OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing	519
Inflammasome activation and regulation: toward a better understanding of complex mechanisms	482
Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro	242
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro	225
The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing	183
SARS-CoV-2 detection with CRISPR diagnostics	176
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro	165
SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2	156
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility	154
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes	149
Emerging roles of ATG proteins and membrane lipids in autophagosome formation	147
SARS-CoV-2 cell tropism and multiorgan infection	143
Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2	129
Activation and targeting of ATG8 protein lipidation	114
Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response	111
Single-copy sensitive, field-deployable, and simultaneous dual-gene detection of SARS-CoV-2 RNA via modified RT–RPA	111
Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients	97
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine	93
Emerging functions of branched ubiquitin chains	93
Plasma membrane integrity in health and disease: significance and therapeutic potential	90
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages	89
Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression	87
Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss	80
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension	79
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication	71

Generation of human blastocyst-like structures from pluripotent stem cells	70
Atomic structure of human TOM core complex	66
SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region	65
A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer	65
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis	64
Autophagosome biogenesis and human health	63
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination	63
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy	63
Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo	60
KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge	57
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease	56
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines	56
Antihypertensive drugs are associated with reduced fatal outcomes and improved clinical characteristics in elderly COVID-19 patients	53
Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo	52
The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes	52
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor	52
CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor	52
Author Correction: Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing	49
Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules	49
A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases	48
Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement	48
SARS-CoV-2 infection in the mouse olfactory system	46
Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence	46
Dysregulated hematopoiesis in bone marrow marks severe COVID-19	46
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter	44
In vivo chemical reprogramming of astrocytes into neurons	44
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	44
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos	43
Genome-wide association study of COVID-19 severity among the Chinese population	42
Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells	40
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients	38
Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma	35
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing	34
Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis	34
CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila	33
Immune memory in convalescent patients with asymptomatic or mild COVID-19	33
Antenna arrangement and energy-transfer pathways of PSI–LHCI from the moss Physcomitrella patens	33
Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection	32
Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome	32
Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans	32
Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture	31
An in vivo strategy for knockdown of circular RNAs	31
RGS12 is required for the maintenance of mitochondrial function during skeletal development	30
Mendelian neurodegenerative disease genes involved in autophagy	30
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing	30
Identification of an intraocular microbiota	30
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant	30
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini	29
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming	29
Dysfunction of dimorphic sperm impairs male fertility in the silkworm	29

RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models	29
Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 2019	29
Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals	28
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication	28
Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos	28
Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy	28
Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq	28
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	28
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries	28
Infection of human sweat glands by SARS-CoV-2	27
Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models	26
Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation	26
Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection	26
TAZ is required for chondrogenesis and skeletal development	25
Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm	24
SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment	24
Single-particle cryo-EM structural studies of the β2AR–Gs complex bound with a full agonist formoterol	24
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma	24
Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s	24
Structural insights into assembly of human mitochondrial translocase TOM complex	24
Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunization	24
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment	24
A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease	24
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses	23
Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase	23
Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays	23
DdCBE-mediated mitochondrial base editing in human 3PN embryos	23
Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication	23
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1	23
A bioenergetic shift is required for spermatogonial differentiation	23
3D landscape of Hepatitis B virus interactions with human chromatins	23
Rett mutations attenuate phase separation of MeCP2	23
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	23
Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	23
Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19	22
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	22
Integrated proteogenomic characterization of medullary thyroid carcinoma	22
RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates	22
Analysis of m6A RNA methylation in Caenorhabditis elegans	22
TMEM151A variants cause paroxysmal kinesigenic dyskinesia	22
Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells	22
CRISPR-edited CART with GM-CSF knockout and auto secretion of IL6 and IL1 blockers in patients with hematologic malignancy	22
SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	21
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	21
High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation	21
ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis	21
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	21
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE	21
SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells	20
LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis	20
Structure and dynamics of the EGFR/HER2 heterodimer	20
Structure of the human RNA polymerase I elongation complex	20
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis	20
Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern	20
Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter	20