OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	240
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	197
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	197
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	110
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	108
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	103
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	96
A spatiotemporal transcriptomic atlas of mouse placentation	89
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	88
Human zygotic genome activation is initiated from paternal genome	84
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	78
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	77
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	75
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	75
Structural characterization reveals substrate recognition by the taurine transporter TauT	74
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	74
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	73
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	72
The building blocks of embryo models: embryonic and extraembryonic stem cells	67
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	66
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	63
Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	63
Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	62
Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	62
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	62

Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	60
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection	59
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	57
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	56
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters	54
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	54
Structural basis for the activity regulation of Medicago calcium channel CNGC15	53
Packaged release and targeted delivery of cytokines by migrasomes in circulation	53
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	53
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	50
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	50
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	50
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	49
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	49
A tissue specific-infection mouse model of SARS-CoV-2	48
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	47
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	47
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	47
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	46
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	46
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	46
Proteogenomic insights into the biology and treatment of pan-melanoma	46
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	46
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	44
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	44
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	44
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	43
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	43
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	42
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	42
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	42
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	40
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine	40
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	39
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	39
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	39
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	39
Synthetic macrolides overcoming MLSBK-resistant pathogens	39
Identification of neutralizing nanobodies protecting against poxvirus infection	38
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	38
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	37
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma	36
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	36
The second messenger c-di-AMP controls natural competence via ComFB signaling protein	35
Molecular basis for the activation of thyrotropin-releasing hormone receptor	35
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	35
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	34
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	34
Structure of small HBV surface antigen reveals mechanism of dimer formation	34
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	33

Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	33
Intercellular genetic tracing by alternative synthetic Notch signaling	33
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2	33
Targeting miR-337 mitigates disuse-induced bone loss	33
Common signatures of neutrophils in diverse disease conditions	32
Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant	32
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	31
Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase	31
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	31
Structural and functional insights into the helicase protein E5 of Mpox virus	31
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	31
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	31
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	31
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	30
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	30
Inhibiting hedgehog signal by a patched-1 antibody	30
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	30
CRISPR signal conductor 2.0 for redirecting cellular information flow	30
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	30
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	30
Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites	30
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	30
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	29
In-cell structural insight into the stability of sperm microtubule doublet	29
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	29
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	28
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	28
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	28
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	27
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	27
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	27
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	27
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	26
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	26
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination	26
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	26
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	26
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	25
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	25
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	25
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	25
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma	25
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	25
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	25
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity	24
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	24
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development	24
Author Correction: Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells	23
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling	23
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	23
Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes	23
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies	23
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout	23
Architecture of the human NALCN channelosome	23
Structure of infective Getah virus at 2.8 Å resolution determined by cryo-electron microscopy	23
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	23