OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacology Research & Perspectives is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Issue Information	100
Pharmacogenomics Education and Knowledge Assessment in Healthcare Curricula: A Scoping Review of the Middle East and North Africa Region	91
Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a₁ receptor) antagonist	59
Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care	47
FDA regulatory considerations for oncology drug development	33
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus	32
Cross‐modal embedding integrator for disease‐gene/protein association prediction using a multi‐head attention mechanism	30
A549 Alveolar Carcinoma Spheroids as a Cytotoxicity Platform for Carboxyl‐ and Amine‐Polyethylene Glycol Gold Nanoparticles	28
The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration	27
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics	25
Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance	23
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	23
Corrigendum	22
The blockade of the TGF‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity	21
Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation	21
	21
Patient safety in home care: A multicenter cross‐sectional study about medication errors and medication management of nurses	21
Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants	19
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [¹⁴C] encor	19
	19
Highlights of basic and clinical pharmacology from Africa	19
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues	19
Jordanian community pharmacists' perceptions and experiences with continuing professional development – A comprehensive analysis	18
Comparative Efficacy of Different Targeted Therapies in Patients With Moderate‐to‐Severe Ulcerative Colitis: Systematic Review/Network Meta‐Analysis and Mechanistic Overview	18
The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele‐Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma R	18

	17
Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross‐Sectional Study	17
Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus	17
Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor	17
CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation	16
Antioxidant potential of chlorogenic acid in Age‐Related eye diseases	16
Impact of a computerized physician order entry system on medication safety in pediatrics—The AVOID study	16
Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights	16
Hearing loss: The final frontier of pharmacology	16
The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial	15
Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials	15
	15
Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats	15
Deciphering the Language of Assessment in Pharmacology Summative Written Assessments	15
Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice	14
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients	14
Introducing a Professional Development Skill Building Platform Into a Biomedical Sciences Graduate Program Curriculum in Pharmacology	14
	14
Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low‐toxic DNA staining dye	14
Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics	13
Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes	13
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study	13
Information overdose: Student performance and perceptions of pharmacology resources on exams	12
Not first‐line antihypertensive agents, but still effective—The efficacy and safety of imidazoline receptor agonists: A network meta‐analysis	12
The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [¹⁴C]Binimetinib 45 mg in Healthy Male Participants	12
The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload	12
The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety‐Like Behaviors in Rats	12
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity	11
Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells	11
Role of G protein‐coupled receptor kinases (GRKs) in β₂‐adrenoceptor‐mediated glucose uptake	11
A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics	11
Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin‐associated proteins	11
Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial	11
Concurrent Prescribing of Opioids and Sedative‐Hypnotic Drugs for Long‐Term Use in Australian General Practice: A Cross‐Sectional Analysis Using MedicineInsight	11
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions	10
Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice	10
Accounting for Time‐Varying Confounding in a Self‐Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen‐Related Events	10
Exploring Australian pharmacists' views toward reducing the risk of medicines‐related harm in aged care residents	10
Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A_2A and A_2B receptor agonists	10
Issue Information	10
Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring	10
Massive presence of off‐label medicines in Danish neonatal departments: A nationwide survey using national hospital purchase data	10
Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants	10
Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study	10
Issue Information	10
Involvement of Piezo 1 mechanoceptors in vascular stiffness in isolated small resistance arteries of male and female Dahl salt‐sensitive hypertensive rats	9
Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women	9
	9
Effect of cyclosporin A on respiratory viral replication in fully differentiated ex vivo human airway epithelia	9
Trends in Lipid‐Lowering Agent Consumption in Croatia: A 25‐Year Observational Study	9

Cannabinoid‐Induced Hyperphagia is Mediated by Increased Meal Frequency and the Orexin‐1 Receptor in Male Rats	9
Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism	9
Pharmacist intervention to improve adherence to medication among heart failure patients at North East Ethiopia hospital	9
Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID‐19: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials	9
Upadacitinib‐Induced Hemolysis in a Patient With Glucose‐6‐Phosphate Dehydrogenase Deficiency—A Possible Adverse Drug Reaction	8
Opioid and analgesic utilization in Ireland in 2000 and 2015: A repeated cross‐sectional study	8
Pharmacology Research & Perspectives: A Decade of Progress	8
Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients	8
In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether	8
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial	8
Evidence‐based safety profile of oral ketorolac in adults: Systematic review and meta‐analysis	8
Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic,	8
Comparison of the mathematical equation and trapezoidal approach for 24 h area under the plasma concentration‐time curve calculation in patients who received intravenous vancomycin in an acute care se	8
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed‐dose combination tablets versus the use of single‐component tablets in healthy subjects	7
Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats	7
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells	7
Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects	7
Absorption, metabolism, and excretion of [¹⁴C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers	7
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes	7
Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase	7
Critical insights to COVID‐19 disease and potential treatments using a systems analysis approach that integrates physiology, pharmacology, and clinical pharmacology	7
The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases	7
The Use of Proton Pump Inhibitors Among Adults in Norway—A Nationwide Drug Utilization Study	7
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes,	7
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers	7
The N‐Acetyltransferase 2 Polymorphism and Susceptibility to Inflammatory Bowel Disease: A Case–Control Study	7
Corrigendum	7
The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment	7
Team‐Based Learning in the Meta Horizon Workroom: A Pilot Study on Its Potential Effectiveness for Pharmacology Teaching	7
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis	7
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	6
Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer	6
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database	6
Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue	6
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate	6
Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways	6
New insights into the role of melatonin in diabetic cardiomyopathy	6
Telmisartan and losartan: The marked differences between their chemical and pharmacological properties may explain the difference in therapeutic efficacy in hospitalized patients with COVID‐19	6
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease	6
Aromatase Inhibitors and Dementia Risk: Putting Safety Into Perspective	6
Supporting Pediatric RSV Clinical Trials Through Close Epidemiological Surveillance During the SARS‐CoV‐2 Pandemic	6
From Psychiatry to Oncology: Exploring the Anti‐Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment	6
A humanized anti‐cocaine mAb antagonizes the cardiovascular effects of cocaine in rats	6
Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats	6
Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model	6
Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor	5
Pharmacology and Regulation of Appetite and Food Intake	5
	5
The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker	5
NMDA Receptor–Mediated Ca²⁺ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin	5
A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra‐Long‐Acting β₂‐Agonists Used for Asthma and COPD	5
Co‐created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus	5
The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies	5
Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse	5
	5
Evaluation and optimization of sample size of neonates and infants for pediatric clinical studies on cefiderocol using a model‐based approach	5
Cognitive and negative symptoms in schizophrenia with L‐Carnosine adjuvant therapy – A randomized double‐blind placebo‐controlled study	5
Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans	5
Metopimazine is primarily metabolized by a liver amidase in humans	5
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants	5
A Randomized, Open‐Label, Single‐Dose, Parallel‐Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia	5
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease	5
Effectiveness of edaravone in preventing contrast‐induced nephropathy in high‐risk patients undergoing coronary angiography: A randomized, double‐blind trial	5
The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	5
Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring	5
Reflections on the Core Concepts of Physiology and Pharmacology	5
Asciminib, a novel allosteric inhibitor of BCR‐ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance	5
A Clinical Practice‐Based Comparison of Conventional and Individualized Dosing Strategies for Therapeutic Enoxaparin	5
Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?	5
HDAC4/5 Inhibitor, LMK‐235 Improves Animal Voluntary Movement in MPTP‐Induced Parkinson's Disease Model	5
Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool	5
Association of Pharmacologic Markers of Anti‐Tumor Necrosis Factor‐α Activity and Etanercept Effectiveness in Juvenile Idiopathic Arthritis	5
Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease	5
The endocannabinoid system in appetite regulation and treatment of obesity	5
	5
Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System	5