Pharmacology Research & Perspectives

Article	Citations
Pharmacogenomics Education and Knowledge Assessment in Healthcare Curricula: A Scoping Review of the Middle East and North Africa Region	111
	96
Histamine in cancer immunology and immunotherapy. Current status and new perspectives	85
Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study	57
A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants	51
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysis	48
Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation	42
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions	33
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	31
Patient safety in home care: A multicenter cross‐sectional study about medication errors and medication management of nurses	30
Corrigendum	30
The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration	28
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics	27
Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance	24
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues	23
The blockade of the TGF‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity	22
Issue Information	21
Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care	20
Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist	19
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus	19
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A549 Alveolar Carcinoma Spheroids as a Cytotoxicity Platform for Carboxyl‐ and Amine‐Polyethylene Glycol Gold Nanoparticles	18
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Cross‐modal embedding integrator for disease‐gene/protein association prediction using a multi‐head attention mechanism	18
FDA regulatory considerations for oncology drug development	18

Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation	18
Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross‐Sectional Study	17
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons	16
Highlights of basic and clinical pharmacology from Africa	16
CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation	16
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [14C] encor	16
Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals	16
Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants	16
Antioxidant potential of chlorogenic acid in Age‐Related eye diseases	15
Hearing loss: The final frontier of pharmacology	15
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study	15
Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights	15
Jordanian community pharmacists' perceptions and experiences with continuing professional development – A comprehensive analysis	15
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Comparative Efficacy of Different Targeted Therapies in Patients With Moderate‐to‐Severe Ulcerative Colitis: Systematic Review/Network Meta‐Analysis and Mechanistic Overview	15
Impact of a computerized physician order entry system on medication safety in pediatrics—The AVOID study	15
The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele‐Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma R	15
Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes	15
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The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial	14
Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials	14
Lumbriculus variegatus: A novel organism for in vivo pharmacology education	14
Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low‐toxic DNA staining dye	14
Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics	14
Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice	14
Polypharmacy and mortality association by chronic kidney disease status: The REasons for Geographic And Racial Differences in Stroke Study	14
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients	14
Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats	14
A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics	14
Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice	14
Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells	13
Issue Information	13
Exploring Australian pharmacists' views toward reducing the risk of medicines‐related harm in aged care residents	13
Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring	13
Information overdose: Student performance and perceptions of pharmacology resources on exams	13
The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety‐Like Behaviors in Rats	12
Concurrent Prescribing of Opioids and Sedative‐Hypnotic Drugs for Long‐Term Use in Australian General Practice: A Cross‐Sectional Analysis Using MedicineInsight	12
Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants	12
The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [14C]Binimetinib 45 mg in Healthy Male Participants	12
Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial	12
Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake	11
The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload	11
Accounting for Time‐Varying Confounding in a Self‐Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen‐Related Events	11
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity	11
Not first‐line antihypertensive agents, but still effective—The efficacy and safety of imidazoline receptor agonists: A network meta‐analysis	11
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions	11
Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study	10
Opioid and analgesic utilization in Ireland in 2000 and 2015: A repeated cross‐sectional study	10
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial	10
Upadacitinib‐Induced Hemolysis in a Patient With Glucose‐6‐Phosphate Dehydrogenase Deficiency—A Possible Adverse Drug Reaction	10

Massive presence of off‐label medicines in Danish neonatal departments: A nationwide survey using national hospital purchase data	10
Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients	10
Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin‐associated proteins	10
EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers	10
Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists	10
Issue Information	10
Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism	9
Pharmacology Research & Perspectives: A Decade of Progress	9
Issue Information	9
Effect of cyclosporin A on respiratory viral replication in fully differentiated ex vivo human airway epithelia	9
Trends in Lipid‐Lowering Agent Consumption in Croatia: A 25‐Year Observational Study	9
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes	9
Pharmacist intervention to improve adherence to medication among heart failure patients at North East Ethiopia hospital	9
Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers	9
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Evidence‐based safety profile of oral ketorolac in adults: Systematic review and meta‐analysis	9
Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID‐19: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials	9
Comparison of the mathematical equation and trapezoidal approach for 24 h area under the plasma concentration‐time curve calculation in patients who received intravenous vancomycin in an acute care se	9
Involvement of Piezo 1 mechanoceptors in vascular stiffness in isolated small resistance arteries of male and female Dahl salt‐sensitive hypertensive rats	9
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers	9
Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women	9
Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers	8
Corrigendum	8
In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether	8
Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats	8
The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment	8
Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase	8
Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue	8
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed‐dose combination tablets versus the use of single‐component tablets in healthy subjects	8
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells	8
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia	8
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes,	8
Critical insights to COVID‐19 disease and potential treatments using a systems analysis approach that integrates physiology, pharmacology, and clinical pharmacology	8
The N‐Acetyltransferase 2 Polymorphism and Susceptibility to Inflammatory Bowel Disease: A Case–Control Study	8
Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats	7
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database	7
From Psychiatry to Oncology: Exploring the Anti‐Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment	7
Telmisartan and losartan: The marked differences between their chemical and pharmacological properties may explain the difference in therapeutic efficacy in hospitalized patients with COVID‐19	7
New insights into the role of melatonin in diabetic cardiomyopathy	7
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis	7
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate	7
Aromatase Inhibitors and Dementia Risk: Putting Safety Into Perspective	7
Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer	7
Effects of sevoflurane and adenosine receptor antagonist on the sugammadex‐induced recovery from rocuronium‐induced neuromuscular blockade in rodent phrenic nerve–hemidiaphragm tissue specimens	7
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	7
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease	7
Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model	7
Supporting Pediatric RSV Clinical Trials Through Close Epidemiological Surveillance During the SARS‐CoV‐2 Pandemic	7
A humanized anti‐cocaine mAb antagonizes the cardiovascular effects of cocaine in rats	7
Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β‐hydroxycortisol/cortisol	7
Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways	7
Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring	6
A Clinical Practice‐Based Comparison of Conventional and Individualized Dosing Strategies for Therapeutic Enoxaparin	6
Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse	6
The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	6
Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor	6
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Cognitive and negative symptoms in schizophrenia with L‐Carnosine adjuvant therapy – A randomized double‐blind placebo‐controlled study	6
The endocannabinoid system in appetite regulation and treatment of obesity	6
The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies	6
Evaluation and optimization of sample size of neonates and infants for pediatric clinical studies on cefiderocol using a model‐based approach	6
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Asciminib, a novel allosteric inhibitor of BCR‐ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance	6
Effectiveness of edaravone in preventing contrast‐induced nephropathy in high‐risk patients undergoing coronary angiography: A randomized, double‐blind trial	6
Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System	6
Jadomycins: A potential chemotherapy for multi‐drug resistant metastatic breast cancer	6
Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans	6
Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool	5
HDAC4/5 Inhibitor, LMK‐235 Improves Animal Voluntary Movement in MPTP‐Induced Parkinson's Disease Model	5
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants	5
The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker	5
Enhancing Student Comprehension of Glucose Metabolism Visualization Through Virtual Simulation Platform: An Educational Approach	5
Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4‐chloro‐2‐[2‐(2‐chloro‐phenoxy)‐acetylamino]‐benzoic acid	5
Distinct atrial remodeling in patients with subclinical atrial fibrillation: Lessons from computed tomographic images	5
Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis	5
Metopimazine is primarily metabolized by a liver amidase in humans	5
NMDA Receptor–Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin	5
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Co‐created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus	5
The influence of SARS‐CoV‐2 infection on expression of drug‐metabolizing enzymes and transporters in a hACE2 murine model	5

Preclinical anti‐angiogenic and anti‐cancer activities of BAY1143269 in glioblastoma via targeting oncogenic protein expression	5
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Management of pharmacovigilance during the COVID‐19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the EU DisCoVeRy clinical	5
Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways	5
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease	5
Reflections on the Core Concepts of Physiology and Pharmacology	5
Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?	5
Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency	5
Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor‐dependent contractions of guinea pig gastric fundus smooth muscle	5
Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects	5
Utility of salivary mycophenolic acid concentration monitoring: Modeling and Monte Carlo validation approach	5