OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing	110
Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease	88
Author Correction: The bright side of fibroblasts: molecular signature and regenerative cues in major organs	84
Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells	78
Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line	66
Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP	57
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration	57
Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment	57
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes	54
Epicardial slices: an innovative 3D organotypic model to study epicardial cell physiology and activation	52
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	48
A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model	48
Modelling urea cycle disorders using iPSCs	42
Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration	40
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	40
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium	39
An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model	38
Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon	35
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A	35
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration	34
Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept	34
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model	34
A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration	32
DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration	31
Implementing systems thinking and data science in the training of the regenerative medicine workforce	30

Perspectives on the cost of goods for hPSC banks for manufacture of cell therapies	30
Author Correction: Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	30
Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis	30
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration	30
Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn	29
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	28
Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue	27
Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	27
Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries	26
Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis	26
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy	26
Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo	25
The one-step fabrication of porous hASC-laden GelMa constructs using a handheld printing system	25
Mammals fail to regenerate organs when wound contraction drives scar formation	25
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration	25
The bright side of fibroblasts: molecular signature and regenerative cues in major organs	24
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea	23
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration	23
A novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles	23
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	23
Targets identified from exercised heart: killing multiple birds with one stone	22
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells	22
Author Correction : SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease	22
Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury	22
Anti-inflammatory Prowess of endothelial progenitor cells in the realm of biology and medicine	22
Author Correction: Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service	22
Utilising an in silico model to predict outcomes in senescence-driven acute liver injury	21
MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis	21
3′mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury	21
LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration	21
Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis	20
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms	20
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible	20
Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs	19
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	19
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice	19
Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage	19
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis	18
Infected wound repair correlates with collagen I induction and NOX2 activation by cold atmospheric plasma	18
CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells	18
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes	18
Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	18
Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle	18
Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	17
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment	17
Myoblast-derived ADAMTS-like 2 promotes skeletal muscle regeneration after injury	17
The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway	17
Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation	17
Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish	17
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties	17

Implication of CXCR2-Src axis in the angiogenic and osteogenic effects of FP-TEB	17
Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds	16
Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels	16
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration	16
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	15
An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration	15
Regeneration of tracheal neotissue in partially decellularized scaffolds	15
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation	15
A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation	14
Pain sensing neurons promote tissue regeneration in adult mice	14
Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease	14
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	14
Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration	14
Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic	14
A cross-species analysis of systemic mediators of repair and complex tissue regeneration	13
Concerns about cell therapy for intervertebral disc degeneration	13
The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment	13
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury	13
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice	13
IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation	12
MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice	12
Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit	12
A therapeutic vascular conduit to support in vivo cell-secreted therapy	12
FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes	12
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity	12
Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart	12
PDGF inhibits BMP2-induced bone healing	12
Stem cell-based therapy for COVID-19 and ARDS: a systematic review	12
Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue	12
ZO-2/Tjp2 suppresses Yap and Wwtr1/Taz-mediated hepatocyte to cholangiocyte transdifferentiation in the mouse liver	12
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration	11
Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine	11
Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential	11
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19	11
Author Correction: Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	11
Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis	11
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI	11
Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing	11
Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice	11
Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells	11
Author Correction: Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction	10
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice	10
The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair	10
Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas	10
Harnessing bioengineered myeloid progenitors for precision immunotherapies	10
Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming	10
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	10
Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside	10
Towards a bioengineered uterus: bioactive sheep uterus scaffolds are effectively recellularized by enzymatic preconditioning	10
Multiomic analysis of stretched osteocytes reveals processes and signalling linked to bone regeneration and cancer	10
Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	10
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	9
Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva	9
DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation	9
Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)	9
Cell-scale porosity minimizes foreign body reaction and promotes innervated myofiber formation after volumetric muscle loss	9
Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review	9
Quantum dots as biocompatible small RNA nanocarriers modulating macrophage polarization to treat Asherman’s syndrome	9
Immune-mediated regeneration of cell-free vascular grafts in an ovine model	9
Parishin A-loaded mesoporous silica nanoparticles modulate macrophage polarization to attenuate tendinopathy	9
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates	9
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease	9
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	9