OOIR: Observatory of International Research

Papers

(The TQCC of BMC Pharmacology & Toxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing	44
Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway	34
Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats	30
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson’s disease model	30
The therapeutic role of naringenin nanoparticles on hepatocellular carcinoma	29
L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis	27
Appropriate use of triazolam in elderly patients considering a quantitative benefit-risk assessment based on the pharmacokinetic-pharmacodynamic modeling and simulation approach supported by real-worl	27
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity	26
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis	26
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	25
Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats	23
Conditioned medium from human adipose-derived mesenchymal stem cells attenuates cardiac injury induced by Movento in male rats: role of oxidative stress and inflammation	23
Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure	22
Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial	21
A real-world disproportionality analysis of the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) events for Durvalumab	21
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy	19
In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation	18
Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice	18
The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice	18
WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka	17
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells	17
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway	17
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol	16
Real-world safety analysis of deutetrabenazine post-marketing: a disproportionality study leveraging the FDA Adverse Event Reporting System (FAERS) database	16
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model	16

Safety analysis of romiplostim, eltrombopag, and avatrombopag post-market approval: a pharmacovigilance study based on the FDA Adverse Event Reporting System	16
Oxidative stress and anti-oxidant status in children with sepsis	16
Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022	15
Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway	15
A phase I study comparing the biosimilarity of the pharmacokinetics and safety of recombinant humanized anti-vascular endothelial growth factor monoclonal antibody injection with Avastin® in healthy C	15
The risk of hyponatremia induced by SSRIs and SNRIs antidepressants: a systematic review and meta-analysis	14
Safety assessment of asenapine in the FAERS database: real adverse event analysis and discussion on neurological and psychiatric side effects	14
Development and validation of simple colorimetric methods for assessing norfloxacin in pure form, in pharmaceutical products and in biological material	14
Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity	14
Acute, sub-acute and developmental toxicity studies of molybdenum disulfide nanoflowers in rats, as per OECD guidelines	14
Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination	14
Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways	13
Effect of renin angiotensin blockers on angiotensin converting enzyme 2 level in cardiovascular patients	13
Development of nanospray loaded with ciclopirox for dermal fungus treatment: determination of pro-inflammatory interleukin IL-2 mRNA expression	13
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats	12
Risk factors for gastrointestinal complications during glucocorticoid therapy in internal medicine inpatients: a real-world retrospective analysis	12
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation	12
Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients	12
Can quercetin reduce arsenic induced toxicity in mouse BALB/c 3T3 fibroblast cells? A study involving in vitro, molecular docking, and ADME predictions	12
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	12
Epoetin alfa has a potent anxiolytic effect on naive female rats	12
Co-treatment of β-carotene with acetamiprid provides protection against acetamiprid induced hepatic and renal toxicity via modulation of the antioxidant system	12
Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm	12
Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder	11
Comparative analysis of safety and efficacy between brand and generic lamotrigine products in the Saudi market	11
Host microbiome associated low intestinal acetate correlates with progressive NLRP3-dependent hepatic-immunotoxicity in early life microcystin-LR exposure	11
The subchronic toxicity of higher olefins in Han Wistar rats	11
A disproportionality analysis of real-world events from the FDA Adverse Event Reporting System (FAERS) for Atezolizumab	11
Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover	11
Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese	11
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs	10
Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin	10
Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice	10
The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials	10
Stratified analysis of the association between anti-obesity medications and digestive adverse events: a real-world study based on the FDA adverse event reporting system database	10
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells	10
Retraction Note: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats	10
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model	10
High dose and hepatobiliary dysfunction are associated with hand-foot syndrome in patients with lymphoma using pegylated liposomal doxorubicin: a retrospective study	10
Neuroprotective effects of berberine in preclinical models of ischemic stroke: a systematic review	10
Eco-friendly green synthesis of silver nanoparticles from guajava leaves extract for controlling organophosphorus pesticides hazards, characterization, and in-vivo toxicity assessment	10
Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis	10
A disproportionality analysis of adverse events associated with loop diuretics in the FDA Adverse Event Reporting System (FAERS)	9
Potential antiviral peptides targeting the SARS-CoV-2 spike protein	9
Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects	9
NSAIDs, analgesics, antiplatelet drugs, and decline in renal function: a retrospective case-control study with SIDIAP database	9
Extracellular vesicle therapy for acute pancreatitis: experimental validation of mesenchymal stem cell-derived nanovesicles	9
Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor	9
Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan	9
Adverse events associated with IL-23 and IL-12/23 inhibitors in the clinical management of psoriasis: a comprehensive pharmacovigilance analysis	9

Investigation of the protective effects of dichloroacetic acid in a rat model of diabetic neuropathy	9
Pulrodemstat, a selective inhibitor of KDM1A, suppresses head and neck squamous cell carcinoma growth by triggering apoptosis	9
Informal sale of antibiotics in Guatemalan convenience stores before and after implementation of federal antibiotic dispensing legislation	8
Synergistic modulation of endoplasmic reticulum stress pathway, oxidative DNA damage and apoptosis by β-amyrin and metformin in mitigating hyperglycemia-induced renal damage using adult zebrafish mode	8
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	8
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs	8
Treatment for Covid-19 with SARS-CoV-2 neutralizing antibody BRII-196(Ambavirumab) plus BRII-198(Lomisivir): a retrospective cohort study	8
Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification	8
Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model	8
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells	8
Ameliorative effects of agomelatine against doxorubicin-induced hepatotoxicity	7
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β	7
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers	7
Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study	7
Retraction Note: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout	7
The efficacy and safety of belzutifan inhibitor in patients with advanced or metastatic clear cell renal cell carcinoma: a meta-analysis	7
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	7
Immunomodulatory effects of detoxification agents on dendritic cell populations in methamphetamine addiction	7
Toxicology study of a tissue anchoring paclitaxel prodrug	7
Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital	7
Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2	7
Intratympanic N-acetylcysteine in the prevention of cisplatin-induced ototoxicity: a systematic review and meta-analysis of randomized controlled trials	7
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation	7
Efficacy of daily versus alternate day oral iron supplementation for management of anaemia among general population: a systematic review and meta-analysis	6
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression	6
Comparison of the prophylactic effect of cefazolin injection versus oral levofloxacin as prophylactic antibiotic in TURP surgery: a randomized clinical trial	6
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	6
Safety, pharmacokinetics, preliminary efficacy, pharmacodynamics, and immunogenicity of QX002N, an anti-IL-17A monoclonal antibody, after short-term treatment of active ankylosing spondylitis	6
Protective effects of Alamandine against doxorubicin-induced liver injury in rats	6
A novel nitidine chloride nanoparticle overcomes the stemness of CD133+EPCAM+ Huh7 hepatocellular carcinoma cells for liver cancer therapy	6
Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation	6
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells	6
Identification and solution of drug-related problems in the neurology unit of a tertiary hospital in China	6
The effectiveness of pregabalin with or without agomelatine in the treatment of chronic low back pain: a double-blind, placebo-controlled, randomized clinical trial	6
Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study	6
Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance	6
Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model	6
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells	6
The effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial	6
Efficacy and safety of a B-cell-driven rituximab regimen for the treatment of refractory idiopathic membranous nephropathy	6
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	6
Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible	6
Correction: Modified diatom-based ocular suspension for sustained diclofenac sodium delivery: a novel drug carrier approach	6
Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats	6