OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Sheep blastocyst-like structure models derived from stem cells	329
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	303
tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells	130
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	116
Human zygotic genome activation is initiated from paternal genome	110
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	96
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	96
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	95
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	95
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	90
A spatiotemporal transcriptomic atlas of mouse placentation	86
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	85
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	83
Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms the early offspring hematopoietic system	82
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	81
Structural characterization reveals substrate recognition by the taurine transporter TauT	81
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	79
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	73
The building blocks of embryo models: embryonic and extraembryonic stem cells	72
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	69
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	69
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	68
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	67
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters	65
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	65

Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	64
Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	64
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	63
Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	63
Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	63
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	62
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	62
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	58
Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	58
Packaged release and targeted delivery of cytokines by migrasomes in circulation	58
Receptor hyper-flexibility of human bitter receptor TAS2R4 revealed by cryo-EM structures in apo and tripeptide-bound states	57
A tissue specific-infection mouse model of SARS-CoV-2	56
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	55
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	55
Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming	53
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	53
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	51
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	50
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	49
Proteogenomic insights into the biology and treatment of pan-melanoma	49
Structural basis for the activity regulation of Medicago calcium channel CNGC15	49
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	49
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	48
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	48
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	47
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	47
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	47
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	47
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	46
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	44
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	44
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	43
Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma	43
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	42
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	41
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	41
Spatial single-cell landscape of tumor-associated macrophages and their crosstalk with the tumor microenvironment	40
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	40
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	39
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	39
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	39
Molecular basis for the activation of thyrotropin-releasing hormone receptor	38
Identification of neutralizing nanobodies protecting against poxvirus infection	37
ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression	36
Structure of small HBV surface antigen reveals mechanism of dimer formation	36
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	35
Synthetic macrolides overcoming MLSBK-resistant pathogens	35
The second messenger c-di-AMP controls natural competence via ComFB signaling protein	34
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	34
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	34

A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox	33
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	33
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	32
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	32
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	32
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	32
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	32
Intercellular genetic tracing by alternative synthetic Notch signaling	31
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	31
Common signatures of neutrophils in diverse disease conditions	31
Structural and functional insights into the helicase protein E5 of Mpox virus	31
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2	31
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	30
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	30
Targeting miR-337 mitigates disuse-induced bone loss	30
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	29
Inhibiting hedgehog signal by a patched-1 antibody	29
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	29
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	29
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	28
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	28
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	28
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	28
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	28
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	28
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	28
Structural basis of human zinc-activated channel (ZAC) signaling and modulation	27
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	27
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	27
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	27
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	26
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	26
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	26
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	26
In-cell structural insight into the stability of sperm microtubule doublet	26
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	25
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	25
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma	25
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	25
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	25
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	25
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	24
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	24
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	24
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	24
Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia	24
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development	24
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling	24
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	24
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies	24
Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast	24
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	24