OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Author Correction: Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	142
Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval	78
Combinatorial extracellular matrix tissue chips for optimizing mesenchymal stromal cell microenvironment and manufacturing	67
Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons	66
Author Correction: The bright side of fibroblasts: molecular signature and regenerative cues in major organs	66
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	64
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing	57
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration	52
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A	52
Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish	46
Implication of CXCR2-Src axis in the angiogenic and osteogenic effects of FP-TEB	43
Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease	43
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	42
An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration	41
Pain sensing neurons promote tissue regeneration in adult mice	41
The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway	40
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis	39
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms	39
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells	37
Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels	35
Infected wound repair correlates with collagen I induction and NOX2 activation by cold atmospheric plasma	35
Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes	35
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	34
Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas	32
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice	32

Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells	32
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment	32
Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside	32
Harnessing bioengineered myeloid progenitors for precision immunotherapies	31
Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors	30
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	29
MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice	29
Stem cell-based therapy for COVID-19 and ARDS: a systematic review	28
A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish	27
Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells	26
Hippo-Yap/Taz signalling in zebrafish regeneration	25
Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction	25
Clinically relevant small-molecule promotes nerve repair and visual function recovery	24
Metformin accelerates zebrafish heart regeneration by inducing autophagy	24
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization	24
Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration	23
The specialist in regeneration—the Axolotl—a suitable model to study bone healing?	23
Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function	23
Epimorphic regeneration in the mammalian tympanic membrane	23
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice	23
Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs	23
Human adipose-derived stromal/stem cells expressing doublecortin improve cartilage repair in rabbits and monkeys	23
Macrophages in heterotopic ossification: from mechanisms to therapy	22
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium	22
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)	22
Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response	22
A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration	22
Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis	21
Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept	21
Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells	21
Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon	21
Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease	20
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration	20
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration	20
Author Correction : SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease	19
Preclinical efficacy and safety of AAVrh10-based plakophilin-2 gene therapy (LX2020) as a treatment for arrhythmogenic cardiomyopathy	19
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible	19
Author Correction: Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service	19
A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation	19
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration	18
Regeneration of tracheal neotissue in partially decellularized scaffolds	18
Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva	18
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation	18
Immune-mediated regeneration of cell-free vascular grafts in an ovine model	18
Author Correction: Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	18
Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart	17
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	17
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease	17
Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures	16
The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair	16

An NF-kB/TNF-alpha signalling feedback loop acts to coordinate tissue regeneration and macrophage behaviour in zebrafish	16
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration	16
A two-way street – cellular metabolism and myofibroblast contraction	15
Longevity leap: mind the healthspan gap	15
Engineered extracellular vesicle-encapsulated CHIP as novel nanotherapeutics for treatment of renal fibrosis	15
Early resistance rehabilitation improves functional regeneration following segmental bone defect injury	15
De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation	15
Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression	15
Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development	15
Systemic factors associated with antler growth promote complete wound healing	15
Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model	14
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration	14
CYR61 delivery promotes angiogenesis during bone fracture repair	14
Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction	14
SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression	14
A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy	14
Rational engineering of lung alveolar epithelium	14
Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium	14
Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury	14
Genetic compensation response contributes to Pleurodeles waltl limb regeneration	14
Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	14
Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury	14
Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles	14
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model	13
Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration	13
DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration	13
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	13
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes	13
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy	13
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	13
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	13
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea	13
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	12
CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells	12
Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation	12
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes	12
Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	12
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration	12
Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)	11
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI	11
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	11
Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation	11
Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing	11
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment	11
Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice	11
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates	11
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury	11
Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β	10
Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration	10
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells	10
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse	10
Integrin-specific hydrogels for growth factor-free vasculogenesis	10
Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues	10
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration	10
An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial	10
Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs	10
Neuronal activation in the axolotl brain promotes tail regeneration	10
Single cell transcriptomics of human kidney organoid endothelium reveals vessel growth processes and arterial maturation upon transplantation	10
Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum	10