Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 143. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Novel pyroptosis-independent functions of gasdermins1394
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage1335
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma1306
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment1134
Greasy hair against obesity976
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages975
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study916
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry790
High-resolution aging niche of human adipose tissues779
Radiopharmaceuticals and their applications in medicine682
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery653
Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer617
RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation598
“Clone-specific” antibody-drug conjugates: an innovative strategy in the treatment of T-cell cancers561
Unexpected little helpers: microbiota stimulate systemic antiviral defenses556
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies542
Alterations of the oral and gut mycobiome and cytokines during long-term follow-up of COVID-19 convalescents536
Mutated trimeric RBD vaccines: a platform against variants of concern534
Identification of glutamine as a potential therapeutic target in dry eye disease532
Retraction Note: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway522
A bivalent recombinant vaccine: a promising strategy against both SARS-CoV-2 variants and wild type of the virus518
PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity516
Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial491
The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers477
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity474
CD5: from antiquated T cell marker to immunotherapy’s new hope471
Targeting strategies for bone diseases: signaling pathways and clinical studies469
The chemokine CCL17 is a novel therapeutic target for cardiovascular aging445
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms441
Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A429
RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern422
Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results419
ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer417
Intestinal eosinophils: characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis412
Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial407
Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity405
Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C403
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5395
Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight384
Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes383
Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA382
c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses382
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma379
Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition365
Correction: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice353
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study352
Pre-activated macrophage membrane-encased aggregation-induced emission featuring nanoparticles: a novel possibility for tuberculosis treatment351
Sensory neurons: unveiling the symphony of wound healing348
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation347
Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study342
Beyond the code: the role of histone methylation in cancer resistance and therapy333
Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease331
Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response323
Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity320
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster320
An emerging artificial nanomachine: a nanoengine with a reversible clutch316
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway309
A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells286
Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism286
Correction: The Hippo signalling pathway and its implications in human health and diseases284
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm284
Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection283
Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial282
Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity280
Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc275
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor272
Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit271
Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis267
Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers264
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells258
Four-wheel-drive immune protection257
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver251
For the sake of longevity: eating less and eating at the right time246
Author Correction: GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer238
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases235
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin235
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids234
Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation233
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing226
Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma221
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment220
SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis218
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models216
Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma216
Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery214
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis212
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis212
Moving towards precision psychiatry: the hard nut of depression212
Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial207
Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients206
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE201
CD4 T cell contact drives macrophage cell cycle G0-G1 transition201
A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants201
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients200
A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues196
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis194
Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer193
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine192
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications191
Correction: The signal pathways and treatment of cytokine storm in COVID-19190
NOL7 facilitates melanoma progression and metastasis189
SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies189
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enh188
Spliceosomal repression: unleashing human cell totipotency188
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis187
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model186
Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant186
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection185
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells185
An mRNA vaccine with broad-spectrum neutralizing protection against Omicron variant sublineages BA.4/5 -included SARS-CoV-2181
Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment179
Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19179
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis177
Supporting tumor therapy by exercise: boosting T cell immunity by myokines176
Landscapes of SARS-CoV-2-reactive CD8+ T cells: heterogeneity of host immune responses against SARS-CoV-2174
Segregating memories: targeting microenvironment of neuronal ensembles173
Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies173
SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency172
Ketogenic diet: new avenues to overcome colorectal cancer169
The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression166
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses165
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis165
FAP senescence: a critical event in muscle regeneration164
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors161
Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation161
Mef2d: a novel transcription factor in type 2 allergic lung inflammation160
The beginning of a new era: pioneering direct screens for RNA modulators158
Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response157
Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice157
STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway155
SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)152
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation152
Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial150
Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study149
Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression148
Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores148
Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation147
Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation146
Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization145
Cancer metastasis chemoprevention prevents circulating tumour cells from germination144
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance143
The loss of epigenetic information: not only consequences but a cause of mammalian aging143
In defence of ferroptosis143
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