OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	315
Sheep blastocyst-like structure models derived from stem cells	297
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	227
tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells	126
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	112
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	102
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	95
A spatiotemporal transcriptomic atlas of mouse placentation	93
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	93
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	90
Human zygotic genome activation is initiated from paternal genome	89
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	84
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	84
Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms the early offspring hematopoietic system	83
Structural characterization reveals substrate recognition by the taurine transporter TauT	78
The building blocks of embryo models: embryonic and extraembryonic stem cells	78
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	78
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	74
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	72
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	71
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	69
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	69
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	68
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	68
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters	64

Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	63
Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	63
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	63
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	63
Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	62
Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	62
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	61
Packaged release and targeted delivery of cytokines by migrasomes in circulation	61
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	61
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	60
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	57
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	56
A tissue specific-infection mouse model of SARS-CoV-2	56
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	55
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	55
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	53
Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming	53
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	51
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	50
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	50
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	50
Structural basis for the activity regulation of Medicago calcium channel CNGC15	49
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	48
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	48
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	47
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	47
Proteogenomic insights into the biology and treatment of pan-melanoma	47
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	47
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	45
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	44
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	44
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	43
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	43
Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma	43
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	41
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	41
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	41
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	41
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	40
Molecular basis for the activation of thyrotropin-releasing hormone receptor	40
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	40
Identification of neutralizing nanobodies protecting against poxvirus infection	39
ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression	38
Structure of small HBV surface antigen reveals mechanism of dimer formation	38
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	37
Synthetic macrolides overcoming MLSBK-resistant pathogens	37
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	36
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	35
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	35
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	35

The second messenger c-di-AMP controls natural competence via ComFB signaling protein	34
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	34
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	33
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	33
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2	33
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	33
Common signatures of neutrophils in diverse disease conditions	32
Structural and functional insights into the helicase protein E5 of Mpox virus	32
Intercellular genetic tracing by alternative synthetic Notch signaling	32
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	31
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	31
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	31
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	31
Targeting miR-337 mitigates disuse-induced bone loss	31
Inhibiting hedgehog signal by a patched-1 antibody	31
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	30
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	30
In-cell structural insight into the stability of sperm microtubule doublet	30
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	30
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	30
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	29
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	29
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	29
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	28
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	28
Structural basis of human zinc-activated channel (ZAC) signaling and modulation	28
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	28
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	28
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	28
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	28
Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia	27
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	27
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	27
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	27
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	26
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	26
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	26
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	26
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	26
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	25
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	25
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	25
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development	25
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma	25
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	24
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	24
Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast	24
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies	24
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling	24
Proteomic characterization of Omicron SARS-CoV-2 host response	24
A tumor-secreted protein utilizes glucagon release to cause host wasting	24
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	24
Author Correction: Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells	24
Structural insights into human organic cation transporter 1 transport and inhibition	24