Pharmacology Research & Perspectives

Article	Citations
	97
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	87
Corrigendum	59
The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration	53
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics	50
Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance	44
Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care	32
Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist	30
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus	30
FDA regulatory considerations for oncology drug development	30
Cross‐modal embedding integrator for disease‐gene/protein association prediction using a multi‐head attention mechanism	27
A549 Alveolar Carcinoma Spheroids as a Cytotoxicity Platform for Carboxyl‐ and Amine‐Polyethylene Glycol Gold Nanoparticles	25
Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation	24
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysis	22
Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study	22
Issue Information	21
Pharmacogenomics Education and Knowledge Assessment in Healthcare Curricula: A Scoping Review of the Middle East and North Africa Region	21
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues	20
The blockade of the TGF‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity	20
Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation	19
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions	19
Patient safety in home care: A multicenter cross‐sectional study about medication errors and medication management of nurses	19
Histamine in cancer immunology and immunotherapy. Current status and new perspectives	18
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Impact of a computerized physician order entry system on medication safety in pediatrics—The AVOID study	17

Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor	17
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Hearing loss: The final frontier of pharmacology	17
Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross‐Sectional Study	16
Jordanian community pharmacists' perceptions and experiences with continuing professional development – A comprehensive analysis	16
Antioxidant potential of chlorogenic acid in Age‐Related eye diseases	16
Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus	16
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [14C] encor	16
Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights	15
Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants	15
CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation	15
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients	15
The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele‐Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma R	15
Highlights of basic and clinical pharmacology from Africa	15
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Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals	15
Comparative Efficacy of Different Targeted Therapies in Patients With Moderate‐to‐Severe Ulcerative Colitis: Systematic Review/Network Meta‐Analysis and Mechanistic Overview	15
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons	15
Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes	15
Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics	14
Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low‐toxic DNA staining dye	14
Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials	14
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The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial	14
Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats	14
Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice	14
Introducing a Professional Development Skill Building Platform Into a Biomedical Sciences Graduate Program Curriculum in Pharmacology	13
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study	13
A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics	13
Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice	12
Exploring Australian pharmacists' views toward reducing the risk of medicines‐related harm in aged care residents	12
The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload	12
Accounting for Time‐Varying Confounding in a Self‐Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen‐Related Events	12
Information overdose: Student performance and perceptions of pharmacology resources on exams	12
Issue Information	12
Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring	11
The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety‐Like Behaviors in Rats	11
The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [14C]Binimetinib 45 mg in Healthy Male Participants	11
Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial	11
Concurrent Prescribing of Opioids and Sedative‐Hypnotic Drugs for Long‐Term Use in Australian General Practice: A Cross‐Sectional Analysis Using MedicineInsight	11
Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants	11
Not first‐line antihypertensive agents, but still effective—The efficacy and safety of imidazoline receptor agonists: A network meta‐analysis	11
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions	11
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity	10
Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake	10
Massive presence of off‐label medicines in Danish neonatal departments: A nationwide survey using national hospital purchase data	10
Involvement of Piezo 1 mechanoceptors in vascular stiffness in isolated small resistance arteries of male and female Dahl salt‐sensitive hypertensive rats	10
Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin‐associated proteins	10
Issue Information	10
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial	10

Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists	10
Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells	10
Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study	10
Effect of cyclosporin A on respiratory viral replication in fully differentiated ex vivo human airway epithelia	10
Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism	10
Team‐Based Learning in the Meta Horizon Workroom: A Pilot Study on Its Potential Effectiveness for Pharmacology Teaching	9
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia	9
Opioid and analgesic utilization in Ireland in 2000 and 2015: A repeated cross‐sectional study	9
EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers	9
Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients	9
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells	9
Trends in Lipid‐Lowering Agent Consumption in Croatia: A 25‐Year Observational Study	9
Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women	9
Evidence‐based safety profile of oral ketorolac in adults: Systematic review and meta‐analysis	9
Pharmacist intervention to improve adherence to medication among heart failure patients at North East Ethiopia hospital	9
Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects	9
Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID‐19: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials	9
Upadacitinib‐Induced Hemolysis in a Patient With Glucose‐6‐Phosphate Dehydrogenase Deficiency—A Possible Adverse Drug Reaction	9
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Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase	8
The N‐Acetyltransferase 2 Polymorphism and Susceptibility to Inflammatory Bowel Disease: A Case–Control Study	8
Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers	8
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers	8
Comparison of the mathematical equation and trapezoidal approach for 24 h area under the plasma concentration‐time curve calculation in patients who received intravenous vancomycin in an acute care se	8
The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment	8
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed‐dose combination tablets versus the use of single‐component tablets in healthy subjects	8
Issue Information	8
Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats	8
Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers	8
Pharmacology Research & Perspectives: A Decade of Progress	8
Corrigendum	7
In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether	7
Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats	7
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database	7
Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer	7
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate	7
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes	7
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes,	7
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease	7
Aromatase Inhibitors and Dementia Risk: Putting Safety Into Perspective	7
A humanized anti‐cocaine mAb antagonizes the cardiovascular effects of cocaine in rats	7
Critical insights to COVID‐19 disease and potential treatments using a systems analysis approach that integrates physiology, pharmacology, and clinical pharmacology	7
The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases	7
Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue	7
Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model	7
Supporting Pediatric RSV Clinical Trials Through Close Epidemiological Surveillance During the SARS‐CoV‐2 Pandemic	7
Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β‐hydroxycortisol/cortisol	7
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	6
The endocannabinoid system in appetite regulation and treatment of obesity	6
Effectiveness of edaravone in preventing contrast‐induced nephropathy in high‐risk patients undergoing coronary angiography: A randomized, double‐blind trial	6
Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans	6
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New insights into the role of melatonin in diabetic cardiomyopathy	6
From Psychiatry to Oncology: Exploring the Anti‐Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment	6
Jadomycins: A potential chemotherapy for multi‐drug resistant metastatic breast cancer	6
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The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies	6
Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways	6
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis	6
Reflections on the Core Concepts of Physiology and Pharmacology	6
Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System	6
Pharmacology and Regulation of Appetite and Food Intake	6
Telmisartan and losartan: The marked differences between their chemical and pharmacological properties may explain the difference in therapeutic efficacy in hospitalized patients with COVID‐19	6
The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker	5
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The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	5
A Clinical Practice‐Based Comparison of Conventional and Individualized Dosing Strategies for Therapeutic Enoxaparin	5
Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor	5
HDAC4/5 Inhibitor, LMK‐235 Improves Animal Voluntary Movement in MPTP‐Induced Parkinson's Disease Model	5
Enhancing Student Comprehension of Glucose Metabolism Visualization Through Virtual Simulation Platform: An Educational Approach	5
Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects	5
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants	5
Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool	5
Evaluation and optimization of sample size of neonates and infants for pediatric clinical studies on cefiderocol using a model‐based approach	5
Cognitive and negative symptoms in schizophrenia with L‐Carnosine adjuvant therapy – A randomized double‐blind placebo‐controlled study	5
Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse	5
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease	5
Utility of salivary mycophenolic acid concentration monitoring: Modeling and Monte Carlo validation approach	5
Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis	5
A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra‐Long‐Acting β2‐Agonists Used for Asthma and COPD	5

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways	5
Metopimazine is primarily metabolized by a liver amidase in humans	5
Asciminib, a novel allosteric inhibitor of BCR‐ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance	5
Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring	5
Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?	5
A Randomized, Open‐Label, Single‐Dose, Parallel‐Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia	5
NMDA Receptor–Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin	5
Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency	5
Co‐created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus	5
Management of pharmacovigilance during the COVID‐19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the EU DisCoVeRy clinical	5