OOIR: Observatory of International Research

Papers

(The TQCC of Acta Crystallographica Section D-Structural Biology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
EMhub: a web platform for data management and on-the-fly processing in scientific facilities	636
Using graphlet degree vectors to predict atomic displacement parameters in protein structures	89
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer-specific Tn-MUC1 epitope	69
Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase	58
Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing	58
Cryo-EM single-particle analysis expanding towards increasingly native samples	47
Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library	46
Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody	45
Crystal structure of DNA polymerase I from Thermus phage G20c	43
Updated restraint dictionaries for carbohydrates in the pyranose form	43
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites	38
Structures of permuted halves of a modern ribose-binding protein	35
X-ray diffraction and in vivo studies reveal the quinary structure of Trypanosoma cruzi nucleoside diphosphate kinase 1: a novel helical oligomer structure	33
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases	32
Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases	31
Data collection from crystals grown in microfluidic droplets	30
A scalable strategy to solve structures of PDZ domains and their complexes	25
Identifying and avoiding radiation damage in macromolecular crystallography	23
Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals	23
On bias, variance, overfitting, gold standard and consensus in single-particle analysis by cryo-electron microscopy	23
Critical evaluation of three cryo-EM structures of particulate methane monooxygenase by quantum refinement	20
A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat	19
Structural studies of NAD ⁺ -dependent methanol dehydrogenase 1 from Bacillus methanolicus MGA3	19
Raw diffraction data are our ground truth from which all subsequent workflows develop	18
A radical approach to radicals	18

Training undergraduate research assistants with an outcome-oriented and skill-based mentoring strategy	18
Analysis and validation of overall N-glycan conformation in Privateer	17
Validation of helical symmetry parameters in the EMDB	16
Overall protein structure quality assessment using hydrogen-bonding parameters	16
Biophysical Chemistry, Second Edition. By Dagmar Klostermeier and Markus G. Rudolph. CRC Press, Boca Raton, 2025, pp. 944. ISBN 9781032060835. Price GBP 57.39 (hardback)	16
Statistical analyses of the oxidized P-clusters in MoFe proteins using the bond-valence method: towards their electron transfer in nitrogenases	15
Crystal structure of coagulation factor XII N-terminal domains 1–5	15
The crystal structure of the N-terminal domain of the backbone pilin LrpA reveals a new closure-and-twist motion for assembling dynamic pili in Ligilactobacillus ruminis	15
Structural and functional analysis of the D-alanyl carrier protein ligase DltA from Staphylococcus aureus Mu50	15
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent	15
Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase	15
Preparation and characterization of inactivated tick-borne encephalitis virus samples for single-particle imaging at the European XFEL	14
Structural studies of β-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus	14
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor	14
Molecular basis of transcriptional repression of anti-CRISPR by anti-CRISPR-associated 2	14
A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands	14
Notes of a protein crystallographer: the advantages of combining new integrated methods of structure solution with traditional data visuals	14
Time-resolved serial femtosecond crystallography on fatty-acid photodecarboxylase: lessons learned	14
Medical contrast agents as promising tools for biomacromolecular SAXS experiments	14
Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the discovery of DNA's Double Helix. By Howard Markel. W. W. Norton & Co., 2021. Hardback, pp. 608. ISBN 978-1324002239.	13
The T₂ structure of polycrystalline cubic human insulin	13
Alexei Vagin (1944–2023)	13
Pillar data-acquisition strategies for cryo-electron tomography of beam-sensitive biological samples	13
Michael James (1940–2023)	13
Submission of structural biology data for review purposes	12
Crystal structures of the molecular class A β-lactamase TEM-171 and its complexes with tazobactam	12
Structural mechanism of Escherichia coli cyanase	12
Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803	12
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket	12
Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin	11
Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization	11
Knowledge-based prediction of DNA hydration using hydrated dinucleotides as building blocks	11
Direct phasing algorithm for protein crystals with high solvent content using low-resolution diffraction data	11
Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase fromBradyrhizobiumsp.	11
Raynals, an online tool for the analysis of dynamic light scattering	11
Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy	11
A new inactive conformation of SARS-CoV-2 main protease	11
Structural and functional characterization of a multi-domain GH92 α-1,2-mannosidase from Neobacillus novalis	11
Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE	11
The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report	10
Dependence of crystallographic atomic displacement parameters on temperature (25–150 K) for complexes of horse liver alcohol dehydrogenase	10
Best practices for time-resolved serial synchrotron crystallography	10
The LH–DH module of bacterial replicative helicases is the common binding site for DciA and other helicase loaders	10
Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets	10
Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects	10
Protonation states of hen egg-white lysozyme observed using D/H contrast neutron crystallography	9
Accelerating crystal structure determination with iterative AlphaFold prediction	9
Buccaneer model building with neural network fragment selection	9
Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase	9
Tomo Live : an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows	9

Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans	9
New system for archiving integrative structures	9
Correcting systematic errors in diffraction data with modern scaling algorithms	9
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum	9
VitroJet: new features and case studies	9
Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase	9
Structural basis for substrate recognition in the Phytolacca americana glycosyltransferase PaGT3	9
Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding	9
Restoration of the 3D structure of insect flight muscle from a rotationally averaged 2D X-ray diffraction pattern	9
Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules	9
Protein–macrocycle polymorphism: crystal form IV of the Ralstonia solanacearum lectin–sulfonato-calix[8]arene complex	8
The impact of molecular variants, crystallization conditions and the space group on ligand–protein complexes: a case study on bacterial phosphotriesterase	8
Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions	8
Post-translational modifications in the Protein Data Bank	8
Mechanistic insight into O=O bond formation upon model-independent visualization of the coordination geometry and ligand composition of Mn₄Ca cofactor in dark-adapted photosystem II structu	8
The High-Pressure Freezing Laboratory for Macromolecular Crystallography (HPMX), an ancillary tool for the macromolecular crystallography beamlines at the ESRF	8
Dynamics and Kinetics in Structural Biology: Unravelling Function Through Time-Resolved Structural Analysis. By Keith Moffat and Eaton E. Lattman. Wiley, New York, 2023, pp. 288. ISBN 978-1-119	8
Atomic model validation using the CCP-EM software suite	8
High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system	8
Errors in structural biology are not the exception	8
XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures	8