OOIR: Observatory of International Research

Papers

(The TQCC of Acta Crystallographica Section D-Structural Biology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
EMhub: a web platform for data management and on-the-fly processing in scientific facilities	534
Using graphlet degree vectors to predict atomic displacement parameters in protein structures	242
Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing	87
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer-specific Tn-MUC1 epitope	64
Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase	59
Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases	53
Data collection from crystals grown in microfluidic droplets	53
X-ray diffraction and in vivo studies reveal the quinary structure of Trypanosoma cruzi nucleoside diphosphate kinase 1: a novel helical oligomer structure	45
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases	44
Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody	40
A scalable strategy to solve structures of PDZ domains and their complexes	40
Structures of permuted halves of a modern ribose-binding protein	40
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites	36
Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals	34
Updated restraint dictionaries for carbohydrates in the pyranose form	31
Crystal structure of DNA polymerase I from Thermus phage G20c	29
Identifying and avoiding radiation damage in macromolecular crystallography	28
On bias, variance, overfitting, gold standard and consensus in single-particle analysis by cryo-electron microscopy	28
A radical approach to radicals	27
A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat	27
Training undergraduate research assistants with an outcome-oriented and skill-based mentoring strategy	26
The crystal structure of the N-terminal domain of the backbone pilin LrpA reveals a new closure-and-twist motion for assembling dynamic pili in Ligilactobacillus ruminis	24
Overall protein structure quality assessment using hydrogen-bonding parameters	23
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent	23
Raw diffraction data are our ground truth from which all subsequent workflows develop	22

Medical contrast agents as promising tools for biomacromolecular SAXS experiments	19
Analysis and validation of overall N-glycan conformation in Privateer	19
Statistical analyses of the oxidized P-clusters in MoFe proteins using the bond-valence method: towards their electron transfer in nitrogenases	18
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor	17
Crystal structure of coagulation factor XII N-terminal domains 1–5	16
Structural and functional analysis of the D-alanyl carrier protein ligase DltA from Staphylococcus aureus Mu50	16
Time-resolved serial femtosecond crystallography on fatty-acid photodecarboxylase: lessons learned	16
A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands	15
Versatile microporous polymer-based supports for serial macromolecular crystallography	15
Structural studies of β-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus	15
Crystal structures of the molecular class A β-lactamase TEM-171 and its complexes with tazobactam	15
Alexei Vagin (1944–2023)	15
On-grid and in-flow mixing for time-resolved cryo-EM	15
Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase	15
Molecular basis of transcriptional repression of anti-CRISPR by anti-CRISPR-associated 2	15
Michael James (1940–2023)	14
Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the discovery of DNA's Double Helix. By Howard Markel. W. W. Norton & Co., 2021. Hardback, pp. 608. ISBN 978-1324002239.	14
Preparation and characterization of inactivated tick-borne encephalitis virus samples for single-particle imaging at the European XFEL	14
The T₂ structure of polycrystalline cubic human insulin	14
Notes of a protein crystallographer: the advantages of combining new integrated methods of structure solution with traditional data visuals	14
Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking	14
Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803	13
Pillar data-acquisition strategies for cryo-electron tomography of beam-sensitive biological samples	13
eSPC: an online data-analysis platform for molecular biophysics	13
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket	13
Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins	13
Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography	12
Thyroxine hormones visualized by the cryo-EM structure of bovine thyroglobulin	12
Submission of structural biology data for review purposes	12
Direct phasing algorithm for protein crystals with high solvent content using low-resolution diffraction data	12
Structural mechanism of Escherichia coli cyanase	12
Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase fromBradyrhizobiumsp.	11
Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin	11
Raynals, an online tool for the analysis of dynamic light scattering	11
The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report	11
Best practices for time-resolved serial synchrotron crystallography	11
Structural and functional characterization of a multi-domain GH92 α-1,2-mannosidase from Neobacillus novalis	11
The LH–DH module of bacterial replicative helicases is the common binding site for DciA and other helicase loaders	11
Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets	11
Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy	10
Dependence of crystallographic atomic displacement parameters on temperature (25–150 K) for complexes of horse liver alcohol dehydrogenase	10
Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization	10
A new inactive conformation of SARS-CoV-2 main protease	10
Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase	10
Knowledge-based prediction of DNA hydration using hydrated dinucleotides as building blocks	10
Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE	10
Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects	10
Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans	9
Accelerating crystal structure determination with iterative AlphaFold prediction	9
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum	9

Correcting systematic errors in diffraction data with modern scaling algorithms	9
Tomo Live: an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows	9
Structural basis for substrate recognition in the Phytolacca americana glycosyltransferase PaGT3	9
New system for archiving integrative structures	9
Buccaneer model building with neural network fragment selection	9
The High-Pressure Freezing Laboratory for Macromolecular Crystallography (HPMX), an ancillary tool for the macromolecular crystallography beamlines at the ESRF	9
Protonation states of hen egg-white lysozyme observed using D/H contrast neutron crystallography	9
Determination of intracellular protein–ligand binding affinity by competition binding in-cell NMR	9
Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding	9
VitroJet: new features and case studies	9
Restoration of the 3D structure of insect flight muscle from a rotationally averaged 2D X-ray diffraction pattern	9
Errors in structural biology are not the exception	8
XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures	8
Atomic model validation using the CCP-EM software suite	8
Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules	8
Dynamics and Kinetics in Structural Biology: Unravelling Function Through Time-Resolved Structural Analysis. By Keith Moffat and Eaton E. Lattman. Wiley, New York, 2023, pp. 288. ISBN 978-1-119	8
Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions	8
The impact of molecular variants, crystallization conditions and the space group on ligand–protein complexes: a case study on bacterial phosphotriesterase	8
Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase	8
High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system	8
Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus	8
Post-translational modifications in the Protein Data Bank	7
Structural and functional analysis of the C-terminal region of Streptococcus gordonii SspB	7
Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies	7
Thermostable homologues of the periplasmic siderophore-binding protein CeuE from Geobacillus stearothermophilus and Parageobacillus thermoglucosidasius	7
Global fitting of multiple data frames from SEC–SAXS to investigate the structure of next-generation nanodiscs	7
Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA	7
Mechanistic insight into O=O bond formation upon model-independent visualization of the coordination geometry and ligand composition of Mn₄Ca cofactor in dark-adapted photosystem II structu	7
Structural features of chloroplast trigger factor determined at 2.6 Å resolution	7
Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2-vWa construct improves crystal order and diffraction limits	7
The CCP4 suite: integrative software for macromolecular crystallography	7
The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report. Corrigendum	7
AutoPX: a new software package to process X-ray diffraction data from biomacromolecular crystals	7
Protein–macrocycle polymorphism: crystal form IV of the Ralstonia solanacearum lectin–sulfonato-calix[8]arene complex	7
Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking byPseudomonas aeruginosa	7
Evaluating the impact of X-ray damage on conformational heterogeneity in room-temperature (277 K) and cryo-cooled protein crystals	7
Probing ligand binding of endothiapepsin by `temperature-resolved' macromolecular crystallography	7
Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography	7
Using deep-learning predictions of inter-residue distances for model validation	7