OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	210
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	175
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	170
Human zygotic genome activation is initiated from paternal genome	108
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	107
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	94
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	86
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	81
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	81
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	78
A spatiotemporal transcriptomic atlas of mouse placentation	76
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	73
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	73
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	71
The building blocks of embryo models: embryonic and extraembryonic stem cells	70
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	68
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	67
Structural characterization reveals substrate recognition by the taurine transporter TauT	66
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	65
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	63
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	63
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters	61
Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	61
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses	61
Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	60

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection	58
Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	54
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	54
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	52
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	52
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	51
Packaged release and targeted delivery of cytokines by migrasomes in circulation	51
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	51
Structural basis for the activity regulation of Medicago calcium channel CNGC15	49
Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	49
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	49
Proteogenomic insights into the biology and treatment of pan-melanoma	48
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	47
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	45
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	45
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	45
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	44
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	44
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	44
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	43
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	43
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	43
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	43
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	43
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	42
A tissue specific-infection mouse model of SARS-CoV-2	42
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	41
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine	41
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	41
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	41
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	41
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	40
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	40
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	40
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	38
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	38
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	37
Synthetic macrolides overcoming MLSBK-resistant pathogens	37
Identification of neutralizing nanobodies protecting against poxvirus infection	37
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	37
Structure of small HBV surface antigen reveals mechanism of dimer formation	37
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	36
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	35
Discovery of new genetic loci for male sexual orientation in Han population	35
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	35
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	34
The second messenger c-di-AMP controls natural competence via ComFB signaling protein	34
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma	34
Molecular basis for the activation of thyrotropin-releasing hormone receptor	34
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	34

Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	33
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	33
Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant	32
Common signatures of neutrophils in diverse disease conditions	32
Intercellular genetic tracing by alternative synthetic Notch signaling	31
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	31
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming	31
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	31
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2	31
Targeting miR-337 mitigates disuse-induced bone loss	31
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	31
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	30
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	30
Structural and functional insights into the helicase protein E5 of Mpox virus	30
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	29
Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	29
Inhibiting hedgehog signal by a patched-1 antibody	29
Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase	29
Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites	28
CRISPR signal conductor 2.0 for redirecting cellular information flow	28
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	28
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	28
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	28
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	28
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing	27
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	27
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	27
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	27
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	27
In-cell structural insight into the stability of sperm microtubule doublet	27
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	27
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	26
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	26
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	26
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	26
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	26
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	26
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	26
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination	25
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	25
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	25
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	25
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	25
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	25
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	25
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	24
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling	24
Structure of the human RNA polymerase I elongation complex	24
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	24
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies	23
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	23
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development	23
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	23