Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 121. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Pyroptosis: mechanisms and diseases863
Inflammation and tumor progression: signaling pathways and targeted intervention766
The role of m6A modification in the biological functions and diseases737
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study704
Therapeutic siRNA: state of the art676
The JAK/STAT signaling pathway: from bench to clinic667
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells660
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives632
Exosomes: key players in cancer and potential therapeutic strategy574
The updated landscape of tumor microenvironment and drug repurposing562
Microbiota in health and diseases542
Pattern recognition receptors in health and diseases528
Ferroptosis: mechanisms and links with diseases523
Viral vector platforms within the gene therapy landscape520
COVID-19: immunopathogenesis and Immunotherapeutics486
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities484
Therapeutic peptides: current applications and future directions483
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer466
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects436
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2434
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets428
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential397
A systematic review of SARS-CoV-2 vaccine candidates392
Antibody drug conjugate: the “biological missile” for targeted cancer therapy388
Application of exosomes as liquid biopsy in clinical diagnosis382
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials381
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome336
The signal pathways and treatment of cytokine storm in COVID-19333
FGF/FGFR signaling in health and disease328
Targeting tumor-associated macrophages to synergize tumor immunotherapy326
Targeting PI3K/Akt signal transduction for cancer therapy322
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development317
SARS-CoV-2 Omicron variant: recent progress and future perspectives316
Circulating tumor cells: biology and clinical significance316
Targeted therapy for hepatocellular carcinoma312
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity301
Targeting macrophages in cancer immunotherapy298
The interaction between ferroptosis and lipid metabolism in cancer294
Overcoming cancer therapeutic bottleneck by drug repurposing292
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics270
Extracellular matrix and its therapeutic potential for cancer treatment270
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches269
Copper homeostasis and cuproptosis in health and disease267
KRAS mutation: from undruggable to druggable in cancer266
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation257
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy253
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy252
G protein-coupled receptors: structure- and function-based drug discovery249
Notch signaling pathway: architecture, disease, and therapeutics248
Liquid–liquid phase separation in human health and diseases246
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer244
Stem cell-based therapy for human diseases243
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin237
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer230
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial227
Lactate metabolism in human health and disease222
Advances in targeted therapy for esophageal cancer221
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1220
Targeting circular RNAs as a therapeutic approach: current strategies and challenges217
Chitinase-3 like-protein-1 function and its role in diseases216
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention215
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling213
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy208
Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis207
Overview of lethal human coronaviruses203
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19203
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents197
NAD+ metabolism, stemness, the immune response, and cancer195
Wnt/β-catenin signaling in cancers and targeted therapies195
Regulated cell death (RCD) in cancer: key pathways and targeted therapies194
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications194
Regulating tumor suppressor genes: post-translational modifications192
Advances in COVID-19 mRNA vaccine development190
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy190
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments190
Signaling pathways and targeted therapy for myocardial infarction186
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance185
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression184
Alternative splicing and cancer: a systematic review183
Comparison of nonhuman primates identified the suitable model for COVID-19180
Targeting TGFβ signal transduction for cancer therapy177
Osteoarthritis: pathogenic signaling pathways and therapeutic targets177
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation176
From purines to purinergic signalling: molecular functions and human diseases175
Targeted protein degradation: mechanisms, strategies and application174
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases172
mRNA-based therapeutics: powerful and versatile tools to combat diseases172
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial171
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2169
Emerging new therapeutic antibody derivatives for cancer treatment165
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat163
COVID-19 in early 2021: current status and looking forward162
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration159
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing158
COVID-19 vaccine development: milestones, lessons and prospects157
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases156
Radiotherapy combined with immunotherapy: the dawn of cancer treatment154
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions150
Macrophages in immunoregulation and therapeutics149
Protein kinase CK2: a potential therapeutic target for diverse human diseases148
Trends in insulin resistance: insights into mechanisms and therapeutic strategy146
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms145
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response142
Structural biology of SARS-CoV-2: open the door for novel therapies141
T cell receptor (TCR) signaling in health and disease141
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms141
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples140
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events138
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway137
Intercellular mitochondrial transfer as a means of tissue revitalization135
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives132
Neoantigens: promising targets for cancer therapy132
The BET family in immunity and disease132
Targeting non-coding RNAs to overcome cancer therapy resistance132
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy131
The sirtuin family in health and disease131
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals128
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19125
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies124
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies123
Emerging role of tumor cell plasticity in modifying therapeutic response122
Epigenetic regulation of aging: implications for interventions of aging and diseases121
0.19880509376526