eLife

Article	Citations
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	1273
ZAF, the first open source fully automated feeder for aquatic facilities	471
Wiring up for controlled flight	377
A double dissociation between semantic and spatial cognition in visual to default network pathways	325
How a gene fuels ear infections	306
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	286
Correction: Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo	274
Risk-sensitive learning is a winning strategy for leading an urban invasion	264
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species	262
A role for RNA knots in Alzheimer’s disease	262
Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps	253
Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex	242
Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns	232
A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome	216
De novo identification of universal cell mechanics gene signatures	209
Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy	201
Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity	200
Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity	194
Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty	193
Discovering root causal genes with high-throughput perturbations	193
Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects	188
Movies reveal the fine-grained organization of infant visual cortex	187
Mapping patterns of thought onto brain activity during movie-watching	185
SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant	174
Reevaluating the neural noise in dyslexia using biomarkers from electroencephalography and high-resolution magnetic resonance spectroscopy	174

The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision	165
UNC-6/Netrin promotes both adhesion and directed growth within a single axon	164
Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP	162
Multi-dimensional social relationships shape social attention in monkeys	159
Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner	158
Is creatine a CNS neurotransmitter?	153
Effects of arousal and movement on secondary somatosensory and visual thalamus	152
Inference of the SARS-CoV-2 generation time using UK household data	149
Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states	147
Putting the theory into ‘burstlet theory’ with a biophysical model of burstlets and bursts in the respiratory preBötzinger complex	146
Neural defensive circuits underlie helping under threat in humans	140
Perturbation of amygdala-cortical projections reduces ensemble coherence of palatability coding in gustatory cortex	138
Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm	137
An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion	134
AAV ablates neurogenesis in the adult murine hippocampus	132
Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1	130
Nonlinear transient amplification in recurrent neural networks with short-term plasticity	126
Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters	126
Lead-OR: A multimodal platform for deep brain stimulation surgery	123
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis	121
Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life	120
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation	119
Characterizing human mobility patterns in rural settings of sub-Saharan Africa	119
Disordered proteins interact with the chemical environment to tune their protective function during drying	115
The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development	115
Daily electrical activity in the master circadian clock of a diurnal mammal	115
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	113
Tracing the substrate translocation mechanism in P-glycoprotein	113
A scenario for an evolutionary selection of ageing	112
A 3D adult zebrafish brain atlas (AZBA) for the digital age	112
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses	112
Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours	112
High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)	110
Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice	106
Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses	106
Hippocampal place cell remapping occurs with memory storage of aversive experiences	106
Cortical activity during naturalistic music listening reflects short-range predictions based on long-term experience	105
Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis	105
A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells	104
How inhibitory and excitatory inputs gate output of the inferior olive	103
Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis	103
Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome	102
Normal and dysregulated crosstalk between iron metabolism and erythropoiesis	101
Using adversarial networks to extend brain computer interface decoding accuracy over time	101
Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion	100
Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth	100
Caspase-1 activates gasdermin A in non-mammals	100
A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse	100
History information emerges in the cortex during learning	98
Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization	97

Regulation of chromatin architecture by transcription factor binding	96
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	96
Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients	95
Fast bacterial growth reduces antibiotic accumulation and efficacy	95
Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3	95
Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs	94
Position representations of moving objects align with real-time position in the early visual response	92
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers	92
Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study	91
Retraction: Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation	90
Retraction: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling	90
An emerging view of neural geometry in motor cortex supports high-performance decoding	89
Correction: The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity	89
Template switching during DNA replication is a prevalent source of adaptive gene amplification	89
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth	88
Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons	88
Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation	87
Supralinear dendritic integration in murine dendrite-targeting interneurons	87
Multimodal mismatch responses in mouse auditory cortex	86
The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2	85
Quantification of Salmonella enterica serovar Typhimurium population dynamics in murine infection using a highly diverse barcoded library	85
Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism	84
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant	84
Multi-dimensional oscillatory activity of mouse GnRH neurons in vivo	84
Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors	83
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	83
The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans	82
Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration	82
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	82
CausalXtract, a flexible pipeline to extract causal effects from live-cell time-lapse imaging data	81
Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition	81
Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability	80
Automated cell annotation in multi-cell images using an improved CRF_ID algorithm	80
The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling	80
Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans	79
Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEG	79
Cortico-striatal action control inherent of opponent cognitive-motivational styles	78
Automated annotation of birdsong with a neural network that segments spectrograms	77
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	77
Dynamics of cooperative excavation in ant and robot collectives	77
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	77
Putting early sensory neurons to sleep	77
Dynamic metabolome profiling uncovers potential TOR signaling genes	76
Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum	76
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens	76
Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor therapy	75
Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs	75
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	75
Engineering multifunctional rhizosphere probiotics using consortia of Bacillus amyloliquefaciens transposon insertion mutants	73
A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT	73
Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet	73
Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways	73
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	72
Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia	72
Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila	71
Multiplexed microfluidic screening of bacterial chemotaxis	71
Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice	71
Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies	70
Structural mechanisms for VMAT2 inhibition by tetrabenazine	70
Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50	70
Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET	70
Nested circuits mediate the decision to vocalize	69
XAB2 dynamics during DNA damage-dependent transcription inhibition	69
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	69
KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization	69
Latent functional diversity may accelerate microbial community responses to temperature fluctuations	69
Contrasting responses to aridity by different-sized decomposers cause similar decomposition rates across a precipitation gradient	69
Cryo-EM structure of the CBC-ALYREF complex	69
N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters	68
Testing the ion-current model for flagellar length sensing and IFT regulation	68
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	68
Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study	68
Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling	67
Distractor effects in decision making are related to the individual’s style of integrating choice attributes	67
Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture	67
A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities	67
Diminishing neuronal acidification by channelrhodopsins with low proton conduction	67
A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development	66
A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell-derived cardiomyocytes	66
Contributions of associative and non-associative learning to the dynamics of defensive ethograms	66

Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	66
Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle	66
Body mass and growth rates predict protein intake across animals	65
Quantitative mapping of proteasome interactomes and substrates using ProteasomeID	65
Paraxial mesoderm organoids model development of human somites	65
Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier	65
Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A	64
The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice	64
The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons	64
Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts	64
Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans	64
Mouse B2 SINE elements function as IFN-inducible enhancers	64
Integrating analog and digital modes of gene expression at Arabidopsis FLC	64
Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2	64
A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex	63
Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX	63
Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification	63
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	63
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1	63
Adaptive biasing of action-selective cortical build-up activity by stimulus history	62
Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation	62
A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets	62
The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate	61
Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus	61
SIRT-1 is required for release of enveloped enteroviruses	61
Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’	61
Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer	61
Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis	60
The layered costs and benefits of translational redundancy	60
Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits	60
ARHGAP18-ezrin functions as an autoregulatory module for RhoA in the assembly of distinct actin-based structures	60
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	60
Aligned and oblique dynamics in recurrent neural networks	60
Gasotransmitter modulation of hypoglossal motoneuron activity	60
Neural interactions in the human frontal cortex dissociate reward and punishment learning	60
Nucleotide-level linkage of transcriptional elongation and polyadenylation	60
Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases	59
A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence	59
Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs	59
Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities	59
Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae	59
Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal	59
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys	59
WRNIP1 prevents transcription-associated genomic instability	58
Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice	58
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	58
Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system	58
Serotonergic amplification of odor-evoked neural responses maps onto flexible behavioral outcomes	58
Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment	58
Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records	57
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	57
Colicin E1 opens its hinge to plug TolC	57
Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury	57
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	57
Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes	57
A dynamic neural resource model bridges sensory and working memory	57
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	57
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	57
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	57
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	56
Evaluation of surface-based hippocampal registration using ground-truth subfield definitions	56
The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase	56
Habitat loss weakens the positive relationship between grassland plant richness and above-ground biomass	56
Sensitive remote homology search by local alignment of small positional embeddings from protein language models	56
Circuit mechanisms underlying embryonic retinal waves	56
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	56
Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model	56
Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank	56
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms	56
A unique cell division protein critical for the assembly of the bacterial divisome	55
Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana	55
A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury	55
Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells	55
Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia	55
A multisite validation of brain white matter pathways of resilience to chronic back pain	55
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	55
Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase	55
Sleep regularity and mortality: a prospective analysis in the UK Biobank	55
Distance and grid-like codes support the navigation of abstract social space in the human brain	54
Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production	54
A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia	54
Pectin methylesterase activity is required for RALF1 peptide signalling output	54
Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making	54
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	54
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity	54
Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons	54
Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila	54
Theoretical principles explain the structure of the insect head direction circuit	54
A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes	54
High-resolution kinetics of herbivore-induced plant volatile transfer reveal clocked response patterns in neighboring plants	54
Guanidine production by plant homoarginine-6-hydroxylases	54
LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling	54
Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes	54
Sub-cone visual resolution by active, adaptive sampling in the human foveola	54
Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity	54