Signal Transduction and Targeted Therapy

Article	Citations
Novel pyroptosis-independent functions of gasdermins	1394
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage	1335
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma	1306
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment	1134
Greasy hair against obesity	976
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages	975
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study	916
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry	790
High-resolution aging niche of human adipose tissues	779
Radiopharmaceuticals and their applications in medicine	682
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery	653
Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer	617
RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation	598
“Clone-specific” antibody-drug conjugates: an innovative strategy in the treatment of T-cell cancers	561
Unexpected little helpers: microbiota stimulate systemic antiviral defenses	556
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies	542
Alterations of the oral and gut mycobiome and cytokines during long-term follow-up of COVID-19 convalescents	536
Mutated trimeric RBD vaccines: a platform against variants of concern	534
Identification of glutamine as a potential therapeutic target in dry eye disease	532
Retraction Note: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway	522
A bivalent recombinant vaccine: a promising strategy against both SARS-CoV-2 variants and wild type of the virus	518
PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity	516
Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial	491
The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers	477
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity	474

CD5: from antiquated T cell marker to immunotherapy’s new hope	471
Targeting strategies for bone diseases: signaling pathways and clinical studies	469
The chemokine CCL17 is a novel therapeutic target for cardiovascular aging	445
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms	441
Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A	429
RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern	422
Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results	419
ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer	417
Intestinal eosinophils: characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis	412
Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial	407
Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity	405
Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C	403
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5	395
Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight	384
Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes	383
Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA	382
c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses	382
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma	379
Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition	365
Correction: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice	353
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study	352
Pre-activated macrophage membrane-encased aggregation-induced emission featuring nanoparticles: a novel possibility for tuberculosis treatment	351
Sensory neurons: unveiling the symphony of wound healing	348
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation	347
Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study	342
Beyond the code: the role of histone methylation in cancer resistance and therapy	333
Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease	331
Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response	323
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster	320
Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity	320
An emerging artificial nanomachine: a nanoengine with a reversible clutch	316
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway	309
Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism	286
A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells	286
Correction: The Hippo signalling pathway and its implications in human health and diseases	284
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm	284
Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection	283
Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial	282
Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity	280
Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc	275
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor	272
Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit	271
Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis	267
Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers	264
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells	258
Four-wheel-drive immune protection	257
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver	251
For the sake of longevity: eating less and eating at the right time	246
Author Correction: GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer	238
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin	235

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases	235
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids	234
Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation	233
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing	226
Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma	221
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment	220
SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis	218
Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma	216
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models	216
Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery	214
Moving towards precision psychiatry: the hard nut of depression	212
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis	212
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis	212
Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial	207
Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients	206
CD4 T cell contact drives macrophage cell cycle G0-G1 transition	201
A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants	201
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE	201
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients	200
A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues	196
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis	194
Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer	193
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine	192
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications	191
Correction: The signal pathways and treatment of cytokine storm in COVID-19	190
NOL7 facilitates melanoma progression and metastasis	189
SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies	189
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enh	188
Spliceosomal repression: unleashing human cell totipotency	188
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis	187
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model	186
Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant	186
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection	185
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells	185
An mRNA vaccine with broad-spectrum neutralizing protection against Omicron variant sublineages BA.4/5 -included SARS-CoV-2	181
Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19	179
Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment	179
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis	177
Supporting tumor therapy by exercise: boosting T cell immunity by myokines	176
Landscapes of SARS-CoV-2-reactive CD8+ T cells: heterogeneity of host immune responses against SARS-CoV-2	174
Segregating memories: targeting microenvironment of neuronal ensembles	173
Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies	173
SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency	172
Ketogenic diet: new avenues to overcome colorectal cancer	169
The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression	166
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis	165
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses	165
FAP senescence: a critical event in muscle regeneration	164
Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation	161
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors	161
Mef2d: a novel transcription factor in type 2 allergic lung inflammation	160
The beginning of a new era: pioneering direct screens for RNA modulators	158
Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response	157
Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice	157
STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway	155
SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)	152
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation	152
Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial	150
Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study	149
Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression	148
Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores	148
Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation	147
Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation	146
Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization	145
Cancer metastasis chemoprevention prevents circulating tumour cells from germination	144
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance	143
The loss of epigenetic information: not only consequences but a cause of mammalian aging	143
In defence of ferroptosis	143
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils	142
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates	142
STING cg16983159 methylation: a key factor for glioblastoma immunosuppression	142
New case of HIV cure: joined forces of haploidentical stem cells and HLA-mismatched cord blood	142
Pyrotinib plus capecitabine could significantly improve overall survival in HER2-positive metastatic breast cancer	139
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys	138
Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy	138
Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma	136
Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease	135
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1	133
Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease	133
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy	132

A microglial compliment: controlling neuronal function from within	132
PD-1 and LAG-3: synergistic fostering of T cell exhaustion	130
Carbon nanotube promotes contraction and electrical activity of neonatal cardiomyocytes by targeting sodium/calcium exchanger NCX1	129
Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling	129
One step at a time: new insights into double-stranded ribonucleic acid virus assembly	127
A bacteria-based system expressing anti-TNF-α nanobody for enhanced cancer immunotherapy	126
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion	124
TET2 cascade: a novel regulator of chromatin structure and leukaemogenesis	124
Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma	123
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure	121
Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression	121
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases	120
Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma	120
Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma	118
Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression	118
Correction: Targeted prebiotics alter the obese gut microbiome in humans	118
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics	116
PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity	115
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study	113
Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2	113
Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis	110
QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study	110
The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease	110
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders	109
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation	109
Mitochondrial apoptosis: facilitator of NK cell-mediated immunotherapy	107
Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies	106
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer	106
Myeloid cells in COVID-19 microenvironment	105
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment	105
Highly efficient gene editing and single cell analysis of hematopoietic stem/progenitor cells from X-linked sideroblastic anemia patients	105
PINK1-mediated Drp1S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission	102
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases	101
Epstein-Barr virus infection: the leading cause of multiple sclerosis	101
Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction	101
Fibroblastic niches in action: CCL19+ reticular cells drive anti-tumor immunity in lung cancer	100
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer	99
Immunological and metabolic characteristics of the Omicron variants infection	98
CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability	97
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders	97
NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy	96
Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis	96
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer	95
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion	94
Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity	94
Mesenchymal stem cell therapy for severe COVID-19	93
Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment	92
Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines	92
Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study	91
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration	90
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications	89
Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology	89
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness	89
Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation	88
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy	88
A new wave of innovations within the DNA damage response	87
A novel alternative for pyrogen detection based on a transgenic cell line	87
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB	86
Hepatocellular carcinoma: signaling pathways and therapeutic advances	86
Cryo-EM advances in RNA structure determination	85
First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular	85
Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis	85
Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer	84
SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway	84
Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy	83
Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy	83
Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial	82
The IL-17 family in diseases: from bench to bedside	82
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants	82
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets	82
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics	81
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)	81
Correction To: Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	81
Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study	80
Targeting epigenetic regulators to overcome drug resistance in cancers	80
Biofilms and exopolysaccharides in Pseudomonas aeruginosa: pathogenesis, immune evasion, and lung–brain signaling during pneumonia	78
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages	78
Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling	78
Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy	78
Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome	78
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects	78
Therapeutic cancer vaccines: advancements, challenges and prospects	77
Scalable biomimetic SARS-CoV‑2 nanovaccines with robust protective immune responses	77
CRISPRing the hypertrophic cardiomyopathy: correcting one pathogenic variant at a time	77
Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment	76
The role of histone modifications: from neurodevelopment to neurodiseases	76
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies	76
Stem cell-based therapy for human diseases	75
Targeted therapy for head and neck cancer: signaling pathways and clinical studies	73
Signal pathways of melanoma and targeted therapy	73
Structural biology of SARS-CoV-2: open the door for novel therapies	73
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases	72
An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity	72
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	71
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques	71