OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Research is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Coacervate-mediated novel pancreatic cancer drug Aleuria Aurantia lectin delivery for augmented anticancer therapy	179
Tumoricidal Efficacy of Artesunate-Eluting Microsphere: Differential Role of Bax/Bak in Orchestration of Cell Death Pathways	127
Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects	107
Erratum to “An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery”	100
Label-Free Prediction of Fluorescently Labeled Fibrin Networks	86
Zein and Trimethyl Chitosan-Based Core–Shell Nanoparticles for Quercetin Oral Delivery to Enhance Absorption by Paracellular Pathway in Obesity Mice	84
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration	84
Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel	81
An injectable, in situ forming and NIR-responsive hydrogel persistently reshaping tumor microenvironment for efficient melanoma therapy	79
Targeting ROS and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots	75
Strategies to Overcome Hurdles in Cancer Immunotherapy	72
Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations	64
Natural bone-mimicking nanopore-incorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration	63
Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury	59
Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles	58
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System	55
Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Oxidative Damage via the miR-191-5p/DAPK1/AKT Axis in Type 2 Diabetes	53
Enhanced Cellular Immunity for Hepatitis B Virus Vaccine: A Novel Polyinosinic-Polycytidylic Acid-Incorporated Adjuvant Leveraging Cytoplasmic Retinoic Acid-Inducible Gene-Like Receptor Activation and	53
Optimized Epigallocatechin Gallate Delivery and Adipogenesis Inhibition through Fluorescent Mesoporous Nanocarriers	52
High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds	50
A Novel Lipopeptide–Functionalized Metal–Organic Framework for Periodontitis Therapy through the Htra1/FAK/YAP Pathway	50
Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection	50
Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment	48
Cellular direct conversion by cell penetrable OCT4-30Kc19 protein and BMP4 growth factor	48
Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system	46

Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate	45
Control of maleic acid-propylene diepoxide hydrogel for 3D printing application for flexible tissue engineering scaffold with high resolution by end capping and graft polymerization	43
The hydrogen storage nanomaterial MgH ₂ improves irradiation-induced male fertility impairment by suppressing oxidative stress	43
Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy	42
Genetically Encoded Fluorescence Resonance Energy Transfer Biosensor for Live-Cell Visualization of Lamin A Phosphorylation at Serine 22	42
A New Perspective on Precision Medicine: The Power of Digital Organoids	41
Harnessing the Intradermal Delivery of Hair Follicle Dermal Papilla Cell Spheroids for Hair Follicle Regeneration in Nude Mice	41
Simultaneously Modulating HIF-1α and HIF-2α and Optimizing Macrophage Polarization through the Biomimetic Gene Vector toward the Treatment of Osteoarthritis	40
Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration	40
An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery	39
Modulation of bioactive calcium phosphate micro/nanoparticle size and shape during in situ synthesis of photo-crosslinkable gelatin methacryloyl based nanocomposite hydrogels for 3D bioprinting and ti	39
The worldwide patent landscape of dental implant technology	38
Injection laryngoplasty of human adipose-derived stem cell spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx	38
Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer	38
Customized Sized Manganese Sulfide Nanospheres as Efficient T ₁ MRI Contrast Agents for Enhanced Tumor Theranostics	37
NIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes	37
mRNA nanodelivery systems: targeting strategies and administration routes	36
Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy	36
Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3	36
Advances in the development of tubular structures using extrusion-based 3D cell-printing technology for vascular tissue regenerative applications	36
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis	34
A drug delivery system constructed by a fusion peptide capturing exosomes targets to titanium implants accurately resulting the enhancement of osseointegration peri-implant	34
Label-Free Enrichment of Highly Metastatic Tumor-Initiating Cells up to a Monoclonal State	33
Regeneration of a Rabbit Segmental Defect with a New Bone Therapy: Autologous Blood Coagulum with Bone Morphogenetic Protein 6 and Synthetic Ceramics	33
Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants	33
Decellularized Extracellular Matrix Scaffolds for Soft Tissue Augmentation: From Host–Scaffold Interactions to Bottlenecks in Clinical Translation	32
Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy	32
Solubilized chlorin e6-layered double hydroxide complex for anticancer photodynamic therapy	31
Rediscovery of poly(ethylene glycol)s as a cryoprotectant for mesenchymal stem cells	31
Recent advances in optical imaging through deep tissue: imaging probes and techniques	30
Application of bioactive glasses in various dental fields	30
Non-interfacial self-assembly of synthetic protocells	30
Boron Nanocomposites for Boron Neutron Capture Therapy and in Biomedicine: Evolvement and Challenges	29
Impact of Culture Duration on the Properties and Functionality of Yeast-Derived Extracellular Vesicles	29
Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration	29
From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds	28
Epitranscriptomic Modulation of TET2 Inhibition Suppressed SARS-CoV-2 Infection and Blocked Viral Nucleocapsid Protein in Induced-Pluripotent-Stem-Cell-Derived Cardiomyocyte Screening Models	28
Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research	28
Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds	28
Mesenchymal Stem Cell-Derived Exosomes Inhibit Stim1-Orai1 Signaling and Calcium Overload-induced Mitochondrial Damage of Tfh in Lupus	27
Low-Molecular-Weight PEGs for Cryopreservation of Stem Cell Spheroids	26
Nucleolin Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy	26
Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies	26
Res@LDH: A Novel Nanohybrid Therapeutic for Ischemia–Reperfusion Injury with Dual Reactive Oxygen Species Scavenging Efficiency	26
PEG-mediated transduction of rAAV as a platform for spatially confined and efficient gene delivery	25
Targeted H ₂ S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane	25
Surface-mediated high antioxidant and anti-inflammatory effects of astaxanthin-loaded ultrathin graphene oxide film that inhibits the overproduction of intracellular reactive oxygen species	25
Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid	25
Lipid Nanoparticle Delivery System for Normalization of Tumor Microenvironment and Tumor Vascular Structure	24
Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment	24

Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment	24
Optimization of the clinically approved Mg-Zn alloy system through the addition of Ca	24
Biomimetic Marine-Sponge-Derived Spicule-Microparticle-Mediated Biomineralization and YAP/TAZ Pathway for Bone Regeneration In Vivo	24
Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming	24
A hydrogel-based first-aid tissue adhesive with effective hemostasis and anti-bacteria for trauma emergency management	24
Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate	23
Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis	22
CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin	22
Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation	22
Preparation of gamma poly-glutamic acid/hydroxyapatite/collagen composite as the 3D-printing scaffold for bone tissue engineering	22
Nanotherapeutic System with Effective Microwave Sensitization and Pyroptosis Programming Enable Synergistic Microwave-Immunotherapy in Bladder Cancer	21
Navigating Latency-Inducing Viral Infections: Therapeutic Targeting and Nanoparticle Utilization	21
Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field	21
A novel DNA double-strand breaks biosensor based on fluorescence resonance energy transfer	21
Highly Efficient Delivery of Novel MiR-13896 by Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Inhibits Gastric Cancer Progression by Targeting ATG2A-Mediated Autophag	20
Smart and versatile biomaterials for cutaneous wound healing	20
Evaluating the validity of lightweight talar replacement designs: rational models and topologically optimized models	20
Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival	20
Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment	20
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration	20
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae	20
Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity	20
Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation	20
Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects	20
Progress of tissue adhesives based on proteins and synthetic polymers	20
Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy	19
Correction: Non-interfacial self-assembly of synthetic protocells	19
A systematic study on the use of multifunctional nanodiamonds for neuritogenesis and super-resolution imaging	19
Erratum to “Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment”	19
The role of cellular traction forces in deciphering nuclear mechanics	19
3D biofabrication of diseased human skin models in vitro	18
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair	18
Hydrogel in the Treatment of Traumatic Brain Injury	18
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model	18
Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers	18
Hyaluronic Acid-Functionalized Bismuth Vanadate/Molybdenum Disulfide Nanoheterojunctions Achieve Efficient Phototherapy of Hypoxic Tumor	18
Application of molecular dynamics simulation in self-assembled cancer nanomedicine	18
Peripheral nerve defects repaired with autogenous vein grafts filled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques	18
Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration	18
Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery	17
Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level	17
The complex of miRNA2861 and cell-penetrating, dimeric α-helical peptide accelerates the osteogenesis of mesenchymal stem cells	17
Hybrid Homodimeric Prodrug Nanoassemblies for Low-Toxicity and Synergistic Chemophotodynamic Therapy of Melanoma	17
Accurately Controlled Tumor Temperature with Silica-Coated Gold Nanorods for Optimal Immune Checkpoint Blockade Therapy	17
The triply periodic minimal surface-based 3D printed engineering scaffold for meniscus function reconstruction	17
Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy	17
MXene/Doxorubicin Complex-Loaded Supramolecular Hydrogels for Near Infrared-Triggered Synergistic Cancer Therapy	17