122
Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study	122
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	121
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	120
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	120
Mechanism of substrate binding and transport in BASS transporters	119
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	116
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	116
Guanidine production by plant homoarginine-6-hydroxylases	115
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	115
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	114
Apoptotic signaling clears engineered Salmonella in an organ-specific manner	114
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	109
Muscarinic receptors mediate motivation via preparatory neural activity in humans	107
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression	106
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	106
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli	105
Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control	104
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	103
Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l	101
Imaging of brain electric field networks with spatially resolved EEG	101
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	100
A quadratic model captures the human V1 response to variations in chromatic direction and contrast	99
Reversal of the adipostat control of torpor during migration in hummingbirds	99
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	99
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria	97
Cortical adaptation to sound reverberation	94
Multi-dimensional social relationships shape social attention in monkeys	94
Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans	93
Conditional and unconditional components of aversively motivated freezing, flight and darting in mice	92
A new early branching armored dinosaur from the Lower Jurassic of southwestern China	92
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice	91
STING mediates immune responses in the closest living relatives of animals	89
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia	89
T cells discriminate between groups C1 and C2 HLA-C	88
Add mass spectrometry to the pandemic toolbox	88

A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology	87
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	87
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	87
Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end	86
Decoding the activated stem cell phenotype of the neonatally maturing pituitary	86
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes	84
Spatial transformation of multi-omics data unlocks novel insights into cancer biology	83
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration	83
Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage	83
TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase	83
Functional visualization of NK cell-mediated killing of metastatic single tumor cells	82
Correction: Drp1 is required for AgRP neuronal activity and feeding	82
Nonlinear transient amplification in recurrent neural networks with short-term plasticity	81
Position representations of moving objects align with real-time position in the early visual response	81
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	81
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	81
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	81
Mutant SF3B1 promotes malignancy in PDAC	81
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity	81
Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys	81
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses	80
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes	80
A connectomics-based taxonomy of mammals	79
Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors	78
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome	78
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	78
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	77
A computationally informed comparison between the strategies of rodents and humans in visual object recognition	77
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	77
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	76
ZAF, the first open source fully automated feeder for aquatic facilities	75
Sex differences and sex bias in human circadian and sleep physiology research	75
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	75
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis	75
Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads	75
PIMT is a novel and potent suppressor of endothelial activation	75
The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions	75
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	74
Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear	73
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	73
Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster	72
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation	72
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	72
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	71
Correction: Highly contiguous assemblies of 101 drosophilid genomes	71
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	71
Becoming less beige with age	71
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	70
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	70
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	70
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	70
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	70
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	69
Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication	69
Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation	69
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	69
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	68
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	68
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	68
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16	67
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	67
De novo identification of universal cell mechanics gene signatures	67
Space as a scaffold for rotational generalisation of abstract concepts	67
The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila	67
The deep-rooted origin of disulfide-rich spider venom toxins	66
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	66
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	66
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	66
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury	65
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	65
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	65
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	65
Major nuclear locales define nuclear genome organization and function beyond A and B compartments	65
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	65
Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9	65
Wiring up for controlled flight	65
Biocalcification in porcelaneous foraminifera	64
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	64
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	64
Goal-directed vocal planning in a songbird	64

Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	64
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	64
Language experience shapes predictive coding of rhythmic sound sequences	64
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	63
An emerging view of neural geometry in motor cortex supports high-performance decoding	63
Allosteric regulation of kinase activity in living cells	63
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	63
Outgrowing self-denial	63
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	63
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	63
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	63
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	63
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	62
Caspases promote cell proliferation after necrosis	62
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	62
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	62
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	62
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity	62
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification	62
Best practices to promote rigor and reproducibility in the era of sex-inclusive research	62
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	61
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	61
A causal role of the NMDA receptor in recurrent processing during perceptual integration	61
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	61
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	61
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	61
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation	60
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	60
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	60
Functional and structural segregation of overlapping helices in HIV-1	60
A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx	60
Phagocytic ‘teeth’ and myosin-II ‘jaw’ power target constriction during phagocytosis	60
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	60
Brain areas for reversible symbolic reference, a potential singularity of the human brain	60
The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity	60
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	59
Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement	59
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface	59
Deciding when to move	59
Shining a light on hematopoietic stem cells	59
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110	58
A direct neural signature of serial dependence in working memory	58
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	58
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances	58
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	58
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	58
osl-dynamics, a toolbox for modeling fast dynamic brain activity	58
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	58
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	58
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis	58
Multisensory integration enhances audiovisual responses in the Mauthner cell	58
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	58
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	58
Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions	58
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans	58
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension	57
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis	57
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	57
Cortico-striatal action control inherent of opponent cognitive-motivational styles	57
Analysis of long and short enhancers in melanoma cell states	57
Direct observation of the neural computations underlying a single decision	57
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	57
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	57
Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling	57
Movies reveal the fine-grained organization of infant visual cortex	57
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	57
Functionally important residues from graph analysis of coevolved dynamic couplings	57
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission	57
Emerging dynamics from high-resolution spatial numerical epidemics	56
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme	56
Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner	56
Temporo-cerebellar connectivity underlies timing constraints in audition	56
State-dependent representations of mixtures by the olfactory bulb	56
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	56
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	56
Are single-peaked tuning curves tuned for speed rather than accuracy?	56
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation	56
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	56
Muscle-specific economy of force generation and efficiency of work production during human running	56
Mechanically transduced immunosorbent assay to measure protein-protein interactions	56
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	56
Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice	56
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation	55
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	55
Lipid hydroperoxides promote sarcopenia through carbonyl stress	55
Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum	55
An annotated introductory reading list for neurodiversity	55
The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging	55
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy	55
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	55
How honey bees make fast and accurate decisions	55
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs	55
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	54
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	54
Larger but younger fish when growth outpaces mortality in heated ecosystem	54