OOIR: Observatory of International Research

Papers

(The TQCC of Acta Crystallographica Section D-Structural Biology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Utilizing anomalous signals for element identification in macromolecular crystallography	411
EMinsight: a tool to capture cryoEM microscope configuration and experimental outcomes for analysis and deposition	209
Slice'N'Dice: maximizing the value of predicted models for structural biologists	83
A web-based dashboard for RELION metadata visualization	56
New insights into the domain of unknown function (DUF) of EccC₅, the pivotal ATPase providing the secretion driving force to the ESX-5 secretion system	51
Michaelis-like complex of mouse ketohexokinase isoform C	49
Racemic crystal structures of A-DNA duplexes	46
SCOMAP-XD: atomistic deuterium contrast matching for small-angle neutron scattering in biology	43
The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme	39
Using graphlet degree vectors to predict atomic displacement parameters in protein structures	38
Current trends in macromolecular model refinement and validation	37
The TR-icOS setup at the ESRF: time-resolved microsecond UV–Vis absorption spectroscopy on protein crystals	35
CSSR: assignment of secondary structure to coarse-grained RNA tertiary structures	34
Room-temperature serial synchrotron crystallography of Drosophila cryptochrome	32
Structure of a hydrophobic leucinostatin derivative determined by host lattice display	30
Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis	26
Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans	26
Scipion Flexibility Hub: an integrative framework for advanced analysis of conformational heterogeneity in cryoEM	24
Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family	24
Unravelling the secrets of multi-domain lytic polysaccharide monooxygenases (LPMOs)	24
Near-atomic resolution reconstructions from in situ revitrified cryo samples	23
Crystallization, structural characterization and kinetic analysis of a GH26 β-mannanase from Klebsiella oxytoca KUB-CW2-3	21
A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography	21
Protonation states of hen egg-white lysozyme observed using D/H contrast neutron crystallography	21
Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum. Corrigendum	20

Structural and functional studies of SAV1707 from Staphylococcus aureus elucidate its distinct metal-dependent activity and a crucial residue for catalysis	20
Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin	19
Modelling covalent linkages in CCP4	18
Control of strain in subgrains of protein crystals by the introduction of grown-in dislocations	17
The structure ofPhocaeicola vulgatussialic acid acetylesterase	17
Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily	15
Databases for intrinsically disordered proteins	15
Predicting the performance of automated crystallographic model-building pipelines	15
α-SAS: an integrative approach for structural modeling of biological macromolecules in solution	14
Are the St John's wort Hyp-1 superstructures different?	14
Validation, analysis and annotation of cryo-EM structures	14
Optimized cryo-EM data-acquisition workflow by sample-thickness determination	14
Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus thermophilus phage Tth15-6	14
Dependence of crystallographic atomic displacement parameters on temperature (25–150 K) for complexes of horse liver alcohol dehydrogenase	13
Determination of intracellular protein–ligand binding affinity by competition binding in-cell NMR	13
Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion	13
Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects	13
Towards the automatic crystal structure solution of nucleic acids: automated model building using the new CAB program	13
Redeployment of automated MrBUMP search-model identification for map fitting in cryo-EM	13
B-factor accuracy in protein crystal structures	13
Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase	13
Factors affecting macromolecule orientations in thin films formed in cryo-EM	12
Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing	12
Likelihood-based interactive local docking into cryo-EM maps in ChimeraX	12
Hydrogen-bond-driven supramolecular helical assembly of a coumarin-substituted phthalonitrile derivative: synthesis andin vitroanticancer activity against colorectal adenocarcinoma	12
Analysis of crystallographic phase retrieval using iterative projection algorithms	11
Neutron crystallographic refinement with REFMAC5 from the CCP4 suite	11
Peter Main (1939–2024)	11
New restraints and validation approaches for nucleic acid structures in PDB-REDO	11
xia2.multiplex: a multi-crystal data-analysis pipeline	11
EMhub: a web platform for data management and on-the-fly processing in scientific facilities	11
Structural basis for substrate recognition in the Phytolacca americana glycosyltransferase PaGT3	11
New system for archiving integrative structures	10
Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase	10
Improving macromolecular structure refinement with metal-coordination restraints	10
MrParse: finding homologues in the PDB and the EBI AlphaFold database for molecular replacement and more	10
Jan Drenth (1925–2025)	10
VitroJet: new features and case studies	10
Accelerating crystal structure determination with iterative AlphaFold prediction	10
Structural dynamics: review of time-resolved cryo-EM	10
Tomo Live: an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows	10
Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family	9
The ManifoldEM method for cryo-EM: a step-by-step breakdown accompanied by a modern Python implementation	9
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites	9
Crystal-packing analysis of translation initiation factor 2 reveals new details of its function	9
Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules	9
High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms	9
Crystal and solution structures of a novel antimicrobial peptide fromChrysomya megacephala	8
Intracellular drug binding affinities by NMR	8
Challenges in solving structures from radiation-damaged tomograms of protein nanocrystals assessed by simulation	8

X-ray diffraction and in vivo studies reveal the quinary structure of Trypanosoma cruzi nucleoside diphosphate kinase 1: a novel helical oligomer structure	8
Photosystem II: light-dependent oscillation of ligand composition at its active site	8
Two states of a light-sensitive membrane protein captured at room temperature using thin-film sample mounts	7
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases	7
Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding	7
Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography	7
Development of CryoVR, a virtual reality training system for hands-on cryoEM operations	7
Structure of the plant growth-promoting factor YxaL from the rhizobacterium Bacillus velezensis and its application to protein engineering	7
Radiation-induced defects in protein crystals observed by X-ray topography	7
Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction	7
Structural and spectrophotometric investigation of two unnatural amino-acid altered chromophores in the superfolder green fluorescent protein	7
Intermediates in allosteric equilibria of DnaK–ATP interactions with substrate peptides	7
Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae	7
Data collection from crystals grown in microfluidic droplets	7
Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2	6
Structural and binding studies of a new chitin-active AA10 lytic polysaccharide monooxygenase from the marine bacterium Vibrio campbellii	6
Structure–function studies of a novel laccase-like multicopper oxidase fromThermothelomyces thermophilaprovide insights into its biological role	6
Kinetic and structural studies of the reaction of Escherichia coli dihydrodipicolinate synthase with (S)-2-bromopropionate	6
Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane-penetrating loop	6
Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase	6
Correcting systematic errors in diffraction data with modern scaling algorithms	6
Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase	6
Crystal structure of DNA polymerase I from Thermus phage G20c	6
Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase	6
Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain	6
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum	6
A scalable strategy to solve structures of PDZ domains and their complexes	6
Raimond B. G. Ravelli (25 March 1968–30 June 2023)	6
Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals	5
The future of biomolecular simulation in the pharmaceutical industry: what we can learn from aerodynamics modelling and weather prediction. Part 1. understanding the physical and computational complex	5
Determining biomolecular structures near room temperature using X-ray crystallography: concepts, methods and future optimization	5
Direct calculation of cryo-EM and crystallographic model maps for real-space refinement	5
Buccaneer model building with neural network fragment selection	5
Notes of a protein crystallographer: the legacy of J.-B. J. Fourier – crystallography, time and beyond	5
Anaerobic fixed-target serial crystallography using sandwiched silicon nitride membranes	5
Robust and automatic beamstop shadow outlier rejection: combining crystallographic statistics with modern clustering under a semi-supervised learning strategy	5
Errors in structural biology are not the exception	5
Structural basis of DNA binding by YdaT, a functional equivalent of the CII repressor in the cryptic prophage CP-933P from Escherichia coli O157:H7	5
HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening	5
Identifying and avoiding radiation damage in macromolecular crystallography	5
Advanced exploitation of unmerged reflection data during processing and refinement with autoPROC and BUSTER	5
The High-Pressure Freezing Laboratory for Macromolecular Crystallography (HPMX), an ancillary tool for the macromolecular crystallography beamlines at the ESRF	5
Updated restraint dictionaries for carbohydrates in the pyranose form	5
Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution	5
30 years of Acta D	5
Structures of permuted halves of a modern ribose-binding protein	5
A tetramerization domain in prokaryotic and eukaryotic transcription regulators homologous to p53	5