Signal Transduction and Targeted Therapy

Article	Citations
Greasy hair against obesity	1716
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells	1561
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection	1405
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver	1179
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster	1088
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE	1007
Moving towards precision psychiatry: the hard nut of depression	982
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis	956
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies	818
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics	818
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure	760
PD-1 and LAG-3: synergistic fostering of T cell exhaustion	752
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5	715
A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease	710
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion	686
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine	681
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry	679
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages	658
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis	657
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates	656
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance	655
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study	651
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis	649
Animal models for COVID-19: advances, gaps and perspectives	648
Correction: The Hippo signalling pathway and its implications in human health and diseases	645

Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells	634
CD4 T cell contact drives macrophage cell cycle G0-G1 transition	595
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer	595
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study	551
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study	550
Identification of glutamine as a potential therapeutic target in dry eye disease	536
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects	535
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis	511
Sensory neurons: unveiling the symphony of wound healing	504
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases	489
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders	488
Signal pathways of melanoma and targeted therapy	479
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness	478
Phototherapy in cancer treatment: strategies and challenges	477
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	471
Neutrophil extracellular traps in homeostasis and disease	462
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms	458
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration	454
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT	446
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications	443
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy	439
Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth	439
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors	432
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies	427
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy	425
TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN	423
Top(ological-operon) secret behind the long-range transcriptional coupling	413
Omicron spike protein: a clue for viral entry and immune evasion	403
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters	389
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism	387
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination	377
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron	370
D-lactate and glycerol as potential biomarkers of sorafenib activity in hepatocellular carcinoma	370
Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver	360
Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant	359
Platelets and diseases: signal transduction and advances in targeted therapy	355
Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair	351
Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis	350
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis	348
Beyond borders: the choroid plexus-immune communication during neuroinflammation	344
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma	340
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy	336
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects	331
Harnessing innate immune pathways for therapeutic advancement in cancer	329
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression	316
SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes	315
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases	315
The RING finger protein family in health and disease	306
Microbiota in health and diseases	302
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss	301

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	299
Base editing: a promising tool to rescue spinal muscular atrophy	295
Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes	291
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine	285
Predicting the next move: tracking the complexity of lung cancer evolution and metastasis	284
Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape	281
Mind-body control: a new perspective on motor neuron function	276
Persistent SARS-CoV-2 infection in asymptomatic young adults	275
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation	274
sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster	272
Nascent mRNA damage: depot and disposal	268
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury	261
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations	259
IRE1α: a gatekeeper of chemotherapy-induced immunogenicity in triple-negative breast cancer	251
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors	248
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants	247
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors	245
Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease	243
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression	240
Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumors	240
Linking B cell metabolism to immune regulation: the neurotransmitter GABA	239
Small molecules in the treatment of COVID-19	238
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread	235
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis	235
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus	234
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation	232
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization	232
RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury	228
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity	227
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer	227
Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies	227
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia	227
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection	227
Lactate metabolism in human health and disease	225
DNA framework signal amplification platform-based high-throughput systemic immune monitoring	223
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy	219
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome	216
Mitochondrial heterogeneity in diseases	216
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	216
Targeting PI3K/Akt signal transduction for cancer therapy	215
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	215
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases	214
Molecular insights of exercise therapy in disease prevention and treatment	212
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	210
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study	209
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets	209
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules	205
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control	204
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus	200
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation	198
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection	194
Glioblastoma at the crossroads: current understanding and future therapeutic horizons	191
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice	184
Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia	183
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness	183
Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study	181
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling	180
Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting	178
B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy	178
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants	178
RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle	177
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer	177
Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function	175
Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma	174
Single-cell genomics: the human biomolecular and cell atlases	174
Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics	172
Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells	172
Programmable synthetic receptors: the next-generation of cell and gene therapies	169
Current landscape of innovative drug development and regulatory support in China	168
SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer	167
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism	164
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19	163
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication	162
Combination therapy for HCC: from CRISPR screening to the design of clinical therapies	162
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration	159
Back to pluripotency: fully chemically induced reboot of human somatic cells	159
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing	157
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	157
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	157
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors	157

RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation	156
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1	156
ELANE: an emerging lane to selective anticancer therapy	154
mRNA-based therapeutics: powerful and versatile tools to combat diseases	154
Signaling pathways and targeted therapies for psoriasis	149
Checkpoint blockade therapy in Hodgkin lymphoma: improved response through combination with JAK inhibition	146
Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution	146
Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing	146
Time’s up: mutation rate and lifespan	143
Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis	142
Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance	142
Activated STING: an ion channel to trigger non-interferon-related functions	141
Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study	138
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates	137
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs	135
Balancing memory in sleep: firing barrages as a circuit breaker for reactivation	133
Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis	133
Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy	132
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation	131
Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells	130
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes	130
Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages	130
Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/II trial	130
Environment impacts sexual preference: dopamine sends signals under pressure to decide which sex you like	129
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis	128
Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells	127
An anti-tumor coup: TIM3 ablation activates the immune arsenal	127
Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications	126
Bat organoid platform: revolutionizing zoonotic virus research and pandemic preparedness	125
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial	125
A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis	124
Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity	123
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies	122
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts	122
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone	121
Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study	121
LIX1-like protein drives hepatic stellate cell activation to promote liver fibrosis by regulation of chemokine mRNA stability	120
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials	118
Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines	117
Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation	116
Redox regulation: mechanisms, biology and therapeutic targets in diseases	115
Signaling pathways in obesity: mechanisms and therapeutic interventions	115
ALYREF mediates RNA m5C modification to promote hepatocellular carcinoma progression	113
To metabolomics and beyond: a technological portfolio to investigate cancer metabolism	112
Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance	112
T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape	110
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future	109
The biological applications of DNA nanomaterials: current challenges and future directions	109
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein	108
Targeted protein degradation: advances in drug discovery and clinical practice	107
CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection	107
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential	107
Artificial intelligence in cancer target identification and drug discovery	107
Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomiz	106
Route, origin & valence matter: towards sophisticated next-generation vaccines to cope with the COVID-19 pandemic	106
Curse and blessing: upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome	105
Safety and efficacy of trifluridine/tipiracil +/− bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial	104
Human genetic basis of coronavirus disease 2019	103
Hypocretin neuron hyperexcitability in the hypothalamus: a newly discovered culprit in aging-related sleep impairment	103
A pan-cancer fingerprint: common molecular denominators of the human tumor microenvironment	102
Correction: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism	102
PARP1-DNA co-condensation: the driver of broken DNA repair	102
Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern	101
Uveal melanoma with a GNA11/GNAQ mutation secretes VEGF for systemic spread	101
Cross-neutralization and cross-protection among SARS-CoV-2 viruses bearing different variant spikes	101
Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial	101
Redox signaling-governed drug-tolerant persister cancer cell: a key spark of treatment failure	100
Artificial intelligence propels lung cancer screening: innovations and the challenges of explainability and reproducibility	100
Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma: a phase II trial	99
Human cross-tissue cell atlases: unprecedented resources towards systematic understanding of physiology and diseases	99
CAR-T cell therapy for cancer: current challenges and future directions	98
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes	97
DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice	97
The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation	97
A systemic look at pancreatic cancer patients: Predicting metastasis by studying the liver	97
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal c	94
Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism	94
DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation	94
Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa	93
The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis	92
NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity	92
Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study	92
The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling	90
METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression	90
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies	89
SCGN deficiency is a risk factor for autism spectrum disorder	89
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications	88
Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma	88
Neoadjuvant oncolytic virus orienx010 and toripalimab in resectable acral melanoma: a phase Ib trial	88
Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches	87
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection	87
The gasdermin family: emerging therapeutic targets in diseases	86
SLC7A11: a new regulator in diabetic wound healing	85
Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder	85
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1	85