Cell Discovery

Article	Citations
Sheep blastocyst-like structure models derived from stem cells	397
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	322
tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells	144
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	126
Human zygotic genome activation is initiated from paternal genome	107
GV-971 remodels the gut microbiota-bile acid-FXR axis to ameliorate obesity and metabolic dysfunction	103
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	102
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	102
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	90
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	89
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	87
A spatiotemporal transcriptomic atlas of mouse placentation	82
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	82
Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms the early offspring hematopoietic system	78
Structural characterization reveals substrate recognition by the taurine transporter TauT	74
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	73
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	73
The building blocks of embryo models: embryonic and extraembryonic stem cells	71
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	71
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	70
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	70
PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis	69
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	69
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	67
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	66

Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	66
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	64
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	64
Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	62
Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	62
Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	61
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	60
Receptor hyper-flexibility of human bitter receptor TAS2R4 revealed by cryo-EM structures in apo and tripeptide-bound states	59
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	59
Packaged release and targeted delivery of cytokines by migrasomes in circulation	57
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	57
A tissue specific-infection mouse model of SARS-CoV-2	55
Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming	55
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	54
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	51
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	51
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	51
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	51
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	50
Proteogenomic insights into the biology and treatment of pan-melanoma	50
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	49
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	49
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	49
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	48
Structural basis for the activity regulation of Medicago calcium channel CNGC15	47
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	47
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	46
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	46
Author Correction: Longitudinal single-cell and TCR repertoire profiling characterizes clonal entrapment in patients with pMMR/MSS locally advanced rectal cancer	44
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	43
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	43
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	42
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	42
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	41
Spatial single-cell landscape of tumor-associated macrophages and their crosstalk with the tumor microenvironment	41
Structural basis for a central permeation pathway in the P2X1 receptor	40
Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma	39
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	38
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	37
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	36
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	35
A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox	35
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	35
Identification of a novel deeply quiescent neural stem cell population in the subventricular zone: a potential source for brain repair	35
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	35
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	34
Synthetic macrolides overcoming MLSBK-resistant pathogens	34
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	34
The second messenger c-di-AMP controls natural competence via ComFB signaling protein	34
Molecular basis for the activation of thyrotropin-releasing hormone receptor	34

Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	33
Structure of small HBV surface antigen reveals mechanism of dimer formation	33
ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression	33
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	33
Identification of neutralizing nanobodies protecting against poxvirus infection	33
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	32
Structural and functional insights into the helicase protein E5 of Mpox virus	32
Intercellular genetic tracing by alternative synthetic Notch signaling	32
Targeting miR-337 mitigates disuse-induced bone loss	32
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	32
Common signatures of neutrophils in diverse disease conditions	32
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	32
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	31
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	31
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	31
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	31
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	30
Inhibiting hedgehog signal by a patched-1 antibody	30
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	29
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	29
In-cell structural insight into the stability of sperm microtubule doublet	28
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	27
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	27
Structural basis of human zinc-activated channel (ZAC) signaling and modulation	27
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	27
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	27
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	27
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	26
Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia	26
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	26
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	26
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	26
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	26
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	26
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	26
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	26
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	26
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	25
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	25
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies	25
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	25
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	25
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	25
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	25
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma	25
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	25
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development	24
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	24
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	24
Author Correction: Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells	24
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling	24
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	24
PCaseek: ultraspecific urinary tumor DNA detection using deep learning for prostate cancer diagnosis and Gleason grading	23
A tumor-secreted protein utilizes glucagon release to cause host wasting	23
Molecular basis for METTL9-mediated N1-histidine methylation	23
Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities	23
Unveiling potential threats: backdoor attacks in single-cell pre-trained models	23
Structural insights into human organic cation transporter 1 transport and inhibition	23
Author Correction: Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM	23
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout	23
Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease	23
Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide	22
A differentiation roadmap of murine placentation at single-cell resolution	22
Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2	22
Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR	22
Structural insights into DNA N6-adenine methylation by the MTA1 complex	22
Molecular mechanisms of PI3Kα activation by small-molecule activator 1938 and cancer-specific mutation H1047R	22
Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast	22
Probing the importance of AIF interaction with endonuclease G in mitochondrial inheritance and neurodegeneration	22
Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z	22
In-depth and high-throughput spatial proteomics for whole-tissue slice profiling by deep learning-facilitated sparse sampling strategy	21
Author Correction: LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation	21
Human SERPINA3 induces neocortical folding and improves cognitive ability in mice	21
Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35	21
Integrated transcriptome profiling of plasma exosomes reveals molecular stratification of exocrine and endocrine disorders and S100A8-mediated cell interactions in chronic pancreatitis	21
Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	21
Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma	21
Mettl3-m6A-NPY axis governing neuron–microglia interaction regulates sleep amount of mice	21
Structural insights into cyanobacterial RuBisCO assembly coordinated by two chaperones Raf1 and RbcX	21
LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination	20

CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor	20
High-precision mapping reveals rare N6-deoxyadenosine methylation in the mammalian genome	20
Author Correction: Artificial intelligence defines protein-based classification of thyroid nodules	20
Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference	20
40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice	20
Author Correction: A genetically encoded ratiometric indicator for tryptophan	20
Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor	20
Designed allosteric protein logic	20
Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq	19
ShennongAlpha: an AI-driven sharing and collaboration platform for intelligent curation, acquisition, and translation of natural medicinal material knowledge	19
Cryo-EM structure of PML RBCC dimer reveals CC-mediated octopus-like nuclear body assembly mechanism	19
Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum	19
MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury	19
Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas	19
Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome	19
Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics	18
Structural analysis of full-length human transmembrane protein 94 argues against its classification as a P-type Mg2+ ATPase	18
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation	18
Author Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	18
Potential of angiotensin II receptor blocker telmisartan in reducing mortality among hospitalized patients with COVID-19 compared with recommended drugs	18
Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis	18
Single-cell profiling reveals a shared proinflammatory macrophage signature across multiple organs in myopia	18
Fast and flexible profiling of chromatin accessibility and total RNA expression in single nuclei using Microwell-seq3	18
Author Correction: Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis	17
Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia	17
Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines	17
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate	17
Structural basis of connexin-36 gap junction channel inhibition	17
TGF-β controls development of TCRγδ+CD8αα+ intestinal intraepithelial lymphocytes	17
Author Correction: Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4	17
Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose	17
Loss of function of CMPK2 causes mitochondria deficiency and brain calcification	17
Deciphering the molecular mechanism of the bacterial division motor TolQRA	17
Multiple-cohort study of the elderly to determine the immunological characteristics and pathogenic mechanisms of severe community-acquired pneumonia caused by the low-virulence virus SARS-CoV-2 Omicro	16
TPM4 condensates glycolytic enzymes and facilitates actin reorganization under hyperosmotic stress	16
Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1	16
Two assembly modes for SIN3 histone deacetylase complexes	16
A pan-disease and population-level single-cell TCRαβ repertoire reference	16
A Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain	16
Molecular architecture of monkeypox mature virus	16
Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05	16
Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6	16
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial	15
Extra-helical allosteric binding site of apomorphine in ADGRG6	15
Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development	15
The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth	15
Sodium oligomannate disrupts the adherence of Ribhigh bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice	15
Structural insights into the activation of the divisome complex FtsWIQLB	15
Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells	15
Perifollicular stromal cells sustain folliculogenesis via MDK–NCL signaling in mice and humans	15
Rapid production of precisely edited cattle and mice via a single AAV delivered miniature IscB#/ωRNA#	15
Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4	15
Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer	15
Structures of the Crimean-Congo hemorrhagic fever virus RNA-dependent RNA polymerase	15
Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B	14
Single-cell transcriptome reveals cellular hierarchies and guides p-EMT-targeted trial in skull base chordoma	14
IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration	14
Author Correction: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities	14
Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC	14
Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment	14
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis	14
A receptor-like kinase recognizes viral proteins at the trans-Golgi network/early endosome and inhibits infection in rice	14
The Omicron BA.2.2.1 subvariant drove the wave of SARS-CoV-2 outbreak in Shanghai during spring 2022	14
Structural insights into histone exchange by human SRCAP complex	14
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming	14
Author Correction: Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial	14
Structural basis of glucosinolate recognition and transport by plant GTR1	14
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways	14
Paternal preconceptional metformin exposure induces metabolic dysregulation in offspring	13
Structure and dynamics of the EGFR/HER2 heterodimer	13
Surgery after induced anti-PD-L1 therapy and chemotherapy for stage I‒III small-cell lung cancer: a phase 2 trial (LungMate-005)	13
TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis	13
Progressive evolution of secondary aquatic adaptation in hippos and cetaceans	13
BRD4-targeting PROTAC as a unique tool to study biomolecular condensates	13
The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway	13
Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection	13
EGFR blockade confers sensitivity to cabozantinib in hepatocellular carcinoma	13
Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells	12
Calcium influx-induced lytic cell death disrupts skin immune homeostasis	12
Author Correction: Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	12
Structure basis for sugar specificity of gustatory receptors in insects	12
Publisher Correction: Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	12
Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells	12
SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration	12
CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety	12
A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors	12
Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma	12