OOIR: Observatory of International Research

Papers

(The TQCC of npj Regenerative Medicine is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing	110
Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease	88
Author Correction: The bright side of fibroblasts: molecular signature and regenerative cues in major organs	84
Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells	78
Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line	66
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration	57
Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment	57
Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP	57
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes	54
Epicardial slices: an innovative 3D organotypic model to study epicardial cell physiology and activation	52
A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model	48
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	48
Modelling urea cycle disorders using iPSCs	42
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	40
Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration	40
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium	39
An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model	38
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A	35
Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon	35
Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept	34
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model	34
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration	34
A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration	32
DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration	31
Author Correction: Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	30

Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis	30
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration	30
Implementing systems thinking and data science in the training of the regenerative medicine workforce	30
Perspectives on the cost of goods for hPSC banks for manufacture of cell therapies	30
Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn	29
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	28
Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	27
Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue	27
Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis	26
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy	26
Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries	26
The one-step fabrication of porous hASC-laden GelMa constructs using a handheld printing system	25
Mammals fail to regenerate organs when wound contraction drives scar formation	25
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration	25
Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo	25
The bright side of fibroblasts: molecular signature and regenerative cues in major organs	24
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration	23
A novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles	23
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	23
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea	23
Author Correction : SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease	22
Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury	22
Anti-inflammatory Prowess of endothelial progenitor cells in the realm of biology and medicine	22
Author Correction: Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service	22
Targets identified from exercised heart: killing multiple birds with one stone	22
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells	22
MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis	21
3′mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury	21
LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration	21
Utilising an in silico model to predict outcomes in senescence-driven acute liver injury	21
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms	20
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible	20
Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis	20
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	19
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice	19
Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage	19
Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs	19
CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells	18
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes	18
Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	18
Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle	18
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis	18
Infected wound repair correlates with collagen I induction and NOX2 activation by cold atmospheric plasma	18
The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway	17
Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation	17
Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish	17
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties	17
Implication of CXCR2-Src axis in the angiogenic and osteogenic effects of FP-TEB	17
Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	17
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment	17

Myoblast-derived ADAMTS-like 2 promotes skeletal muscle regeneration after injury