OOIR: Observatory of International Research

Papers

(The TQCC of BMC Pharmacology & Toxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats	44
Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression	43
In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria	39
Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats	35
Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis	30
Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis	29
High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines	28
Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence	26
A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia	22
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis	20
Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole	20
Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days	19
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia	19
18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice	19
Adverse event profiles of dipeptidyl peptidase-4 inhibitors: data mining of the public version of the FDA adverse event reporting system	19
Safety of natural anthraquinone emodin: an assessment in mice	18
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma	18
Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells	18
Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock	18
Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method	18
Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis	17
Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis	17
Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients	17
Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence	16
Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model	15

A protein interaction map identifies existing drugs targeting SARS-CoV-2	15
Furosemide and spironolactone doses and hyponatremia in patients with heart failure	14
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment	14
The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line	14
Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells	14
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice	13
Oritavancin for the treatment of complicated gram-positive infection in persons who inject drugs	13
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test	13
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β	12
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile	12
Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib	12
The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT)	12
Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway	12
Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells	11
Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid	11
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model	11
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer	11
Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies	11
Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model	10
Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial	10
Transcriptome investigation of anti‐inflammation and immuno‐regulation mechanism of taurochenodeoxycholic acid	10
Effects of coal-fired PM2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE−/− mice	10
Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity	10
Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats	10
Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease	10
The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice	10
Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells	10
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study	10
Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Ira	9
Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells	9
Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases	9
Efficacy and safety of bempedoic acid alone or combining with other lipid-lowering therapies in hypercholesterolemic patients: a meta-analysis of randomized controlled trials	9
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma	9
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro	9
The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study	9
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs	9
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression	9
Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway	9
Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874	8
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	8
Epidemiology, clinical presentation, treatment, and follow‐up of chronic mercury poisoning in China: a retrospective analysis	8
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	8
Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine	8
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects	8
Profile and outcomes of acute poisoning in the toxicology treatment and control center at Tanta University Hospital, Egypt	7
Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS)	7
5-Hydroxytryptamine-3 receptor antagonist and dexamethasone as prophylaxis for chemotherapy-induced nausea and vomiting during moderately emetic chemotherapy for solid tumors: a multicenter, prospecti	7
The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism	7
Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study	7
Effect of aerosolized nicotine on human bronchial epithelial cells is amplified after co-administration with cannabidiol (CBD): a pilot in vitro study	7

The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats	7
Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate	7
Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure	7
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	6
Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression	6
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs	6
The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation	6
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	6
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling	6
Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway	6
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	6
Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells	6
Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin	6
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19	6
The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication	6
Long-term low-dose exposure of permethrin induces liver and kidney damage in rats	6
Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells	6
Electrolytes supplementation can decrease the risk of nephrotoxicity in patients with solid tumors undergoing chemotherapy with cisplatin	6