Signal Transduction and Targeted Therapy

Article	Citations
Pyroptosis: mechanisms and diseases	829
Inflammation and tumor progression: signaling pathways and targeted intervention	726
The role of m6A modification in the biological functions and diseases	710
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study	669
Therapeutic siRNA: state of the art	661
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells	649
The JAK/STAT signaling pathway: from bench to clinic	639
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives	600
Exosomes: key players in cancer and potential therapeutic strategy	559
The updated landscape of tumor microenvironment and drug repurposing	549
Pattern recognition receptors in health and diseases	505
Microbiota in health and diseases	504
Viral vector platforms within the gene therapy landscape	503
Ferroptosis: mechanisms and links with diseases	498
COVID-19: immunopathogenesis and Immunotherapeutics	478
Therapeutic peptides: current applications and future directions	459
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer	457
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	454
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2	431
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects	419
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets	410
A systematic review of SARS-CoV-2 vaccine candidates	392
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential	380
Application of exosomes as liquid biopsy in clinical diagnosis	373
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials	371

Antibody drug conjugate: the “biological missile” for targeted cancer therapy	365
The signal pathways and treatment of cytokine storm in COVID-19	331
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome	330
FGF/FGFR signaling in health and disease	319
Targeting tumor-associated macrophages to synergize tumor immunotherapy	314
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development	312
SARS-CoV-2 Omicron variant: recent progress and future perspectives	310
Targeted therapy for hepatocellular carcinoma	303
Targeting PI3K/Akt signal transduction for cancer therapy	299
Circulating tumor cells: biology and clinical significance	298
Targeting macrophages in cancer immunotherapy	287
Overcoming cancer therapeutic bottleneck by drug repurposing	287
The interaction between ferroptosis and lipid metabolism in cancer	283
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity	279
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches	266
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation	255
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics	254
KRAS mutation: from undruggable to druggable in cancer	251
Extracellular matrix and its therapeutic potential for cancer treatment	251
G protein-coupled receptors: structure- and function-based drug discovery	241
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy	238
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin	236
Liquid–liquid phase separation in human health and diseases	236
Copper homeostasis and cuproptosis in health and disease	236
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	233
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer	231
Notch signaling pathway: architecture, disease, and therapeutics	228
Stem cell-based therapy for human diseases	224
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial	222
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer	218
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1	214
Targeting circular RNAs as a therapeutic approach: current strategies and challenges	213
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling	212
Advances in targeted therapy for esophageal cancer	211
Lactate metabolism in human health and disease	208
Chitinase-3 like-protein-1 function and its role in diseases	207
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19	203
Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis	203
Overview of lethal human coronaviruses	201
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy	201
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention	192
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents	188
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications	187
NAD+ metabolism, stemness, the immune response, and cancer	186
Wnt/β-catenin signaling in cancers and targeted therapies	185
Regulating tumor suppressor genes: post-translational modifications	185
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy	185
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	183
Advances in COVID-19 mRNA vaccine development	181
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression	179

Comparison of nonhuman primates identified the suitable model for COVID-19	179
Alternative splicing and cancer: a systematic review	177
Signaling pathways and targeted therapy for myocardial infarction	176
Regulated cell death (RCD) in cancer: key pathways and targeted therapies	174
Targeting TGFβ signal transduction for cancer therapy	173
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation	172
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial	170
From purines to purinergic signalling: molecular functions and human diseases	169
Targeted protein degradation: mechanisms, strategies and application	166
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2	165
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments	165
mRNA-based therapeutics: powerful and versatile tools to combat diseases	165
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat	162
COVID-19 in early 2021: current status and looking forward	159
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases	159
Osteoarthritis: pathogenic signaling pathways and therapeutic targets	154
Emerging new therapeutic antibody derivatives for cancer treatment	154
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration	153
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing	152
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases	151
COVID-19 vaccine development: milestones, lessons and prospects	148
Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells	148
Radiotherapy combined with immunotherapy: the dawn of cancer treatment	144
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response	142
Protein kinase CK2: a potential therapeutic target for diverse human diseases	141
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms	141
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples	140
Structural biology of SARS-CoV-2: open the door for novel therapies	139
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms	138
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	138
A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia	135
Trends in insulin resistance: insights into mechanisms and therapeutic strategy	133
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events	133
T cell receptor (TCR) signaling in health and disease	132
Intercellular mitochondrial transfer as a means of tissue revitalization	132
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway	129
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives	127
The BET family in immunity and disease	127
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals	126
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy	123
Macrophages in immunoregulation and therapeutics	123
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19	122
The sirtuin family in health and disease	121
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies	121
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies	120
Emerging role of tumor cell plasticity in modifying therapeutic response	118
Neoantigens: promising targets for cancer therapy	117
Targeting non-coding RNAs to overcome cancer therapy resistance	117
Signal pathways of melanoma and targeted therapy	117
Action mechanisms and research methods of tRNA-derived small RNAs	116
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention	114
Recent progress in targeted delivery vectors based on biomimetic nanoparticles	113
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota	112
Epigenetic regulation of aging: implications for interventions of aging and diseases	111
The glycosylation in SARS-CoV-2 and its receptor ACE2	109
The biological applications of DNA nanomaterials: current challenges and future directions	109
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer	107
Progress in the mechanism and targeted drug therapy for COPD	105
The STING1 network regulates autophagy and cell death	104
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations	103
Targeting fibrosis: mechanisms and clinical trials	101
Inflammasomes as therapeutic targets in human diseases	101
Correction: Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study	100
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties	100
The interactions between cGAS-STING pathway and pathogens	99
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins	98
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response	98
Targeting integrin pathways: mechanisms and advances in therapy	98
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients	95
Functional characterization of SOX2 as an anticancer target	95
Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients	94
Omicron: increased transmissibility and decreased pathogenicity	94
A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair	92
Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2	92
Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines	91
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion	91
Human organoids in basic research and clinical applications	91
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages	91
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy	90
Molecular regulations of circadian rhythm and implications for physiology and diseases	90

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis	90
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)	89
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis	89
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics	88
Colorectal liver metastasis: molecular mechanism and interventional therapy	88
COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm	87
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression	87
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome	87
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer	86
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification	86
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	85
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis	85
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation	85
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins	85
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions	84
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis	84
Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19	83
The blood–brain barrier: structure, regulation, and drug delivery	83
Alternative approaches to target Myc for cancer treatment	83
SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies	83
Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src	83
The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys	82
CRISPR/Cas9 therapeutics: progress and prospects	82
ACE2-independent infection of T lymphocytes by SARS-CoV-2	82
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics	81
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)	79
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity	78
The Hippo signalling pathway and its implications in human health and diseases	78
Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1	78
Artificial intelligence in cancer target identification and drug discovery	78
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions	77
CD146, from a melanoma cell adhesion molecule to a signaling receptor	77
Overview of current targeted therapy in gallbladder cancer	77
Monkeypox: epidemiology, pathogenesis, treatment and prevention	77
NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1	76
Signaling pathways in obesity: mechanisms and therapeutic interventions	76
RNA modifications: importance in immune cell biology and related diseases	76
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy	75
The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma	75
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need	75
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials	75
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development	74
Signaling pathways and intervention therapies in sepsis	74
Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro	73
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	73
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence	73
PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC	72
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting	72
Inflammation and aging: signaling pathways and intervention therapies	71
Functional hair follicle regeneration: an updated review	71
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	71
Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling	70
Dynamic blood single-cell immune responses in patients with COVID-19	69
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases	69
Spatiotemporal control of CRISPR/Cas9 gene editing	69
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine	68
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer	68
Neurological complications and infection mechanism of SARS-CoV-2	68
Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes	68
Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design	68
Targeting p53 pathways: mechanisms, structures, and advances in therapy	67
m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance	67
Signaling pathways of chronic kidney diseases, implications for therapeutics	67
Role of neuroinflammation in neurodegeneration development	66
N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding	66
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response	66
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy	65
Natural killer cell homing and trafficking in tissues and tumors: from biology to application	65
The role of histone modifications: from neurodevelopment to neurodiseases	65
The key roles of cancer stem cell-derived extracellular vesicles	64
Omicron adopts a different strategy from Delta and other variants to adapt to host	64
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications	64
NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease	62
Small molecule metabolites: discovery of biomarkers and therapeutic targets	61
The role of histone methylation in the development of digestive cancers: a potential direction for cancer management	61
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma	61
Clinical and translational values of spatial transcriptomics	61
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients	61
Mesenchymal stem cell therapy for severe COVID-19	61
POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy	60
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis	60
Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway	60
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth	60
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules	60
Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19	60
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies	60
Signaling pathways in rheumatoid arthritis: implications for targeted therapy	59
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants	59
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19	58
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment	58
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19	58
Targeting lysosomes in human disease: from basic research to clinical applications	58
SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern	58
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis	57
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer	57