eLife

Article	Citations
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants	1134
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3	826
A connectome and analysis of the adult Drosophila central brain	568
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants	555
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission	374
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset	300
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm	289
COVID-19 medical papers have fewer women first authors than expected	270
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm	263
How to measure and evaluate binding affinities	262
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics	260
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities	249
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2	244
Evidence for transmission of COVID-19 prior to symptom onset	241
DunedinPACE, a DNA methylation biomarker of the pace of aging	234
The connectome of the adult Drosophila mushroom body provides insights into function	222
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway	207
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?	204
An electrophysiological marker of arousal level in humans	198
DNA damage—how and why we age?	191
Antimicrobial resistance and COVID-19: Intersections and implications	190
Sampling alternative conformational states of transporters and receptors with AlphaFold2	185
A 10-year follow-up study of sex inclusion in the biological sciences	178
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane	176
Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products	174

Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy	167
The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy	166
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration	163
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study	163
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices	162
A whole-brain connectivity map of mouse insular cortex	162
Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner	159
Structure of the bacterial ribosome at 2 Å resolution	157
Sex differences in biological aging with a focus on human studies	154
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection	153
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation	151
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition	151
Accurate and versatile 3D segmentation of plant tissues at cellular resolution	151
Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture	148
Standardizing workflows in imaging transcriptomics with the abagen toolbox	145
Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis	144
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study	141
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types	141
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress	140
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell	138
Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq	138
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses	137
The OpenNeuro resource for sharing of neuroscience data	137
TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields	135
Beyond the RNA-dependent function of LncRNA genes	135
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment	133
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes	132
Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study	130
A single-cell survey of Drosophila blood	129
SpikeInterface, a unified framework for spike sorting	128
The genomic consequences of hybridization	128
Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events	128
Reporting and misreporting of sex differences in the biological sciences	126
SON and SRRM2 are essential for nuclear speckle formation	124
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes	123
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy	123
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains	123
An open label trial of anakinra to prevent respiratory failure in COVID-19	121
Mapping single-cell atlases throughout Metazoa unravels cell type evolution	121
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics	121
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens	118
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids	117
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation	117
Challenges for assessing replicability in preclinical cancer biology	114
Racial inequity in grant funding from the US National Institutes of Health	114
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population	113
An open-source, high-performance tool for automated sleep staging	112
Microglial calcium signaling is attuned to neuronal activity in awake mice	112
A community-maintained standard library of population genetic models	111
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation	110

Investigating the replicability of preclinical cancer biology	110
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site	110
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice	108
Training deep neural density estimators to identify mechanistic models of neural dynamics	108
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC	107
Dynamic metastable long-living droplets formed by sticker-spacer proteins	107
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals	107
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons	105
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance	105
Highly contiguous assemblies of 101 drosophilid genomes	104
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs	104
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning	104
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation	103
Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans	103
Patterns of within-host genetic diversity in SARS-CoV-2	101
Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols	101
Diverse viral proteases activate the NLRP1 inflammasome	100
Generation of vascularized brain organoids to study neurovascular interactions	100
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer	100
Hyperalignment: Modeling shared information encoded in idiosyncratic cortical topographies	99
EDF1 coordinates cellular responses to ribosome collisions	99
Ageing compromises mouse thymus function and remodels epithelial cell differentiation	99
Diversity and asynchrony in soil microbial communities stabilizes ecosystem functioning	99
A new genetic strategy for targeting microglia in development and disease	99
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth	98
Inhibition stabilization is a widespread property of cortical networks	98
The LOTUS initiative for open knowledge management in natural products research	97
An interactive meta-analysis of MRI biomarkers of myelin	97
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness	97
A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0	97
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women	95
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets	95
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice	94
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids	94
Real-time, low-latency closed-loop feedback using markerless posture tracking	93
Topographic gradients of intrinsic dynamics across neocortex	93
Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C	93
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds	93
Self-blinding citizen science to explore psychedelic microdosing	93
Temporal integration of auxin information for the regulation of patterning	92
Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?	92
Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples	91
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis	91
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator	90
Information flow, cell types and stereotypy in a full olfactory connectome	90
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent	90
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection	90
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning	90
The diversity and function of sourdough starter microbiomes	88
An ER translocon for multi-pass membrane protein biogenesis	87
Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence	87
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth	86
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time	86
Efficient targeted integration directed by short homology in zebrafish and mammalian cells	86
Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)	85
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement	85
Small molecule cognitive enhancer reverses age-related memory decline in mice	85
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness	85
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence	85
A cell atlas of the chick retina based on single-cell transcriptomics	84
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance	83
Structural basis for SARM1 inhibition and activation under energetic stress	83
How many neurons are sufficient for perception of cortical activity?	83
Virtual conferences raise standards for accessibility and interactions	83
A quantitative inventory of yeast P body proteins reveals principles of composition and specificity	83
Single nuclei RNA-seq of mouse placental labyrinth development	83
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs	83
Standardized and reproducible measurement of decision-making in mice	82
A taxonomy of seizure dynamotypes	81
FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences	81
A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs	81
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background	80
TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs	80
DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels	80
How subtle changes in 3D structure can create large changes in transcription	80
Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways	80
Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage	79
The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline	79
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models	79
Plasma proteomic biomarker signature of age predicts health and life span	79

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy	79
Bmal1 integrates mitochondrial metabolism and macrophage activation	78
True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field	78
Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis	78
The architecture of EMC reveals a path for membrane protein insertion	78
The frequency gradient of human resting-state brain oscillations follows cortical hierarchies	78
Genetic mapping of etiologic brain cell types for obesity	78
COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest	77
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming	77
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis	77
Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)	77
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates	77
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage	77
GENESPACE tracks regions of interest and gene copy number variation across multiple genomes	77
Dynamics of gaze control during prey capture in freely moving mice	77
TMEM95 is a sperm membrane protein essential for mammalian fertilization	77
Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change	77
Visualizing anatomically registered data with brainrender	76
HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells	76
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e	76
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion	76
A transcriptomic taxonomy of Drosophila circadian neurons around the clock	76
Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization	76
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing	75
A Bayesian and efficient observer model explains concurrent attractive and repulsive history biases in visual perception	75
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation	75
An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes	74
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks	74
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex	73
Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox	73
AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions	73
Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes	73
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling	73
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation	73
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic	73
Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii	73
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation	72
Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli	72
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons	72
The unlimited potential of the great pond snail, Lymnaea stagnalis	72
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat	72
A visual pathway for skylight polarization processing in Drosophila	72
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila	72
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism	72
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3	71
Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations	71
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia	71
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo	71
Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates	71
Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes	71
Structural basis of mitochondrial translation	71
Performance of a deep learning based neural network in the selection of human blastocysts for implantation	70
Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation	70
Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees	70
SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters	70
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response	70
Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair	69
A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors	69
Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay	69
Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions	69
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection	69
Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015	68
Remyelination alters the pattern of myelin in the cerebral cortex	68
Freshwater monitoring by nanopore sequencing	68
Hippocampal remapping as hidden state inference	68
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo	68
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans	68
Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making	68
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice	67
Demographic history mediates the effect of stratification on polygenic scores	67
Functional specialization within the inferior parietal lobes across cognitive domains	67
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation	67
Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3	67
A modular platform for automated cryo-FIB workflows	67
The brain in motion: How ensemble fluidity drives memory-updating and flexibility	67
Neurovascular coupling and bilateral connectivity during NREM and REM sleep	66
Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration	66
Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)	66
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination	66
Bidirectional synaptic plasticity rapidly modifies hippocampal representations	66
Early analysis of the Australian COVID-19 epidemic	66
Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis	65
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics	65
Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila	65
Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures	65
Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy	64
Charting brain growth and aging at high spatial precision	64
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients	64
Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior	64
Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state	64
Predicting geographic location from genetic variation with deep neural networks	64
Respiration aligns perception with neural excitability	64
The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions	63
Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications	63
Stable task information from an unstable neural population	63