Pharmacology Research & Perspectives

Article	Citations
Diversity of molecular targets and signaling pathways for CBD	126
Molnupiravir: A new candidate for COVID‐19 treatment	73
“LONG COVID”—A hypothesis for understanding the biological basis and pharmacological treatment strategy	68
Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double‐blind, controlled trial	63
Drug discovery: Insights from the invertebrate Caenorhabditis elegans	48
Nucleotide analogues as inhibitors of SARS‐CoV Polymerase	40
Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent	37
The antimicrobial effect behind Cannabis sativa	37
Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy	37
Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature	33
Gut bacterial microbiome composition and statin intake—A systematic review	32
Strategies to apply 3Rs in preclinical testing	31
Spermidine and spermine exert protective effects within the lung	29
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19	28
The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D‐adrenoceptors	28
Drug‐drug interactions with candidate medications used for COVID‐19 treatment: An overview	27
Adverse pregnancy outcomes associated with first‐trimester exposure to angiotensin‐converting enzyme inhibitors or angiotensin II receptor blockers: A systematic review and meta‐analysis	26
Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology	26
The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment	24
Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract	24
Identification of the metabolites of ivermectin in humans	23
Inter‐ethnic differences in pharmacokinetics—is there more that unites than divides?	23
Drug interactions with apixaban: A systematic review of the literature and an analysis of VigiBase, the World Health Organization database of spontaneous safety reports	22
Histamine in cancer immunology and immunotherapy. Current status and new perspectives	22
Climate change in healthcare: Exploring the potential role of inhaler prescribing	22

CCN5 activation by free or encapsulated EGCG is required to render triple‐negative breast cancer cell viability and tumor progression	22
An overview of diagnosis and management of drug‐induced hypomagnesemia	22
Polypharmacy, potentially serious clinically relevant drug‐drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life	22
The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial	21
Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next‐generation HIV‐1 maturation inhibitor	21
Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID‐19 and response to treatment	20
The cerebrovascular response to norepinephrine: A scoping systematic review of the animal and human literature	20
Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autor	19
Unraveling the complexity of therapeutic drug monitoring for monoclonal antibody therapies to individualize dose in oncology	19
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8	19
Gut microbiota disorder caused by diterpenoids extracted from Euphorbia pekinensis aggravates intestinal mucosal damage	18
Pros and cons for statins use and risk of Parkinson's disease: An updated perspective	18
A systematic review and meta‐analysis of the use of renin‐angiotensin system drugs and COVID‐19 clinical outcomes: What is the evidence so far?	18
The therapeutic effects of naringenin on bronchial pneumonia in children	17
Alleviation of cisplatin‐induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase‐3 activity	17
An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data	17
Evaluation of claims‐based computable phenotypes to identify heart failure patients with preserved ejection fraction	17
Development of a machine learning algorithm for early detection of opioid use disorder	17
Relevance of physicochemical properties and functional pharmacology data to predict the clinical safety profile of direct oral anticoagulants	16
Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?	16
Protective effect of baicalin against pulmonary arterial hypertension vascular remodeling through regulation of TNF‐α signaling pathway	16
Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation	16
Circ_0001821 knockdown suppresses growth, metastasis, and TAX resistance of non‐small‐cell lung cancer cells by regulating the miR‐526b‐5p/GRK5 axis	16
The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs	16
Design of a foundational sciences curriculum: Applying the ICAP framework to pharmacology education in integrated medical curricula	16
Drp1‐dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia	15
Mechanistic insights into antiretroviral drug‐induced liver injury	15
p‐cymene impairs SARS‐CoV‐2 and Influenza A (H1N1) viral replication: In silico predicted interaction with SARS‐CoV‐2 nucleocapsid protein and H1N1 nucleoprotein	15
Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID‐19 patients	15
Impact of CYP2C19, CYP3A4, ABCB1, and FMO3 genotypes on plasma voriconazole in Thai patients with invasive fungal infections	15
Long‐term benzodiazepines and z‐drug prescribing in Australian general practice between 2011 and 2018: A national study	14
Defining and unpacking the core concepts of pharmacology education	14
Hearing loss: The final frontier of pharmacology	14
Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers	14
Do proton pump inhibitors increase mortality? A systematic review and in‐depth analysis of the evidence	14
Protective effect of tolvaptan against cyclophosphamide‐induced nephrotoxicity in rat models	14
In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel	14
Addressing opioid tolerance and opioid‐induced hypersensitivity: Recent developments and future therapeutic strategies	14
Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation	13
Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract	13
Carrageenan nasal spray may double the rate of recovery from coronavirus and influenza virus infections: Re‐analysis of randomized trial data	13
Tolvaptan add‐on therapy in patients with acute heart failure: A systematic review and meta‐analysis	13
Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID‐19	13
Dexmedetomidine ameliorates high‐fat diet‐induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice	13
Physicochemical analysis and biological characterization of FKB327 as a biosimilar to adalimumab	13
Risk of genital and urinary tract infections associated with SGLT‐2 inhibitors as an add‐on therapy to metformin in patients with type 2 diabetes mellitus: A retrospective cohort study in Korea	12
Recombinant botulinum neurotoxin serotype A1 in vivo characterization	12
Cannabidiol‐mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage	12
Endothelium‐derived dopamine modulates EFS‐induced contractions of human umbilical vessels	12
The contribution of nano‐based strategies in overcoming ceftriaxone resistance: a literature review	12

The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19	12
Identifying the core concepts of pharmacology education	12
Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS‐1 (832/3) cell glucose‐stimulated insulin secretion	12
The 5‐HT2C receptor as a therapeutic target for alcohol and methamphetamine use disorders: A pilot study in treatment‐seeking individuals	12
Spinal glial cells in itch modulation	11
Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology	11
SMTP‐44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti‐inflammatory activities	11
ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer	11
Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice	11
Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 dono	11
Drug repurposing strategies of relevance for Parkinson’s disease	11
Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic	10
Characterization of T‐DM1‐resistant breast cancer cells	10
Medication‐related problems and adverse drug reactions in Ethiopia: A systematic review	10
Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population‐based assessment	10
Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox	10
Caffeine preserves quiet sleep in preterm neonates	10
The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors	10
Nonsteroidal anti‐inflammatory drugs in acute viral respiratory tract infections: An updated systematic review	10
Poloxamer 188 Protects Isolated Adult Mouse Cardiomyocytes from Reoxygenation Injury	10
Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel disease	10
The metabolic effects of mirabegron are mediated primarily by β3‐adrenoceptors	10
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	10
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysis	10
An analysis of the trends, characteristics, scope, and performance of the Zimbabwean pharmacovigilance reporting scheme	10
The effect of Fingolimod on patients with moderate to severe COVID‐19	10
The signaling and selectivity of α‐adrenoceptor agonists for the human α2A, α2B and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	10
Long noncoding RNA highly upregulated in liver cancer promotes the progression of hepatocellular carcinoma and attenuates the chemosensitivity of oxaliplatin by regulating miR‐383‐5p/vesicle‐associate	10
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP	10
Chronic everolimus treatment of high‐fat diet mice leads to a reduction in obesity but impaired glucose tolerance	9
ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain	9
No relation between docetaxel administration route and high‐grade diarrhea incidence	9
Impact of polymorphisms of pharmacokinetics‐related genes and the inflammatory response on the metabolism of voriconazole	9
Declines and pronounced regional disparities in meperidine use in the United States	9
Effects of omecamtiv mecarbil on calcium‐transients and contractility in a translational canine myocyte model	9
Self‐medication among pregnant women attending outpatients' clinics in northern Jordan‐a cross‐sectional study	9
Nuances to precision dosing strategies of targeted cancer medicines	9
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	9
Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes	9
Bridging the gap: Can International Consortium of Health Outcomes Measurement standard sets align outcomes accepted for regulatory and health technology assessment decision‐making of oncology medicine	9
Side‐effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta‐analysis of randomized controlled trials	9
Upregulated UCA1 contributes to oxaliplatin resistance of hepatocellular carcinoma through inhibition of miR‐138‐5p and activation of AKT/mTOR signaling pathway	9
Alignment between outcomes and minimal clinically important differences in the Dutch type 2 diabetes mellitus guideline and healthcare professionals’ preferences	9
New insights into the role of melatonin in diabetic cardiomyopathy	9
Synthesis, in vitro bioassays, and computational study of heteroaryl nitazoxanide analogs	9
Nicorandil inhibits cardiomyocyte apoptosis and improves cardiac function by suppressing the HtrA2/XIAP/PARP signaling after coronary microembolization in rats	9
Anticancer effects of myricetin derivatives in non‐small cell lung cancer in vitro and in vivo	9
The relationship between vancomycin AUC/MIC and trough concentration, age, dose, renal function in Chinese critically ill pediatric patients	8
Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin	8
Pharmacokinetic, pharmacodynamic, and pharmacogenetic assays to monitor clopidogrel therapy	8
The efficacy of steroids in reducing morbidity and mortality from extreme hyperthermia and heatstroke—A systematic review	8
The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	8
Pan‐cancer population pharmacokinetics and exposure‐safety and ‐efficacy analyses of atezolizumab in patients with high tumor mutational burden	8
Reciprocal interference between the NRF2 and LPS signaling pathways on the immune‐metabolic phenotype of peritoneal macrophages	8
A practical treatment for COVID‐19 and the next pandemic	8
Psychedelic‐assisted therapy for functional neurological disorders: A theoretical framework and review of prior reports	8
Exploring the Food and Drug Administration’s review and approval of Entresto (sacubitril/valsartan)	8
Association between low body weight and cytochrome P‐450 enzyme activity in patients with anorexia nervosa	8
Pharmacological inhibition of STAT3 by BP‐1‐102 inhibits intracranial aneurysm formation and rupture in mice through modulating inflammatory response	8
Jadomycins: A potential chemotherapy for multi‐drug resistant metastatic breast cancer	8
Association of income and educational levels with adherence to direct oral anticoagulant therapy in patients with incident atrial fibrillation: A Finnish nationwide cohort study	8
Serious cardiovascular adverse events with fluoroquinolones versus other antibiotics: A self‐controlled case series analysis	8
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia	8
Pitolisant, a wake‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol	8
Real‐life efficacy and safety of elexacaftor/tezacaftor/ivacaftor on severe cystic fibrosis lung disease patients	8
Casticin protected against neuronal injury and inhibited the TLR4/NF‐κB pathway after middle cerebral artery occlusion in rats	8
In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions	8
Augmented renal clearance in critically ill patients with cancer (ARCCAN Study): A prospective observational study evaluating prevalence and risk factors	8
Patients receiving a high burden of antibiotics in the community in Spain: a cross‐sectional study	8
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions	8
Developing a new undergraduate pharmacology core curriculum: The British Pharmacological Society Delphi Method	7
Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK‐Nrf2 signaling pathway	7
[8]‐Gingerol exerts anti‐myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L‐type Ca2+ channels	7
Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging	7
In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study	7
Antibiotic use and associated factors in adult outpatients from 2000 to 2019	7
Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans	7
Statin withdrawal and treating COVID‐19 patients	7
Honokiol attenuate the arsenic trioxide‐induced cardiotoxicity by reducing the myocardial apoptosis	7
Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders	7

A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties	7
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions	7
Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology	7
Stathmin dynamics modulate the activity of eribulin in breast cancer cells	7
Buying time: Drug repurposing to treat the host in COVID‐19H	7
Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review	7
Identification of the organic anion transporting polypeptides responsible for the hepatic uptake of the major metabolite of epyrifenacil, S‐3100‐CA, in mice	7
Health service use and costs associated with fluoroquinolone‐related tendon injuries	7
EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers	7
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial	7
Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels	7
Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constants	7
Intervention by clinical pharmacists can improve blood glucose fluctuation in patients with diabetes and acute myocardial infarction: A propensity score‐matched analysis	7
Pharmacokinetics and biodistribution of a collagen‐targeted peptide amphiphile for cardiovascular applications	7
Diabetes medication regimens and patient clinical characteristics in the national patient‐centered clinical research network, PCORnet	7